RESUMEN
BACKGROUND: 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL). OBJECTIVE: To evaluate the effectiveness of 0.5% COL cream versus 5% 5-FU cream in the treatment of CFC. METHOD: This was a randomized, open, self-controlled clinical trial. Forty-five patients (90 forearms), with three to ten actinic keratoses (AK) on each forearm, used 0.5% COL cream 2×/day for seven days on one forearm, and 5% 5-FU cream 2× /day, for 21 days, on the other forearm. The dosages were defined based on previous clinical trials for each drug. Adverse effects were evaluated after 14 days and outcomes after 90 days of inclusion. The primary outcome was complete AK clearance and the secondary outcomes were: partial clearance (≥50%), reduction in AK count, assessment of the Forearm Photoaging Scale (FPS), AK Severity Score (AKSS), and adverse effects. RESULTS: After 90 days, there was complete clearance of AK in 37% (95% CI 24%-49%) and partial clearance in 85% (95% CI 76%-93%) of the forearms treated with 5-FU,versus 17% (95% CI 7%-27%) and 78% (95% CI 66%-88%) for COL (p > 0.07). There was a percentage reduction of 75% in the AK count of the forearms treated with 5-FU (95% CI 66%-83%) and 64% in those treated with COL (95% CI 55%-72%). Regarding FPS and AKSS, there was improvement in both groups, with no difference regarding FPS (p = 0.654), and 5-FU superiority for AKSS (p = 0.012). STUDY LIMITATIONS: Single-center study. CONCLUSIONS: 5-FU and COL are effective for treating CFC, with neither showing superiority regarding the reduction in AK counts.
Asunto(s)
Colchicina , Fluorouracilo , Queratosis Actínica , Crema para la Piel , Humanos , Fluorouracilo/administración & dosificación , Fluorouracilo/efectos adversos , Fluorouracilo/uso terapéutico , Colchicina/administración & dosificación , Colchicina/efectos adversos , Colchicina/uso terapéutico , Queratosis Actínica/tratamiento farmacológico , Masculino , Femenino , Anciano , Resultado del Tratamiento , Persona de Mediana Edad , Crema para la Piel/administración & dosificación , Anciano de 80 o más Años , Administración Cutánea , Antimetabolitos Antineoplásicos/administración & dosificación , Antimetabolitos Antineoplásicos/efectos adversos , Antimetabolitos Antineoplásicos/uso terapéutico , Índice de Severidad de la Enfermedad , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/patología , Factores de TiempoRESUMEN
BACKGROUND: Melasma is a chronic dermatosis that impacts the patient's quality of life and can present considerable challenges in terms of effective treatment. OBJECTIVE: To evaluate the effectiveness, tolerability, and safety of 5% cysteamine combined with 4% nicotinamide in female subjects with melasma. METHODS: This single-center, single-arm, prospective, open-label study evaluated patients with melasma using a combination cream of 5% cysteamine and 4% nicotinamide in a progressive regimen (60 min in the first month, 120 min in the second month, and 180 min in the third month). RESULTS: Overall, 35 treated subjects exhibited reduced modified Melasma Area and Severity Index (mMASI) (p < 0.001) and decreased MelasQoL scores (p < 0.001), accompanied by improved brightness, luminosity, homogeneity, and spot intensity (p < 0.001). Photographic and colorimetric analysis revealed smaller spots and improved homogeneity. LIMITATIONS: Adherence to progressive daily treatment could not be evaluated long-term. CONCLUSION: A combination cream comprising 5% cysteamine and 4% nicotinamide was effective, tolerable, and safe for treating melasma.
