RESUMEN
Corticosteroid-resistant asthma (CRA) is a severe form of disease and clinically important, since patients do not respond to mainstay corticosteroid therapies. Thus, new therapies are needed. However, a big limiting factor in the understanding of CRA is the existence of different immunological and inflammatory phenotypes, a fact that makes it difficult to reproduce experimentally. Photobiomodulation (PBM) emerges as an alternative therapy based on earlier studies. This study aims to evaluate the effect of PBM using infrared light-emitting diode (ILED) on the development of corticosteroid-resistant asthma. Therefore, groups of rats were sensitized and challenged with ovalbumin plus Freund's adjuvant for the induction of CRA, and treated or not with ILED directly in the respiratory tract on the skin (wavelength 810 nm; power 100 mW; density energy 5 J/cm; total energy 15 J; time 150 s). Our experimental model was capable to induce neutrophilic asthma. Besides that, the corticosteroid treatment did not reverse the lung cell migration as well as the levels of leukotriene B4, and interleukins 17 and 6. The treatment with ILED reduced the lung cell migration; myeloperoxidase activity; mast cell degranulation; and the levels of leukotriene B4, thromboxane B2, prostaglandin E2, tumoral necrosis factor alpha, and interleukins 17 and 6. Still, ILED increased the level of interleukin 10. In conclusion, we showed promisor effects of ILED when irradiated directly in the respiratory tract as adjuvant treatment of corticosteroid-resistant asthma.
Asunto(s)
Asma , Terapia por Luz de Baja Intensidad , Corticoesteroides , Animales , Asma/tratamiento farmacológico , Asma/radioterapia , Humanos , Pulmón , Mastocitos , Ratas , PielRESUMEN
Asthma is a chronic inflammatory disease characterized by recurrent and reversible episodes of wheezing, dyspnea, chest stiffness, and cough. Its treatment includes several drugs, high cost, and considerable side effects. Photobiomodulation (PBM) emerges as an alternative treatment, showing good results, and it can be applied locally or systemically. Here, we aim to evaluate the effect of transcutaneous systemic photobiomodulation (TSPBM) by red diode light. Therefore, adult rats were sensitized and challenged with ovalbumin (OVA) plus alum for induction of asthma and irradiated or not with TSPBM in the caudal vein (wavelength 660 ± 10 nm; total radiant emission 15 J; area 2.8 cm2; energy density 5.35 J/cm2; irradiance 33.3 mW/cm2; exposure time 150 s). Our investigations prioritized the cell migration into the alveolar space and lung, tracheal responsiveness, release and gene expression of cytokines, mast cell degranulation, and anaphylactic antibodies. Our results showed that TSPBM reduced the cell migration and mast cell degranulation without altering the tracheal responsiveness and ovalbumin antibody titers. Indeed, TSPBM increased the levels of interleukin 10 (IL-10) in the BAL fluid without altering the gene expression of cytokines in the lung tissue. Thus, this study showed that transcutaneous systemic irradiation reduced lung inflammation by altering mast cells degranulation and IL-10 level. Considering that this study is a pioneer in the used of light by the systemic route to treat asthma, the data are interesting and instigate future investigations, mainly in relation to the mechanisms involved and in dosimetry.
Asunto(s)
Asma , Neumonía , Animales , Asma/tratamiento farmacológico , Asma/radioterapia , Degranulación de la Célula , Citocinas/metabolismo , Modelos Animales de Enfermedad , Interleucina-10/metabolismo , Pulmón/efectos de la radiación , Mastocitos/metabolismo , Ratones , Ratones Endogámicos BALB C , Modelos Teóricos , Ovalbúmina/metabolismo , Ovalbúmina/farmacología , RatasRESUMEN
Infection, the invasion of pathogenic microorganisms and viruses, causes reactive inflammation mediated by endogenous signals, with influx of leucocytes with distinct properties and capable of mounting a cellular or antibody response. Different forms of inflammation may also occur in response to tumours, in allergy and autoimmune disorders. Pneumonia, respiratory tract infection and septic shock for instance can arise as serious complications of the Covid-19 virus. While radiotherapy has been most widely used to control malignant tumours, it has also been used for treatment of non-malignant diseases, including acute and chronic inflammation in situations where anti-inflammatory drugs may be ineffective or contraindicated. The present review examines the history and prospects for low-dose anti-inflammatory radiation treatments, the present interest largely being motivated by the increased incidence of pulmonary disease associated Covid-19 infections. Evidence in support of the suggested efficacy are covered, together with an appraisal of one of the number of potential convenient sources that could complement external beam arrangements.
