RESUMEN
Hearing loss is a common consequence of the strong acidosis induced by bromate poisoning. Partial hearing recovery has been achieved through medical or rehabilitative therapy but reports of surgical otology treatment for this condition are rare. We report the case of a 48-year-old female patient who underwent cochlear implantation after bromate intoxication had induced bilateral deafness. In cases with life-threatening renal damage, the diagnosis of hearing loss is sometimes delayed, but in our case, hearing impairment was unavoidable despite early detection of symptoms and early disruption of the use of diuretics that could cause hearing damage. Hearing loss 12 hours after bromate ingestion was successfully reversed through cochlear implantation (CI) six months after completing acute phase treatment, including dialysis for acute kidney injury. The benefit of CI for deafness by bromate intoxication is highlighted by this case.
Asunto(s)
Bromatos/envenenamiento , Implantación Coclear , Pérdida Auditiva Bilateral/cirugía , Compuestos de Sodio/envenenamiento , Lesión Renal Aguda/inducido químicamente , Femenino , Pérdida Auditiva Bilateral/inducido químicamente , Humanos , Persona de Mediana Edad , Diálisis Renal , Resultado del TratamientoAsunto(s)
Lesión Renal Aguda/inducido químicamente , Bromatos/envenenamiento , Pérdida Auditiva Sensorineural/inducido químicamente , Compuestos de Sodio/envenenamiento , Intento de Suicidio , Lesión Renal Aguda/terapia , Carbón Orgánico/administración & dosificación , Femenino , Lavado Gástrico , Hemodiafiltración , Humanos , Persona de Mediana Edad , Respiración Artificial , Tiosulfatos/administración & dosificación , Resultado del TratamientoRESUMEN
Accidental or deliberate ingestion of bromate solution has been reported in pediatric as well as adult cases; however there have been no reports of such intoxication in the elderly. We report a 78-year-old woman who suffered severe acute renal failure due to the accidental ingestion of sodium bromate solution. The patient was successfully treated with hemodialysis therapy and renal function recovered without hearing loss. This case suggests that emergency therapeutic measures, including hemodialysis, should be taken as soon as possible, and the rapid removal of bromate is essential to prevent severe intoxication and its sequelae. To the best of our knowledge this is the first report of an elderly patient that demonstrates the clinical benefit of hemodialysis therapy for bromate intoxication.
Asunto(s)
Lesión Renal Aguda/inducido químicamente , Bromatos/envenenamiento , Compuestos de Sodio/envenenamiento , Lesión Renal Aguda/patología , Lesión Renal Aguda/terapia , Anciano , Femenino , Humanos , Riñón/patología , Diálisis RenalRESUMEN
Acute renal failure with hearing loss due to sodium bromate intoxication is described. A 48-year-old woman who ingested permanent wave neutralizer in a suicide attempt and developed anuria was admitted to our hospital for hemodialysis. Bromate intoxication was suspected and hemodialysis was carried out; she required maintenance dialysis 3 times a week. Irreversible severe sensorineural hearing loss continued and peripheral polyneuropathy developed in the lower limbs. We measured the concentration of bromine in the serum before and after the first hemodialysis and found its removal rate to be 61.3%. This is the first report that proved the utility of hemodialysis for bromate intoxication in a clinical setting.
Asunto(s)
Lesión Renal Aguda/inducido químicamente , Bromatos/envenenamiento , Pérdida Auditiva Sensorineural/inducido químicamente , Compuestos de Sodio/envenenamiento , Intento de Suicidio , Lesión Renal Aguda/terapia , Femenino , Humanos , Persona de Mediana Edad , Diálisis RenalAsunto(s)
Bromatos/envenenamiento , Implantes Cocleares , Sordera/etiología , Femenino , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Lesión Renal Aguda/inducido químicamente , Lesión Renal Aguda/terapia , Bromatos/envenenamiento , Preparaciones para el Cabello/envenenamiento , Lesión Renal Aguda/diagnóstico , Adolescente , Antídotos/administración & dosificación , Femenino , Lavado Gástrico , Pérdida Auditiva Sensorineural/inducido químicamente , Humanos , Enfermedades del Sistema Nervioso/inducido químicamente , Diálisis Renal , Intento de Suicidio , Tiosulfatos/administración & dosificaciónRESUMEN
Efforts to link the observed signs in a canine poisoning event with 1 or more possible permanent wave solution chemicals ingested are described. A scenario is presented describing the mechanisms by which the most likely of those compounds, ammonium thioglycolate and sodium or potassium bromate, could have acted to cause both the immediate and delayed signs of acute vestibular dysfunction.