Asunto(s)
Cisteamina , Combinación de Medicamentos , Melanosis , Niacinamida , Índice de Severidad de la Enfermedad , Adulto , Femenino , Humanos , Persona de Mediana Edad , Adulto Joven , Administración Cutánea , Cisteamina/administración & dosificación , Cisteamina/efectos adversos , Melanosis/tratamiento farmacológico , Melanosis/diagnóstico , Niacinamida/administración & dosificación , Niacinamida/efectos adversos , Estudios Prospectivos , Calidad de Vida , Crema para la Piel/administración & dosificación , Crema para la Piel/efectos adversos , Resultado del TratamientoRESUMEN
The appearance of skin strongly influences people´s self-esteem and well-being. Among the characteristics that affect the most, we can cite acne and wrinkles. Therefore, minimizing those characteristics by using cosmetics has important value for the consumer. Nowadays, there is a demand for natural ingredients, mainly concerning cosmetic products. The use of clays in beauty care is old, with therapeutic uses since Prehistory. There is an essential advantage in using clays for cosmetic purposes, as it is a low-cost, environmentally friendly, natural, and abundant ingredient, which is chemically inert with a low level of toxicity (when in adequate conditions), easy to apply and remove, dries, and hardens fast. In this research work, we aimed at developing and investigating the effect of formulations containing red, green, and black clays as active components in oiliness reduction, and firmness and elasticity improvement in vivo, as well as characterizing clays mineralogically. All clays presented different compositions. Black clay was the one with the simplest mineralogic content, lowest density, and smallest particle size. It was the richest in Si and Al. Green clay presented expandable smectite and the highest density. Red clay presented the largest particle average size and was the richest in iron content. By thermal analysis, clays presented two characteristic events: the water loss (dehydration) and the dihydroxylation of kaolinite, turning into meta kaolinite. In Sebumetry, clays showed a significant reduction of skin oiliness on the forehead in both concentrations after 2h of contact compared to control, baseline, and placebo. However, after 4h (2h after removal), no significant difference was observed with the control. In the Cutometry, clays did not present significant efficacy in skin firmness and elasticity improvement when compared to control and placebo sites, thus, further studies should be performed comparing the efficacy of different vehicles with dispersed clays. Finally, clay mask formulations were developed with black, red, and green clay dispersed in an oil-free gel vehicle, which proved to be adequate for oily skin
A aparência da pele influencia fortemente autoestima e o bem-estar das pessoas. Dentre as características que mais afetam podemos citar acne e rugas. Portanto, minimizar estas características com o uso de cosméticos tem um valor importante para o consumidor. Atualmente existe uma procura por ingredientes naturais, principalmente no que diz respeito a produtos cosméticos. O uso das argilas nos cuidados de beleza é antigo, com usos terapêuticos desde a Pré-História. Há uma vantagem essencial na utilização de argilas para fins cosméticos, pois é um ingrediente de baixo custo, ecologicamente correto, natural, e abundante, que é quimicamente inerte e tem baixo nível de toxicidade (quando usado em condições adequadas), fácil de aplicar e remover, seca, e endurece rapidamente. Neste trabalho de pesquisa, objetivamos desenvolver e investigar o efeito de formulações contendo argilas vermelha, verde e preta como componentes ativos na redução da oleosidade e na melhoria da firmeza e elasticidade in vivo, bem como caracterizar mineralogicamente as argilas. Todas as argilas apresentaram diferentes composições. A argila preta foi a de conteúdo mineralógico mais simples, mais baixa densidade, e menor tamanho de partícula. Foi a mais rica em Si e Al. A argila verde apresentou esmectita expansível e mais alta densidade. A argila vermelha apresentou o maior tamanho médio de partícula e foi a mais rica em ferro. Segundo a análise térmica, as argilas apresentaram dois eventos característicos: a perda de água (desidratação) e a desidroxilação da caulinita, transformando-se em meta-caulinita. Na Sebumetria, as argilas demonstraram significativa redução na oleosidade da pele na testa em ambas as concentrações após 2h de contato comparada ao controle, basal e placebo. Porém, após 4h (2h após remoção), nenhuma diferença significativa foi observada com o controle. Na Cutometria, as argilas não apresentaram Eficácia significativa na melhora da firmeza e elasticidade quando comparadas aos sítios controle e placebo, portanto, mais estudos devem ser realizados comparando a eficácia de diferentes veículos com argilas dispersas. Finalmente, as formulações de máscaras de argilas foram desenvolvidas com argilas preta, vermelha e verde dispersas em um veículo em gel livre de oleosidade, o qual provou ser adequado para pele oleosa
Asunto(s)
Arcilla/clasificación , Máscaras Faciales , Crema para la Piel/análisis , Acné Vulgar/patología , Cosméticos/efectos adversos , Evaluación de Eficacia-Efectividad de IntervencionesRESUMEN
Background: 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL). Objective: To evaluate the effectiveness of 0.5% COL cream versus 5% 5-FU cream in the treatment of CFC. Method: This was a randomized, open, self-controlled clinical trial. Forty-five patients (90 forearms), with three to ten actinic keratoses (AK) on each forearm, used 0.5% COL cream 2×/day for seven days on one forearm, and 5% 5-FU cream 2× /day, for 21 days, on the other forearm. The dosages were defined based on previous clinical trials for each drug. Adverse effects were evaluated after 14 days and outcomes after 90 days of inclusion. The primary outcome was complete AK clearance and the secondary outcomes were: partial clearance (≥50%), reduction in AK count, assessment of the Forearm Photoaging Scale (FPS), AK Severity Score (AKSS), and adverse effects. Results: After 90 days, there was complete clearance of AK in 37% (95% CI 24%49%) and partial clearance in 85% (95% CI 76%93%) of the forearms treated with 5-FU,versus 17% (95% CI 7%27%) and 78% (95% CI 66%88%) for COL (p > 0.07). There was a percentage reduction of 75% in the AK count of the forearms treated with 5-FU (95% CI 66%83%) and 64% in those treated with COL (95% CI 55%72%). Regarding FPS and AKSS, there was improvement in both groups, with no difference regarding FPS (p = 0.654), and 5-FU superiority for AKSS (p = 0.012). Study limitations: Single-center study.
Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Neoplasias Cutáneas/terapia , Colchicina/administración & dosificación , Queratosis Actínica/terapia , Fluorouracilo/administración & dosificación , Antimetabolitos Antineoplásicos/administración & dosificación , Resultado del Tratamiento , Crema para la Piel/uso terapéuticoRESUMEN
Abstract The locust bean gum (LBG) is a polysaccharide with thickening, stabilizing and gelling properties and it has been used in the preparation of pharmaceutical formulations. Hydrogels (HGs) are obtained from natural or synthetic materials that present interesting properties for skin application. This study aimed to develop HGs from LBG using indole-3-carbinol (I3C) as an asset model for cutaneous application. HGs were prepared by dispersing LBG (2%, 3% and 4% w/v) directly in cold water. The formulations showed content close to 0.5 mg/g (HPLC) and pH ranging from 7.25 to 7.41 (potentiometry). The spreadability factor (parallel plate method) was inversely proportional to LBG concentration. The rheological evaluation (rotational viscometer) demonstrated a non-Newtonian pseudoplastic flow behavior (Ostwald De Weale model), which is interesting for cutaneous application. The HET-CAM evaluation showed the non-irritating characteristic of the formulations. The bioadhesive potential demonstrated bioadhesion in a concentration-dependent manner. Permeation in human skin using Franz cells showed that the highest LBG concentration improved the skin distribution profile with greater I3C amounts in the viable skin layers. The present study demonstrated the feasibility of preparing HGs with LBG and the formulation with the highest polymer concentration was the most promising to transport active ingredients through the skin.
Asunto(s)
Polisacáridos/análisis , Goma/análisis , Hidrogeles/análisis , Potenciometría/instrumentación , Preparaciones Farmacéuticas/administración & dosificación , Cromatografía Líquida de Alta Presión/métodos , Crema para la Piel/clasificaciónRESUMEN
Abstract Because it promotes the lightening of pigment spots, tyrosinase inhibition is one of the mechanisms of depigmenting cosmetic products. Considering the adverse effects produced by synthetic depigmenting actives, the search for new therapeutic options is desirable, and plant extracts are possible candidates for hyperpigmentation treatment. Glycolic extracts of Cecropia pachystachya Trécul are, therefore, the focus of this study. Its chemical characterization, antioxidant activity, tyrosinase inhibition, and cell viability were evaluated. Glycolic extracts were obtained by macerating the leaves of C. pachystachya in grain alcohol and glycerin or propylene glycol. Both had a similar chemical constitution, the glycerin being more efficient in concentrating phenolic compounds and flavonoids. Analyses by UHPLC-MS detected quinic acid, chlorogenic acid isomers, proanthocyanidin dimers type B and C, catechin/epicatechin, orientin/isoorientin, isoorientin 2"-O-xyloside, vitexin/isovitexin, and rutin. 5-O-caffeoylquinic acid was then quantified was then quantified, with predominance in the extract produced with propylene glycol. These extracts showed a high antioxidant capacity by the method of DPPH, ß-carotene, and nitric oxide. As for depigmenting activity, both extracts were able to inhibit tyrosinase. Cell viability assay also revealed that the extracts could safely be used in concentrations of ≤ 125 µg/mL. Thus, this study demonstrated for the first time that the glycolic extracts of C. pachystachya have promising chemical and biological characteristics for the development of a multifunctional cosmetic with antioxidant and tyrosinase-inhibition activities
Asunto(s)
Cosméticos/clasificación , Cecropia/efectos adversos , Blanqueadores/clasificación , Crema para la Piel/análisis , Extractos Vegetales/efectos adversos , Antioxidantes/farmacologíaRESUMEN
UVB radiation-mediated inflammation and the oxidative process involve the transient receptor potential vanilloid 1 (TRPV1) channel activation in neuronal and non-neuronal cells. Once diosmetin has been identified as a novel TRPV1 antagonist, we evaluated the action of diosmetin from the inflammatory [ear oedema, myeloperoxidase (MPO) activity, histological changes, and cytokines levels] and oxidative [nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and SOD activities] parameters in mice exposed to UVB radiation (0.5 j/cm2). We also verified the action of diosmetin on UVB radiation-induced inflammatory parameters after cutaneous nerve fibers denervation by RTX (50 µg/kg s.c.). The topical treatment with the novel TRPV1 antagonist, diosmetin (1%; 15 mg/ear), reduced ear oedema, MPO activity, and MIP-2 and IL-1ß cytokines levels by 82 ± 8%, 59 ± 10%, 40 ± 12%, and 85 ± 9%, respectively. The action of diosmetin on ear oedema and inflammatory cell infiltration was histologically confirmed. Topical diosmetin (1%) also reduced NADPH oxidase activity by 67 ± 10% and reverted SOD activity by 81 ± 13%. After cutaneous nerve fibers denervation using RTX, diosmetin reduced ear oedema, but not the inflammatory cell infiltration in mice exposed to UVB radiation. Diosmetin can be a promising molecule against skin inflammatory disorders as a result of sunburn induced by UVB radiation exposure.