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Asma/radioterapia , COVID-19/radioterapia , Neumonía/radioterapia , Síndrome de Dificultad Respiratoria/radioterapia , Humanos , Dosificación RadioterapéuticaRESUMEN
It is largely known that photobiomodulation (PBM) has beneficial effects on allergic pulmonary inflammation. Our previous study showed an anti-inflammatory effect of the PBM in an acute experimental model of asthma, and we see that this mechanism is partly dependent on IL-10. However, it remains unclear whether the activation of regulatory T cells is mediated by PBM in a chronic experimental model of asthma. In this sense, the objective of this study was to verify the anti-inflammatory role of the PBM in the pulmonary inflammatory response in a chronic experimental asthma model. The protocol used for asthma induction was the administration of OVA subcutaneously (days 0 and 14) and intranasally (3 times/week, for 5 weeks). On day 50, the animals were sacrificed for the evaluation of the different parameters. The PBM used was the diode, with a wavelength of 660 nm, a power of 100 mW, and 5 J for 50 s/point, in three different application points. Our results showed that PBM decreases macrophages, neutrophils, and lymphocytes in the bronchoalveolar lavage fluid (BALF). Moreover, PBM decreased the release of cytokines by the lung, mucus, and collagen in the airways and pulmonary mechanics. When we analyzed the percentage of Treg cells in the group irradiated with laser, we verified an increase in these cells, as well as the release of IL-10 in the BALF. Therefore, we conclude that the use of PBM therapy in chronic airway inflammation attenuated the inflammatory process, as well as the pulmonary functional and structural parameters, probably due to an increase in Treg cells.
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Asma , Interleucina-10 , Terapia por Luz de Baja Intensidad , Animales , Antiinflamatorios/farmacología , Asma/tratamiento farmacológico , Asma/radioterapia , Linfocitos T CD4-Positivos , Modelos Animales de Enfermedad , Factores de Transcripción Forkhead , Inflamación , Interleucina-10/metabolismo , Pulmón , Ratones , Ratones Endogámicos BALB C , OvalbúminaRESUMEN
Recent studies show that low-level laser therapy (LLLT) has an important anti-inflammatory action in acute lung inflammation. The present work explored if laser therapy is able to antagonize eosinophils and allergic inflammation induced by oxidative stress in Balb/c mice. Forty-eight hours after challenge, the leukocyte counting, ROS and nitrite/nitrate level, RANTES, CCL3, CCL8 as well as eotaxins were measured in the bronchoalveolar lavage fluid (BALF) of laser-treated mice or not. Into the lung, some chemokines receptors, the iNOS activity and mRNA expression, and the activities of superoxide dismutase (SOD), catalase, gluthatione, NADPH oxidase activities and thiobarbituric acid reactive species (T-Bars) were measured. Laser-treated allergic mice presented reduction of both the ICAM-1 and eosinophil in the lungs. RANTES, CCL8, CCL3 and eotaxins were reduced in BALF of laser-treated allergic mice. In allergic mice lung LLLT decreased the CCR1 and CCR3 and restored the oxidative stress balance as well. Laser decreased the lipidic peroxidation in allergic mice lung as much as increased SOD, GPx and GR. It shows that LLLT on allergic lung inflammation involves leukocyte-attractant chemokines and endogenous antioxidant. Based on results, LLLT may ultimately become a non- invasive option in allergic lung disease treatment. The top figure illustrates the laser decreasing the eosinophils migration into BALF and the bottom figure shows the laser upregulating the expression of heme-oxygenase (anti-oxidant enzyme) in lung tissue anti-oxidant.
