RESUMEN
Higher cardiorespiratory fitness has been associated with improved cognitive control in preadolescent children, with various studies highlighting related brain health benefits. This cross-sectional study aimed to provide novel insights into the fitness-cognition relationship by investigating task-related changes in effective connectivity within two brain networks involved in cognitive control: the cingulo-opercular and fronto-parietal networks. Twenty-four higher-fit and twenty-four lower-fit preadolescent children completed a modified flanker task that modulated inhibitory control demand while their EEG and task performance were concurrently recorded. Effective connectivity for correct trials in the theta band was estimated using directed transfer function. The results indicate that children with higher fitness levels demonstrated greater connectivity in specific directions within the cingulo-opercular network (average effect size, d = 0.72). Brain-behavior correlations demonstrated a positive association between the majority of these connections and general task accuracy, which was also higher in higher fit children (average correlation coefficient, ρ = 0.34). The findings further support a positive relationship between fitness and cognitive performance in children. EEG findings offer novel insights into the potential brain mechanisms underlying the fitness-cognition relationship. The study suggests that increased task-related connectivity within the cingulo-opercular network may mediate the cognitive benefits associated with higher fitness levels in preadolescent children.
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Capacidad Cardiovascular , Cognición , Electroencefalografía , Humanos , Niño , Cognición/fisiología , Masculino , Femenino , Capacidad Cardiovascular/fisiología , Estudios Transversales , Red Nerviosa/fisiología , Giro del Cíngulo/fisiología , Encéfalo/fisiologíaRESUMEN
PURPOSE: Improving cardiorespiratory fitness (CRF) through exercise training is associated with lower morbidity and mortality in patients with atrial fibrillation (AF). Smaller CRF improvements have been suggested in females than males with cardiovascular disease following exercise training. This systematic review compared changes in CRF (primary) and additional physical and mental health outcomes following exercise training between females and males with AF. REVIEW METHODS: Five bibliographic databases were searched to identify prospective studies implementing exercise training in patients with AF. The mean difference (MD) in the change following exercise training was compared between sexes using random-effects meta-analyses. SUMMARY: Sex-specific data were obtained from 19 of 63 eligible studies, with 886 participants enrolled in exercise training (n = 259 [29%] females; female: 68 ± 7 years, male: 66 ± 8 years). Exercise training was 6 weeks to 1 year in duration and mostly combined moderate- to vigorous-intensity aerobic and resistance training, 2 to 6 d/wk. Changes in CRF did not differ between sexes (MD = 0.15: 95% CI, -1.08 to 1.38 mL O2/kg/min; P = .81; I2 = 27%). Severity of AF (MD = 1.00: 95% CI, 0.13-1.87 points; I2 = 0%), general health perceptions (MD = -3.71: 95% CI, -6.88 to -0.55 points; I2 = 22%), and systolic blood pressure (MD = 3.11: 95% CI, 0.14-6.09 mmHg; I2 = 42%) improved less in females than in males. Females may benefit from more targeted exercise training programs given their smaller improvement in several health outcomes than males. However, our findings are largely hypothesis-generating, considering the limited sample size and underrepresentation of females (29% females in our review vs 47% females with AF globally).
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Fibrilación Atrial , Capacidad Cardiovascular , Terapia por Ejercicio , Humanos , Fibrilación Atrial/fisiopatología , Fibrilación Atrial/rehabilitación , Fibrilación Atrial/terapia , Capacidad Cardiovascular/fisiología , Terapia por Ejercicio/métodos , Femenino , Masculino , Factores SexualesRESUMEN
Technique-specific high-intensity interval training (HIITTS) has been proven to be an effective method to enhance the sport-specific bio-motor abilities of taekwondo athletes. However, studies regarding its effects on comprehensive measures of cardiorespiratory fitness are limited. Furthermore, there is a lack of clarity regarding the extent of individual adaptations to this method compared to HIIT in the form of repeated sprints (HIITRS). This study compared the individual adaptations to HIITRS and HIITTS on cardiorespiratory fitness and anaerobic power in trained taekwondo athletes (age = 19.8 ± 1.3 years; body mass = 75.4 ± 9.1 kg; height = 1.73 ± 0.0 .m). All participants completed three sessions per week of a 60-minute regular taekwondo training. Following the 60-minute training, participants completed 3 sets of 10 × 4 s all-out HIITRS or same sets of repeated kicks with both legs (HIITTS) over a 6-week training period. In both groups, rest intervals were set at 15 seconds between efforts and one minute between sets. Before and after the training period, participants underwent a series of lab- and field-based tests to evaluate cardiorespiratory fitness and bio-motor abilities. Both interventions resulted in significant improvements in maximum oxygen uptake (VÌO2max), O2 pulse (VÌO2/HR), first ventilatory threshold (VT1), second ventilatory threshold (VT2), cardiac output (QÌmax), stroke volume (SV), peak power output (PPO), average power output (APO), squat jump (SJ), and countermovement jump (CMJ). However, linear speed (20-m speed time) and taekwondo-specific agility test (TSAT) only responded to HIITRS. HIITRS resulted in greater changes in VÌO2max, VÌO2/HR, VT2, and QÌmax, and higher percentage of responders in measured parameters than HIITTS. In addition, HIITRS elicited lower inter-individual variability (CV) in percent changes from pre- to post-training in all measured variables. These results suggest that incorporating 3 sessions per week of HIITRS into regular taekwondo training results in significantly greater and more homogenized adaptations in cardiorespiratory fitness and bio-motor abilities than HIITTS among trained taekwondo athletes.
