RESUMEN

El síndrome de absorción intravascular en histeroscopia se origina por la rápida absorción vascular de soluciones isotónicas e hipotónicas utilizadas en irrigación intrauterina, ocasionando hipervolemia y dilución de electrolitos, especialmente hiponatremia. Cuando este síndrome es debido a intoxicación por glicina al 1,5% causa acidosis severa y neurotoxicidad. La incidencia de este síndrome es baja pero puede aumentar por factores como: falta de control de altura de bolsas de irrigación, ausencia de equilibrio de fluidos de soluciones de irrigación, tejidos altamente vascularizados como miomas uterinos y uso de sistema de electrocirugía monopolar. Se reporta el caso de una paciente con miomas uterinos, programada para resección mediante histeroscopia que cursa con síndrome de absorción intravascular por glicina, el temprano diagnóstico y rápido tratamiento intraoperatorio y postoperatorio permitió una evolución favorable. El manejo se basó en el uso de diuréticos, restricción de fluidos y soluciones hipertónicas de sodio.

Intravascular absorption syndrome in hysteroscopy is caused by rapid vascular absorption of isotonic and hypotonic solutions used in intrauterine irrigation, causing hypervolemia and electrolyte dilution, especially hyponatremia. When this syndrome is due to 1.5% glycine toxicity, it causes severe acidosis and neurotoxicity. The incidence of this syndrome is low but may increase due to factors such as: lack of control of the height of irrigation bags, lack of fluid balance in irrigation solutions, highly vascularized tissues such as uterine myomas and use of a monopolar electrosurgery system. The case of a patient with uterine myomas, scheduled for resection by hysteroscopy, who presents with intravascular glycine absorption syndrome, is reported. Early diagnosis and rapid intraoperative and postoperative treatment allowed a favorable evolution. Management was based on the use of diuretics, fluid restriction, and hypertonic sodium solutions.

Asunto(s)

RESUMEN

OBJECTIVE: The aim of this study was to analyze the effects of fluid overload related to mechanical ventilation, renal replacement therapy, and evolution to discharge or death in critically ill children. METHODS: A retrospective study in a Pediatric Intensive Care Unit for two years. Patients who required invasive ventilatory support and vasopressor and/or inotropic medications were considered critically ill. RESULTS: 70 patients were included. The mean age was 6.8 ± 6 years. There was a tolerable increase in fluid overload during hospitalization, with a median of 2.45% on the first day, 5.10% on the third day, and 8.39% on the tenth day. The median fluid overload on the third day among those patients in pressure support ventilation mode was 4.80% while the median of those who remained on controlled ventilation was 8.45% (p = 0.039). Statistical significance was observed in the correlations between fluid overload measurements on the first, third, and tenth days of hospitalization and the beginning of renal replacement therapy (p = 0.049) and between renal replacement therapy and death (p = 0.01). The median fluid overload was 7.50% in patients who died versus 4.90% in those who did not die on the third day of hospitalization (p = 0.064). There was no statistically significant association between death and the variables sex or age. CONCLUSIONS: The fluid overload on the third day of hospitalization proved to be a determinant for the clinical outcomes of weaning from mechanical ventilation, initiation of renal replacement therapy, discharge from the intensive care unit, or death among these children.

Asunto(s)

RESUMEN

A dor abdominal no paciente com lúpus eritematoso sistêmico tem amplo espectro clínico, variando desde condições inespecí- ficas, como diarreia e vômitos, até eventos de importante morbi- mortalidade, como o abdome agudo inflamatório e/ou perfura- tivo. A seguir, descreve-se um caso de paciente do sexo feminino, de 23 anos, internada por dor abdominal associada a vômitos e à diarreia crônica e progressiva. Foi diagnosticada com lúpus eritematoso sistêmico há 2 anos. Durante a internação, evoluiu com quadro de abdome agudo, e foi realizada tomografia compu- tadorizada de abdome, revelando importante edema de parede intestinal difuso. Isso, somado a alterações clínico-laboratoriais, permitiu o diagnóstico de enterite lúpica. Foi realizado tratamen- to conservador, com corticoterapia e terapia de suporte com correção de distúrbios eletrolíticos severos, sendo iniciado ciclo- fosfamida, com resolução dos sintomas gastrintestinais.

