RESUMEN
OBJECTIVE: To assess joint effects of heterocyclic amine (HCA), fruit, and vegetable intake on DNA damage in a general population. METHODS: A cross-sectional survey (ISA-Capital) was performed among adults and older adults in Brazil. We selected 73 participants with high HCA intake and 73 sex- and age-matched participants with non-HCA intake (n = 146) for the present study. Diet was assessed by a 24-h dietary recall and a structured questionnaire with cooking methods and levels of meat doneness. DNA damage was measured by 8-oxo-2'-deoxyguanosine (8-OHdG). The association between DNA damage and dietary intake was analyzed by linear regression models. RESULTS: Fruit intake showed significantly inverse association with 8-OHdG (ß, -0.787; P = 0.035), whereas HCA intake was significantly associated with increased DNA damage (ß, 1.621; P = 0.036) after adjusting for covariates, including sex, age, body mass index, energy intake, smoking, physical activity, and C-reactive protein. Vegetable intake was not significantly associated with 8-OHdG. We also found a significant association between joint fruit and HCA intake and DNA damage, and the difference in 8-OHdG levels was significantly higher between participants with the lowest fruit intake and highest HCA intake and those with the highest fruit intake and non-HCA intake (P = 0.049). CONCLUSIONS: Lower intake of fruits and higher intake of HCAs were associated with higher DNA damage levels and showed an additive effect pattern.
Asunto(s)
Aminas/administración & dosificación , Daño del ADN/efectos de los fármacos , Dieta , Frutas , Compuestos Heterocíclicos/administración & dosificación , Verduras , 8-Hidroxi-2'-Desoxicoguanosina , Aminas/efectos adversos , Aminas/química , Índice de Masa Corporal , Peso Corporal , Brasil , Proteína C-Reactiva/metabolismo , Estudios Transversales , Desoxiguanosina/análogos & derivados , Desoxiguanosina/metabolismo , Ejercicio Físico , Femenino , Compuestos Heterocíclicos/efectos adversos , Compuestos Heterocíclicos/química , Humanos , Modelos Lineales , Masculino , Carne , Recuerdo Mental , Persona de Mediana Edad , Evaluación Nutricional , Factores de Riesgo , Encuestas y CuestionariosRESUMEN
OBJECTIVE: To determine the role of meat consumption and related mutagens in the etiology of lung cancer, we conducted a case-control study among Uruguayan males in the time period 1996-2004. METHODS: The study included 846 cases and 846 controls, frequency matched on age and residence. Both series were drawn from the four major public hospitals in Montevideo, Uruguay. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) of lung cancer by quartiles of meat intake and mutagens. RESULTS: The highest vs. the lowest quartile of intake of total meat (OR = 2.04, 95% CI 1.42-2.92), red meat (OR = 2.33, 95% CI 1.63-3.32), and processed meat (OR = 1.79, 95% CI 1.22-2.65) was associated with increased risk of lung cancer, while intake of total white meat, poultry and fish was not. Heterocyclic amines (IQ, MeIQx, PhIP), nitrosamines and benzo[a]pyrene were directly associated with the risk of lung cancer (OR for PhIP 2.16, 95% CI 1.48-3.15). Moreover, both red meat and meat mutagens displayed higher risks among former smokers compared with current smokers. CONCLUSIONS: This study suggests that red and processed meat and meat mutagens may play a role in the etiology of lung cancer.
