RESUMEN
Lipoblastoma-like tumor is a very rare mesenchymal tumor believed to be restricted to female patients and only recently reported in the spermatic cord of a male patient. We describe herein an additional case of lipoblastoma-like tumor occurring in the spermatic cord, describing its histopathological, immunohistochemical, and molecular features.
Asunto(s)
Neoplasias de los Genitales Masculinos/patología , Lipoblastoma/patología , Cordón Espermático/patología , Adolescente , Biomarcadores de Tumor/análisis , Biomarcadores de Tumor/genética , Neoplasias de los Genitales Masculinos/química , Neoplasias de los Genitales Masculinos/genética , Neoplasias de los Genitales Masculinos/cirugía , Humanos , Inmunohistoquímica , Lipoblastoma/química , Lipoblastoma/genética , Lipoblastoma/cirugía , Masculino , Técnicas de Diagnóstico Molecular , Cordón Espermático/química , Cordón Espermático/cirugíaRESUMEN
OBJECTIVE: To study the clinicopathologic features and differential diagnosis of solitary fibrous tumor (SFT) in the urogenital system. METHODS: The clinical data and pathologic characteristics of eight cases of SFT in the urogenital system were analyzed, and the relevant literature was reviewed. RESULTS: The cohort included six male and two female patients, with age of onset ranging from 25 to 80 years. Five occurred in the kidney (three in the right kidney), one case each occurred in the bladder, the prostate and the spermatic cord. Most patients showed no obvious clinical symptoms or only had low back pain and swelling. The diameter of the tumor was ranged from 2.5 to 11.8 cm (median 5.2 cm). Microscopy showed at low magnification, the tumor cells were spindle-shaped and arranged in bundles or helicoid pattern. The regional mesenchymal fibroblasts showed hyperplasia, with obvious collagenization and formed hemangiopericytoma-like structure. One case showed increased mitotic figures (>5 cells/10 HPF) and focal necrosis. By immunohistochemistry, the tumor cells were positive for CD34 and STAT6 in all eight cases, CD99 and vimentin in six cases, bcl-2 in four cases and SMA in one case. All seven cases with follow-up did not show any tumor recurrence or metastasis. CONCLUSIONS: SFT is rare in the urogenital system and most patients show good prognosis. SFT expresses CD34 and STAT6 and needs to be distinguished from other spindle cell tumors.
Asunto(s)
Neoplasias de los Genitales Masculinos/patología , Neoplasias Renales/patología , Neoplasias de la Próstata/patología , Tumores Fibrosos Solitarios/patología , Cordón Espermático , Neoplasias de la Vejiga Urinaria/patología , Adulto , Anciano , Anciano de 80 o más Años , Diagnóstico Diferencial , Femenino , Neoplasias de los Genitales Masculinos/química , Hemangiopericitoma/patología , Humanos , Inmunohistoquímica , Neoplasias Renales/química , Masculino , Persona de Mediana Edad , Neoplasias de la Próstata/química , Factor de Transcripción STAT6/análisis , Tumores Fibrosos Solitarios/química , Cordón Espermático/química , Cordón Espermático/patología , Neoplasias de la Vejiga Urinaria/química , Vimentina/análisisRESUMEN
We report a case of advanced stomach cancer metastatic to the spermatic cord 1 year after curative distal gastrectomy. The patient underwent distal gastrectomy with D2 lymph node dissection. There was no metastasis to the liver or peritoneum, and cytologic examination of the peritoneal lavage fluid was negative for cancer cells (CY0). Histological examination revealed a moderately differentiated tubular adenocarcinoma that had penetrated the serosa (T4a). Postoperative staging was T4aN1M0, stage IIIA, according to the Japanese gastric carcinoma classification scale. One year after the operation, the patient was readmitted with right groin pain. Percutaneous fine needle aspiration biopsy of the inguinal tumor revealed a tubular adenocarcinoma. Extirpation of the inguinal tumor with wedge resection of the right iliac-femoral vein was performed. Pathological examination revealed a moderately differentiated tubular adenocarcinoma that had diffusely infiltrated the connective tissue surrounding the spermatic cord. Immunohistochemical studies showed the tumor cells were reactive for CK7 but not for CK20. These findings were consistent with the diagnosis of a spermatic cord tumor metastatic from a known gastric primary cancer. Laparoscopic exploration showed invagination of the peritoneum with small nodules from the median umbilical fold to the lateral umbilical fold and a markedly decreased distance between the folds. Pathological examination in this area revealed a tubular structure consisting of mesothelial cells within the cancer tissue which was associated with dense fibrosis, suggesting that the invagination of the peritoneum had been caused by minimal peritoneal metastasis.