Abdominal pain in patients with systemic lupus erythematosus has a broad clinical spectrum, ranging from nonspecific symp- toms, such as diarrhea and vomiting, to events of significant morbidity and mortality, such as acute inflammatory and/or per- forating abdomen. This article describes a case of a 23-year-old female patient hospitalized for abdominal pain, associated with vomiting and progressive chronic diarrhea. She was diagnosed with systemic lupus erythematosus 2 years ago. During hospita- lization, the patient progressed with acute abdomen, and an ab- dominal computed tomography scan was performed, revealing major diffuse intestinal wall edema. This, added to clinical and laboratories alterations, allowed the diagnosis of lupus enteritis. A conservative treatment with corticotherapy and supportive therapy with correction of severe electrolyte disturbances were initiated, as well as the prescription of cyclophosphamide, with resolution of gastrointestinal symptoms.

Asunto(s)

RESUMEN

Ascites is a major complication of cirrhosis. There are several evidence-based articles and guidelines for the management of adults, but few data have been published in relation to children. In the case of a pediatric patient with cirrhotic ascites (PPCA), the following questions are raised: How are the clinical assessment and ancillary tests performed? When is ascites considered refractory? How is it treated? Should fresh plasma and platelets be infused before abdominal paracentesis to prevent bleeding? What are the hospitalization criteria? What are the indicated treatments? What complications can patients develop? When and how should hyponatremia be treated? What are the diagnostic criteria for spontaneous bacterial peritonitis? How is it treated? What is hepatorenal syndrome? How is it treated? When should albumin be infused? When should fluid intake be restricted? The recommendations made here are based on pathophysiology and suggest the preferred approach to diagnostic and therapeutic aspects, and preventive care.

La ascitis es una complicación grave de la cirrosis. Existen numerosos artículos y guías basadas en la evidencia para adultos, pero poco se ha publicado para niños. Ante un paciente pediátrico con ascitis secundaria a cirrosis (PPAC), se plantean las siguientes preguntas: ¿Cómo se realiza la evaluación clínica y los exámenes complementarios? ¿Cuándo se considera que la ascitis es refractaria; cómo se trata? ¿Debe infundirse plasma fresco y plaquetas antes de la paracentesis abdominal para evitar el sangrado? ¿Cuáles son los criterios de hospitalización? ¿Cuáles son los tratamientos indicados? ¿Qué complicaciones puede presentar? ¿Cuándo y cómo debe tratarse la hiponatremia? ¿Qué criterios diagnósticos tiene la peritonitis bacteriana espontánea; cómo se trata? ¿Qué es el síndrome hepatorrenal; cómo se trata? ¿Cuándo debe infundirse albúmina? ¿Cuándo debe restringirse el aporte líquido? Las recomendaciones que efectuamos, basadas en la fisiopatología, sugieren el enfoque preferido para encarar sus aspectos diagnósticos, terapéuticos y los cuidados preventivos.

Asunto(s)

RESUMEN

Hypokalemia and hyperkalemia are the most common electrolyte disorders managed in the emergency department. The diagnosis of these potentially life-threatening disorders is challenging due to the often vague symptomatology a patient may express, and treatment options may be based upon very little data due to the time it may take for laboratory values to return. This review examines the most current evidence with regard to the pathophysiology, diagnosis, and management of potassium disorders. In this review, classic paradigms, such as the use of sodium polystyrene and the routine measurement of serum magnesium, are tested, and an algorithm for the treatment of potassium disorders is discussed.

Asunto(s)

Asunto(s)

RESUMEN

Hypokalemia and hyperkalemia are the most common electrolyte disorders managed in the emergency department. The diagnosis of these potentially life-threatening disorders is challenging due to the often vague symptomatology a patient may express, and treatment options may be based upon very little data due to the time it may take for laboratory values to return. This review examines the most current evidence with regard to the pathophysiology, diagnosis, and management of potassium disorders. In this review, classic paradigms, such as the use of sodium polystyrene and the routine measurement of serum magnesium, are tested, and an algorithm for the treatment of potassium disorders is discussed. [Points & Pearls is a digest of Emergency Medicine Practice].

