RESUMEN
BACKGROUND: Graft-versus-host disease (GVHD) is an immune system reaction that occurs in patients with a history of hematopoietic stem cell transplantation (HSCT), in which the grafted donor's cells attack those of the host. The objective of this systematic review was to present a study on oral squamous cell carcinoma (OSSC) that developed from GVHD areas in patients undergoing HSCT. MATERIAL AND METHODS: An electronic search was conducted in the databases PUBMED, WEB OF SCIENCE, SCOPUS, MEDLINE and SCIENCE DIRECT, according to PRISMA guidelines. RESULTS: Of the 1582 results, 23 articles were included, resulting in 81 cases. The most common underlying disease for performing the transplant was Myeloid Leukemia (55.6%). The mean age was 39 years, with a predilection for males (64.2%). The tongue was the site of GVHD that most frequently underwent transformation to SCC (59.3%). The average time between transplantation and the development of GVHD was of approximately of 8 months, while the average period of development between transplantation and the development of OSCC was of approximately of 111 months. The most common treatment to GVHD was cyclosporine associated with corticosteroids. CONCLUSIONS: OSCCs arising from areas of GVHD present a different evolution from conventional oral carcinomas, since they affect younger patients, smoking and alcohol are not important etiological factors and finally because they present good prognosis, but further studies with larger number cases followed are needed to confirm our findings.
Asunto(s)
Carcinoma de Células Escamosas , Enfermedad Injerto contra Huésped , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Masculino , Humanos , Adulto , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas de Cabeza y Cuello/complicaciones , Neoplasias de la Boca/etiología , Enfermedad Injerto contra Huésped/complicaciones , Neoplasias de Cabeza y Cuello/complicacionesRESUMEN
Cowden Syndrome (CS) is a rare genetic disease caused by mutations in the PTEN tumor suppressor gene, often presenting a challenging diagnosis due to its diverse clinical manifestations. Although extensively linked to several types of cancer, the precise association between CS and oral malignancies, particularly squamous cell carcinoma (SCC), remains poorly understood. This report describes a unique case of late diagnosis of CS in a 53-year-old female patient who later developed SCC in the inferior alveolar ridge, even without exposure to classic risk factors. The need to increase awareness in the medical and dental communities about CS and its manifestations in the oral cavity is highlighted. Early recognition and management of conditions associated with CS have a significant impact on patients' quality of life. Encouraging the publication of similar cases is recommended to encourage detailed analyzes and investigations in order to better understand the possible association between the syndrome and the development of malignancies in the oral cavity.
Asunto(s)
Carcinoma de Células Escamosas , Síndrome de Hamartoma Múltiple , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Femenino , Humanos , Persona de Mediana Edad , Síndrome de Hamartoma Múltiple/complicaciones , Síndrome de Hamartoma Múltiple/diagnóstico , Síndrome de Hamartoma Múltiple/genética , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas de Cabeza y Cuello/complicaciones , Calidad de Vida , Neoplasias de la Boca/complicaciones , Neoplasias de la Boca/diagnóstico , Fosfohidrolasa PTEN/genética , Neoplasias de Cabeza y Cuello/complicacionesRESUMEN
24-year-old man with positive HIV, with a giant exofitic anal condyloma, with a clinical presentation of a painfull suppurative anal condyloma with a pathology report of an in situ squamous cell carcinoma. The purpose of the investigation is a case report and the procedure was observational. The finding was a Buschke-Lowenstein tumor.
Varón de 24 años, con infección por el virus de la inmunodeficiencia humana, que presenta una tumoración exofítica, dolorosa y supurativa, con reporte positivo de virus de papiloma humano y reporte histopatológico de carcinoma espinocelular sin evidencia de diseminación (in situ). El propósito de la investigación es un reporte de caso y el procedimientos fue observacional. El hallazgo fue un tumor de Buschke-Lowenstein.