Asunto(s)
Flavonoides/administración & dosificación , Piel/efectos de los fármacos , Piel/efectos de la radiación , Quemadura Solar/tratamiento farmacológico , Canales Catiónicos TRPV/antagonistas & inhibidores , Rayos Ultravioleta/efectos adversos , Animales , Relación Dosis-Respuesta a Droga , Inflamación/tratamiento farmacológico , Inflamación/metabolismo , Masculino , Ratones , Piel/metabolismo , Crema para la Piel/administración & dosificación , Quemadura Solar/metabolismo , Canales Catiónicos TRPV/metabolismoRESUMEN
Hesperidin, a secondary orange (Citrus sinensis) metabolite, was extracted from orange bagasse. No organic solvents or additional energy consumption were used in the clean and sustainable process. Hesperidin purity was approximately 98% and had a yield of 1%. Hesperidin is a known supplement due to antioxidant, chelating, and anti-ageing properties. Herein, hesperidin application to eliminate dark eye circles, which are sensitive and thin skin regions, was studied. In addition, the proposed method for its aqueous extraction was especially important for human consumption. Further, the most effective methods for hesperidin nanonization were explored, after which the nanoemulsions were incorporated into a cream formulation that was formulated for a tropical climate. Silky cream formulations (oil in water) were tested in vitro on artificial 3D skin from cultured cells extracted from skin residues after plastic surgery. The proposed in vitro assay avoided tests of the different formulations in human volunteers and animals. It was shown that one of the nanonized hesperidin formulations was the most skin-friendly and might be used in cosmetics.
Asunto(s)
Envejecimiento/fisiología , Hesperidina/aislamiento & purificación , Hesperidina/farmacología , Nanopartículas/química , Envejecimiento/efectos de los fármacos , Quelantes/farmacología , Colagenasas/metabolismo , Emulsiones/química , Hesperidina/química , Hesperidina/toxicidad , Humanos , Masculino , Nanopartículas/ultraestructura , Tamaño de la Partícula , Crema para la Piel/farmacología , Espectrometría de Fluorescencia , Espectroscopía Infrarroja por Transformada de Fourier , Electricidad Estática , TermodinámicaRESUMEN
OBJECTIVES: A previous study reported that the hexane fraction (HF) obtained from Pereskia aculeata leaves showed promising topical anti-inflammatory activity. Intending its future use in clinical practice, a herbal medicine cream named INFLATIV was developed. Its anti-inflammatory and antipsoriatic potential were investigated. INFLATIV was subjected to preliminary accelerated stability tests and to a degradation profile assessment. METHODS: INFLATIV was prepared at 6% and 12%. The anti-inflammatory activity was assessed by croton oil single and multiple application challenge in mice. Mouse tail test was used for antipsoriatic potential investigation. Cutaneous atrophy test was performed. Preliminary accelerated stability tests were performed together with a degradation profile by GC-MS analysis. KEY FINDINGS: The anti-inflammatory activity shown by INFLATIV was comparable to dexamethasone. However, the skin atrophy caused by that drug was not observed. INFLATIV modified skin parakeratotic differentiation into orthokeratosis, which revealed its antipsoriatic potential. The ingredients used were suitable to carry the bioactives as they were well permeated by the skin. The preliminary accelerated stability tests indicated that INFLATIV 6% is more stable than 12%. CONCLUSIONS: The results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies.
