RESUMEN

BACKGROUND: Venipuncture is one of the most commonly performed medical procedures in paediatric care, but it can also be one of the most painful and distressing experiences for patients. Finding effective strategies to manage pain and fear associated with venipuncture is crucial for improving the paediatric patient experience and promoting positive health outcomes. This study aimed to evaluate the efficacy of a combined approach using a topical analgesic cream (TKTX cream) and a distraction technique (Trace Image and Colouring for Kids-Book, TICK-B) in reducing pain intensity and fear levels in children undergoing venipuncture procedures. METHODS: We conducted this randomised controlled trial among 176 children aged 6-12 years undergoing venipuncture. Participants were randomly assigned to four groups: TICK-B, TKTX cream, TICK-B+TKTX cream and a control group. Pain and fear were measured using the Wong-Baker FACES Pain Rating Scale and Children's Fear Scale. The study was carried out from 20 February 2024 to 1 June 2024 at the emergency unit of Heevi paediatric teaching hospital in the Kurdistan region of Iraq. In the intervention groups, TICK-B was applied for 2-3 min before needle insertion, and TKTX cream was applied 20 min before the venipuncture procedure. All outcome measures were evaluated 2-3 min after the completion of the venipuncture procedure. RESULTS: The combined TICK-B (colouring book) and TKTX cream (topical anaesthetic) intervention was the most effective in reducing both pain intensity (mean score 2.80 vs 7.24 in the control, p<0.001) and fear levels (mean score 0.93 vs 2.83 in the control, p<0.001) during and after venipuncture procedures compared with individual interventions and control. CONCLUSIONS: The combined TICK-B distraction and TKTX cream topical anaesthetic intervention was the most effective in reducing pain intensity and fear during and after venipuncture in children, providing a practical strategy for healthcare providers to optimise needle procedure management. TRIAL REGISTRATION NUMBER: NCT06326125.

Asunto(s)

Ansiedad , Manejo del Dolor , Flebotomía , Humanos , Flebotomía/efectos adversos , Niño , Masculino , Femenino , Manejo del Dolor/métodos , Ansiedad/terapia , Ansiedad/etiología , Ansiedad/prevención & control , Dimensión del Dolor , Anestésicos Locales/administración & dosificación , Anestésicos Locales/uso terapéutico , Dolor/psicología , Dolor/prevención & control , Dolor/etiología , Dolor/tratamiento farmacológico , Combinación Lidocaína y Prilocaína , Resultado del Tratamiento , Irak

RESUMEN

OBJECTIVE: This study aimed to explore the effect of preoperative nursing visit on anxiety and postoperative complications in patients undergoing radical prostatectomy and to provide a better perioperative management plan for patients with prostate cancer (PCa) undergoing surgical treatment. METHODS: The medical records of 199 patients who underwent PCa treatment in our hospital from June 2021 to June 2023 were retrospectively analysed. The reference group received preoperative routine nursing, whereas the observation group implemented preoperative nursing visit. The stress indexes, quality of life, negative emotion level and incidence of complications were compared between the two groups. RESULTS: Before management, no significant difference in the levels of epinephrine, norepinephrine and cortisol was found between the two groups (p > 0.05). After management, the levels of the abovementioned stress indicators in the observation group were lower than those in the reference group (p < 0.001). Before management, no significant difference in Short-Form-36 Health Survey (SF-36) scores was observed between the two groups (p > 0.05). After management, the observation group had higher SF-36 score than the reference group (p < 0.001). Before management, no significant difference in Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores was found between the two groups (p > 0.05). After management, the observation group had lower HAMA and HAMD scores than the reference group (p < 0.001). Furthermore, no significant difference in the incidence of complications was found between the two groups (p > 0.05). CONCLUSIONS: Preoperative nursing visit can reduce the anxiety of patients with PCa to a certain extent. This scheme can promote the postoperative recovery of patients, and it has certain clinical application and promoting values.