Asunto(s)
Tumor de Buschke-Lowenstein , Carcinoma de Células Escamosas , Condiloma Acuminado , Masculino , Humanos , Tumor de Buschke-Lowenstein/cirugía , Tumor de Buschke-Lowenstein/patología , Condiloma Acuminado/complicaciones , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/cirugía , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/cirugía , Canal AnalRESUMEN
Background: Marjolin's ulcer is the malignant degeneration of any chronic wound, with a latency period from tissue injury to variable malignant transformation that may occur up to 30 years later. Among the associated neoplasms, squamous cell carcinoma (SCC) is the predominant lineage in up to 71% of cases. The verrucous carcinoma variant has been estimated to have a low presentation, being described in the literature as 2% of all SCC and reported anecdotally in immunosuppressed patients, which justifies the objective of this publication. Clinical case: 65-year-old female patient with a history of being a carrier of human immunodeficiency virus (HIV) infection, who presented a verrucous carcinoma associated to a Marjolin ulcer secondary to herpes zoster and infection of soft tissues in the right leg, with a latency period of 10 years from the initial infectious process to histopathological confirmation. Conclusions: The finding of a verrucous carcinoma on a Marjolin ulcer has been little described in literature, with a lower incidence in the context of a patient with a history of being a carrier of HIV infection, finding 7 case reports, the oldest from 1998. For this reason, it is important to have diagnostic suspicion, to carry out an adequate study protocol and always making clinical-pathological correlation, in order to establish timely and individualized treatment.
Introducción: la úlcera de Marjolin es la degeneración maligna de cualquier herida crónica, con un periodo de latencia desde la lesión tisular a la transformación maligna variable que puede presentarse hasta 30 años después. De las neoplasias asociadas, el carcinoma espinocelular es la estirpe predominante hasta en 71% de los casos. La variante de carcinoma verrugoso se ha estimado con una presentación baja, pues ha sido descrito en la literatura como el 2% de todos los carcinomas espinocelulares y reportado de manera anecdótica en pacientes inmunosuprimidos, lo que justifica el objetivo de esta publicación. Caso clínico: mujer de 65 años con el antecedente de ser portadora de infección por virus de inmunodeficiencia humana (VIH), que presentó un carcinoma verrugoso asociado a una úlcera de Marjolin secundaria a herpes zóster e infección de tejidos blandos en pierna derecha, con un periodo de latencia de 10 años desde el proceso infeccioso inicial hasta la confirmación histopatológica. Conclusiones: el hallazgo de un carcinoma verrugoso asentado sobre una úlcera de Marjolin ha sido poco descrito en la literatura, con una menor incidencia en el contexto de un paciente con antecedente de ser portador de infección por VIH, ante lo cual encontramos 7 reportes de caso, el más antiguo de 1998. Por este motivo es importante contar con la sospecha diagnóstica, para poder hacer un protocolo de estudio adecuado y siempre haciendo correlación clínico-patológica, con la finalidad de instaurar un tratamiento oportuno e individualizado.
Asunto(s)
Carcinoma de Células Escamosas , Carcinoma Verrugoso , Infecciones por VIH , Neoplasias Cutáneas , Úlcera Cutánea , Femenino , Humanos , Anciano , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/diagnóstico , Úlcera/complicaciones , Úlcera Cutánea/etiología , Úlcera Cutánea/patología , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/diagnóstico , Carcinoma Verrugoso/complicaciones , Carcinoma Verrugoso/diagnóstico , Huésped InmunocomprometidoRESUMEN
The aim of this study was to alert the ophthalmic community to an atypical manifestation of ocular surface squamous neoplasia, which may delay diagnosis and treatment and result in a guarded visual prognosis and significant sequelae. A 61-year-old immunocompetent man presented with an initial diagnosis of necrotizing scleritis in the right eye for 3 months. He was treated with systemic prednisone but experienced persistent pain and low visual acuity. Conjunctival biopsy of the affected region confirmed the diagnosis of invasive ocular surface squamous neoplasia, which progressed with intraocular and orbital invasion; thus, exenteration was performed. Masquerade syndrome should be suspected in patients with nodulo-ulcerative lesions of the conjunctiva and sclera. This clinical can be more aggressive, with a greater likelihood of intraocular and orbital involvement. The earlier the diagnosis and treatment, the better the patient prognosis.
Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de la Conjuntiva , Escleritis , Masculino , Humanos , Persona de Mediana Edad , Neoplasias de la Conjuntiva/patología , Conjuntiva/patología , Escleritis/diagnóstico , Escleritis/patología , Esclerótica/patología , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/diagnósticoAsunto(s)
Carcinoma de Células Escamosas , Encefalitis , Neoplasias de la Lengua , Humanos , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/diagnóstico por imagen , Carcinoma de Células Escamosas/patología , Neoplasias de la Lengua/complicaciones , Neoplasias de la Lengua/diagnóstico por imagen , Neoplasias de la Lengua/patología , Lengua/patologíaRESUMEN
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is a multifactorial disease. The individual effect of each risk factor for OSCC may be conditioned by the frequency of other factors. The objective of this study was to identify the association between chronic mechanical irritation (CMI) and OSCC and to analyse the influence of CMI on other important risk factors for OSCC. MATERIALS AND METHODS: A prospective and age/sex-matched case-control study was performed in two institutions from Argentina between 2009 and 2019, with consecutive and newly diagnosed OSCC. The frequencies of tobacco, alcohol, and CMI were analysed using conditional logistic regression. Cumulative tobacco consumption and the presence of CMI were analysed using the Mann-Whitney test. RESULTS: CMI and OSCC were associated with an OR of 7.02 (95% CI 3.57-13.78, p < 0.001). The combination of CMI and alcohol demonstrated the highest risk of OSCC (OR 53.83, CI 95% 8.04-360, p < 0.0001), followed by the combination of CMI, tobacco, and alcohol (OR 48.06, CI 95% 8.47-272, p < 0.0001). The combination of CMI and tobacco was also significant (OR 5.61, CI 95% 1.07-29.54, p = 0.042). Patients with CMI developed OSCC with less cumulative tobacco use compared with those without CMI. CONCLUSION: CMI is an independent risk factor for OSCC, and it could act as a risk modifier among tobacco and alcohol users having an enhancing effect. CLINICAL RELEVANCE: Elimination of CMI could decrease the risk of OSCC.
Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Argentina/epidemiología , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/etiología , Estudios de Casos y Controles , Neoplasias de Cabeza y Cuello/complicaciones , Humanos , Neoplasias de la Boca/epidemiología , Neoplasias de la Boca/etiología , Neoplasias de la Boca/patología , Estudios Prospectivos , Factores de Riesgo , Fumar/efectos adversos , Carcinoma de Células Escamosas de Cabeza y Cuello , Nicotiana , Uso de Tabaco/efectos adversos , Uso de Tabaco/epidemiologíaRESUMEN
El macizo facial es una región anatómica compleja que alberga órganos sensoriales. El desarrollo de una enfermedad oncológica, así como su tratamiento, causan defectos funcionales y estéticos con un alto costo físico y psíquico para el paciente y su entorno. Es por ello que la reconstrucción representa un reto. Las diferentes posibilidades incluyen prótesis obturatríces, colgajos libres, pediculados o microvascularizados. En este artículo se describirá el colgajo de músculo temporal y se desarrolla un caso clínico de cirugía oncológica maxilar reconstruido mediante éste en un paciente que presenta una lesión exofítica en cuadrante superior derecho, que se extiende sobre el flanco vestibular, reborde alveolar y zona palatina, desde zona de premolares hasta la zona del segundo molar inclusive, impidiéndole usar la prótesis dental. Esta cirugía es una técnica económica, que requiere menor tiempo quirúrgico que otras técnicas, asociándose a poco porcentaje de fracaso y pocas complicaciones post operatorias.