Asunto(s)
Antiinflamatorios/administración & dosificación , Cactaceae , Edema/prevención & control , Extractos Vegetales/administración & dosificación , Psoriasis/tratamiento farmacológico , Piel/efectos de los fármacos , Administración Cutánea , Animales , Antiinflamatorios/aislamiento & purificación , Antiinflamatorios/metabolismo , Cactaceae/química , Aceite de Crotón , Modelos Animales de Enfermedad , Edema/inducido químicamente , Edema/metabolismo , Edema/patología , Masculino , Ratones , Permeabilidad , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/metabolismo , Hojas de la Planta , Psoriasis/metabolismo , Psoriasis/patología , Piel/metabolismo , Piel/patología , Absorción Cutánea , Crema para la PielRESUMEN
Abstract Background: Higher skin pH in atopic dermatitis contributes to impaired epidermal barrier. A moisturizer compatible with physiological pH could improve atopic dermatitis. Objective: To determine the effect of a physiologically compatible pH moisturizer in atopic dermatitis. Methods: A randomized half body, double blind, controlled trial involving patients with stable atopic dermatitis was performed. pH-modified moisturizer and standard moisturizer were applied to half body for 6 weeks. Results: A total of 6 (16.7%) males and 30 (83.3%) females participated. Skin pH reductions from week 0, week 2 and 6 were significant at the forearms (5.315 [0.98] to 4.85 [0.54] to 5.04 [0.78], p = 0.02) and abdomen (5.25 [1.01], 4.82 [0.64], 5.01 [0.59], p = 0.00) but not at the shins (5.01 [0.80], 4.76 [0.49], 4.85 [0.79], p = 0.09) with pH-modified moisturizer. Transepidermal water loss (TEWL) at the forearms decreased (4.60 [2.55] to 3.70 [3.10] to 3.00 [3.55], p = 0.00), abdomen (3.90 [2.90] to 2.40 [3.45] to 2.70 [2.25], p = 0.046). SCORAD improved from 14.1 ± 12.75 to 10.5 ± 13.25 to 7 ± 12.25, p = 0.00. In standard moisturizer group, pH reductions were significant at the forearms (5.29 [0.94] to 4.84 [0.55] to 5.02 [0.70], p = 0.00) and abdomen (5.25 [1.09], 4.91 [0.63], 5.12 [0.66], p = 0.00). TEWL at the forearm were (4.80 [2.95], 4.10 [2.15], 4.60 [3.40], p = 0.67), shins (3.80 [1.40], 3.50 [2.35], 4.00 [2.50], p = 0.91) and abdomen (3.70 [2.45], 4.10 [3.60], 3.40 [2.95], p = 0.80). SCORAD improved from 14.2 ± 9.1 to 10.9 ± 10.65 to 10.5 ± 11, p = 0.00. Reduction in pH was observed with both moisturizers while TEWL significantly improved with pH-modified moisturizer. pH-modified moisturizer resulted in greater pH, TEWL and SCORAD improvements however the differences were not significant from standard moisturizer. Study limitation: Skin hydration was not evaluated. Conclusion: Moisturization is beneficial for atopic dermatitis; use of physiologically compatible pH moisturizer is promising.
Asunto(s)
Humanos , Masculino , Femenino , Niño , Adolescente , Adulto , Adulto Joven , Dermatitis Atópica/tratamiento farmacológico , Fármacos Dermatológicos/uso terapéutico , Fármacos Dermatológicos/química , Crema para la Piel/uso terapéutico , Crema para la Piel/química , Valores de Referencia , Factores de Tiempo , Índice de Severidad de la Enfermedad , Método Doble Ciego , Resultado del Tratamiento , Estadísticas no Paramétricas , Epidermis/efectos de los fármacos , Epidermis/química , Concentración de Iones de Hidrógeno , Persona de Mediana EdadRESUMEN
BACKGROUND: Higher skin pH in atopic dermatitis contributes to impaired epidermal barrier. A moisturizer compatible with physiological pH could improve atopic dermatitis. OBJECTIVE: To determine the effect of a physiologically compatible pH moisturizer in atopic dermatitis. METHODS: A randomized half body, double blind, controlled trial involving patients with stable atopic dermatitis was performed. pH-modified moisturizer and standard moisturizer were applied to half body for 6 weeks. RESULTS: A total of 6 (16.7%) males and 30 (83.3%) females participated. Skin pH reductions from week 0, week 2 and 6 were significant at the forearms (5.315 [0.98] to 4.85 [0.54] to 5.04 [0.78], p=0.02) and abdomen (5.25 [1.01], 4.82 [0.64], 5.01 [0.59], p=0.00) but not at the shins (5.01 [0.80], 4.76 [0.49], 4.85 [0.79], p=0.09) with pH-modified moisturizer. Transepidermal water loss (TEWL) at the forearms decreased (4.60 [2.55] to 3.70 [3.10] to 3.00 [3.55], p=0.00), abdomen (3.90 [2.90] to 2.40 [3.45] to 2.70 [2.25], p=0.046). SCORAD improved from 14.1±12.75 to 10.5±13.25 to 7±12.25, p=0.00. In standard moisturizer group, pH reductions were significant at the forearms (5.29 [0.94] to 4.84 [0.55] to 5.02 [0.70], p=0.00) and abdomen (5.25 [1.09], 4.91 [0.63], 5.12 [0.66], p=0.00). TEWL at the forearm were (4.80 [2.95], 4.10 [2.15], 4.60 [3.40], p=0.67), shins (3.80 [1.40], 3.50 [2.35], 4.00 [2.50], p=0.91) and abdomen (3.70 [2.45], 4.10 [3.60], 3.40 [2.95], p=0.80). SCORAD improved from 14.2±9.1 to 10.9±10.65 to 10.5±11, p=0.00. Reduction in pH was observed with both moisturizers while TEWL significantly improved with pH-modified moisturizer. pH-modified moisturizer resulted in greater pH, TEWL and SCORAD improvements however the differences were not significant from standard moisturizer. STUDY LIMITATION: Skin hydration was not evaluated. CONCLUSION: Moisturization is beneficial for atopic dermatitis; use of physiologically compatible pH moisturizer is promising.