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Capacidad Cardiovascular , Entrenamiento de Intervalos de Alta Intensidad , Artes Marciales , Consumo de Oxígeno , Humanos , Capacidad Cardiovascular/fisiología , Entrenamiento de Intervalos de Alta Intensidad/métodos , Adulto Joven , Artes Marciales/fisiología , Masculino , Frecuencia Cardíaca/fisiología , Adaptación Fisiológica , Femenino , Umbral Anaerobio/fisiología , Rendimiento Atlético/fisiologíaRESUMEN
Objective: The aim of this study was to assess temporal changes in physical fitness of Chinese adolescents aged 13-18 years from 1985 to 2019. Methods: Body size /composition and physical fitness indicators, including body height, weight, body mass index (BMI), speed, power, flexibility, muscular endurance, and cardiorespiratory fitness (CRF), were selected from Chinese boys and girls aged 13-18 years from eight Chinese National Surveillance on Students' Constitution and Health from 1985 to 2019. Temporal changes in means were estimated by sample-weighted linear regression at the test × sex × age level, and national trends were estimated by a post-stratification population weighting procedure. Results: Overall mean body height, weight and BMI increased significantly for Chinese adolescents over 34 years. There was a small improvement for boys in speed (Effect size [ES] = -0.21, 95% confidence interval [CI] = -0.44 ~ 0.02), a small improvement for boys in power (ES = 0.24, 95% CI = -0.20 ~ 0.69), a small improvement for girls in flexibility (ES = 0.45, 95% CI = 0.15 ~ 0.76), a moderate decline for boys (ES = -0.53 95% CI = -0.84 ~ -0.21) and a moderate improvement for girls (ES = 0.61, 95% CI = -0.03 ~ 1.26) in muscular endurance, and large declines in cardiorespiratory fitness (CRF) for boys (ES = 0.93, 95% CI = 0.64 ~ 1.21) and girls (ES = 0.93, 95% CI = 0.58 ~ 1.27) from 1985 to 2019. These trends in each component of fitness were more positive for adolescents aged 13-15 years than that of adolescents aged 16-18 years in both sexes, except for girls in flexibility. Conclusion: The decline in CRF was most pronounced among Chinese children and adolescents from 1985 to 2019, suggesting a future decline in population health that needs attention.
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Aptitud Física , Humanos , Adolescente , Masculino , Femenino , Aptitud Física/fisiología , China , Índice de Masa Corporal , Encuestas y Cuestionarios , Capacidad Cardiovascular/fisiologíaRESUMEN
PURPOSE: Following acute myocardial infarction (AMI), patients with diabetes mellitus (DM) have a poorer prognosis than those without DM. This study aimed to investigate the benefit of cardiac rehabilitation on cardiorespiratory fitness in patients with AMI, examining whether this effect varied depending on DM and glycated hemoglobin (HbA1c) levels. METHODS: Data were collected from the medical records of 324 patients diagnosed with AMI who were subsequently referred to participate in a supervised exercise-based cardiac rehabilitation program. Cardiorespiratory fitness was assessed using cardiopulmonary exercise testing before and at 3 and 6 mo after the start of cardiac rehabilitation. Linear mixed models were used to evaluate changes in cardiorespiratory fitness between patients with and without DM during the follow-up period. RESULTS: In total, 106 patients (33%) had DM. Both patients with and without DM showed a significant improvement in cardiorespiratory fitness from baseline to the 6-mo follow-up. However, the improvement was significantly lower in patients with DM than in those without DM (1.9 ± 1.5 vs. 3.7 ± 3.2 mL/kg/min, P < .001). Among patients with DM, those with HbA1c levels < 7% showed a greater improvement in cardiorespiratory fitness than those with HbA1c ≥ 7% (2.7 ± 1.5 vs. 1.1 ± 1.8 mL/kg/min, P < .001) during the follow-up period. CONCLUSIONS: Improvements in cardiorespiratory fitness following cardiac rehabilitation were significantly lower in patients with AMI and DM. The response to cardiac rehabilitation in patients is influenced by HbA1c levels. These findings suggest potential implications for individualizing cardiac rehabilitation programming and ensuring optimal glycemic control in patients with AMI and DM.