Asunto(s)
Bromatos/envenenamiento , Enfermedades de los Perros/inducido químicamente , Preparaciones para el Cabello/envenenamiento , Animales , Perros , Masculino , Nistagmo Patológico/inducido químicamente , Tioglicolatos/envenenamientoRESUMEN
The clinical manifestations of sodium bromate intoxication include among others acute renal failure and deafness. Most of the toxic manifestations are reversible with the exception of renal failure and deafness. This patient ingested about 7.5 g of sodium bromate powder, which produced gastrointestinal irritation, hypotension, fatigue, deafness, acute renal failure, anemia and peripheral neuropathy. Hemodialysis was performed three times due to acute renal failure, although the renal function improved, it did not recover completely. The patient was discharged with BUN: 42 mg/dL and creatinine: 3.4 mg/dL; she was still deaf.
Asunto(s)
Lesión Renal Aguda/inducido químicamente , Bromatos/envenenamiento , Sordera/inducido químicamente , Enfermedades del Sistema Nervioso/inducido químicamente , Compuestos de Sodio/envenenamiento , Adulto , Femenino , HumanosRESUMEN
We confirmed a cerebral lesion due to sodium bromate intoxication on MRI, SPECT, auditory brainstem response (ABR) and sensory evoked potential (SEP). The patient was 34 years old, and ingested sodium bromate (14 g) to commit suicide. Vomiting, epigastralgia, watery diarrhea and anuria appeared after 30 minutes and he became deaf within 12 hours. Renal function recovered after hemodialysis. Renal biopsy revealed acute renal tubular necrosis. After one month, burning pain appeared in bilateral lower extremities. Sporadic, clear and small high intensity spots were observed in the deep white matter of the right occipitotemporal border zone and bilateral centrum semiovale on T2 and proton weighted images of brain MRI. IMP-SPECT disclosed partial low perfusion in the left parietal gray matter. Central conduction time was delayed on ABR and SEP. The clinical symptoms and course together with laboratory studies suggest that the cerebral lesion was due to direct sodium bromate intoxication.
Asunto(s)
Encefalopatías/inducido químicamente , Bromatos/envenenamiento , Compuestos de Sodio , Sodio/envenenamiento , Adulto , Encefalopatías/diagnóstico , Potenciales Evocados Auditivos del Tronco Encefálico , Potenciales Evocados Somatosensoriales , Humanos , Imagen por Resonancia Magnética , Masculino , Tomografía Computarizada de Emisión de Fotón ÚnicoRESUMEN
We report two children who suffered from sodium bromate intoxication due to ingestion of the second preparation for permanent hair waving (the second permanent preparation). One child suffered from gastrointestinal symptoms only. The other exhibited slight acute renal insufficiency. Results of the histological examination of the kidney in the sick child with acute renal insufficiency showed sporadic epithelial separation of the proximal tubuli under light microscopy. In addition, we could demonstrate more clearly epithelial separation and unbroken tubular basement membranes under electron microscopy (EM). To our knowledge, this is the first report of EM findings in this disease. The mechanism of epithelial injuries by bromate is not clear.
