RESUMEN
Taste changes caused by the use of platinum drugs have been described. However, few studies qualify the impaired tastes and whether these changes are derived exclusively from chemotherapy (QTx). AIMS: Evaluation of changes in sweet, sour, salty, bitter, and umami tastes in patients receiving QTx with platinum drugs was the aim of this study. METHODS: A total of 43 subjects, 21 from the study group and 22 from the control, were studied in two time periods, one before the start of QTx (T0) and another after two cycles of QTx (T1). The usual dietary intake, body mass index (BMI), handgrip strength and fatigue (through the fatigue pictogram) were evaluated to characterize the group studied. Taste Strips tests were performed for all 4 tastes and umami was studied by comparing Likert's scale using monosodium glutamate (GMS) food. Statistical analysis was performed using repeated measures (ANOVA), mixed model, with significance level p≤0.05. RESULTS: Salty and sour were the most affected tastes in the study group (p = 0.001 and 0.05); as well as the ionotropic receptors (p = 0.02) responsible for identifying these tastes. There was a difference between the times for BMI, dynamometry and impact in daily activities, by the fatigue pictogram (p = 0.008, 0.009 and 0.006 respectively). CONCLUSION: These findings suggest an important role in altering taste recognition, mainly in salty and sour tastes, identified by ionotropic receptors, which seems to be related to dietary changes. QTx has demonstrated a contribution to impairment of functionality and fatigue.
Asunto(s)
Antineoplásicos/efectos adversos , Compuestos de Platino/efectos adversos , Trastornos del Gusto/inducido químicamente , Gusto/efectos de los fármacos , Adulto , Anciano , Carboplatino/efectos adversos , Estudios de Casos y Controles , Cisplatino/efectos adversos , Disgeusia/inducido químicamente , Disgeusia/fisiopatología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias/tratamiento farmacológico , Neoplasias/fisiopatología , Oxaliplatino/efectos adversos , Receptores Ionotrópicos de Glutamato/efectos de los fármacos , Receptores Ionotrópicos de Glutamato/fisiología , Receptores de Glutamato Metabotrópico/efectos de los fármacos , Receptores de Glutamato Metabotrópico/fisiología , Gusto/fisiología , Trastornos del Gusto/fisiopatologíaRESUMEN
OBJECTIVE: This study was conducted to evaluate salivary dehydroepiandrosterone (DHEA) levels, salivary flow rate (SFR), depression, and hopelessness in patients with the complaint of burning mouth (BM). STUDY DESIGN: Thirty female patients with BM and 30 age-matched control women without any complaint of burning mouth were enrolled. After anamnesis and oral examination, the salivary flow rate was determined. Depression and hopelessness were evaluated by the application of inventories. Two saliva samples were collected for DHEA analysis. RESULTS: Dysgeusia (P = .045) and xerostomia (P = .003) were significantly higher in the BM group. The BM patients showed significantly lower salivary flow rate, both under stimulation (P = .001) and at rest (P < .001). Significant differences between the groups were not found in the depression (P = .416) or hopelessness (P = .597) scores. The BM group revealed significantly lower salivary DHEA levels in the morning samples (P = .003). CONCLUSION: Patients with BM exhibit decreased morning salivary DHEA as well as dysgeusia and hyposalivation more frequently than control subjects. Additional investigations are needed to clarify this association.
Asunto(s)
Síndrome de Boca Ardiente/metabolismo , Deshidroepiandrosterona/análisis , Saliva/química , Adulto , Anciano , Anciano de 80 o más Años , Síndrome de Boca Ardiente/fisiopatología , Síndrome de Boca Ardiente/psicología , Estudios de Casos y Controles , Ritmo Circadiano , Depresión/psicología , Disgeusia/fisiopatología , Disgeusia/psicología , Femenino , Humanos , Enfermedades de los Labios/metabolismo , Enfermedades de los Labios/fisiopatología , Enfermedades de los Labios/psicología , Persona de Mediana Edad , Moral , Saliva/metabolismo , Tasa de Secreción/fisiología , Método Simple Ciego , Enfermedades de la Lengua/metabolismo , Enfermedades de la Lengua/fisiopatología , Enfermedades de la Lengua/psicología , Xerostomía/fisiopatología , Xerostomía/psicologíaRESUMEN
A number of non-oral causes for oral malodor have been discussed. Several well documented etiologies for non-oral malodor include renal failure, cirrhosis of the liver, and diabetes mellitus. Each of these conditions has been examined using analytical instrumentation. In addition there appear to be several other metabolic conditions involving enzymatic and transport anomalies (such as trimethylaminuria) which lead to the systemic production of volatile malodors that manifest themselves as halitosis and/or altered chemoreception. Our studies include patients who have been referred to us after being examined by numerous clinical specialists with no identification or relief from their problem. This is due in part to the intermittent nature of many of these problems as well as an apparent lack of knowledge concerning many of these metabolic problems and their relation to oral symptoms.