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Rehabilitación Cardiaca , Capacidad Cardiovascular , Diabetes Mellitus , Hemoglobina Glucada , Infarto del Miocardio , Humanos , Masculino , Hemoglobina Glucada/análisis , Femenino , Infarto del Miocardio/rehabilitación , Infarto del Miocardio/fisiopatología , Infarto del Miocardio/sangre , Capacidad Cardiovascular/fisiología , Persona de Mediana Edad , Rehabilitación Cardiaca/métodos , Diabetes Mellitus/fisiopatología , Diabetes Mellitus/sangre , Anciano , Terapia por Ejercicio/métodos , Prueba de Esfuerzo/métodos , Estudios RetrospectivosRESUMEN
The aim of this study was to investigate the effects of a supplement rich in ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) and antioxidant vitamins on physical performance and body composition following a period of high-intensity functional training (HIFT). Nineteen healthy young adults (nine males, ten females) underwent an 8-week HIFT program (3 days·week-1) where they were randomized 1:1 into either the supplement group (SG)-n = 10, receiving a 20 mL daily dose of a dietary cocktail formula (Neuroaspis™ PLP10) containing a mixture of ω-3 and ω-6 PUFAs (12,150 mg), vitamin A (0.6 mg), vitamin E (22 mg), and γ-tocopherol (760 mg)-or the placebo group (PG)-n = 9, receiving a 20 mL daily dose of virgin olive oil. Body composition, cardiorespiratory fitness, muscle strength, and muscle endurance were assessed before and after the training period. Body mass did not change, but muscle mass increased by 1.7 ± 1.9% or 0.40 ± 0.53 kg in the SG (p = 0.021) and decreased by 1.2 ± 1.6% or 0.28 ± 0.43 kg (p = 0.097) in the PG, compared with baseline. VO2max, vertical jump, squat 1RM, bench press 1RM, and muscle endurance increased similarly in both groups. The effects of HIFT on physical performance parameters, muscle damage, and inflammation indices were not affected by the supplementation. In conclusion, HIFT combined with high doses of ω-3 and ω-6 PUFAs and antioxidant vitamins resulted in a small but significant increase in muscle mass and fat reduction compared with HIFT alone.
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Antioxidantes , Composición Corporal , Suplementos Dietéticos , Ácidos Grasos Omega-3 , Ácidos Grasos Omega-6 , Humanos , Masculino , Femenino , Ácidos Grasos Omega-3/administración & dosificación , Ácidos Grasos Omega-3/farmacología , Ácidos Grasos Omega-6/administración & dosificación , Antioxidantes/administración & dosificación , Método Doble Ciego , Composición Corporal/efectos de los fármacos , Adulto Joven , Adulto , Fuerza Muscular/efectos de los fármacos , Ejercicio Físico/fisiología , Vitaminas/administración & dosificación , Vitaminas/farmacología , Capacidad Cardiovascular/fisiología , Vitamina E/administración & dosificación , Vitamina E/farmacología , Entrenamiento de Intervalos de Alta Intensidad/métodosRESUMEN
Executive function (EF) has a significant impact on career achievement in adolescence and later adulthood, and there are many factors that influence EF. Cardiorespiratory fitness (CRF) is an important factor in the physical fitness of adolescents and is of great significance to healthy development. However, the current association between CRF and EF in Chinese adolescents is still unclear. For this reason, this study analysed the association between CRF and EF. A three-stage stratified cluster sampling method was used to investigate the demographic information, CRF, EF and multiple covariates of 1245 adolescents in China. One-way analysis of variance and chi-square test were used to compare the EF status of different CRFs. The association between CRF and EF was analysed using multiple linear regression analysis and logistic regression analysis. Multiple linear regression analysis showed that, after adjusting for relevant confounding factors, compared with Chinese adolescents with VO2max < P25, the inhibition function reaction time, 1back reaction time, 2back reaction time, and cognitive flexibility response time of adolescents with VO2max > P75 decreased by 1.41 ms, 238.73 ms, 273.09 ms, 74.14 ms. Logistic regression analysis showed that compared with Chinese adolescents with VO2max > P75, Chinese adolescents with VO2max < P25 developed inhibitory function dysfunction (OR 2.03, 95% CI: 1.29, 3.20), 1back dysfunction (OR 6.26, 95% CI 3.94, 9.97), 2back dysfunction (OR 8.94, 95% CI 5.40, 14.82), cognitive flexibility dysfunction (OR 2.26, 95% CI 1.44, 3.57) The risk was higher (P < 0.01). There is a positive association between CRF and EF in Chinese adolescents. High-grade CRF adolescents have higher EF levels, that is, shorter response times. This study provides reference and lessons for better promoting adolescents' executive function development in the future.
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Capacidad Cardiovascular , Función Ejecutiva , Humanos , Capacidad Cardiovascular/fisiología , Adolescente , Función Ejecutiva/fisiología , Femenino , Masculino , China , Pueblo Asiatico , Tiempo de Reacción/fisiología , Niño , Pueblos del Este de AsiaRESUMEN
This study investigated the effects of different exercise interventions on cardiopulmonary function in male tobacco-dependent college students. Forty-five male tobacco-dependent college students were recruited as the tobacco-dependent (TB) group, and 45 non-tobacco-dependent college students were recruited as the control group. The TB group was randomly assigned to three subgroups: non-exercise (NE), high-intensity interval training (HIIT), and moderate-intensity continuous training (MICT). The HIIT and MICT groups underwent a 10-week exercise training, while the NE group received no intervention. Cardiac parameters, including maximal oxygen uptake (VO2max), heart rate max (HRmax), and heart rate reserve (HRR), and pulmonary indicators, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), vital capacity (VC), maximum ventilation volume (MVV), and peak expiratory flow (PEF) were investigated. The results showed that the TB group had significantly lower cardiopulmonary function than the control group. The degree of tobacco dependence was negatively correlated with VO2max, FVC, FEV1, FEV1/FVC, and MVV. Furthermore, both HIIT and MICT training improved cardiopulmonary function. HIIT training exhibited superior efficacy compared to MICT in improving HRmax, HRR, FVC, FEV1, FEV1/FVC, and PEF. In conclusion, tobacco dependence adversely affects cardiopulmonary function in male college students. Both HIIT and MICT effectively improved cardiopulmonary function, with HIIT showing superior efficacy.