The facial mass is a complex anatomical region that houses sensory organs. The development of an oncologic disease, as well as its treatment, causes functional and esthetic defects with a high physical and psychological cost for the patient and his environment. This is why reconstruction represents a challenge. The different possibilities include obturator-root prostheses, free, pedicled or microvascularized flaps. In this article the temporal muscle flap will be described and a clinical case of maxillary oncologic surgery reconstructed by means of it is developed in a patient who presents an exophytic lesion in the right upper quadrant, which extends over the vestibular flank, alveolar ridge and palatal area, from the premolar area up to and including the second molar area, preventing him from using the dental prosthesis. This surgery is an economical technique that requires less surgical time than other techniques, and is ass
A massa facial é uma região anatômica complexa que abriga órgãos sensoriais. O desenvolvimento de uma doença oncológica, assim como seu tratamento, causa defeitos funcionais e estéticos com alto custo físico e psicológico para o paciente e seu ambiente. A reconstrução é, portanto, um desafio. As diferentes possibilidades incluem as próteses de raiz obturadora, abas livres, pediculadas ou microvascularizadas. Este artigo descreve o retalho muscular temporal e descreve um caso clínico de cirurgia oncológica maxilar reconstruída utilizando-o em um paciente com lesão exofítica no quadrante superior direito, estendendo-se pelo flanco vestibular, rebordo alveolar e área palatina, desde a área do pré-molar até a área do segundo molar inclusive, impedindo-o de utilizar a prótese dentária. Esta cirurgia é uma técnica econômica, que requer menos tempo cirúrgico que outras.
Asunto(s)
Humanos , Femenino , Anciano , Músculo Temporal/cirugía , Carcinoma de Células Escamosas/cirugía , Neoplasias Maxilares/cirugía , Colgajos Tisulares Libres/cirugía , Carcinoma de Células Escamosas/complicaciones , Neoplasias Maxilares/complicaciones , Reconstrucción Mandibular/métodosRESUMEN
PURPOSE: The aim of this study is to investigate the association between hydrochlorothiazide (HCTZ) use and the risk of cutaneous and lip squamous cell carcinoma development. METHODOLOGY: We performed a systematic review and meta-analysis of case-control studies. We searched the Cochrane Library, PubMed, Scopus, Web of Science and LILACS. This study was registered in PROSPERO under protocol CRD42019129710. The meta-analysis was performed using the software Stata (version 12.0). RESULTS: A total of 2181 published studies referring to the theme were identified, from which six were included in this systematic review. Men were more frequently affected by cutaneous and lip squamous cell carcinoma than women, with a 1.42:1 ratio. The mean age for cutaneous and lip squamous cell carcinoma development was 73.7 years. This meta-analysis demonstrated a chance of developing cutaneous and lip squamous cell carcinoma in any region of the body in hydrochlorothiazide users of 1.76-fold higher than in non-users. In addition, a risk factor of 1.80 higher (CI 95% = 1.71-1.89) of cutaneous squamous cell carcinoma in the head and neck region was observed in HCTZ users. Moreover, in the analysis of the dose used, the chance of developing squamous cell carcinoma was 3.37-fold lower when the concentration of HCTZ used was less than 50,000 mg. CONCLUSIONS: Our results confirm the association between the use of hydrochlorothiazide and the cutaneous and lip squamous cell carcinoma development.
Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de los Labios , Neoplasias Cutáneas , Anciano , Carcinoma de Células Escamosas/inducido químicamente , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/epidemiología , Femenino , Humanos , Hidroclorotiazida/efectos adversos , Labio/patología , Neoplasias de los Labios/inducido químicamente , Neoplasias de los Labios/complicaciones , Neoplasias de los Labios/epidemiología , Masculino , Neoplasias Cutáneas/inducido químicamente , Neoplasias Cutáneas/epidemiologíaRESUMEN
The association between inflammatory bowel disease (IBD) and anal canal squamous cell carcinoma (SCC) has a low prevalence and is mainly supported by articles that include a series of cases. We describe the clinical, endoscopic and histological findings of a patient with Crohn's disease (CD) who developed SCC while undergoing biological therapy with active disease.