Asunto(s)
Lesión Renal Aguda/inducido químicamente , Bromatos/envenenamiento , Preparaciones para el Cabello/envenenamiento , Túbulos Renales Proximales/patología , Compuestos de Sodio , Sodio/envenenamiento , Lesión Renal Aguda/patología , Preescolar , Células Epiteliales , Femenino , Enfermedades Gastrointestinales/inducido químicamente , Humanos , Lactante , Túbulos Renales Proximales/ultraestructura , Masculino , Microscopía ElectrónicaRESUMEN
Se trataron 8 pacientes intoxicados por diferentes métodos: hemoperfusión, hemodiálisis, diálisis peritoneal afectados de diferentes tóxicos (se desarrolla botulismo, bromato de potasio y metanol), se discuten las indicaciones de tratamiento
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Intoxicación/terapia , Botulismo/terapia , Bromatos/envenenamiento , Hemoperfusión , Lesión Renal Aguda/etiología , Diálisis Peritoneal , Diálisis Renal , Fenformina/efectos adversos , Intoxicación/diagnóstico , Intoxicación/tratamiento farmacológico , Alprazolam/envenenamiento , Bromazepam/envenenamiento , Hemoperfusión/instrumentación , Hemoperfusión , Coma/etiología , Coma/terapia , Metanol/envenenamiento , Metanol/metabolismo , Glicoles de Etileno/envenenamiento , Metotrimeprazina/envenenamiento , Acidosis Láctica/etiología , Acidosis Láctica/tratamiento farmacológico , Acidosis Láctica/terapia , Barbitúricos/envenenamientoRESUMEN
Se trataron 8 pacientes intoxicados por diferentes métodos: hemoperfusión, hemodiálisis, diálisis peritoneal afectados de diferentes tóxicos (se desarrolla botulismo, bromato de potasio y metanol), se discuten las indicaciones de tratamiento
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Hemoperfusión/métodos , Diálisis Renal/estadística & datos numéricos , Intoxicación/terapia , Bromatos/envenenamiento , Botulismo/terapia , Diálisis Peritoneal/estadística & datos numéricos , Lesión Renal Aguda/etiología , Intoxicación/diagnóstico , Intoxicación/tratamiento farmacológico , Hemoperfusión/instrumentación , Hemoperfusión/estadística & datos numéricos , Acidosis Láctica/etiología , Acidosis Láctica/tratamiento farmacológico , Acidosis Láctica/terapia , Coma/etiología , Coma/terapia , Fenformina/efectos adversos , Metanol/envenenamiento , Metanol/metabolismo , Glicoles de Etileno/envenenamiento , Alprazolam/envenenamiento , Metotrimeprazina/envenenamiento , Bromazepam/envenenamiento , Barbitúricos/envenenamientoRESUMEN
Se trataron 8 pacientes intoxicados por diferentes métodos: hemoperfusión, hemodiálisis, diálisis peritoneal afectados de diferentes tóxicos (se desarrolla botulismo, bromato de potasio y metanol), se discuten las indicaciones de tratamiento
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Hemoperfusión/métodos , Diálisis Renal/estadística & datos numéricos , Intoxicación/terapia , Bromatos/envenenamiento , Botulismo/terapia , Diálisis Peritoneal/estadística & datos numéricos , Diálisis/etiología , Intoxicación/diagnóstico , Intoxicación/tratamiento farmacológico , Hemoperfusión/instrumentación , Hemoperfusión/estadística & datos numéricos , Acidosis Láctica/etiología , Acidosis Láctica/tratamiento farmacológico , Acidosis Láctica/terapia , Coma/etiología , Coma/terapia , Fenformina/efectos adversos , Metanol/envenenamiento , Metanol/metabolismo , Glicoles de Etileno/envenenamiento , Alprazolam/envenenamiento , Metotrimeprazina/envenenamiento , Bromazepam/envenenamiento , Barbitúricos/envenenamientoRESUMEN
We experienced a case of a 44 year old man who had ingested potassium bromate solution for suicide attempt. Soon after the ingestion, nausea, vomiting, abdominal pain and diarrhea developed in him. Several hours later, he began to complain of auditory disturbance and, in addition, anuric acute renal failure occurred. Direct hemoperfusion and hemodialysis was performed on the patient for the treatment purpose. Five weeks later, he was released from hemodialysis procedure. Gradually, on the other hand, progressing anemia was observed until 90th hospital day, which slowly improved thereafter. Further, pruritus, lower leg pain, headache, tinnitus and loss of sense of taste, etc. were observed in the clinical course. Renal biopsy was performed on the 119th hospital day and the specimen showed the regenerative stage of acute tubular necrosis. In our case, acute renal failure was reversible and, many other clinical manifestations were observed. However slight anemia and irreversible severe auditory disturbance remained unimproved.