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Frecuencia Cardíaca , Entrenamiento de Intervalos de Alta Intensidad , Consumo de Oxígeno , Tabaquismo , Humanos , Masculino , Frecuencia Cardíaca/fisiología , Adulto Joven , Consumo de Oxígeno/fisiología , Capacidad Vital , Tabaquismo/fisiopatología , Tabaquismo/terapia , Estudiantes , Pulmón/fisiología , Capacidad Cardiovascular/fisiología , Pruebas de Función Respiratoria , Volumen Espiratorio ForzadoRESUMEN
PURPOSE: To analyze cardiorespiratory fitness (CRF) levels using the gold-standard, laboratory-based cardiopulmonary exercise test (CPET) in community-dwelling older adults (N = 145) with amnestic mild cognitive impairment (aMCI), specifically CPET feasibility, CRF prediction, and CRF status in comparison to published sedentary, cognitively normal, age- and sex-adjusted normative data. METHOD: Peak oxygen consumption (VO2Peak [mL/kg/min]) was assessed by CPET, which was categorized as submaximal, near-maximal, or maximal tests. VO2Max predicted was compared to VO2Max measured to assess its utility. Data were analyzed with t tests. RESULTS: Participants' mean age was 73.77 years (SD = 5.74 years), with 51.7% males, 91.7% Caucasian, 68.3% married, and 16.9 years (SD = 2.88 years) of education. Mean VO2Peak measured was 17.07 (SD = 4.92) for the total sample (18.29 [SD = 4.64] for males, 15.78 [SD = 4.91] for females). Sixteen (11.03%) CPETs were submaximal, 53 (36.55%) were near-maximal, and 76 (52.41%) were maximal. Mean VO2Max predicted was 28.59 (SD = 21.94) for the total sample (29.36 [SD = 22.3] for males, 27.76 [SD = 21.68] for females) and was significantly higher than VO2Max measured (p < 0.0001). Among participants with maximal CPETs, VO2Peak measured was significantly lower than sedentary normative data (p < 0.0001). CONCLUSION: CPET was feasible for older adults with aMCI. VO2Max predicted overly inflates CRF estimates. Low levels of CRF in older adults with aMCI suggest aerobic exercise as an important intervention. [Journal of Gerontological Nursing, 50(9), 31-36.].
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Enfermedad de Alzheimer , Capacidad Cardiovascular , Disfunción Cognitiva , Prueba de Esfuerzo , Humanos , Masculino , Femenino , Anciano , Disfunción Cognitiva/fisiopatología , Capacidad Cardiovascular/fisiología , Enfermedad de Alzheimer/fisiopatología , Prueba de Esfuerzo/métodos , Anciano de 80 o más Años , Consumo de Oxígeno , Ejercicio FísicoRESUMEN
BACKGROUND: Limited evidence supports the effects of short-interval high-intensity interval training (HIIT) for improving cardiorespiratory fitness (VÌO2peak) after stroke. We aimed to compare the effects of 12 weeks of short-interval HIIT versus moderate-intensity continuous training (MICT) on VÌO2peak, cardiovascular risk factors, and mobility outcomes among individuals ≥6 months poststroke. METHODS: This study was a multi-site, 12-week randomized controlled trial (NCT03614585) with an 8-week follow-up. Participants were randomized into 3 d/wk of HIIT (10×1 minute 80%-100% heart rate reserve interspersed with 1 minute 30% heart rate reserve [19 minutes]) or MICT (20-30 minutes 40%-60% heart rate reserve). Secondary outcomes of the trial, including VÌO2peak, cardiovascular risk factors (carotid-femoral pulse wave velocity, blood pressure, and waist-hip ratio), and mobility (6-minute walk test, 10 m gait speed), were reported. Linear mixed model analyses with a group×study time point interaction evaluated between-group differences. RESULTS: Of the 305 potential participants, 82 consented (mean [SD] age 64.9 [9.3] years, 32 females [39%], 1.8 [1.2] years poststroke) and were randomized to HIIT (n=42, mean [SD] baseline VÌO2peak 17.3 [5.9] mL/kg·min) or MICT (n=40, mean [SD] baseline VÌO2peak 17.2 [6.0] mL/kg·min). Participants attended 82% of visits (n=2417/2952). No adverse events occurred during the study period. A significant group×study time point interaction was found (χ2=8.46; P=0.015) for VÌO2peak at 12 weeks (mean difference, 1.81 [95% CI, 0.58-3.04]; P=0.004) whereby the HIIT group had greater gains in VÌO2peak (∆3.52 mL/kg·min [95% CI, 2.47-4.57]; P<0.001) compared with the MICT group (∆1.71 mL/kg·min [95% CI, 0.55-2.86]; P=0.001). There was no between-group difference in VÌO2peak (mean difference, 1.08 [95% CI, -0.26 to 2.42]; P=0.11) at 8-week follow-up. No group×study time point interactions were found for cardiovascular risk factors or mobility outcomes. CONCLUSIONS: Short-interval HIIT may be an effective alternative to MICT for improving VÌO2peak at 12 weeks postintervention. REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT03614585.