Asunto(s)

Ansiedad , Complicaciones Posoperatorias , Cuidados Preoperatorios , Prostatectomía , Humanos , Prostatectomía/efectos adversos , Prostatectomía/métodos , Estudios Retrospectivos , Masculino , Complicaciones Posoperatorias/prevención & control , Complicaciones Posoperatorias/etiología , Ansiedad/etiología , Ansiedad/epidemiología , Persona de Mediana Edad , Anciano , Neoplasias de la Próstata/cirugía

RESUMEN

AIM: Pain and anxiety levels in palliative care patients negatively impact their quality of life, highlighting the need for research on non-pharmacological methods. This study aimed to evaluate the effects of music and aromatherapy interventions on pain, anxiety, and stress levels in these patients. MATERIAL AND METHODS: The research was designed as a single-blind, four-group, randomized controlled trial. The sample consisted of 88 patients hospitalized in a palliative care center (receiving palliative care services with terminal or advanced diseases). Patients were randomly assigned to four groups (n = 22, music, aromatherapy, music and aromatherapy, and control group). Patients in the experimental groups received the intervention to which they were assigned for 20 min each day for three consecutive days: music, aromatherapy, or music accompanied by aromatherapy. No intervention was applied to the control group. The patients' levels of pain, anxiety, and stress were assessed before and after the intervention using the Visual Analog Scale (VAS), the Facial Anxiety Scale (FAS), and the Distress Thermometer. RESULTS: No significant differences were found in the demographic characteristics of the groups (p > 0.05). The Wilcoxon Signed-Rank and Kruskal-Wallis tests indicated statistically significant differences in pre- and post-intervention scores for VAS, FAS, and Distress across all experimental groups on all follow-up days (p < 0.05). CONCLUSION: Implementing music, aromatherapy, and their combination effectively reduced pain, anxiety, and stress levels in palliative care patients, suggesting these non-pharmacological interventions can improve their quality of life. TRIAL REGISTRATION: ClinicalTrails.gov (Registration number: NCT06024954) at 05-SEP-2024.

Asunto(s)

Ansiedad , Aromaterapia , Musicoterapia , Cuidados Paliativos , Estrés Psicológico , Humanos , Aromaterapia/métodos , Cuidados Paliativos/métodos , Femenino , Masculino , Musicoterapia/métodos , Ansiedad/terapia , Ansiedad/etiología , Persona de Mediana Edad , Método Simple Ciego , Estrés Psicológico/terapia , Estrés Psicológico/etiología , Anciano , Calidad de Vida , Dimensión del Dolor , Adulto , Manejo del Dolor/métodos , Dolor/etiología , Dolor/psicología

RESUMEN

This study aims to evaluate the impact of integrating pain nursing with hospice care on the quality of life among patients with advanced lung cancer. This study involving 60 advanced lung cancer patients admitted from January 2022 to January 2023. Participants were randomly assigned to 2 groups: the observation group received a combination of pain nursing and hospice care, while the control group received standard nursing care. The study assessed changes in the numeric rating scale for pain, self-rating anxiety scale (SAS), self-rating depression scale (SDS), cancer fatigue scale (CFS), death attitude, and various quality of life dimensions as measured by the Quality of Life Questionnaire-Core 30. Post-intervention, both groups exhibited reductions in numeric rating scale, SAS, SDS, and CFS scores compared to baseline, with more significant improvements observed in the observation group (P < .05). Additionally, post-intervention scores for death attitude and Quality of Life Questionnaire-Core 30 domains (physical, cognitive, social, role, and emotional functioning, as well as overall health) increased in both groups, with the observation group showing greater improvements than the control group (P < .05). The combination of pain nursing and hospice care significantly reduces pain, anxiety, and depression, decreases cancer-related fatigue, and improves the quality of life and death attitudes in patients with advanced lung cancer, highlighting the benefits of this integrative approach in palliative care settings.

Asunto(s)

Cuidados Paliativos al Final de la Vida , Neoplasias Pulmonares , Calidad de Vida , Humanos , Neoplasias Pulmonares/enfermería , Neoplasias Pulmonares/complicaciones , Neoplasias Pulmonares/psicología , Masculino , Femenino , Persona de Mediana Edad , Anciano , Cuidados Paliativos al Final de la Vida/métodos , Ansiedad/etiología , Manejo del Dolor/métodos , Manejo del Dolor/enfermería , Depresión/etiología , Actitud Frente a la Muerte , Fatiga/etiología , Encuestas y Cuestionarios