Asunto(s)
Dermatitis Atópica/tratamiento farmacológico , Fármacos Dermatológicos/química , Fármacos Dermatológicos/uso terapéutico , Crema para la Piel/química , Crema para la Piel/uso terapéutico , Adolescente , Adulto , Niño , Método Doble Ciego , Epidermis/química , Epidermis/efectos de los fármacos , Femenino , Humanos , Concentración de Iones de Hidrógeno , Masculino , Persona de Mediana Edad , Valores de Referencia , Índice de Severidad de la Enfermedad , Estadísticas no Paramétricas , Factores de Tiempo , Resultado del Tratamiento , Adulto JovenRESUMEN
OBJECTIVES: In a longitudinal case-control observational study, we evaluated the benefits of a self-management programme for hands developed for patients with SSc. METHODS: Patients with SSc included in the intervention group (IG) received a concise self-management programme with emphasis on hand exercises and were evaluated during 24 weeks regarding hand pain, hand function, range of motion, grip and tip and key pinch strength. Results were compared with a control group (CG) with no intervention using an analysis of variance for repeated measures with variables transformed into ranks (P ≤ 0.05). Effect sizes were calculated using Cohen's test. RESULTS: Of 90 patients who were evaluated, seven were excluded at enrolment and 26 were excluded during the follow-up. Data from 57 subjects (IG 40, CG 17) were used for analysis. Groups were similar at baseline, except for the Scleroderma HAQ and tip and key pinch strength. Outcome improvements were noted only in the IG (P ≤ 0.05, large effect size). In the CG, variables did not change or had even worsened (hand grip strength and finger motion). CONCLUSIONS: This self-management programme based on hand exercises for SSc resulted in pain reduction and hand function, strength and range of motion improvement. It can be a simple and useful intervention, especially when a regular rehabilitation programme is not available.
Asunto(s)
Terapia por Ejercicio/métodos , Mano , Esclerodermia Sistémica/rehabilitación , Automanejo/métodos , Adulto , Anciano , Análisis de Varianza , Estudios de Casos y Controles , Femenino , Fuerza de la Mano , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Dolor/rehabilitación , Dimensión del Dolor/métodos , Evaluación de Programas y Proyectos de Salud , Rango del Movimiento Articular , Crema para la Piel/administración & dosificación , Resultado del TratamientoRESUMEN
BACKGROUND: The aim of this study was to evaluate the effects of capsaicin (Cap), moderate exercise (Ex), and their combination on arterial blood pressure (BP) and metabolic complications in hypoestrogenic (HE) obese (HEOb) rats. Female Wistar rats were ovariectomized and given 300 g L-1 sucrose solution (HEOb), or purified water (HE) ad libitum, for 28 weeks. After shaving the abdominal skin, cold cream vehicle was applied to sedentary (Sed) and exercise (Ex) groups, and 0.75 g kg-1 Cap cream was applied to Ex groups. Ex groups ran on a treadmill every day for 20 min at speeds from 0.15 to 0.3 m s-1 . For combination groups (Cap + Ex), topical Cap was applied 90 min before Ex. The treatments were performed for 6 weeks, and BP was recorded before and at the end of the experimental protocol. The animals were killed by decapitation, and blood and tissues were obtained to perform oxidative profile, as well as to undertake biochemical and histologic studies. RESULTS: Compared with individual treatments, the combined therapy (Cap + Ex) in HEOb rats caused a higher reduction in the caloric intake, body weight, abdominal fat percentage, oxidative stress, and hepatic steatosis. In HEOb groups, Cap was the only treatment that reduced BP and prevented dyslipidemia and oxidative stress. CONCLUSION: The present data show that Cap improves the metabolic alterations induced by obesity and hypoestrogenism, suggesting that Cap can be considered as an excellent candidate for therapy of these clinical conditions. © 2020 Society of Chemical Industry.