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Capacidad Cardiovascular , Entrenamiento de Intervalos de Alta Intensidad , Rehabilitación de Accidente Cerebrovascular , Accidente Cerebrovascular , Humanos , Femenino , Masculino , Persona de Mediana Edad , Entrenamiento de Intervalos de Alta Intensidad/métodos , Capacidad Cardiovascular/fisiología , Anciano , Rehabilitación de Accidente Cerebrovascular/métodos , Accidente Cerebrovascular/fisiopatología , Accidente Cerebrovascular/terapia , Consumo de Oxígeno/fisiología , Frecuencia Cardíaca/fisiología , Terapia por Ejercicio/métodosRESUMEN
INTRODUCTION: Skeletal muscle dysfunction is a significant factor contributing to exercise limitation in patients with chronic obstructive pulmonary disease (COPD). Although exercise training is often recommended to enhance patient outcomes, there continues to be ongoing debate regarding its exact effects. OBJECTIVE: The aim of this study is to evaluate the effectiveness of endurance exercise, strength training and combined exercise on cardiorespiratory fitness (including maximal oxygen uptake, maximal minute ventilation, and the 6-minute walk test), strength of lower limbs (measured by leg press), and quality of life (using the COPD Assessment Test) in patients with COPD. By conducting a systematic review and meta-analysis of randomized controlled trials (RCTs), our objective is to provide tailored training methods and intensity recommendations for patients with COPD in order to improve their quality of life. METHODS: The meta-analysis included 10 randomized controlled trials (RCTs) of exercise rehabilitation programs involving 180 patients with COPD that were retrieved from electronic databases (PubMed, Cochrane Library, and Embase). Two reviewers independently assessed the topical relevance, trial quality, and extracted data for the meta-analysis. RESULTS: Meta-analysis showed that primary outcomes representing exercise endurance were elevated under different exercise interventions compared to pre-test, such as maximal oxygen uptake (VO2max (ml/kg/min)) [SMD = 0.40, 95% CI (0.15, 0.64)] and the 6-min walk test (6MWT) [MD = 33.90, 95% CI (25.25, 42.55)], and primary outcomes representing strength also increased, such as leg press (1RM) [MD = 24.59, 95% CI (16.08, 33.11)], while secondary outcomes such as assessments of life such as the COPD Assessment Test (CAT) recovered [MD = 2.51, 95% CI (2.01, 3.00)], with all differences being statistically significant (p < 0.05). However, Maximum minute ventilation (VEmax (L)) [MD = 0.91, 95%CI (3.61, 5.43)] was not statistically significant (p > 0.05) when compared with the post-test data. The sensitivity test data were stable, and the results were reliable. We subgrouped the data from different types of exercise interventions and found that different types of exercise affected the experimental results. CONCLUSION: Exercise interventions have a positive effect on the treatment of patients with COPD, significantly improving functional capacity, aerobic capacity, and exercise tolerance, but they should be individualized and developed according to the patient's condition to achieve the best therapeutic effect.
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Terapia por Ejercicio , Enfermedad Pulmonar Obstructiva Crónica , Calidad de Vida , Ensayos Clínicos Controlados Aleatorios como Asunto , Enfermedad Pulmonar Obstructiva Crónica/terapia , Enfermedad Pulmonar Obstructiva Crónica/rehabilitación , Enfermedad Pulmonar Obstructiva Crónica/fisiopatología , Humanos , Terapia por Ejercicio/métodos , Tolerancia al Ejercicio , Pronóstico , Fuerza Muscular , Entrenamiento de Fuerza/métodos , Prueba de Paso , Capacidad Cardiovascular/fisiología , Consumo de Oxígeno , Masculino , FemeninoRESUMEN
Despite evidence that aerobic exercise benefits the aging brain, in particular the hippocampus and memory, controlled clinical trials have not comprehensively evaluated effects of aerobic exercise training on human memory in older adults. The central goal of this study was to determine chronic effects of moderate-to-vigorous intensity aerobic exercise on the hippocampus and memory in non-demented, inactive adults ages 55-80 years. We determine effects of aerobic exercise training with a 6-month randomized controlled trial (RCT) comparing 150 min/week of home-based, light intensity exercise with progressive moderate-to-vigorous intensity aerobic exercise. For the first time in a large trial, we examined temporal mechanisms by determining if individual differences in the rapid, immediate effects of moderate intensity exercise on hippocampal-cortical connectivity predict chronic training-related changes over months in connectivity and memory. We examined physiological mechanisms by testing the extent to which chronic training-related changes in cardiorespiratory fitness are a critical factor to memory benefits. The Exercise Effects on Brain Connectivity and Learning from Minutes to Months (Brain-EXTEND) trial is conceptually innovative with advanced measures of hippocampal-dependent learning and memory processes combined with novel capture of the physiological changes, genetic components, and molecular changes induced by aerobic exercise that change hippocampal-cortical connectivity. Given that hippocampal connectivity deteriorates with Alzheimer's and aerobic exercise may contribute to reduced risk of Alzheimer's, our results could lead to an understanding of the physiological mechanisms and moderators by which aerobic exercise reduces risk of this devastating and costly disease.