Asunto(s)

RESUMEN

Hydroelectrolytic disorders are one of the most common metabolic complications in cancer patients. Although often metabolic alterations affecting various ions are part of the manifestations of the oncological disease, even in the form of paraneoplastic syndrome, we must not forget that very often, these disorders could be caused by various drugs, including some of the antineoplastic agents most frequently used, such as platin derivatives or some biologics. These guidelines review major management of diagnosis, evaluation and treatment of the most common alterations of sodium, calcium, magnesium and potassium in cancer patients. Aside from life-sustaining treatments, we have reviewed the role of specific drug treatments aimed at correcting some of these disorders, such as intravenous bisphosphonates for hypercalcemia or V2 receptor antagonists in the management of syndrome of inappropriate antidiuretic hormone secretion-related hyponatremia.

Asunto(s)

Asunto(s)

RESUMEN

Dysnatremia is among the most common electrolyte disorders in clinical medicine and its improper management can have serious consequences associated with increased morbidity and mortality of patients. The aim of this study is to update the pathophysiology of dysnatremia and review some simple clinical and laboratory tools, easy to interpret, that allow us to make a quick and simple approach. Dysnatremia involves water balance disorders. Water balance is directly related to osmoregulation. There are mechanisms to maintain plasma osmolality control; which are triggered by 1-2% changes. Hypothalamic osmoreceptors detect changes in plasma osmolality, regulating the secretion of Antidiuretic Hormone (ADH), which travels to the kidneys resulting in more water being reabsorbed into the blood; therefore, the kidney is the main regulator of water balance. When a patient is suffering dysnatremia, it is important to assess how his ADH-renal axis is working. There are causes of this condition easy to identify, however, to differentiate a syndrome of inappropriate ADH secretion from cerebral salt-wasting syndrome is often more difficult. In the case of hypernatremia, to suspect insipidus diabetes and to differentiate its either central or nephrogenic origin is essential for its management. In conclusion, dysnatremia management requires pathophysiologic knowledge of its development in order to make an accurate diagnosis and appropriate treatment, avoiding errors that may endanger the health of our patients.

Asunto(s)

RESUMEN

Acute kidney injury (AKI) is associated with electrolyte and acid-base disturbances such as hyperkalemia, metabolic acidosis, hypocalcemia and hyperphosphatemia. The initiation of dialysis in AKI can efficiently treat these complications. The choice of dialysis modality can be made based on their operational characteristics to tailor the therapy according to the clinical scenario. Each dialysis modality can also trigger significant electrolyte and acid-base disorders, such as hypokalemia, hypophosphatemia and metabolic alkalosis, which may direct changes in fluid delivery and composition. Continuous techniques may be particularly useful in these situations as they allow more time for correction and to maintain balance. This review provides an overview of the electrolyte and acid-base disturbances occurring in AKI and after the initiation of dialysis and discusses therapeutic options in this setting.

Asunto(s)

RESUMEN

In 1954, McKittrick and Wheelock described for the first time a syndrome presenting chronic lost of fluid and electrolytes secondary to chronic diarrhea, associated to large rectal villous adenomas. We report a case of a 75-year-old female who presented chronic diarrhea (3 to 4 depositions per day in the last year), accompanied by acute renal failure. In the rectal tact, we objective the presence of a mass of soft consistency with an irregular surface, occupying approximately two thirds of the circumference, at about 3 cm from the anal margin. It was confirmed by the colonoscopy and the patology was informed as villous adenoma, producing chronic diarrhea or McKittrick-Wheelock syndrome. We decide the surgical approach after the normalization of patient's general status and a proctectomy with coloanal anastomosis was performed. We conclude that we must think about this syndrome in aged patients with chronic diarrhea, alterations of the electrolyte balance and presence of renal failure. Surgery treatment after the replacement of water and electrolytes is the unique curative treatment. The absence of this can cause the death of these patients.