Asunto(s)
Adenocarcinoma/secundario , Adenocarcinoma/cirugía , Gastrectomía , Neoplasias de los Genitales Masculinos/secundario , Cordón Espermático/patología , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugía , Adenocarcinoma/química , Anciano , Biomarcadores de Tumor/análisis , Biopsia con Aguja Fina , Gastroscopía , Neoplasias de los Genitales Masculinos/química , Neoplasias de los Genitales Masculinos/cirugía , Humanos , Inmunohistoquímica , Escisión del Ganglio Linfático , Metástasis Linfática , Masculino , Estadificación de Neoplasias , Tomografía de Emisión de Positrones , Reoperación , Cordón Espermático/química , Cordón Espermático/cirugía , Neoplasias Gástricas/química , Factores de Tiempo , Resultado del TratamientoRESUMEN
We report the extremely unusual occurrence of a cellular angiofibroma (CAF) with atypical (bizarre) cells in the spermatic cord. We present a 63-year-old man, who was referred to the Urology Service with a six-month history of a slowly growing painless nodule in the right inguino-scrotal area. The clinical impression was that of a lipoma. The mass was locally excised. Gross examination showed a well-circumscribed neoplasm attached to the spermatic cord and measuring 5cm in the greatest dimension. Microscopic examination of the tumor showed the appearance of CAF with scattered severely atypical (bizarre) cells distributed throughout the lesion. By immunohistochemistry, atypical cells showed diffuse expression of p16, CDK-4, CD34 and vimentin. Keratin AE1/AE3, S-100 protein, p53, and epithelial membrane antigen were negative. The patient is free of disease two months after tumor excision. To the best of our knowledge, this is the third case of CAF with atypical (bizarre) cells occurring in the paratesticular area. Pathologists should be aware of this morphological variation of CAF to avoid misdiagnosis and over-treatment.
Asunto(s)
Angiofibroma/patología , Neoplasias de los Genitales Masculinos/patología , Cordón Espermático/patología , Angiofibroma/química , Angiofibroma/cirugía , Biomarcadores de Tumor/análisis , Neoplasias de los Genitales Masculinos/química , Neoplasias de los Genitales Masculinos/cirugía , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Cordón Espermático/química , Cordón Espermático/cirugía , Resultado del Tratamiento , Carga TumoralRESUMEN
INTRODUCTION: Spermatic cord tumors represent 4% of scrotal tumors. The most common neoplasms are lipomas. Spermatic cord sarcomas (SCS) of the genitourinary tract account for 2% of all urological tumors. Herein we presented our experience in the treatment of these tumors and a review of the literature. PATIENTS AND METHODS: A review of the literature was performed using the Medline database with no restriction on language and date of published papers. The literature search used the following terms: epidemiology, surgery, chemotherapy, radiotherapy and spermatic cord sarcomas. Four cases treated from December 2009 to May 2010 are described. RESULTS: All patients were treated with radical orchiectomy. The final pathological report showed different types of sarcomas. Two of the patients were treated with adjuvant chemotherapy. 12 months after surgery, 2/4 patients were alive without signs of relapse. CONCLUSION: SCS are very rare tumors with a poor prognosis. SCS's prognostic factors have been identified in grading, size, depth of invasion and surgical margin status. Age and performance status of the patient are however very important. Lymphatic and hematogenous dissemination is uncommon. Surgery is the most important treatment both in the first approach and in local relapse. The role of adjuvant chemotherapy and radiation therapy is still debated.