Asunto(s)
Bromatos/envenenamiento , Lesión Renal Aguda/inducido químicamente , Adulto , Anemia/inducido químicamente , Sordera/inducido químicamente , Humanos , Masculino , SuicidioRESUMEN
Potassium bromate (KBrO3) is an oxidizing agent that has been used as a food additive, mainly in the bread-making process. Although adverse effects are not evident in animals fed bread-based diets made from flour treated with KBrO3, the agent is carcinogenic in rats and nephrotoxic in both man and experimental animals when given orally. It has been demonstrated that KBrO3 induces renal cell tumors, mesotheliomas of the peritoneum, and follicular cell tumors of the thyroid. In addition, experiments aimed at elucidating the mode of carcinogenic action have revealed that KBrO3 is a complete carcinogen, possessing both initiating and promoting activities for rat renal tumorigenesis. However, the potential seems to be weak in mice and hamsters. In contrast to its weak mutagenic activity in microbial assays, KBrO3 showed relatively strong potential inducing chromosome aberrations both in vitro and in vivo. Glutathione and cysteine degrade KBrO3 in vitro; in turn, the KBrO3 has inhibitory effects on inducing lipid peroxidation in the rat kidney. Active oxygen radicals generated from KBrO3 were implicated in its toxic and carcinogenic effects, especially because KBrO3 produced 8-hydroxydeoxyguanosine in the rat kidney. A wide range of data from applications of various analytical methods are now available for risk assessment purposes.
Asunto(s)
Pan , Bromatos/toxicidad , Carcinógenos/toxicidad , Carcinoma de Células Renales/inducido químicamente , Aditivos Alimentarios/toxicidad , Preparaciones para el Cabello/envenenamiento , Neoplasias Renales/inducido químicamente , Compuestos de Potasio , Adenocarcinoma/inducido químicamente , Administración Oral , Animales , Pan/análisis , Bromatos/efectos adversos , Bromatos/farmacocinética , Bromatos/envenenamiento , Bromuros/análisis , Bromuros/toxicidad , Pruebas de Carcinogenicidad , Carcinógenos/farmacocinética , Aberraciones Cromosómicas , Cocarcinogénesis , Cricetinae , Cisteína/metabolismo , Relación Dosis-Respuesta a Droga , Productos Pesqueros , Aditivos Alimentarios/efectos adversos , Manipulación de Alimentos , Glutatión/metabolismo , Pérdida Auditiva/inducido químicamente , Humanos , Japón/epidemiología , Enfermedades Renales/inducido químicamente , Concentración Máxima Admisible , Mesocricetus , Mesotelioma/inducido químicamente , Ratones , Pruebas de Mutagenicidad , Enfermedades Profesionales/inducido químicamente , Enfermedades Profesionales/epidemiología , Neoplasias Peritoneales/inducido químicamente , Potasio/análisis , Potasio/toxicidad , Ratas , Ratas Endogámicas F344 , Especificidad de la Especie , Neoplasias de la Tiroides/inducido químicamente , Reino Unido , Estados Unidos/epidemiologíaRESUMEN
A 17-year-old hairdresser developed sodium bromate poisoning after drinking a cup of hair neutralizer in a suicide attempt. She presented 1 week later with anuria, required hemodialysis for 5 days, and subsequently recovered. Sensorineural hearing loss, often a characteristic finding, was absent. Early diagnosis of bromate intoxication requires an appreciation that it commonly occurs in hairdressers, may be accompanied by deafness, and may present with insidious anuria.