Asunto(s)

RESUMEN

En situaciones de urgencia, la hemodiálisis es la técnica más empleada en pacientes portadores de Insuficiencia Renal Crónica, Insuficiencia Renal Crónica Agudizada y en Insuficiencia Renal Aguda Se realizó un estudio observacional descriptivo de corte transversal. Fueron estudiados todos los pacientes que requirieron hemodiálisis de urgencia en la Unidad de Terapia Intensiva del Instituto de Nefrología Dr. Abelardo Buch, en el período del 1ro. de marzo al 30 de septiembre del 2010, para determinar las causas y para comportamiento de las mismas fueron revisadas todas las historias clínicas y los registros de Enfermería. Se utilizó la técnica estadística de análisis de distribución de frecuencias; absolutas y relativas. De un total de 44 pacientes, predominó el sexo femenino con 54,5 por ciento, la edad mayor de 40 años, 95,5 por ciento, entre 60-69 años, y mayores de 69 años con 25 por ciento respectivamente; la enfermedad de base más frecuente fue la hipertensión arterial. Las causas de indicación de hemodiálisis de urgencia que prevalecieron fueron la hipervolemia (52,2 por ciento) y la hiperazoemia (27,3 por ciento). El 92,9 por ciento de los hemodializados de urgencia no presentaron ninguna complicación durante el proceder. Los resultados expuestos demuestran la experiencia acumulada y calidad de los cuidados que se brindan a estos pacientes en la realización de hemodiálisis de urgencia en nuestro Centro(AU)

All the patients who received urgent hemodialysis at the intensive care unit of the Nephrology Institute Dr Abelardo Buch in the period of March 1st to September 30th 2010 were studied through out an observational descriptive method of transversal cut. Every medical history and nursing register related to these urgent hemodialysis were carefully studied in order to determine the causes that provoked them and their ulterior behavior. It was used the statistical technique of analysis of frequency distributions and the absolute and relative frequencies were calculated. This technique came to show that of 44 patients most of them were female of white race with an age between 40 and 69 years. The most frequent base illness was hypertension. Hypervolemia and Hyperazoemia were the most suggesting causes for urgent hemodialysis. There were not significant complications(AU)

Asunto(s)

RESUMEN

An investigation was made on the effectiveness of using semipermeable membrane on the skin of preterm infants on the evolution of weight loss and blood glucose values, water share, urine specific gravity and sodium. This is an experimental study, of the randomized clinical trial type, carried out from March to August 2008 in the Neonatal Intensive Care Unit of the Teaching Maternity Assis Chateaubriand (TMAC) in the city of Fortaleza-Ceará. The sample consisted of 42 preterm infants. The data were presented in tables and charts. In the application of the semipermeable membrane, the preterm infants of the intervention group (IG) had a decrease in the sodium levels and the daily flow demands, they also presented fewer hyperglycemia episodes and the urinary density was kept within normal patterns. The semipermeable membrane is, in fact, an effective therapeutic resource to minimize transepidermal water losses.

Asunto(s)

RESUMEN

Neste estudo, investigou-se a eficácia do uso da membrana semipermeável na pele de recém-nascido pré-termo sobre a evolução da perda ponderal e valores da glicemia, cota hídrica, densidade urinária e sódio. Estudo experimental, tipo ensaio clínico randomizado, realizado no período de março a agosto de 2008, na Unidade de Terapia Intensiva Neonatal, de uma maternidade pública, na cidade de Fortaleza-Ceará, Brasil. A amostra foi constituída de 42 recém-nascidos pré-termo. Os dados foram apresentados em tabelas e quadros. Na aplicação da membrana semipermeável, os recém-nascidos pré-termos do Grupo de Intervenção tiveram uma diminuição de níveis de sódio e de exigências fluidas diárias, como também apresentaram menores episódios de hiperglicemia e a densidade urinária foi mantida dentro dos padrões de normalidade. A membrana semipermeável é, de fato, um recurso terapêutico eficaz para minimizar as perdas de água transepidérmicas.

An investigation was made on the effectiveness of using semipermeable membrane on the skin of preterm infants on the evolution of weight loss and blood glucose values, water share, urine specific gravity and sodium. This is an experimental study, of the randomized clinical trial type, carried out from March to August 2008 in the Neonatal Intensive Care Unit of the Teaching Maternity Assis Chateaubriand (TMAC) in the city of Fortaleza-Ceará. The sample consisted of 42 preterm infants. The data were presented in tables and charts. In the application of the semipermeable membrane, the preterm infants of the intervention group (IG) had a decrease in the sodium levels and the daily flow demands, they also presented fewer hyperglycemia episodes and the urinary density was kept within normal patterns. The semipermeable membrane is, in fact, an effective therapeutic resource to minimize transepidermal water losses.