Asunto(s)
Neoplasias del Ano , Carcinoma de Células Escamosas , Enfermedad de Crohn , Enfermedades Inflamatorias del Intestino , Neoplasias del Ano/epidemiología , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/terapia , Enfermedad de Crohn/complicaciones , Enfermedad de Crohn/terapia , Humanos , Enfermedades Inflamatorias del Intestino/complicacionesRESUMEN
Introducción: La cirugía es el tratamiento de elección que ofrece la curación a un grupo de pacientes afectados de cáncer pulmonar, aun así, la supervivencia global para todos los estadios a 5 años se mantiene baja. Objetivo: Caracterizar los pacientes operados de cáncer pulmonar en el período comprendido desde el 1ro de marzo del 2015 hasta el 1ro de agosto del 2020. Métodos: Se realizó un estudio, observacional, retrospectivo de corte transversal, para describir el comportamiento de la morbimortalidad quirúrgica de los pacientes portadores de cáncer pulmonar en el Hospital Provincial Universitario "Manuel Ascunce Domenech" de la ciudad de Camagüey, desde marzo del 2015 y agosto del 2020. El universo de estudio se conformó por 211 pacientes operados con diagnóstico de cáncer pulmonar. Resultados: La edad que predominó fue entre 61 a 70 años y el sexo masculino. El adenocarcinoma y el carcinoma epidermoide fueron los diagnósticos histológicos más frecuentes. La lobectomía superior derecha fue la resección que con más frecuencia se realizó, así como algún tipo de linfadenectomía mediastinal fue realizada en más de la mitad de los casos. Las complicaciones más frecuentes fueron las relacionadas con la fuga de aire. El índice de fallecidos fue bajo encontrándose las complicaciones cardiovasculares y el tromboembolismo pulmonar, las causas de mayor frecuencia. Conclusiones: La cirugía en el cáncer pulmonar es el tratamiento de elección en etapas tempranas con una baja morbilidad y mortalidad en pacientes que reúnan las condiciones de operabilidad(AU)
Introduction: Surgery is the treatment of choice that offers cure to a group of patients affected by pulmonary cancer; yet five-year overall survival for all stages remains low. Objective: To characterize the patients operated on for pulmonary cancer in the period from March 1, 2015 to August 1, 2020. Methods: An observational, retrospective and cross-sectional study was carried out to describe the behavior of surgical morbidity and mortality since March 2015 and August 2020 in patients with pulmonary cancer at Manuel Ascunce Domenech University Provincial Hospital in Camagüey City. The study universe was made up of 211 patients operated on with a diagnosis of pulmonary cancer. Results: There was a predominance of the age 61-70 years and the male sex. Adenocarcinoma and squamous cell carcinoma were the most frequent histological diagnoses. Right upper lobectomy was the most frequently performed resection, as well as some type of mediastinal lymphadenectomy, performed in more than half of the cases. The most frequent complications were those related to air leakage. The death rate was low, with cardiovascular complications and pulmonary thromboembolism being the most frequent causes. Conclusions: Surgery is the treatment of choice for pulmonary cancer in early stages, with low morbidity and mortality in patients who meet operability conditions(AU)
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Anciano , Neumonectomía/métodos , Carcinoma de Células Escamosas/complicaciones , Indicadores de Morbimortalidad , Neoplasias Pulmonares/diagnóstico , Adenocarcinoma , Estudios Transversales , Estudios Retrospectivos , Estudios Observacionales como AsuntoRESUMEN
A 75-year-old man was hospitalised for bronchoscopy with biopsy due to a suspicious pulmonary mass at chest tomography. He had significant dyspnoea, constipation, nausea, vomiting, anorexia and a 33% loss of weight in the past 3 months. Biopsy revealed a pulmonary squamous cell carcinoma, which was inoperable. Tramadol used at home for 3 months was replaced by morphine on admission. The patient remained constipated despite prokinetics and laxatives, leading to the diagnostic hypothesis of paraneoplastic motility disorder and opioid-induced constipation. Abdominal tomography ruled out the possibility of mechanical obstruction. As complications, the patient presented superior vena cava syndrome and opioid (morphine) intoxication. The patient died a few days later. The management of this case highlights the importance of multidisciplinary care and the challenges of palliative oncology care. Paraneoplastic motility disorder must always be considered among the mechanisms of intestinal dysfunction in patients with advanced oncological disease.