Asunto(s)
Asma/radioterapia , Quimiocinas/metabolismo , Inflamación/radioterapia , Terapia por Luz de Baja Intensidad , Estrés Oxidativo , Animales , Pulmón/fisiopatología , Pulmón/efectos de la radiación , Ratones , Ratones Endogámicos BALB CRESUMEN
Although safe doses of radiation have been determined, concerns about the harmful effects of low-dose radiation persist. In particular, to date, few studies have investigated the correlation between low-dose radiation and disease development. Asthma is a common chronic inflammatory airway disease that is recognized as a major public health problem. In this study, we evaluated the effects of low-dose-rate chronic irradiation on allergic asthma in a murine model. Mice were sensitized and airway-challenged with ovalbumin (OVA) and were exposed to continuous low-dose-rate irradiation (0.554 or 1.818 mGy/h) for 24 days after initial sensitization. The effects of chronic radiation on proinflammatory cytokines and the activity of matrix metalloproteinase-9 (MMP-9) were investigated. Exposure to low-dose-rate chronic irradiation significantly decreased the number of inflammatory cells, methylcholine responsiveness (PenH value), and the levels of OVA-specific immunoglobulin E, interleukin (IL)-4, and IL-5. Furthermore, airway inflammation and the mucus production in lung tissue were attenuated and elevated MMP-9 expression and activity induced by OVA challenge were significantly suppressed. These results indicate that low-dose-rate chronic irradiation suppresses allergic asthma induced by OVA challenge and does not exert any adverse effects on asthma development. Our findings can potentially provide toxicological guidance for the safe use of radiation and relieve the general anxiety about exposure to low-dose radiation.
Asunto(s)
Asma/radioterapia , Rayos gamma/uso terapéutico , Inmunoglobulina E/genética , Pulmón/efectos de la radiación , Animales , Asma/inducido químicamente , Asma/inmunología , Asma/patología , Pruebas de Provocación Bronquial , Líquido del Lavado Bronquioalveolar/química , Colina/administración & dosificación , Colina/análogos & derivados , Modelos Animales de Enfermedad , Relación Dosis-Respuesta en la Radiación , Femenino , Expresión Génica , Humanos , Interleucina-4/genética , Interleucina-4/inmunología , Interleucina-5/genética , Interleucina-5/inmunología , Pulmón/inmunología , Pulmón/patología , Metaloproteinasa 9 de la Matriz/genética , Metaloproteinasa 9 de la Matriz/inmunología , Ratones , Ratones Endogámicos C57BL , Moco/química , OvalbúminaRESUMEN
This article provides a historical assessment of the role of X-ray therapy in the treatment of bronchial asthma. This analysis revealed that X-ray therapy in the treatment of bronchial asthma spanned the first six decades of the 20th century, and involved nearly 6,000 patients in published clinical case studies. Patients selected typically had at least moderate to severe asthma and were refractory to other commonly employed treatments. The results of more than 60 studies indicated that about 70% of patients had rapid and marked reductions in clinical symptoms with about half of these patients showing complete symptom relief. The duration of the beneficial responses was variable but was approximately 1-6 months for about 50% of the benefited patients, and between 1 to 4 years for the upper 25% of benefited patients. The use of X rays to treat such patients fell into disfavor during the 1950s due to mounting concerns over possible enhanced risks of cancer that coincided with the discoveries and use of antihistamine medications, antibiotics and the methyl xanthine bronchodilators aminophylline and theophylline.