Investigar la eficacia del uso de membrana semipermeable en piel de recién nacido prematuro acerca de evolución de pérdida ponderal y valores de glucemia, cota hídrica, densidad urinaria y sodio. Estudio experimental, tipo ensayo clínico randomizado, realizado de marzo a agosto de 2008 en Unidad de Terapia Intensiva Neonatal de una maternidad pública en Fortaleza-Ceará, Brasil. La muestra se constituyó de 42 recién nacidos prematuros. Los datos se presentaron en tablas y cuadros. En aplicación de membrana semipermeable, los recién nacidos prematuros del Grupo de Intervención tuvieron una disminución de niveles de sodio y de exigencias fluidas diarias, también presentaron episodios menores de hiperglucemia y la densidad urinaria se mantuvo dentro de los patrones normales. La membrana semipermeable es, de hecho, un recurso terapéutico eficaz para minimizar las pérdidas de agua transepidérmicas.

Asunto(s)

RESUMEN

Magnesium (Mg) is the main intracellular divalent cation, and under basal conditions the small intestine absorbs 30-50% of its intake. Normal serum Mg ranges between 1.7-2.3 mg/dl (0.75-0.95 mmol/l), at any age. Even though eighty percent of serum Mg is filtered at the glomerulus, only 3% of it is finally excreted in the urine. Altered magnesium balance can be found in diabetes mellitus, chronic renal failure, nephrolithiasis, osteoporosis, aplastic osteopathy, and heart and vascular disease. Three physiopathologic mechanisms can induce Mg deficiency: reduced intestinal absorption, increased urinary losses, or intracellular shift of this cation. Intravenous or oral Mg repletion is the main treatment, and potassium-sparing diuretics may also induce renal Mg saving. Because the kidney has a very large capacity for Mg excretion, hypermagnesemia usually occurs in the setting of renal insufficiency and excessive Mg intake. Body excretion of Mg can be enhanced by use of saline diuresis, furosemide, or dialysis depending on the clinical situation.

Asunto(s)

RESUMEN

BACKGROUND: Hyponatremia is an important cause of morbidity in some groups of hospitalized children. Our aim is to describe the incidence and severity of intraoperative hyponatremia in children undergoing craniofacial surgery, and determine the associated risk factors. METHODS: A descriptive retrospective study of children who underwent primary craniofacial surgery between March 1994 and February 2008 was performed. All administered fluids contained a minimum sodium concentration of 140 mmol.l(-1). Hyponatremia was classified as follows: severe < or =125 mmol.l(-1); moderate 126-130 mmol.l(-1); and, mild 131-134 mmol.l(-1). RESULTS: Hundred and seven cases are reported. Severe, moderate and mild intraoperative hyponatremia occurred in 14 (13%), 21 (19%) and 23 (22%) children respectively. Mannitol was given to 31 (29%) children, but was not associated with the development of hyponatremia. Neither the type nor duration of surgery, type of fluid replacement nor hourly urinary output, was associated with development of hyponatremia. Most episodes of significant intraoperative hyponatremia (44%) were detected between the 2nd and the 4th hour of surgery. There were no identified neurological sequelae (e.g. coma, neurological deficit) attributable to the hyponatremia. CONCLUSION: Despite strict avoidance of low sodium solutions (<140 mmol.l(-1)), hyponatremia occurs frequently in children undergoing craniofacial surgery in our practice; and is unrelated to the administration of mannitol. Although the mechanisms are yet to be determined, anesthesiologists should be aware of this issue and be prepared to monitor and treat this potentially serious complication.