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Capacidad Cardiovascular , Ejercicio Físico , Hipocampo , Humanos , Anciano , Masculino , Femenino , Persona de Mediana Edad , Ejercicio Físico/fisiología , Capacidad Cardiovascular/fisiología , Anciano de 80 o más Años , Imagen por Resonancia Magnética , Aprendizaje/fisiología , Memoria/fisiología , Encéfalo/diagnóstico por imagen , Encéfalo/fisiologíaRESUMEN
In pre-pubertal children the factors affecting maximal oxygen uptake have yet to be fully understood. Therefore, the purpose of this analysis is to present cardiorespiratory fitness in prepubertal boys and girls and to determine if there are any differences based on sex, exercise testing modality or if maximal or peak oxygen consumption metrics are used. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed. For statistical analysis, multilevel models grounded in Bayesian principles were used. Selected studies obtained: maximal effort during the test, peak or maximal oxygen consumption (VÌO2) values, boys and girls (sex specific groups only) age under 11, cycle ergometry or treadmill, pre-intervention or no intervention data. In boys using cycle ergometry, 118 studies were included in the analysis, in boys using treadmill 115, in girls using cycle ergometry 83 and in girls using treadmill testing 95 study entries were included. As children get older, their cardiorespiratory fitness increases (P ≈ 100%). Studies with participants having smaller body mass have higher VÌO2 relative to body mass values (P ≈ 100%). Boys have higher VÌO2 values than girls (P ≈ 100%). Studies using treadmill reported higher values than those using cycle ergometer (P ≈ 100%). Regarding the influence of measurement method (max vs. peak) on VÌO2 values we did not find significant differences. In conclusion, we present reference values for cardiorespiratory fitness in prepubertal boys and girls using cycle ergometry or treadmill. Prepubertal boys have higher cardiorespiratory fitness than girls and using treadmill testing might be a preferred method to cycle ergometry, especially in older children. Maximal or peak oxygen consumption metrics might be used interchangeably in prepubertal children.
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Capacidad Cardiovascular , Prueba de Esfuerzo , Consumo de Oxígeno , Humanos , Consumo de Oxígeno/fisiología , Niño , Prueba de Esfuerzo/métodos , Capacidad Cardiovascular/fisiología , Femenino , Masculino , Factores SexualesRESUMEN
OBJECTIVE: To assess the validity of the Ekblom-Bak cycle ergometer test in patients with cardiovascular disease admitted to cardiac rehabilitation. METHODS: Estimated peak oxygen consumption from the Ekblom-Bak test was compared with directly measured peak oxygen consumption from a treadmill cardiopulmonary exercise test. Patients completed the cardiopulmonary exercise test first, followed by the Ekblom-Bak test after 24 h rest. Pearson's correlation coefficient (r) was used to establish the correlation between estimated and measured peak oxygen consumption, and Bland-Altman plots with limits of agreement were used to determine the bias between the 2 tests. RESULTS: Twenty-six patients were included in the final analysis. The Ekblom-Bak test significantly overestimated peak oxygen consumption. Agreement between estimated and measured peak oxygen consumption was: bias = 4.3 mL/kg/min (limits of agreement: -4.0-12.6 mL/kg/min). CONCLUSION: The Ekblom-Bak test overestimated peak oxygen consumption to such an extent that it cannot accurately assess cardiorespiratory fitness in patients with cardiovascular disease. Thus, the cardiopulmonary exercise test remains the test of choice.
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Enfermedades Cardiovasculares , Prueba de Esfuerzo , Consumo de Oxígeno , Humanos , Prueba de Esfuerzo/métodos , Consumo de Oxígeno/fisiología , Masculino , Enfermedades Cardiovasculares/fisiopatología , Femenino , Persona de Mediana Edad , Anciano , Reproducibilidad de los Resultados , Rehabilitación Cardiaca , Capacidad Cardiovascular/fisiologíaRESUMEN
BACKGROUND: This study was designed to evaluate the effect of using maximal cadence criteria cut points established during overground and treadmill walking, on intensity outputs measured during community ambulation. The second aim was to establish the relationship between cardiovascular fitness (predicted VO2 max capacity) and community ambulation intensity performance, in typically developing individuals. RESEARCH QUESTION: What is the effect on intensity measures when using cadence cut point criteria derived from overground and treadmill walking and does predicted VO2 max correlate with exercise related community activity in a typically developing population? METHODS: A group of 37 typically developing participants between 8 and 27 years of age, underwent a graded submaximal VO2 testing protocol followed by a typical week of community ambulation, recorded with a step activity monitor. Maximum cadence criteria established during overground and treadmill walking were applied and the data were compared. The weekly step activity variables included: total steps, total ambulatory time, intensity, duration, and volume. Predicted VO2 Max was calculated, and correlations calculated to step activity outputs. RESULTS: Results showed significant differences (p<0.001) between cadence cut point criteria across all intensity measures except in the amount of time spent in the 30-60â¯% intensity category (p=0.182). Predicted VO2 max did not significantly correlate with step activity outputs related to exercise (moderate+ intensity and long duration ambulatory bouts; p>0.277). SIGNIFICANCE: This study illustrates the importance of close consideration in applying recommended cut off criteria when assessing intensity outputs from step activity data. Cadence from both overground and treadmill walking were collected in a controlled lab setting, but the influence of the treadmill mechanical and forced cadence criteria must be considered when selecting intensity cut points.