RESUMEN

Patients with diabetes have physical and psychological issues due to chronic illness. According to the guidelines of the Chinese Diabetes Society, after the diagnosis of patients with diabetes, they should receive routine health education, but this is the passive installation method of education. Nurses have made important contributions to the follow-up, education, and support of patients with diabetes and their families. The objective of this study was to evaluate the effectiveness of nurse-led follow-up care in routine health education and follow-up for patients with diabetes. Medical records of 721 patients with type 1 and type 2 diabetes were reviewed. Patients received nurse-led follow-up care including educational programs + Tai Chi exercises (patients received nurse-led follow-up care including educational programs for 6 months, n = 108), routine health education and follow-up + Tai Chi exercises (patients received routine health education and follow-up for 6 months, n = 205), or Tai Chi exercises only, but did not receive nurse-led follow-up care or routine health education and follow-up (patients received Tai Chi exercises only for 6 months, n = 408) for 6-months. The Zung Self-Rating Depression and Anxiety Scale and Summary of Diabetes Self-Care Activities were used to evaluate anxiety, depression, and self-care activities, respectively. Before the start of follow-up care (BFC), knowledge regarding diabetes and its threat was ≤1.75, anxiety and depression scores were ≥52 each, and self-care activities were ≤37. After 6 months of follow-up care, patients in the patients received nurse-led follow-up care including educational programs for 6 months improved their knowledge regarding diabetes and its threat, anxiety, depression, and self-care activities as compared to their before the start of follow-up care conditions and patients in the RF and patients received Tai Chi exercises only for 6 months at after 6 months of follow-up care conditions (P < .001 for all). Chinese type 1 or 2 diabetes patients had worse physical and psychological conditions and less knowledge regarding diabetes and its threat. Nurse-led aftercare, including educational programs with Tai Chi exercises for 6 months, decreased anxiety and depression and improved knowledge regarding diabetes and its threat and self-care activities in diabetic patients (Level of Evidence: IV; Technical Efficacy: Stage 5).

Asunto(s)

Diabetes Mellitus Tipo 2 , Educación del Paciente como Asunto , Autocuidado , Humanos , Masculino , Femenino , Persona de Mediana Edad , Diabetes Mellitus Tipo 2/enfermería , Diabetes Mellitus Tipo 2/terapia , Diabetes Mellitus Tipo 2/psicología , Autocuidado/métodos , Educación del Paciente como Asunto/métodos , Adulto , Taichi Chuan/métodos , Anciano , Educación en Salud/métodos , Diabetes Mellitus Tipo 1/enfermería , Diabetes Mellitus Tipo 1/terapia , Diabetes Mellitus Tipo 1/psicología , Ansiedad/etiología , Estudios de Seguimiento , Cuidados Posteriores/métodos

RESUMEN

Poststroke aphasia hinders patients' emotional processing and social adaptation. This study estimated the risks of depression and related symptoms in patients developing or not developing aphasia after various types of stroke. Using data from the US Collaborative Network within the TriNetX Diamond Network, we conducted a retrospective cohort study of adults experiencing their first stroke between 2013 and 2022. Diagnoses were confirmed using corresponding International Classification of Diseases, Tenth Revision, Clinical Modification codes. Patients were stratified by poststroke aphasia status and stroke type, with propensity score matching performed to control for confounders. The primary outcome was depression within one year post-stroke; secondary outcomes included anxiety, fatigue, agitation, emotional impact, and insomnia. Each matched group comprised 12,333 patients. The risk of depression was significantly higher in patients with poststroke aphasia (hazard ratio: 1.728; 95% CI 1.464-2.038; p < 0.001), especially those with post-hemorrhagic-stroke aphasia (hazard ratio: 2.321; 95% CI 1.814-2.970; p < 0.001). Patients with poststroke aphasia also had higher risks of fatigue, agitation, and emotional impact. Anxiety and insomnia risks were higher in those with post-hemorrhagic-stroke aphasia. Poststroke aphasia, particularly post-hemorrhagic-stroke aphasia, may increase the risks of depression and associated symptoms, indicating the need for comprehensive psychiatric assessments.