Asunto(s)

Asunto(s)

RESUMEN

Presentamos un caso donde la conexión entre la hiponatremia, la mielinólisis pontina y la rabdomiólisis evidencia la necesidad de que el tratamiento se realice tomando en cuentael carácter agudo o crónico del desequilibrio electrolítico, así como la ponderación adecuada de su expresión clínica. Varón de 41 años que ingresó por vómitos,convulsiones tonicoclónicas generalizadas y rigidez. Al llegar a Urgencias, el paciente estabaestuporoso, con respuestas limitadas alos estímulos dolorosos y una fuerte hipertonía fundamentalmente de la musculatura axial. Ingresó en la Unidad de Cuidados Intensivosy se detectó un desequilibrio electrolíticoimportante, ya que sus cifras de sodio(100 mM/L), potasio (2,5 mM/L) y cloro (65 mM/L) eran inquietantemente bajas, elemento que se asoció al incremento sustancial de losniveles séricos de mioglobina (2.077 ng/L) creatinfosfocinasa (1.401 U/L) y, en menor grado, creatinina (171 mM/L). Una resonancia magnética en corte sagital ponderado en T1 poscontraste y corte axial ponderadoen T2 mostró un área hiperdensa en laprotuberancia dorsomedial, lo que se corresponde con una mielinólisis pontina....

Asunto(s)

RESUMEN

O Triatlon Ironman caracteriza-se por ser uma atividade de resistência constituída por 3,8km de natação, 180km de ciclismo e 42,2km de corrida, no qual o atleta exercita-se, em média, por cerca de 13 horas. Neste contexto, o atleta exposto a tal carga de esforço e adversidades ambientais, experimenta alterações orgânicas agudas em seus sistemas biológicos, incluindo os distúrbios hidroeletrolíticos. O objetivo deste estudo é descrever as alterações hídricas e eletrolíticas encontradas em atletas de triatlon Ironman. De 2002 a 2005 foram avaliados 109 atletas voluntários antes e imediatamente após as provas realizadas em Florianópolis-SC Brasil, com análise sanguínea dos eletrólitos sódio, e potássio, e medida de massa corporal. Os dados do sódio sérico de 89 atletas foram correlacionados com o grau de desidratação e modificações percentuais de peso corporal. Dados de 77 atletas, quanto ao potássio sérico, foram avaliados isoladamente de forma descritiva. Seis atletas (6,7 por cento) apresentaram-se euhidratados ou superhidratados ao final da prova, 50 atletas desidrataram de 0 a 3 por cento (56,2 por cento), 29 de 3 a 6 por cento (32,6 por cento) e 4 atletas (4,5 por cento) desidrataram mais que 6 por cento. Houve uma tendência a ocorrer hiponatremia entre aqueles que desidrataram menos ou ganharam peso. O potássio teve um comportamento dentro dos limites da normalidade em toda amostra. Conclui-se que os distúrbios hidroeletrolíticos (hiponatremia e desidratação) são incidentes nesta modalidade esportiva, sendo a superhidratação a etiologia provável da hiponatremia denotada pelo ganho ou perdas discretas de peso.

The Ironman Triathlon is characterized for being an endurance activity consisting of 3.8 km of swimming, 180 km of cycling and 42.2 km of running, in which the athlete exercises an average of about 13 hours. In this context, the athlete exposed to such load of effort and environmental adversities, experiences acute organic alterations in his biological systems, including hydroelectrolytic disturbs. The objective of this study is to describe the hydric and electrolytic alterations found in Ironman triathlon athletes. From years 2002 to 2005, 109 volunteer athletes have been evaluated before and immediately after the events which took place in Florianópolis-SC Brazil, with blood analysis of sodium and potassium electrolytes, and body mass measurement. Sodium serum data from 89 athletes have been correlated with the degree of dehydration and percentage alterations of body weight. Data of 77 athletes concerning the serum potassium were separately evaluated in a descriptive way. Six athletes (6.7 percent) were euhydrated or superhydrated at the end of the test; 50 athletes were dehydrated from 0 to 3 percent (56.2 percent); 29 from 3 to 6 percent (32.6 percent) and 4 athletes (4.5 percent) were dehydrated more than 6 percent. There was a tendency to hyponatremia among those who had dehydrated less or gained weight. Potassium behaved within the limits of normality in the entire sample. It was concluded that hydroelectrolytic disturbs (hyponatremia and dehydration) are recurrent in this sportive modality, being superhydration the probable etiology of hyponatremia denoted from profit or small weight loss.

Asunto(s)