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Prueba de Esfuerzo , Consumo de Oxígeno , Caminata , Humanos , Niño , Masculino , Femenino , Consumo de Oxígeno/fisiología , Adolescente , Caminata/fisiología , Adulto , Adulto Joven , Capacidad Cardiovascular/fisiologíaRESUMEN
Emerging evidence suggests that altered myelination is an important pathophysiologic correlate of several neurodegenerative diseases, including Alzheimer and Parkinson's diseases. Thus, improving myelin integrity may be an effective intervention to prevent and treat age-associated neurodegenerative pathologies. It has been suggested that cardiorespiratory fitness (CRF) may preserve and enhance cerebral myelination throughout the adult lifespan, but this hypothesis has not been fully tested. Among cognitively normal participants from two well-characterized studies spanning a wide age range, we assessed CRF operationalized as the maximum rate of oxygen consumption (VO2max) and myelin content defined by myelin water fraction (MWF) estimated through our advanced multicomponent relaxometry MRI method. We found significant positive correlations between VO2max and MWF across several white matter regions. Interestingly, the effect size of this association was higher in brain regions susceptible to early degeneration, including the frontal lobes and major white matter fiber tracts. Further, the interaction between age and VO2max exhibited i) a steeper positive slope in the older age group, suggesting that the association of VO2max with MWF is stronger at middle and older ages and ii) a steeper negative slope in the lower VO2max group, indicating that lower VO2max levels are associated with lower myelination with increasing age. Finally, the nonlinear pattern of myelin maturation and decline is VO2max-dependent with the higher VO2max group reaching the MWF peak at later ages. This study provides evidence of an interconnection between CRF and cerebral myelination and suggests therapeutic strategies for promoting brain health and attenuating white matter degeneration.
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Envejecimiento , Capacidad Cardiovascular , Imagen por Resonancia Magnética , Vaina de Mielina , Consumo de Oxígeno , Sustancia Blanca , Humanos , Capacidad Cardiovascular/fisiología , Vaina de Mielina/metabolismo , Envejecimiento/fisiología , Masculino , Femenino , Anciano , Persona de Mediana Edad , Sustancia Blanca/metabolismo , Sustancia Blanca/diagnóstico por imagen , Consumo de Oxígeno/fisiología , Adulto , Anciano de 80 o más Años , Encéfalo/metabolismo , Encéfalo/diagnóstico por imagenRESUMEN
Objective: The aim of this study was to evaluate the effect of HIIT and SIT programmes on body composition, blood pressure, lipid profile, glucose, cardiorespiratory fitness, and strength of adolescents and to compare the effect between those different protocols. Methods: Sixty adolescents were recruited from a high school and were randomly placed into three groups. SIT and HIIT undertook a training for 8 weeks, twice a week, for 12 min per session, during their Physical Education lessons. SIT group performed 6 sets of 60 s of work (90-95%HRmax) / 60 s of rest (50-55%HRmax), and HIIT group performed 3 sets of 2 min of work (80-85%HRmax) / 2 min of rest (50-55%HRmax). Results: After adjustment by sex, both experimental groups exhibited a significant reduction in fat mass (p < 0.01), and trunk fat mass (p < 0.01), as well as a significant increase in lean mass (p = 0.01; <0.01), hand-grip strength (p < 0.01) and standing long jump (p = 0.05-0.04, respectively). In addition, HIIT showed a significant (p < 0.05) improvement in blood pressure, diastolic blood pressure, heart rate and VO2max, and a tendency toward a significant reduction in low density lipoprotein. Conclusion: The implementation of a HIIT protocol within high school Physical Education sessions, maintained for 8 weeks, at a rate of 3 sets of 2 min of work (80-85% RHR)/2 min of rest (50-55% RHR) generated adaptations such as improved fitness condition, changes in body composition, and improvements in blood parameters and blood pressure. However, the group of adolescents who performed SIT, shorter but more intense sets, did not experience as many benefits.
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Biomarcadores , Composición Corporal , Entrenamiento de Intervalos de Alta Intensidad , Aptitud Física , Humanos , Adolescente , Masculino , Femenino , Aptitud Física/fisiología , Biomarcadores/sangre , Presión Sanguínea/fisiología , Lípidos/sangre , Capacidad Cardiovascular/fisiología , Glucemia/metabolismo , Glucemia/análisisRESUMEN
Background: With the spread and spread of COVID-19 around the world, youth's learning, lifestyle and health have been greatly affected. Based on the current research, there is no adequate analysis of the development of young people's physique and heart and lung health during COVID-19, and there is a lack of relevant targeted research. The aim of this study was to investigate the changes of BMI and Maximum Oxygen Absorption (VO2max) in 12-14 year old teenagers before and after COVID-19. Method: The BMI, 1,000/800 m running time and associated data related to 29,813 individuals between 2019 and 2022 were collected by cluster sampling, and the changes of BMI Z and VO2max before and after the outbreak were analyzed. Moreover, the relationship between BMI and cardiovascular endurance was analyzed by means of multi-linear stepwise regression. Results: The covariance analysis models indicated that compared with 2019, adolescent weight, BMI, and 1,000/800 m running time showed varying degrees of growth in 2020, while lung capacity decreased. All indicators achieved rapid rebound in 2021 and 2022 (p < 0.01); the one-way analysis of variance models indicated that The BMI Z score and VO2max of adolescents showed growth and decline in 2020, respectively, and achieved rapid recovery and development in 2021 and 2022 (p < 0.01). The results of the multiple linear stepwise regression analysis indicate that, after the years of BMI Z and novel coronavirus infection were included (â³R2 = 0.179), adolescents' overweight and obesity were positively correlated with the maximum oxygen uptake (B = 0.643, 95%CI = 0.634 ~ 0.652); There is a negative correlation between weight loss and maximum oxygen uptake (B = -0.510, 95%CI = -0.537~-0.484); The year of novel coronavirus infection was positively correlated with the maximum oxygen uptake of adolescents (B = 0.116, 95%CI = 0.107~0.125). Conclusion: This study shows that the impact of COVID-19 on BMI and heart and lung health in adolescents is significant. Young people of all ages and sexes showed similar developmental trends.