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Asma/tratamiento farmacológico , Asma/radioterapia , Terapia por Rayos X/historia , Antibacterianos/uso terapéutico , Asma/historia , Antagonistas de los Receptores Histamínicos/uso terapéutico , Historia del Siglo XX , Humanos , Teofilina/uso terapéutico , Xantinas/uso terapéuticoAsunto(s)
Asma/radioterapia , Psoriasis/radioterapia , Terapia Ultravioleta/métodos , Vitíligo/radioterapia , Anciano , Asma/inmunología , Pruebas Respiratorias , Citocinas/metabolismo , Volumen Espiratorio Forzado/fisiología , Humanos , Neutrófilos/inmunología , Óxido Nítrico/metabolismo , Psoriasis/inmunología , Psoriasis/fisiopatología , Esputo , Células TH1 , Células Th17/inmunología , Resultado del Tratamiento , Gemelos Monocigóticos , Capacidad Vital/fisiología , Vitíligo/inmunologíaRESUMEN
Low-level laser therapy (LLLT) controls bronchial hyperresponsiveness (BHR) associated with increased RhoA expression as well as pro-inflammatory mediators associated with NF-kB in acute lung inflammation. Herein, we explore if LLLT can reduce both BHR and Th2 cytokines in allergic asthma. Mice were studied for bronchial reactivity and lung inflammation after antigen challenge. BHR was measured through dose-response curves to acetylcholine. Some animals were pretreated with a RhoA inhibitor before the antigen. LLLT (660 nm, 30 mW and 5.4 J) was applied on the skin over the right upper bronchus and two irradiation protocols were used. Reduction of BHR post LLLT coincided with lower RhoA expression in bronchial muscle as well as reduction in eosinophils and eotaxin. LLLT also diminished ICAM expression and Th2 cytokines as well as signal transducer and activator of transduction 6 (STAT6) levels in lungs from challenged mice. Our results demonstrated that LLLT reduced BHR via RhoA and lessened allergic lung inflammation via STAT6.
Asunto(s)
Remodelación de las Vías Aéreas (Respiratorias)/efectos de la radiación , Asma/radioterapia , Broncoconstricción/efectos de la radiación , Citocinas/metabolismo , Hipersensibilidad/radioterapia , Terapia por Luz de Baja Intensidad , Remodelación de las Vías Aéreas (Respiratorias)/efectos de los fármacos , Remodelación de las Vías Aéreas (Respiratorias)/fisiología , Amidas/farmacología , Animales , Asma/tratamiento farmacológico , Asma/fisiopatología , Bronquios/efectos de los fármacos , Bronquios/fisiopatología , Bronquios/efectos de la radiación , Hiperreactividad Bronquial/tratamiento farmacológico , Hiperreactividad Bronquial/fisiopatología , Hiperreactividad Bronquial/radioterapia , Broncoconstricción/efectos de los fármacos , Broncoconstricción/fisiología , Inhibidores Enzimáticos/farmacología , Hipersensibilidad/tratamiento farmacológico , Hipersensibilidad/fisiopatología , Pulmón/efectos de los fármacos , Pulmón/fisiopatología , Pulmón/efectos de la radiación , Masculino , Ratones , Ratones Endogámicos BALB C , Músculo Liso/efectos de los fármacos , Músculo Liso/fisiopatología , Músculo Liso/efectos de la radiación , Ovalbúmina/efectos adversos , Neumonía/tratamiento farmacológico , Neumonía/fisiopatología , Neumonía/radioterapia , Piridinas/farmacología , Factor de Transcripción STAT6/metabolismo , Proteínas de Unión al GTP rho/antagonistas & inhibidores , Proteínas de Unión al GTP rho/metabolismo , Proteína de Unión al GTP rhoARESUMEN
Asthma is a complex chronic inflammatory disease of the airways that involves the activation of many inflammatory and other types of cells. We investigated the effect of low-level laser therapy (LLLT) on allergic asthma in rats and compared its effect with that of the glucocorticoid budesonide. Asthma was induced by challenge and repeated exposure to ovalbumin. Asthmatic rats were then treated with LLLT or budesonide suspension. LLLT at 8 J/cm(2) once daily for 21 days could relieve pathological damage and airway inflammation in asthmatic rats. LLLT could decrease the total numbers of cells and eosinophils in bronchoalveolar lavage fluid. LLLT could reduce levels of IL-4 and increase IFN-γ levels in bronchoalveolar lavage fluid and serum, meanwhile reduce serum IgE levels. Flow cytometry assay showed that LLLT can regulate the Th1/Th2 imbalance of asthmatic rats. LLLT had a similar effect to that of budesonide. These findings suggest that the mechanism of LLLT treatment of asthma is by adjustment of Th1/Th2 imbalance. Thus, LLLT could take over some of the effects of budesonide for the treatment of asthma, thereby reducing some of the side effects of budesonide.