Asunto(s)
Capsaicina/administración & dosificación , Dislipidemias/prevención & control , Estrógenos/sangre , Terapia por Ejercicio , Hígado Graso/prevención & control , Obesidad/complicaciones , Obesidad/terapia , Animales , Presión Sanguínea/efectos de los fármacos , Terapia Combinada , Femenino , Humanos , Masculino , Obesidad/sangre , Obesidad/tratamiento farmacológico , Ratas , Ratas Wistar , Crema para la Piel/administración & dosificaciónRESUMEN
Prosopis juliflora is an invasive plant distributed throughout the world and presents metabolites of interest for cosmetology. The aim of this work was to develop a new polysaccharide-based ingredient from P. juliflora and analyze its application in a solid core formulation that upon contact with water instantly forms a gel to improve moisturizing and anti-aging skin properties. Purified extracts by gel chromatography were characterized by NMR and LC-DAD-MS-MS. The in vitro and in vivo safety, antioxidant activity, formulation development and clinical evaluation were performed. The extract was characterized as containing an α-glucan and phenolics. It was non-cytotoxic, non-phototoxic and no skin reactions were observed in vivo. Antioxidant activity were present through different mechanisms. Clinical evaluation reinforced the potential of P. juliflora in skin hydration and microrelief improvement. This innovative form proved to be a prototype of a new product and the first study of an α-glucan as a cosmetic ingredient.
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Antioxidantes/farmacología , Geles/farmacología , Extractos Vegetales/farmacología , Prosopis/química , Crema para la Piel/farmacología , Adulto , Anciano , Animales , Antioxidantes/química , Antioxidantes/aislamiento & purificación , Antioxidantes/toxicidad , Células 3T3 BALB , Femenino , Flavonoides/química , Flavonoides/aislamiento & purificación , Flavonoides/farmacología , Flavonoides/toxicidad , Frutas/química , Geles/química , Geles/aislamiento & purificación , Geles/toxicidad , Glucanos/química , Glucanos/aislamiento & purificación , Glucanos/farmacología , Glucanos/toxicidad , Humanos , Masculino , Ratones , Persona de Mediana Edad , Fenoles/química , Fenoles/aislamiento & purificación , Fenoles/farmacología , Fenoles/toxicidad , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/toxicidad , Piel/efectos de los fármacos , Crema para la Piel/química , Adulto JovenRESUMEN
Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as physical approaches, is considered complex and ineffective due to the high rate of relapses. Thus, new strategies are needed to manage CBM; in this regard, the present work reports the evolution of lesions in patients successfully treated with imiquimod. Of note, classic treatment was not effective in healing the lesions of two of them, but single topical treatment with imiquimod healed the lesions.
Asunto(s)
Cromoblastomicosis/tratamiento farmacológico , Fonsecaea/aislamiento & purificación , Imiquimod/administración & dosificación , Crema para la Piel/administración & dosificación , Adulto , Brasil , Cromoblastomicosis/diagnóstico , Cromoblastomicosis/microbiología , Cromoblastomicosis/patología , Mano , Humanos , Masculino , Persona de Mediana Edad , Piel/microbiología , Piel/patología , Resultado del TratamientoRESUMEN
BACKGROUND: Facial chemical exfoliation (peeling) involves using a chemical agent to insult the skin and damage the cutaneous barrier, to reduce the signs of aging. The use of a moisturizer is advised postprocedure to promote repair of the epidermis. Biomimic moisturizer formulations may be effective treatment options for repair following facial peeling. AIMS: The aim of this study was to assess the local tolerance and cosmetic efficacy of three topical moisturizers (Physiogel® moisturizing creams), used after a 70% glycolic acid facial peel. METHODS: Three randomized, evaluator-blind, parallel group studies were performed. Subjects were healthy females aged 30-60 years with moderate to advanced photoaged skin (Glogau photoaging type II-III). All included a screening visit, a 7-day washout period, a 70% glycolic acid facial peeling procedure, and randomization to a 14-day treatment period with one of the three test products vs control. RESULTS: The primary endpoint was reached in all three studies; all completed subjects in the test groups received a favorable dermatologist global assessment score for tolerance at Day 14 (postchemical peel). Secondary assessments of local tolerance based on dermatologist and subject self-assessment scores demonstrated improvements from baseline. No treatment-related adverse events were reported in any study. Benefits for the test products were also observed in secondary efficacy analyses of transepidermal water loss and moisturization. CONCLUSIONS: These studies have demonstrated the local tolerance and cosmetic efficacy of three moisturizing skin care products, when used for skin recovery after superficial chemical peeling on the face.
