Asunto(s)
Inhibidores de la Aromatasa/historia , Androstadienos/historia , Androstadienos/farmacología , Androstadienos/uso terapéutico , Androstenodiona/análogos & derivados , Androstenodiona/historia , Androstenodiona/farmacología , Bencimidazoles/historia , Bencimidazoles/farmacología , Bencimidazoles/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/enzimología , Neoplasias de la Mama/metabolismo , Estrógenos/biosíntesis , Femenino , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Masculino , Maryland , Neoplasias de la Próstata/tratamiento farmacológico , Neoplasias de la Próstata/enzimología , Neoplasias de la Próstata/metabolismoAsunto(s)
Bencimidazoles/historia , Defensa del Consumidor/historia , Aprobación de Drogas/historia , Disfunciones Sexuales Psicológicas/historia , Comités Consultivos , Bencimidazoles/efectos adversos , Bencimidazoles/uso terapéutico , Depresión/tratamiento farmacológico , Aprobación de Drogas/métodos , Femenino , Historia del Siglo XXI , Humanos , Libido/efectos de los fármacos , National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division , Disfunciones Sexuales Psicológicas/tratamiento farmacológico , Estados Unidos , United States Food and Drug AdministrationRESUMEN
Gastroesophageal reflux disease (GERD) has evolved from a scarcely reported, little understood disease process just a century ago to a now highly prevalent disease with up to 25% of the population complaining of symptoms of reflux. Throughout history attempts have been made to delineate the esophagus and related pathologies, but it has not been until relatively recently that enough has been understood about its screening, diagnosis and treatment to make a substantial impact on sufferers. Although the use of antacids and thereafter histamine 2 receptor antagonists dramatically improved the management of GERD, it was the advent of the proton pump inhibitor (PPI) class of drugs that revolutionized medical care. Although the relationship of hiatus hernia to reflux was well accepted, the modest results of open fundoplication fell into further disregard given the efficacy of PPIs. The PPIs are currently the most effective form of therapy and are equivalent on a milligram for milligram basis. While currently no novel drugs or devices are of proven efficacy for GERD, the development of an acid-suppressive agent of equal efficiency to a PPI but with a more rapid onset of action and a greater duration of effectiveness would be of particular clinical utility for the future.