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Asma/radioterapia , Láseres de Semiconductores/uso terapéutico , Terapia por Luz de Baja Intensidad , Animales , Asma/sangre , Asma/inmunología , Inmunoglobulina E/sangre , Interferón gamma/sangre , Interleucina-4/sangre , Masculino , Ratas Wistar , Células TH1/inmunología , Células Th2/inmunología , Resultado del TratamientoRESUMEN
Exposure to UV radiation can cause suppression of specific immune responses. The pathways leading to the down-regulation are complex, starting from the absorption of UV photons by chromophores in the skin and ending with local and systemic changes in immune mediators, the generation of T and B regulatory cells and inhibition of effector and memory T cell activation. The consequences for human health are thought to be both beneficial and adverse. The former are illustrated by protection against polymorphic light eruption, and possible protection against T cell-mediated autoimmune diseases and asthma. The latter are illustrated by skin cancer, cutaneous lupus erythematosus and infectious diseases including vaccination. Many outstanding questions remain in this rapidly developing and controversial area, not least what advice to give the general public regarding their sun exposure. While considerable advances have been made in the development of strategies that preserve the health benefits of sunlight exposure and decrease its detrimental effects, further research is required before optimal levels of protection are achieved.
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Linfocitos B/efectos de la radiación , Tolerancia Inmunológica/efectos de la radiación , Inmunidad/efectos de la radiación , Terapia de Inmunosupresión , Linfocitos/efectos de la radiación , Piel/efectos de la radiación , Asma/radioterapia , Enfermedades Autoinmunes/radioterapia , Linfocitos B/citología , Enfermedades Transmisibles/etiología , Humanos , Memoria Inmunológica/efectos de la radiación , Lupus Eritematoso Cutáneo/etiología , Lupus Eritematoso Cutáneo/inmunología , Lupus Eritematoso Cutáneo/patología , Linfocitos/citología , Fotones/efectos adversos , Neoplasias Cutáneas/etiología , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/patología , Luz Solar/efectos adversos , Rayos Ultravioleta/efectos adversos , Terapia Ultravioleta/métodos , Vacunación/efectos adversosRESUMEN
This meta-analysis assessed the efficacy and safety of a novel intervention for asthma, bronchial thermoplasty (BT), in patients with moderate-to-severe persistent asthma. An electronic literature search identified three randomized controlled trials (RCT) of BT that recruited 421 patients in total. Outcomes of interest were the Asthma Quality of Life Questionnaire (AQLQ) score, morning peak expiratory flow (PEF), tolerability and safety. Compared with standard medications and sham BT treatment, BT significantly improved AQLQ scores and PEF from baseline to the end of the trials. There were more respiratory adverse events and hospitalizations for adverse respiratory events with BT than with medications or sham treatment during the treatment period, but most events resolved, on average, within a week. This effect of BT treatment was not seen during the posttreatment period. Additional long-term RCT are required to confirm whether BT provides benefit to patients with moderate-to-severe persistent asthma.