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Quimioexfoliación/efectos adversos , Epidermis/efectos de los fármacos , Glicolatos/efectos adversos , Envejecimiento de la Piel/efectos de los fármacos , Crema para la Piel/administración & dosificación , Administración Cutánea , Adulto , Quimioexfoliación/métodos , Cara , Femenino , Humanos , Masculino , Persona de Mediana Edad , Rejuvenecimiento , Resultado del Tratamiento , Pérdida Insensible de Agua/efectos de los fármacosRESUMEN
BACKGROUND: All over the world, people face the same skin problems. However, their skin characteristics are different. Thus, it is a challenge to prescribe treatments that will be effective on different skin types. Therefore, it is very important to consider the skin biology when indicating a dermocosmetic treatment. OBJECTIVES: To assess skin biophysical parameters in French and Brazilian subjects and to verify the efficacy of four dermocosmetic treatments in these populations. METHODS: Five test areas were defined on each volar forearm of the eighteen Brazilian and eighteen French participants using a randomized design. Biophysical measurements in terms of skin hydration, skin barrier function, skin brightness, and skin viscoelasticity were performed before and after 60 minutes of treatment. RESULTS: Skin biophysical differences between populations were found. French skin has been shown to be more hydrated regarding epidermal mechanic properties and stratum corneum water content and more radiant when compared with Brazilian skin. However, it showed more signs of cutaneous aging and fatigue effects on skin. The Brazilian skin showed better skin barrier function. In addition, the treatments were effective in both populations. CONCLUSIONS: Despite the differences found in French and Brazilian skin, the proposed dermocosmetic treatments showed effective in both populations.
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Blanqueadores/administración & dosificación , Técnicas Cosméticas , Envejecimiento de la Piel/efectos de los fármacos , Crema para la Piel/administración & dosificación , Piel/efectos de los fármacos , Adulto , Brasil , Elasticidad/efectos de los fármacos , Elasticidad/fisiología , Francia , Geografía , Humanos , Piel/química , Envejecimiento de la Piel/fisiología , Resultado del Tratamiento , Viscosidad/efectos de los fármacos , Pérdida Insensible de Agua/efectos de los fármacos , Pérdida Insensible de Agua/fisiología , Adulto JovenRESUMEN
Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation. (AU)
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Animales , Ratones , Úlceras Bucales/terapia , Curcuma , Medicamento Fitoterápico , Crema para la Piel/uso terapéuticoRESUMEN
Ochronosis is a cutaneous disorder caused by the accumulation of phenols, either endogenously as homogentisic acid in patients with alkaptonuria (autosomal recessive disorder with deficiency of the enzyme homogentisic acid oxidase), or exogenously in patients using phenol products such as topical creams containing hydroquinone or the intramuscular application of antimalarial drugs. Exogenous ochronosis (EO) typically affects the face and was reported in patients with dark skin such as Black South Africans or Hispanics who use skin-lightening products containing hydroquinone for extended periods. Recently more cases have been reported worldwide even in patients with lighter skin tones, to include Eastern Indians, Asians, and Europeans. However, just 39 cases of EO have been reported in the US literature from 1983 to 2020. Here we present two cases; a 69 and a 45-year-old female who were seen for melasma, given hydroquinone 4% cream daily and tretinoin 0.05%. Both patients noticed brown spots on their cheeks, which progressively enlarged and darkened in color. The diagnosis of ochronosis was confirmed by characteristic histopathological features on the punch biopsy. Unfortunately, neither patient responded to multiple treatments (to include, tazarotene 0.1% gel and pimecrolimus ointment, topical corticosteroids, and avoidance of hydroquinone containing products). We also present a case of classic (endogenous) ochronosis in a patient with alkaptonuria to picture the histological similarities of these two entities. EO is an important clinical consideration because early diagnosis and treatment may offer the best outcome for this notoriously refractory clinical diagnosis.