Asunto(s)
Neoplasias de los Genitales Masculinos/terapia , Orquiectomía , Sarcoma/terapia , Cordón Espermático/cirugía , Adolescente , Anciano de 80 o más Años , Biomarcadores de Tumor/análisis , Biopsia , Quimioterapia Adyuvante , Resultado Fatal , Neoplasias de los Genitales Masculinos/química , Neoplasias de los Genitales Masculinos/patología , Humanos , Inmunohistoquímica , Neoplasias Pulmonares/secundario , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Radioterapia Adyuvante , Sarcoma/química , Sarcoma/secundario , Cordón Espermático/química , Cordón Espermático/patología , Factores de Tiempo , Resultado del TratamientoRESUMEN
We report a hitherto not documented case of primary mucinous cystadenoma arising in the spermatic cord within the right inguinal canal of a78-year-old man. The tumor was painless, hard and mobile. A computed tomography scan on the pelvis revealed an oval shaped, low attenuation mass, measuring 5.0x2.5x2.1 cm, that was present adjacent to the vas deferens. Grossly, the excised mass was multicystic mucinous tumor, filled with thick mucoid materials. Microscopically, the cystic wall was irregularly thickened. The cystic epithelium commonly showed short papillae lined by a single layer of columnar to cuboidal mucinous epithelial cells without significant stratification or cytologic atypia. Goblet cells were also frequently present. Immunohistochemically, the neoplastic cells showed positive reaction to carcinoembryonic antigen, cytokeratin 20, CDX2, epithelial membrane antigen, and CD15. However, they were negative for PAX8 and Wilms' tumor 1 protein. Pathological diagnosis was a papillary mucinous cystadenoma of the spermatic cord. Although mucinous cystadenoma in this area is extremely rare, it is important that these lesions be recognized clinically and pathologically in order to avoid unnecessary radical surgery. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1720965948762004.
Asunto(s)
Cistoadenoma Mucinoso/patología , Cistoadenoma Papilar/patología , Neoplasias de los Genitales Masculinos/patología , Cordón Espermático/patología , Anciano , Biomarcadores de Tumor/análisis , Cistoadenoma Mucinoso/química , Cistoadenoma Mucinoso/cirugía , Cistoadenoma Papilar/química , Cistoadenoma Papilar/cirugía , Neoplasias de los Genitales Masculinos/química , Neoplasias de los Genitales Masculinos/cirugía , Células Caliciformes/patología , Humanos , Inmunohistoquímica , Conducto Inguinal , Masculino , Cordón Espermático/química , Cordón Espermático/cirugía , Tomografía Computarizada por Rayos X , Procedimientos Quirúrgicos Urológicos MasculinosRESUMEN
Testicular cancer is broadly divided into seminoma and non-seminoma types for treatment planning because seminomas are more sensitive to radiation therapy. Non-seminomatous germ-cell testis tumors represent a majority of all testicular neoplasms and include yolk sac tumor, embryonal carcinoma, choriocarcinoma, teratoma and undifferentiated tumors. Malignant neoplasms account for approximately 25% of neoplasms of the paratesticular tissues and most of them are sarcomas. We report a case of completely undifferentiated germ cell tumor of spermatic cord and discuss its diagnosis.
Asunto(s)
Germinoma/patología , Neoplasias Testiculares/patología , Biomarcadores de Tumor/análisis , Supervivencia sin Enfermedad , Germinoma/cirugía , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Cordón Espermático/química , Cordón Espermático/patología , Neoplasias Testiculares/química , Neoplasias Testiculares/cirugíaRESUMEN
We present a case of spermatic cord cavernous hemangioma. A 32-year-old man presented with a circumscribed, painless mass in the left side of the spermatic cord. An orchiectomy of the left testicle was performed. A 3 x 3 x 2.5-cm mass was present in the spermatic cord area. Histologic examination and immunohistochemical study showed a benign vascular tumor composed of vascular spaces of varying size. Although cavernous hemangioma can occur in any location, the spermatic cord is an extremely rare site, and, to our knowledge, only a few cases have been previously reported.