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Asma/radioterapia , Ablación por Catéter/métodos , Volumen Espiratorio Forzado/efectos de la radiación , Hipertermia Inducida/métodos , Adolescente , Adulto , Anciano , Asma/tratamiento farmacológico , Asma/fisiopatología , Bronquios/efectos de los fármacos , Bronquios/patología , Bronquios/efectos de la radiación , Broncodilatadores/uso terapéutico , Femenino , Volumen Espiratorio Forzado/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Placebos , Calidad de Vida , Ensayos Clínicos Controlados Aleatorios como Asunto , Proyectos de Investigación , Índice de Severidad de la Enfermedad , Encuestas y Cuestionarios , Resultado del TratamientoRESUMEN
The morphometry and electrophoretic mobility of red blood cells from patients with infection-dependent asthma were comparatively studied prior to and following treatment. The patients who had underwent intravenous laser irradiation of blood (ILIB) in addition to conventional therapy had better morphofunctional parameters of red blood cells, by restoring their normal forms, decreasing their transitional ones, and increasing their electrophoretic mobility to normal values. Those who received traditional drug therapy showed no considerable morphofunctional changes of erythrocytes. Thus, in asthmatic patients, the changes in the morphology and function of red blood cells may suggest their membranous structural changes for whose correction ILIB should used.
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Asma/radioterapia , Sangre/efectos de la radiación , Terapia por Luz de Baja Intensidad/métodos , Adulto , Anciano , Anciano de 80 o más Años , Asma/sangre , Electroforesis , Eritrocitos/patología , Eritrocitos/fisiología , Eritrocitos/efectos de la radiación , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto JovenAsunto(s)
Asma/terapia , Rinitis/terapia , Sinusitis/terapia , Terapia por Acupuntura , Adulto , Asma/complicaciones , Asma/radioterapia , Enfermedad Crónica , Femenino , Humanos , Terapia por Luz de Baja Intensidad , Masculino , Persona de Mediana Edad , Rinitis/complicaciones , Sinusitis/complicaciones , Adulto JovenRESUMEN
A hundred and thirty-eight patients with infection-dependent bronchial asthma, including 73 with moderate persistent asthma and 65 with severe persistent one, were examined. Four modes of a combination of traditional (drug) therapy (DT) and untraditional (halotherapy (HT) and endobronchial helium-neon laser irradiation (ELI) one were used. The efficiency of the treatment performed was evaluated, by determining the time course of clinical symptoms of the disease on the basis of scores of their magnitude and the patients' condition. The findings indicated that in moderate persistent asthma, both HT and ELI in combination with DT exerted an equal therapeutic effect, which provided a good and excellent condition in 83.3% of cases. In severe persistent asthma, such a condition was achieved in 93.75% of cases only when multimodality treatment involving DT, HT, and ELI had been performed.
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Asma/radioterapia , Bronquios/efectos de la radiación , Terapia por Luz de Baja Intensidad/métodos , Antagonistas Adrenérgicos beta/uso terapéutico , Adulto , Antibacterianos/uso terapéutico , Asma/tratamiento farmacológico , Vías de Administración de Medicamentos , Quimioterapia Combinada , Expectorantes/uso terapéutico , Estudios de Seguimiento , Glucocorticoides/uso terapéutico , Humanos , Inducción de Remisión/métodos , Índice de Severidad de la Enfermedad , Resultado del TratamientoRESUMEN