Asunto(s)
Carcinoma de Células Escamosas/complicaciones , Estreñimiento/etiología , Gastroparesia/etiología , Neoplasias Pulmonares/complicaciones , Síndromes Paraneoplásicos del Sistema Nervioso/etiología , Anciano , Antieméticos/uso terapéutico , Carcinoma de Células Escamosas/diagnóstico por imagen , Estreñimiento/diagnóstico , Estreñimiento/tratamiento farmacológico , Estreñimiento/fisiopatología , Fármacos Gastrointestinales/uso terapéutico , Enfermedades Gastrointestinales/diagnóstico , Enfermedades Gastrointestinales/tratamiento farmacológico , Enfermedades Gastrointestinales/etiología , Enfermedades Gastrointestinales/fisiopatología , Motilidad Gastrointestinal , Gastroparesia/diagnóstico , Gastroparesia/tratamiento farmacológico , Gastroparesia/fisiopatología , Glicerol/uso terapéutico , Humanos , Lactulosa/uso terapéutico , Neoplasias Pulmonares/diagnóstico por imagen , Masculino , Metoclopramida/análogos & derivados , Metoclopramida/uso terapéutico , Morfina/efectos adversos , Estreñimiento Inducido por Opioides/diagnóstico , Cuidados Paliativos , Síndromes Paraneoplásicos del Sistema Nervioso/diagnóstico , Síndromes Paraneoplásicos del Sistema Nervioso/fisiopatología , Tramadol/efectos adversosRESUMEN
Fundamento:la incidencia de cáncer de pulmón en la provincia Sancti Spíritus es alta y su diagnóstico por lo general, se realiza en etapas avanzadas por lo cual el tratamiento quirúrgico no siempre es posible.Objetivo:analizar las principales características y resultados de los pacientes operados por cáncer de pulmón.Métodos:se realizó un estudio observacional descriptivo de corte transversal en el servicio de Cirugía General del Hospital Universitario General Camilo Cienfuegos en la provincia Sancti Spiritus en el período comprendido entre enero de 1996 y diciembre de 2019. El universo consistió en 83 pacientes operados con cáncer de pulmón que se sometieron a resección acompañados de muestreo de ganglios linfáticos mediastinales. Resultados: el sexo masculino predominó en el grupo estudiado. Los grupos de edades más frecuentes para ambos sexos fueron los de 51 a 60 años y los mayores de 60 años. El hábito de fumar estuvo presente en la mayoría de los pacientes. La localización tumoral más predominó fue en los lóbulos superiores y la lobectomía fue la técnica más realizada. Las etapas patológicas que predominaron fueron la lB y llB, seguidas de la lllA. El carcinoma de células escamosas fue el tipo histológico más frecuente. Las atelectasias y las infecciones respiratorias fueron las complicaciones más frecuentes. Los fallecidos fueron pocos.Conclusiones:las características demográficas de los pacientes estudiados se corresponden a otras series de pacientes con cáncer del pulmón. La localización tumoral en los lóbulos superiores, el carcinoma epidermoide, así como las etapas tempranas, predominaron en la serie estudiada. La lobectomía fue la técnica quirúrgica que se utilizó con mayor frecuencia y dentro de las complicaciones, las respiratorias fueron las más frecuentes.[AU]
Asunto(s)
Neoplasias Pulmonares/cirugía , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/complicaciones , Neumonectomía/métodos , Carcinoma de Células Escamosas/complicacionesRESUMEN
A woman aged 63 years presented at the gynecological oncology outpatient clinic with the following medical history: smoking history (smoking index of 10); systemic arterial hypertension diagnosed 6 years ago; menarche at 16 years; menopause at 52 years; 4 pregnancies, 4 deliveries; beginning of active sexual life at 18 years; 3 sexual partners; and no early cancer detection method in her life. Her performance status per ECOG criteria was 1. The patient presented with transvaginal bleeding with 5 months of evolution. Upon physical exploration, a 5 x 5 cm tumor in the cervix was detected, with the following characteristics: exophytic, friable, bleeding, with invasion to the lower third of the vagina, affection to the cul-de-sac and parametria, and bilaterally fixed to the pelvic wall. A biopsy of the cervix showed moderately differentiated invasive squamous cell carcinoma.