Asunto(s)

Afasia , Depresión , Accidente Cerebrovascular , Humanos , Femenino , Masculino , Afasia/etiología , Depresión/etiología , Depresión/complicaciones , Accidente Cerebrovascular/complicaciones , Anciano , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , Ansiedad/etiología , Fatiga/etiología , Trastornos del Inicio y del Mantenimiento del Sueño/etiología , Trastornos del Inicio y del Mantenimiento del Sueño/complicaciones , Anciano de 80 o más Años

RESUMEN

BACKGROUND: SARS-CoV-2 (COVID-19) has disrupted lives worldwide, affecting individuals from all walks of life. Individuals who have a spinal cord injury (SCI) are also affected by this phenomenon. This survey compares the quality of life (QOL), depression, and anxiety of SCI patients before and during COVID-19 in Wuhan City, China. METHODS: A cross-sectional survey utilized an online questionnaire to assess the QOL, levels of anxiety, and depression among 189 SCI patients admitted to Wuhan Tongji Hospital during pandemic from November 2020 to April 2021. Data before COVID-19 outbreak from November to December 2019 was retrieved from hospital records with the same assessment previously performed in-person or during a follow up visit. However, some participants were excluded for various reasons, such as declining to participate, not being admitted to a rehabilitation program due to the pandemic, or being under 18 years old. The World Health Organization's (WHO) QOL-Brief Version (BREF) and disability (DIS) modules, which focus on disability-related QOL, were used to assess the participants' QOL. RESULTS: SCI patients had lower QOL scores during the pandemic compared to pre-pandemic times. Mean scores on the 12-item DIS module significantly differed before and during the COVID-19 period. Participants showed higher adherence to self-isolation and quarantine measures for high-risk encounters (64.94%), but lower compliance with home disinfection and proper rest practices (23.38%). CONCLUSIONS: The COVID-19 pandemic has had a detrimental effect on the QOL of SCI patients in China, highlighting the urgent requirement for telehealth-based rehabilitation to mitigate its impact. It is crucial to provide essential.

Asunto(s)

Ansiedad , COVID-19 , Depresión , Calidad de Vida , Traumatismos de la Médula Espinal , Humanos , Traumatismos de la Médula Espinal/psicología , Traumatismos de la Médula Espinal/epidemiología , Traumatismos de la Médula Espinal/rehabilitación , COVID-19/psicología , COVID-19/epidemiología , Estudios Transversales , Masculino , Femenino , Persona de Mediana Edad , Adulto , China/epidemiología , Ansiedad/etiología , Ansiedad/epidemiología , Ansiedad/psicología , Depresión/psicología , Depresión/epidemiología , Depresión/etiología , Encuestas y Cuestionarios , Pandemias , Anciano , Adulto Joven , SARS-CoV-2 , Bienestar Psicológico

RESUMEN

Hyperhidrosis is associated with social and emotional stress, affecting quality of life. Microwave energy technology treats primary axillary hyperhidrosis by thermolysis of sweat glands. The successful reduction of sweating in patients with primary axillary hyperhidrosis after microwave treatment has been studied, but there is limited evidence on the psychological and long-term effects. This study examined patient- reported outcome measures including depression and anxiety in patients with primary axillary hyperhidrosis and the effect of microwave therapy on these parameters. Patients received 1 or 2 microwave-based treatments, within 3-month intervals. All patients were finally examined at approximately 1 year after the first treatment using the Hyperhidrosis Disease Severity Scale, Hyperhidrosis Quality of Life©, Dermatology Life Quality Index, and Hospital Anxiety and Depression Scale©. A total of 103 individuals with primary axillary hyperhidrosis were included in the study, with a Hyperhidrosis Disease Severity Scale score of 3 or 4. Statistically significant improvement in quality of life, anxiety, and depression scores were observed at 1-year follow-up. The primary endpoint, Hyperhidrosis Disease Severity Scale of 2 or less 1 year after the first treatment, was achieved by 88.2% of patients. No serious adverse side effects were observed.

Asunto(s)

Ansiedad , Axila , Depresión , Hiperhidrosis , Microondas , Calidad de Vida , Índice de Severidad de la Enfermedad , Humanos , Hiperhidrosis/psicología , Hiperhidrosis/terapia , Hiperhidrosis/diagnóstico , Microondas/efectos adversos , Microondas/uso terapéutico , Femenino , Adulto , Masculino , Ansiedad/psicología , Ansiedad/etiología , Depresión/psicología , Depresión/etiología , Resultado del Tratamiento , Adulto Joven , Factores de Tiempo , Persona de Mediana Edad , Sudoración , Medición de Resultados Informados por el Paciente , Estudios de Seguimiento , Adolescente