Asunto(s)
Neoplasias de los Genitales Masculinos/patología , Hemangioma Cavernoso/patología , Cordón Espermático/patología , Adulto , Antígenos CD34/análisis , Endotelio Vascular/química , Endotelio Vascular/patología , Neoplasias de los Genitales Masculinos/química , Neoplasias de los Genitales Masculinos/cirugía , Hemangioma Cavernoso/química , Hemangioma Cavernoso/cirugía , Humanos , Técnicas para Inmunoenzimas , Masculino , Cordón Espermático/química , Cordón Espermático/cirugía , Vimentina/análisisRESUMEN
Malignant fibrous histiocytoma (MFH) of the spermatic cord is rare, and most published cases are single case reports that emphasize clinical presentation and management. We describe in detail the histopathologic features of 2 cases of high-grade storiform-pleomorphic MFH arising in the spermatic cord. Both tumors occurred in elderly men, 65 years and 70 years, and were 4 cm (Case 1) and 5 cm (Case 2) in greatest dimension. The tumor mass in Case 1 was associated with satellite tumor nodules. At last follow-up, in Case 1 the patient died of metastasis, and in Case 2, the patient is alive and well 46 months after diagnosis. Review of the literature reveals 33 additional cases published in English (17 cases) or Japanese (16 cases) that include histologic description. Including the 2 cases in this report, most of the tumors occurred in older (than 50 years) patients (28 of 35 cases, 80%) and occurred as solitary masses that ranged in diameter from less than 1 cm to more than 20 cm. Nine patients presented with satellite tumor nodules. Twenty-nine (83%) tumors were of the storiform-pleomorphic type, with 3 giant cell type, 2 inflammatory type, and 1 myxoid type. These features do not differ significantly from MFH in other anatomic sites. Clinical follow-up is available in 33 cases (3-174 months; mean, 31.5 months). Twelve patients developed recurrence and metastasis; at least 4 patients died of the disease. Tumor size does not predict the clinical progression; however, patients with progressive tumors were commonly associated with satellite nodules at time of presentation, an indication of early local metastasis.
Asunto(s)
Neoplasias de los Genitales Masculinos/patología , Histiocitoma Fibroso Benigno/patología , Cordón Espermático/patología , Anciano , Antígenos CD/análisis , Antígenos de Diferenciación Mielomonocítica/análisis , Biomarcadores de Tumor/análisis , Resultado Fatal , Neoplasias de los Genitales Masculinos/química , Neoplasias de los Genitales Masculinos/cirugía , Histiocitoma Fibroso Benigno/química , Histiocitoma Fibroso Benigno/cirugía , Humanos , Inmunohistoquímica , Masculino , Muramidasa/análisis , Recurrencia Local de Neoplasia , Cordón Espermático/química , Cordón Espermático/cirugía , Vimentina/análisisRESUMEN
The behavior of leiomyosarcoma (LMS) is site related, but there are limited data on such tumors presenting in the paratesticular region. Cases diagnosed as LMS of the paratesticular region from the files of three institutions were reviewed. Immunohistochemistry was performed in cases with available blocks, and follow-up information was obtained. From 31 cases originally diagnosed as LMS, 24 were retained after review. These were from men aged 34-86 years (mean 62 years; median 64 years) and involved the testicular tunica (10), spermatic cord (10), scrotal subcutis and dartos muscles (1 each), and the epididymis (1). Tumors ranged in size from 2-9 cm (mean 5 cm; median 4 cm). On immunohistochemical staining they expressed muscle-specific actin (13 of 14), smooth muscle actin (10 of 10), desmin (16 of 17), and CD34 (3 of 9); all of the latter three were strongly desmin-positive. Focal reactivity for cytokeratin (3 of 8) and S-100 protein (1 of 8) was seen. Follow-up information was available in 14 patients. Four (29%) had recurrences, in one case four times. Metastases to lymph nodes, lungs, or liver were seen in four patients (29%), of whom two had prior recurrences. Ten were alive with no evidence of disease (ANED), and four were dead of disease (DOD). Comparing outcome with tumor grade, all seven patients with grade 1 tumors (of whom two had recurrences) and all three with grade 2 tumors were ANED, whereas all four patients with grade 3 tumors were DOD. In summary, paratesticular LMSs are rare neoplasms. The majority in this site are low-grade, although high-grade lesions behave aggressively.