Asunto(s)
Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/patología , Insuficiencia Renal/patología , Neoplasias del Cuello Uterino/complicaciones , Neoplasias del Cuello Uterino/patología , Femenino , Humanos , Persona de Mediana Edad , Invasividad Neoplásica , Insuficiencia Renal/etiologíaRESUMEN
Introdução: O pênfigo paraneoplásico é uma doença autoimune caracterizada pela produção de autoanticorpos por células tumorais neoplásicas. O primeiro sinal da doença são úlceras orais em 45% dos casos. Sua persistência e progressão são características de malignidade, reconhecida ou oculta. O difícil manejo dessa complicação, devido à doença de base não controlada, leva à piora dos sintomas e perda da qualidade de vida do doente. Objetivos: Relato de uma patologia rara, pouco relacionada a neoplasias sólidas, refratária a maioria dos tratamentos e com alta taxa de morbimortalidade. Métodos: Relato de caso de uma paciente com diagnóstico de carcinoma epidermoide de colo do útero, estadio IVa, com doença fora de controle e manifestações de pênfigo paraneoplásico cutâneo e mucoso. Resultados: A paciente apresentou o pênfigo paraneoplásico como complicação do câncer, com dificuldade de diagnóstico pela raridade da doença. Atualmente, sintomática com pouca resposta à corticoterapia. Conclusões: A raridade de algumas doenças torna o atraso no diagnóstico uma dificuldade ao tratamento. Assim como, o padrão de apresentação e a pouca experiência com patologias raras leva, muitas vezes, ao subdiagnóstico e subtratamento de nossos doentes, com perda da qualidade de vida
Background: Paraneoplastic pemphigus is an autoimmune disease characterized by autoantibody production by malignant tumor cells. The first sign of the disease is oral ulcer in 45% of cases. Their persistence and progression are features of malignancy, recognized or hidden. The difficult management of this complication due to uncontrolled underlying disease leads to the worsening of symptoms and loss of the patients' quality of life. Objective: Report a rare pathology, uncommonly related to solid neoplasms, refractory to most procedures and with high rates of morbidity and mortality. Methods: Case report of a patient diagnosed with squamous cell carcinoma of the cervix, stage IVa, with disease out of control and manifestations of skin and mucous paraneoplastic pemphigus. Results: The patient presented paraneoplastic pemphigus as a complication of the cancer, with a difficult diagnosis because of the rarity of the disease. Currently, symptomatic with little response to corticosteroid therapy. Conclusions: The uncommonness of some diseases makes the delay in diagnosing an obstacle to treatment. The presentation pattern and the little experience in rare diseases often lead to the underdiagnosis and undertreatment of our patients and loss of quality of life.
Asunto(s)
Humanos , Femenino , Adulto , Carcinoma de Células Escamosas/complicaciones , Pénfigo , /complicaciones , NeoplasiasRESUMEN
RESUMEN Se presentó el caso de un paciente masculino de 60 años, blanco, que fue atendido en la Consulta de Oftalmología, del Hospital "Dr. Mario Muñoz", del municipio de Colón, provincia de Matanzas. Refirió que llevaba aproximadamente 20 días, con sensación de cuerpo extraño en el ojo izquierdo, enrojecimiento, secreción constante, fotofobia y una lesión que le había aumentado de tamaño durante este período; la que se tornaba dolorosa durante el parpadeo. Se decidió realizar este trabajo con el objetivo de mostrar los beneficios obtenidos al concluir el tratamiento aplicado a este tipo de tumor (AU).