RESUMEN

OBJECTIVE: To examine the associations between self-reported screen time and symptoms of stress, anxiety, and depression in adolescents. METHODS: A cross-sectional study was conducted with 982 adolescents aged between 12 and 15 years, enrolled in public schools in Jacarezinho (PR), Brazil. Screen time was assessed by the question "Considering a typical day, how much time do you spend watching TV, playing videogame, using computer or smartphone?" The DASS-21 questionnaire (short form) was used to assess symptoms of depression, anxiety, and stress. Crude and adjusted analyses (age, sex, and maternal level of education) between screen time and mental disorders symptoms were performed using general linear regression models, with Poisson distribution, with significance level at p<0.05. RESULTS: Higher depressive symptoms were observed in adolescents who reported screen time of 4-6 hours/day (PR 1.35, 95%CI 1.13-1.61) and ≥6 hours/day (PR 1.88, 95%CI 1.62-2.19), compared with their pairs with <2 hours/day. The same was observed for anxiety symptoms with screen time of 4-6 hours/day (PR 1.23, 95%CI 1.04-1.46) and ≥6 hours/day (PR 1.50, 95%CI 1.28-1.77); and stress, with 4-6 hours/day (PR 1.25, 95%CI 1.08-1.44) and ≥6 hours/day (PR 1.49, 95%CI 1.30-1.71), also compared with their pairs with <2 hours/day. CONCLUSIONS: Screen time was positively associated with depressive, anxiety, and stress symptoms in adolescents. Special attention should be given to those who spend more than four hours a day in front of a screen.

Asunto(s)

Ansiedad , Depresión , Tiempo de Pantalla , Estrés Psicológico , Humanos , Adolescente , Femenino , Masculino , Estudios Transversales , Depresión/epidemiología , Depresión/diagnóstico , Depresión/psicología , Ansiedad/epidemiología , Ansiedad/diagnóstico , Ansiedad/psicología , Ansiedad/etiología , Estrés Psicológico/epidemiología , Estrés Psicológico/psicología , Niño , Brasil/epidemiología , Factores de Tiempo , Autoinforme

Asunto(s)

Ansiedad , Cuidadores , Neoplasias , Calidad de Vida , Apoyo Social , Humanos , Neoplasias/psicología , Ansiedad/psicología , Ansiedad/etiología , Cuidadores/psicología , Personalidad , Actitud Frente a la Muerte

RESUMEN

OBJECTIVES: To investigate the relationship among patients' apathy, cognitive impairment, depression, anxiety, and caregiver burden in amyotrophic lateral sclerosis (ALS). DESIGN: A cross-sectional study design was used. SETTING: The study was conducted at a tertiary hospital in Wuhan, Hubei, China. PARTICIPANTS: A total of 109 patients with ALS and their caregivers were included. OUTCOME MEASURES: Patients with ALS were screened using the Edinburgh Cognitive and Behavioural Screen, Beck Depression Inventory-II, Generalised Anxiety Disorder-7 and Apathy Scale to assess their cognition, depression, anxiety and apathy, respectively. The primary caregivers completed the Zarit Burden Interview. The association between apathy, cognitive impairment, depression, anxiety and caregiver burden was analysed using logistic regression. Mediation models were employed to investigate the mediating effect of patients' apathy on the relationship between depression/anxiety and caregiver burden. RESULTS: Patients in the high caregiver burden group exhibited significantly higher levels of depression, anxiety and apathy compared with those in the low caregiver burden group (p<0.05). There was a positive association observed between caregiver burden and disease course (rs=0.198, p<0.05), depression (rs=0.189, p<0.05), anxiety (rs=0.257, p<0.05) and apathy (rs=0.388, p<0.05). There was a negative association between caregiver burden and the Revised ALS Functional Rating Scale (rs=-0.275, p<0.05). Apathy was an independent risk factor for higher caregiver burden (OR 1.121, 95% CI 1.041 to 1.206, p<0.05). Apathy fully mediated the relationship between depression and caregiver burden (ß=0.35, 95% CI 0.16 to 0.54, p<0.05) while partially mediating the relationship between anxiety and caregiver burden (ß=0.34, 95% CI 0.16 to 0.52, p<0.05). CONCLUSIONS: Apathy, depression and anxiety exerted a detrimental impact on caregiver burden in individuals with ALS. Apathy played a mediating role in the relationship between depression and caregiver burden and between anxiety and caregiver burden. These findings underscore the importance of identifying apathy and developing interventions for its management within the context of ALS.