BACKGROUND: Over recent decades, there has been a significant global increase in the prevalence of asthma, an inflammatory disease of the respiratory system. While ultraviolet radiation (UV) has been used successfully in the treatment of inflammatory conditions such as psoriasis, studies of UV-induced regulation of allergic respiratory responses have been rare, and have not analysed in vivo measurements of airway hyperresponsiveness (AHR) or the antigen specificity of the UV-induced effects. OBJECTIVE: To investigate the regulatory properties of erythemal ultraviolet B (UVB) irradiation of the skin and the induction of allergen-induced airway immunity in a murine asthma model, and to examine the mechanisms involved. METHODS: BALB/c mice were exposed to a single erythemal dose of UV 3 days before intraperitonial sensitization (day 0) and boost (day 14) with the antigen, ovalbumin (OVA). Airway-associated, asthma-like responses to aerosolized OVA at day 21 were analysed including (a) AHR measured in vivo, (b) OVA-specific proliferative responses and cytokine production by cells from the lung-draining lymph nodes (LDLN), and (c) inflammatory cells and cytokines in the bronchoalveolar lavage fluid. To determine UVB-induced mechanisms of regulation, LDLN cells from UVB irradiated, OVA-sensitized mice were adoptively transferred into naïve BALB/c mice that were subsequently sensitized and challenged with OVA, or a non-specific antigen. RESULTS: UVB irradiation of skin significantly suppressed AHR to methacholine and OVA-specific responses in the LDLN and in the lung compartment. Reduced OVA-specific responses by LDLN cells from both UVB irradiated mice and mice that received 5 x 10(6) LDLN cells from UVB irradiated, but not from non-irradiated, OVA-sensitized mice suggested that UVB-induced regulatory cells are responsible for many of the asthma-reducing effects of dorsal UVB exposure. CONCLUSION: UVB irradiation of skin suppresses AHR and cellular responses of the airways to respiratory allergens. Further, this study implicates UVB or its downstream mediators as a potential approach to reducing the severity of asthma.
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Asma/inmunología , Hiperreactividad Bronquial/inmunología , Terapia Ultravioleta , Animales , Asma/inducido químicamente , Asma/radioterapia , Hiperreactividad Bronquial/inducido químicamente , Hiperreactividad Bronquial/radioterapia , Líquido del Lavado Bronquioalveolar/química , Líquido del Lavado Bronquioalveolar/citología , Citocinas/análisis , Modelos Animales de Enfermedad , Femenino , Inmunidad Celular , Inmunización/métodos , Inmunoglobulina E/sangre , Ganglios Linfáticos/inmunología , Masculino , Cloruro de Metacolina/efectos adversos , Ratones , Ratones Endogámicos BALB C , Ovalbúmina/efectos adversos , Fenotipo , Ratas , Ratas Sprague-Dawley , Rayos UltravioletaRESUMEN
The study of efficacy of bronchial asthma children's rehabilitation at Pyatigorsk spa with different schemes of treatment has shown that combined treatment with dry air-radon baths and halotherapy is more effective than each of these modalities alone.
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Asma/terapia , Balneología/métodos , Radón/uso terapéutico , Terapia Respiratoria/métodos , Adolescente , Asma/radioterapia , Niño , Terapia Combinada , Femenino , Colonias de Salud , Humanos , Inmunoglobulinas/sangre , Masculino , Pruebas de Función Respiratoria , Federación de Rusia , Resultado del TratamientoAsunto(s)
Asma/radioterapia , Hipertensión/complicaciones , Rayos Infrarrojos/uso terapéutico , Terapia por Luz de Baja Intensidad/métodos , Magnetismo/uso terapéutico , Modalidades de Fisioterapia , Adolescente , Adulto , Anciano , Asma/complicaciones , Terapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
AIM: To investigate action of intravascular laser blood irradiation (ILBI) on production of active oxygen forms (AOF) in patients with bronchial asthma (BA). MATERIAL AND METHODS: The trial included 59 BA patients aged 20 to 60 years (mean age 40.2 +/- 3.1 years). AOF generation in whole blood was registered with luminol-dependent chemiluminescence (CL). Basic therapy was given to 42 patients. ILBI was added to basic therapy in 17 patients. RESULT: . CL of whole blood in BA patients depended on severity of inflammation. BA patients with intensive CL exposed to ILBI retained free radical oxidation defects and the disease symptoms. In low intensity of blood CL, ILBI activated A OF generation and raised treatment effectiveness. CONCLUSION: ILBI raises AOF production in the whole blood of BA patients. CL registration can be used for validation of ILBI administration in BA patients and control of effectiveness of laser therapy.