Asunto(s)
Dieta , Neoplasias Pulmonares/epidemiología , Neoplasias Pulmonares/etiología , Carne/efectos adversos , Mutágenos/efectos adversos , Adulto , Anciano , Anciano de 80 o más Años , Animales , Benzo(a)pireno/efectos adversos , Estudios de Casos y Controles , Compuestos Heterocíclicos/efectos adversos , Humanos , Masculino , Productos de la Carne/efectos adversos , Persona de Mediana Edad , Nitrosaminas/efectos adversos , Factores de Riesgo , Encuestas y Cuestionarios , UruguayRESUMEN
Consumption of red meat and its heterocyclic amines (HCA) content has been associated with an increased risk for colorectal cancer and, with less consistency, with stomach, oesophagus, pancreas, breast, prostate and kidney cancers. Uruguay and Argentina's rates for breast and colon cancer are among the highest in the world. The main type of meat consumed in these countries is beef, of which consumption rank first and second, respectively in the world, with about 60 kg per year per capita. Beef is cut in different ways following the customs of different countries and regions. The predominant consumption of different cuts and ways of cooking, are described for different regions within Argentina as well as frequencies of consumption of different kinds of meats. These differences reflect not only habits and customs but also socioeconomic variations among regions.A review of epidemiological studies performed in South American countries related to meat consumption, ways of cooking, HCA, and different cancers is presented. It is concluded that comparisons among studies generated in countries or regions with different meat types, beef cuts consumption usage and cooking methods must be very careful. Hence, future research for the verification of the observed associations between HCA and cancer, should be conducted through in-depth, chemically validated questionnaires based on local data.
Asunto(s)
Dieta , Carne/efectos adversos , Neoplasias/epidemiología , Aminas/efectos adversos , Animales , Culinaria , Femenino , Compuestos Heterocíclicos/efectos adversos , Humanos , Masculino , Productos de la Carne/efectos adversos , Neoplasias/etiología , Oportunidad Relativa , Factores de Riesgo , América del Sur/epidemiologíaRESUMEN
Introducción: Considerando el amplio uso de los antidepresivos evaluamos la existencia y características del síndrome de discontinuación de antidepresivos. Métodos. Usando MEDLINE identificamos reportes y artículos de revisión relevantes acerca de síntomas secundarios al retiro de antidepresivos. Resultados. Existe amplia evidencia acerca de un síndrome de discontinuación tras el retiro de antidepresivos tricíclicos, inhibidores de la monoaminooxidasa e inhibidores de recaptura de serotonina, habiéndose descrito desde molestias leves a cuadros severos con síntomas psicóticos y agitación, siendo en general más graves los síntomas asociados a discontinuación de inhibidores de la manoamino-oxidasa y tricíclicos. Conclusiones. La información obtenida debe ser considerada por los clínicos al momento de prescribir el inicio o retiro de antidepresivos. Debe tenerse en cuenta el síndrome de discontinuación de antidepresivos en pacientes que presentan bruscas exacerbaciones sintomáticas. Se sugiere como medida preventiva la disminución gradual de las dosis antes de suspender un antidepresivo
Asunto(s)
Humanos , Fluoxetina , Paroxetina , Sertralina , Síndrome de Abstinencia a Sustancias/diagnóstico , Antidepresivos Tricíclicos/efectos adversos , Acatisia Inducida por Medicamentos , Ansiedad , Compuestos Heterocíclicos/efectos adversos , Mareo , Cefalea , Inhibidores de la Monoaminooxidasa , Náusea , Psicosis Inducidas por SustanciasRESUMEN
To examine the risk of upper aerodigestive tract cancers (UADC: oral cavity, pharynx, larynx, and esophagus) associated with dietary heterocyclic amine (HCA) exposure, a case-control study involving 140 cases and 286 controls was conducted in Montevideo, Uruguay. Beef and red meat intakes were positively associated with risk of UADC [odds ratio (OR) for red meat intake = 2.8, 95% confidence interval (CI) = 1.4-6.0], whereas no association was observed with white meat (poultry plus fish) intake. When meat intake was examined by cooking method, no association was observed for fried meat. On the other hand, broiled and boiled meat were associated with a significant increase in risk of UADC (OR for broiled meat = 2.0, 95% CI = 1.0-4.3). Total HCA intake was associated with an increased risk (OR = 2.2, 95% CI = 1.1-4.2) of UADC. The HCA effect was similar among the different cancer sites.