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Índice de Masa Corporal , COVID-19 , Humanos , COVID-19/epidemiología , Adolescente , Masculino , Femenino , China/epidemiología , Estudios Longitudinales , Estudios de Seguimiento , Niño , Consumo de Oxígeno/fisiología , Resistencia Física/fisiología , SARS-CoV-2 , Capacidad Cardiovascular/fisiología , Pandemias , Pueblos del Este de AsiaRESUMEN
Introduction: The purpose of the present study was to investigate the impact of the FIT FIRST FOR ALL school-based physical activity program on health-related physical fitness in Faroese schoolchildren. The program aimed to add three weekly sessions of organized high-intensity physical activity to the standard weekly physical education sessions for all pupils across the entire school. Methods: A non-randomized controlled design was used to evaluate the effects of the program. Two schools participated, including one intervention school (INT; n =179) and one control school (CON; n =181), with pupils aged 7-16 years (grades 1-9). The FIT FIRST FOR ALL program consisted of three weekly 40-minute sessions of age-adjusted high-intensity physical activity over 10 weeks for the INT school, while the CON school continued their normal school program. Pre- and post-intervention assessments included cardiorespiratory fitness (Yo-Yo IR1C test), agility (Arrowhead Agility test), postural balance (Stork Stand), standing long jump performance, body composition, blood pressure, and resting heart rate. Results: A significant time × group effect (pâ <â 0.001) was observed for cardiorespiratory fitness, which increased by 31% [23;39] in INT (pâ <â 0.001) and remained unaltered in CON (7% [-2;16], pâ =â 0.13). In addition, a time × group effect (pâ <â 0.001) was observed for agility, which improved by 2.1% [1.0;3.2] in INT (pâ <â 0.001) and regressed by 3.3% [2.3;4.4] in CON (pâ <â 0.001). No significant between-group effects were found for standing long jump and balance. A time × group effect (pâ <â 0.001) was observed for changes in total muscle mass, which increased by 1.4 kg [1.2;1.5] in INT (pâ <â 0.001) and by 0.4 kg [0.3;0.6] in CON (p < 0.05). Furthermore, a time × group effect (pâ <â 0.001) was observed for total fat percentage, which decreased by -2.3% [-2.8;-1.9] in INT (pâ <â 0.001) and remained unchanged in CON (-0.3% [-0.7;0.1], pâ =â 0.16). No significant time × group effects were found for blood pressure and resting heart rate. Discussion: The FIT FIRST FOR ALL program significantly improved cardiorespiratory fitness and agility, and it led to favorable changes in body composition in the intervention school. These findings suggest that the program is highly effective in enhancing physical fitness and health status across all investigated age groups when implemented at a school-wide level.
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Composición Corporal , Capacidad Cardiovascular , Ejercicio Físico , Humanos , Niño , Masculino , Femenino , Capacidad Cardiovascular/fisiología , Adolescente , Ejercicio Físico/fisiología , Instituciones Académicas , Educación y Entrenamiento Físico , Promoción de la Salud/métodos , Servicios de Salud Escolar , Dinamarca , Evaluación de Programas y Proyectos de Salud , Aptitud Física/fisiología , Frecuencia Cardíaca/fisiologíaRESUMEN
INTRODUCTION: Physical activity (PA) is believed to play an important part in many aspects during childhood and adolescence, especially cardiorespiratory fitness and cardiometabolic health. However, whether different levels of PA in daily life influence the structure or function of heart in school-aged children remains unknown. We aimed to investigate the association between PA and cardiovascular parameters in 7-year-old children. METHODS: Follow-up data from the Shanghai Prenatal Cohort Study and the Shanghai Birth Cohort was analyzed. Perinatal information including both maternal and offspring datum was recorded. A refined questionnaire was used to evaluate the frequency and duration of children's PA levels. Blood pressure, echocardiography, and anthropometry assessment were conducted during the follow-up of 7-year-old children. RESULTS: Overall, high PA level was associated with higher left ventricle posterior wall thickness in diastole (LVPWd, ß coefficient: 0.36, 95% CI: 0.12, 0.61), higher left ventricle mass index (LVMI, ß = 0.28, 95% CI: 0.07, 0.48), mitral E/a ratio (ß = 0.47, 95% CI: 0.22, 0.71) and slower heart rate (ß = -0.32, 95% CI: -0.57, -0.07), compared to low PA level. Medium PA level was associated with lower diastolic blood pressure (DBP, ß = -0.18, 95% CI: -0.35, -0.01). In subgroup analysis, increased relative wall thickness (RWT) was found in high PA level boys (ß = 0.36, 95% CI: 0.05, 0.67), and systolic blood pressure (SBP) showed a significant decrease in high PA level girls (ß = -0.42, 95% CI: -0.78, -0.06). CONCLUSIONS: This study suggested non-athlete children having higher PA level were associated with thicker left ventricle (LV) walls and better LV diastolic function, as well as slower heart rate and DBP at the age of 7. Furthermore, disparity in the association between PA level with morphological heart patterns and blood pressure existed in different sex category.