RESUMEN
Relaxation times T1 of normal and abnormal urine samples were measured with a 0.02 tesla MRI device in a spectrometric mode. Protein containing urine from patients with glomerulonephritis showed a slight shortening of T1 relaxation time. Radiographic contrast medium, pH, osmolality or glucose in diabetes did not significantly change the T1 relaxation time of urine. Urine can be used as a T1 relaxation reference in MR imaging of the pelvis even if the patient has received radiographic contrast medium or has diabetes or proteinuria for any reason.
Asunto(s)
Espectroscopía de Resonancia Magnética , Orina/análisis , Diatrizoato/orina , Glucosuria/orina , Humanos , Concentración Osmolar , Proteinuria/orinaRESUMEN
A sensitive, specific, high-performance liquid-chromatographic method for the determination of iosulamide in plasma and urine is described. The method was used to determine pharmacokinetic parameters of iosulamide after intravenous administration to rhesus monkeys. The mean (+/- SE) distribution and disposition half-lives were 0.19 (+/- 0.03) and 1.5 (+/- 0.3) hr, respectively. The mean (+/- SE) model-dependent and model-independent volumes of distribution at steady state were 0.41 +/- (0.078) and 0.49 (+/- 0.039) liters/kg, respectively. Total urinary excretion of iosulamide represented a mean (+/- SE) of 12.5 (+/- 0.6)% of the administered dose and was virtually complete in 3 hr. The results of the pharmacokinetic study indicate that iosulamide is rapidly cleared from the body and that renal clearance is a minor route of elimination from the body.
Asunto(s)
Diatrizoato/análogos & derivados , Animales , Cromatografía Líquida de Alta Presión , Medios de Contraste/metabolismo , Diatrizoato/administración & dosificación , Diatrizoato/sangre , Diatrizoato/orina , Femenino , Semivida , Humanos , Infusiones Parenterales , Cinética , Macaca mulatta , Análisis de RegresiónAsunto(s)
Lesión Renal Aguda/inducido químicamente , Diatrizoato/farmacología , Orina , Lesión Renal Aguda/orina , Angiografía , Animales , Cloruros/orina , Diatrizoato/efectos adversos , Diatrizoato/orina , Diuréticos Osmóticos/farmacología , Perros , Humanos , Yotalamato de Meglumina/farmacología , Concentración Osmolar , Factores de Tiempo , Urografía , Vasopresinas/farmacologíaAsunto(s)
Medios de Contraste/orina , Yodobenzoatos/orina , Ácidos Triyodobenzoicos/orina , Animales , Diatrizoato/orina , Diuresis/efectos de los fármacos , Femenino , Inyecciones Intravenosas , Yodo/orina , Yohexol , Yopamidol , Ácido Yotalámico/análogos & derivados , Ácido Yotalámico/orina , Ácido Yoxáglico , Riñón/metabolismo , Masculino , Metrizamida/orina , Conejos , Espectrometría por Rayos X , Espectrofotometría Ultravioleta , Factores de Tiempo , UrografíaAsunto(s)
Diatrizoato/orina , Adulto , Anciano , Femenino , Humanos , Ácido Yodohipúrico/orina , Lisina , Masculino , Meglumina/orina , Tasa de Depuración Metabólica , Persona de Mediana Edad , SodioRESUMEN
The excretion of sodium and meglumine diatrizoate was examined following one or two weeks of unilateral ureteric occlusion. No difference between the two diatrizoate salts was found. A slow compensatory increase of the function of the intact kidney occurred, but after two weeks it was still insufficient at high blood concentration levels.
Asunto(s)
Diatrizoato de Meglumina/orina , Diatrizoato/análogos & derivados , Diatrizoato/orina , Riñón/fisiopatología , Obstrucción Ureteral/fisiopatología , Animales , Diatrizoato/administración & dosificación , Diatrizoato de Meglumina/administración & dosificación , Inyecciones Intramusculares , Radioisótopos de Yodo , Conejos , Sodio/administración & dosificación , Sodio/orina , Factores de TiempoAsunto(s)
Urografía , Adulto , Factores de Edad , Niño , Medios de Contraste/efectos adversos , Medios de Contraste/sangre , Medios de Contraste/orina , Creatinina/sangre , Diatrizoato/sangre , Diatrizoato/orina , Hipersensibilidad a las Drogas , Humanos , Riñón/diagnóstico por imagen , Enfermedades Renales/diagnóstico por imagen , Trasplante de Riñón , Tomografía por Rayos X , Trasplante Homólogo , Uréter/diagnóstico por imagen , Vejiga Urinaria/diagnóstico por imagen , Urografía/efectos adversos , Urografía/mortalidadRESUMEN
A Gastrografin test is described for diagnosing perforations and dehiscence of anastomoses in the gastro-intestinal tract by carrying out a simple urine analysis. False positive and false negative results can be avoided by obtaining radiographs of urine samples under standard conditions. The accuracy of the method was checked in 97 patients by comparing the results of the urine analysis with radiographic examinations and with the clinical course. From this, it appears that the test is reliable, simple and capable of being used anywhere. The test is therefore recommended a) where there is a lack of radiographic facilities, b) for immobile patients, c) where there is clinical suspicion of a perforation or dehiscence of an anastomosis in the absence of radiographic findings and d) in individual cases where the radiographic changes are positive.