Asunto(s)
Alérgenos/inmunología , Medios de Contraste , Diatrizoato/inmunología , Hipersensibilidad a las Drogas/inmunología , Exantema/inmunología , Hipersensibilidad Tardía/inmunología , Prurito/inmunología , Ácidos Triyodobenzoicos/inmunología , Anciano , Alérgenos/efectos adversos , Medios de Contraste/efectos adversos , Diatrizoato/efectos adversos , Hipersensibilidad a las Drogas/tratamiento farmacológico , Exantema/inducido químicamente , Exantema/tratamiento farmacológico , Femenino , Humanos , Hipersensibilidad Tardía/inducido químicamente , Hipersensibilidad Tardía/tratamiento farmacológico , Melanoma/diagnóstico por imagen , Prurito/inducido químicamente , Prurito/tratamiento farmacológico , Pruebas Cutáneas , Tomografía Computarizada por Rayos X/métodos , Ácidos Triyodobenzoicos/efectos adversosRESUMEN
Among 4178 patients who between 1980 and 1986 had undergone left-heart catheterization with left-heart injections and coronary angiography there were 76 (1.8%) with previous reactions to contrast media. These latter patients were given, three days before the planned investigation, 6 alpha-methylprednisolone, 24 mg daily by mouth, and phenhydramine hydrogenmaleinate, 150 mg daily, and two hours before the investigation 80 mg 6 alpha-methylprednisolone hemisuccinate intravenously. The effect of this prophylactic regimen was tested prospectively. Diatrizoate 76% was the contrast medium used. Of 4102 patients without known contrast-medium intolerance 137 (3.34%) had a reaction, 27 of them (0.66%) severe enough to require treatment. Among the 76 patients with known previous reactions, nine (11.8%) had reactions, one very severe requiring treatment, the others mild. The described pre-injection regimen thus allows indicated left-heart contrast-medium injection to be undertaken at a justifiable risk.
Asunto(s)
Medios de Contraste/inmunología , Angiografía Coronaria , Diatrizoato , Hipersensibilidad a las Drogas/prevención & control , Glucocorticoides/administración & dosificación , Antagonistas de los Receptores Histamínicos H1/administración & dosificación , Cateterismo Cardíaco , Diatrizoato/inmunología , Humanos , Premedicación , RiesgoAsunto(s)
Antígenos/inmunología , Medios de Contraste/inmunología , Diatrizoato de Meglumina/inmunología , Diatrizoato/análogos & derivados , Diatrizoato/inmunología , Animales , Medios de Contraste/efectos adversos , Diatrizoato/efectos adversos , Diatrizoato de Meglumina/efectos adversos , Femenino , Cobayas , Humanos , Ratones , Conejos , Ratas , Ratas EndogámicasRESUMEN
In a further exploration of idiosyncratic reactions to injections of contrast media, a systematic study of immediate or delayed hypersensitivity in guinea pigs injected with contrast media analogs was performed. No evidence of immediate or delayed hypersensitivity could be ascertained to either contrast media analogs alone, or analogs bound to protein carriers. This does not represent conclusive evidence against the notion of antibody formation as a factor in the production of some adverse reactions, but makes such a pathogenesis less likely.