RESUMEN
Methicillin-resistant Staphylococcus aureus (MRSA) has been emerging worldwide as one of the most important problems in communities and hospitals. Therefore, new agents are needed to treat acute oral infections from MRSA. In this study, antibacterial compounds from the roots of Atractylodes japonica (A. japonica) were isolated and characterized. The compounds were isolated from the root extracts using HPLC-piloted activity-guided fractionations. Four A. japonica compounds were isolated and identified as atractylenolide III (1), atractylenolide I (2), diacetylatractylodiol [(6E,12E)-tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetate, TDEYA, 3). and (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEA, 4), which was obtained by hydrolysis of TDEYA. The minimum inhibitory concentrations (MICs) was determined in the setting of clinical MRSA isolates. Compound 4 showed anti-MRSA activity with a MIC value of 4-32 µg/mL. The overall results provide promising baseline information for the potential use of the extract of A. japonica as well as some of the isolated compounds in the treatment of bacterial infections.
Asunto(s)
Antibacterianos , Atractylodes/química , Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos , Extractos Vegetales/química , Infecciones Estafilocócicas/tratamiento farmacológico , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Atractylodes/anatomía & histología , Humanos , Estructura Molecular , Raíces de Plantas/químicaRESUMEN
OBJECTIVE: To study the change rules of specific leaf weight, dry weight of rhizoma and the drying rate of annual and biennial Atractylodes macrocephala. METHODS: We measured the specific leaf weight and dry weight of rhizoma, and accounted the drying rate and correlation by dugging the annual and biennial plants each 15 days. There were 3 rhizoma types of biennial Atractylodes macrocephala with Drumstick/Frog type, Er-cha type and Wu-zi type. RESULTS: It showed the curve of specific leaf weight of annual plant was "N" style, which of biennial plant was linear. The dry weight and the drying rate of all rhizoma types increased point-blank during the whole growth period. CONCLUSION: The correlation between specific leaf weight and dry weight of rhizoma is obvious in biennial Atractylodes macrocephala but is contrary in annual Atractylodes macrocephala.
Asunto(s)
Atractylodes/fisiología , Plantas Medicinales/fisiología , Rizoma/fisiología , Atractylodes/anatomía & histología , Atractylodes/clasificación , Biomasa , Fotosíntesis , Hojas de la Planta/crecimiento & desarrollo , Hojas de la Planta/fisiología , Control de Calidad , Rizoma/anatomía & histología , Estaciones del Año , Luz SolarRESUMEN
OBJECTIVE: To study the ecological environments of Atractylodes lancea by biomass structural analysis. METHOD: Through the scientific investigation in Maoshan, the sampling spots were set up, the relation between growth and ecological environments was researched and the ecological environments of A. lancea were divided as following: the vegetation layer, the shrub layer, the shrub-weed layer and the weed layer. The ramet biomass, height, leaves and coverage of A. lancea were studied. RESULT: The several factors (ramet biomass, height, leaves and coverage) showed the regular change. Among maximum, minimum and average, the shrub layer was the biggest, the shrub and weed layer was the second biggest and the vegetation layer and the weed layer was the least. CONCLUSION: A. lancea tends to distribute in the shrub layer and the shrub-weed layer.
Asunto(s)
Atractylodes/crecimiento & desarrollo , Biomasa , Ecosistema , Atractylodes/anatomía & histología , Medicamentos Herbarios Chinos , Estructuras de las Plantas/anatomía & histología , Estructuras de las Plantas/crecimiento & desarrolloRESUMEN
OBJECTIVE: To explore the differentiation mechanism of population biology between "Cangzhu" and "Baizhu", commonly used traditional Chinese drugs. METHOD: The wild populations of Atractylodes in Anhui Province were investigated successively, in which specimens were studied, and the cultivated population was observed. RESULT: The wild A. macrocephala and A. lancea, A. lancea subsp. luotianensis and A. lancea presented a series of successive transitions, which was caused by the change of ecological environment. A. macrocephala, A. lancea and A. lancea subsp. luotianensis were extreme types of the series of transitions, which were the germplasm of "Baizhu", "Cangzhu" and "Hancangzhu". The transitional types between A. macrocephala and A. lancea were similar of A. japonica, whose effect was the intermediate of "Baizhu" and "Cangzhu". CONCLUSION: The development and differentatiation of commodites, the source of germplasm and the selection of geo-herbs of "Baizhu", "Cangzhu" and "Hancangzhu" are corresponding with the development of population biology of genus Atractylodes.
Asunto(s)
Atractylodes/crecimiento & desarrollo , Biodiversidad , Plantas Medicinales/crecimiento & desarrollo , Altitud , Atractylodes/anatomía & histología , Atractylodes/clasificación , Evolución Biológica , China , Hojas de la Planta/anatomía & histología , Hojas de la Planta/crecimiento & desarrollo , Raíces de Plantas/anatomía & histología , Raíces de Plantas/crecimiento & desarrollo , Plantas Medicinales/anatomía & histología , Plantas Medicinales/clasificación , Dinámica PoblacionalRESUMEN
In the investigation of Baizhu (Atractylodis macrocephala Koidz.) cultivated population in Zhejiang Province, the plant descriptions and the influence of different sits on plant growth, as well as the relationship between the descriptions and commercial class of rhizome were studied. The results showed that the differentiation within a population was large; the correlation between each character was obvious; the commercial rhizome class was significant with some descriptions. And those will provide basic data for improving the variety of Baizhu.