ABSTRACT The authors present the case of a white male patient, aged 60 years, who assisted the Consultation of Ophthalmology of the Hospital "Dr. Mario Muñoz", of the municipality of Colon. He referred feeling a foreign body in the left eye for already 20 days, presence of redness, constant secretion, photophobia and a lesion that had grown during that period, painful when blinking. The authors decided to write this article with the objective of showing the benefits obtained with the applied treatment in this kind of tumor (AU).
Asunto(s)
Humanos , Masculino , Adulto , Signos y Síntomas , Carcinoma de Células Escamosas/epidemiología , Oftalmología/métodos , Carcinoma de Células Escamosas/cirugía , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/diagnóstico , Cuerpos Extraños en el Ojo/complicaciones , Cuerpos Extraños en el Ojo/diagnóstico , Factores de Riesgo , Córnea/anomalías , Fotofobia/complicaciones , Fotofobia/diagnósticoRESUMEN
BACKGROUND: The objectives of the present study were to evaluate angiogenesis and mast cell density in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: This was an observational, retrospective and quantitative study. The samples consisted of 60 tissue specimens from patients with squamous cell carcinoma, epithelial dysplasia and controls (n=20/group). Immunohistochemistry was performed using an anti-tryptase antibody to mast cells and anti-CD31 and anti-CD34 for blood vessels and we count the number of mast cells and determine the percentage of CD31 and CD34 antibody staining (vascular density). RESULTS: The mast cells had lower density in OSCC compared to control and dysplasia (p = 0.009). In angiogenesis, the expression of CD31 showed a higher percentage of blood vessels in OSCC (p < 0.001), however, CD34 showed no difference between groups (p=0.092). The CD31 antibody presented as a high immunostaining in oral mucosa than CD34. CONCLUSIONS: The increased vascularity in squamous cell carcinoma suggests that angiogenesis begins when malignant transformation starts that seems to be inversely associated with the number of mast cells.
Asunto(s)
Biomarcadores de Tumor/análisis , Vasos Sanguíneos/patología , Carcinogénesis/patología , Carcinoma de Células Escamosas/complicaciones , Mastocitos/patología , Neoplasias de la Boca/complicaciones , Neovascularización Patológica/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Carcinogénesis/inmunología , Carcinoma de Células Escamosas/irrigación sanguínea , Carcinoma de Células Escamosas/inmunología , Carcinoma de Células Escamosas/patología , Estudios de Casos y Controles , Femenino , Estudios de Seguimiento , Humanos , Masculino , Mastocitos/inmunología , Persona de Mediana Edad , Neoplasias de la Boca/irrigación sanguínea , Neoplasias de la Boca/inmunología , Neoplasias de la Boca/patología , Neovascularización Patológica/etiología , Pronóstico , Estudios RetrospectivosRESUMEN
Caso clínico: femenino de 18 años con diagnóstico de epidermolisis ampollosa distrófica (EAD) quién desarrolló una neoformación nodular sobre una úlcera crónica. Se diagnosticó carcinoma epidermoide (CE) invasor al que se realizó resección. Sin embargo, 5 meses después del tratamiento quirúrgico presentó metástasis a ganglios, pulmón e hígado con desenlace fatal. Comentarios: el CE es la causa más importante de muerte en pacientes con EAD. Suele ser agresivo y metastásico. Se recomienda una vigilancia cada 3 a 6 meses para realizar diagnóstico y tratamiento oportunos (AU)
Case report: 18-year-old female patient with dystrophic epidermolysis bullosa (DEB) who developed a tumor over a chronic ulcer. She was diagnosed with invasive squamous cell carcinoma (SCC) and underwent surgical resection. However, 5 months later she presented metastases to the lymph nodes, lung and liver with a fatal outcome. Comments: SCC is the most important cause of death in patients with DEB. It is usually aggressive and metastatic. Surveillance every 3 to 6 months is recommended for prompt diagnosis and treatment (AU)