Asunto(s)

Esclerosis Amiotrófica Lateral , Ansiedad , Apatía , Carga del Cuidador , Depresión , Humanos , Esclerosis Amiotrófica Lateral/psicología , Masculino , Femenino , Estudios Transversales , Persona de Mediana Edad , Ansiedad/psicología , Ansiedad/etiología , Depresión/psicología , Depresión/etiología , China/epidemiología , Carga del Cuidador/psicología , Anciano , Cuidadores/psicología , Adulto , Disfunción Cognitiva/etiología , Disfunción Cognitiva/psicología , Escalas de Valoración Psiquiátrica , Modelos Logísticos , Costo de Enfermedad

RESUMEN

Background: Functional dyspepsia is a common functional gastrointestinal disorder that is often challenging to treat. Psychotherapeutic interventions have been proposed as an alternative or adjunctive approach to conventional treatments, but their efficacy remains unclear. Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of psychotherapeutic interventions in the treatment of functional dyspepsia. Methods: A comprehensive search of electronic databases was conducted, from inception to March 2023, for randomized controlled trials (RCTs) that evaluated the effects of psychotherapeutic interventions on patients with functional dyspepsia. The primary outcome measures were gastrointestinal symptoms, quality of life, depression, and anxiety. Data were extracted and analyzed using Review Manager 5.3 software. The risk of bias of the included studies was assessed using the Cochrane Risk of Bias tool. Results: Sixteen RCTs comprising 1550 patients with functional dyspepsia were included in the meta-analysis. The types of psychotherapeutic interventions used in the included studies were cognitive-behavioral therapy (CBT), hypnotherapy, and mindfulness-based stress reduction (MBSR). The control groups were usual care, placebo, supportive therapy, or no treatment. The meta-analysis showed that psychotherapeutic interventions had a significant effect on reducing gastrointestinal symptoms,depression and anxiety in patients with functional dyspepsia. However, no significant improvement was observed in the quality-of-life scores of patients who received psychotherapeutic interventions compared to those in the control group. Conclusion: Psychotherapeutic interventions, such as CBT, hypnotherapy, and MBSR, could be a useful adjunct to conventional treatments for functional dyspepsia, as they were found to significantly reduce gastrointestinal symptoms and anxiety in patients. However, further studies are needed to assess the long-term effects and generalizability of these interventions.

Asunto(s)

Dispepsia , Calidad de Vida , Humanos , Dispepsia/terapia , Dispepsia/psicología , Terapia Cognitivo-Conductual/métodos , Psicoterapia/métodos , Ensayos Clínicos Controlados Aleatorios como Asunto , Depresión/terapia , Ansiedad/terapia , Ansiedad/etiología , Hipnosis/métodos , Atención Plena/métodos , Resultado del Tratamiento

RESUMEN

Consumption of palatable food (PF) can alleviate anxiety, and pain in humans. Contrary, spontaneous withdrawal of long-term PF intake produces anxiogenic-like behavior and abnormal pain sensation, causing challenges to weight-loss diet and anti-obesity agents. Thus, we examined α7-nicotinic acetylcholine receptors (α7nAChR) involvement since it plays essential role in nociception and psychological behaviors. METHODS: Adult male C57BL/6 mice were placed on a Standard Chow (SC) alone or with PF on intermittent or continuous regimen for 6 weeks. Then, mice were replaced with normal SC (spontaneous withdrawal). Body weight, food intake, and calories intake with and without the obesogenic diet were measured throughout the study. During PF withdrawal, anxiety-like behaviors and pain sensitivity were measured with PNU-282987 (α7nAChR agonist) administration. RESULTS: Six weeks of SC + PF-intermittent and continuous paradigms produced a significant weight gain. PF withdrawal displayed hyperalgesia and anxiety-like behaviors. During withdrawal, PNU-282987 significantly attenuated hyperalgesia and anxiety-like behaviors. CONCLUSION: The present study shows that a PF can increase food intake and body weight. Also, enhanced pain sensitivity and anxiety-like behavior were observed during PF withdrawal. α7nAChR activation attenuated anxiolytic-like behavior and hyperalgesia in PF abstinent mice. These data suggest potential therapeutic effects of targeting α7 nAChRs for obesity-withdrawal symptoms in obese subjects.

Asunto(s)

Ansiedad , Benzamidas , Compuestos Bicíclicos con Puentes , Hiperalgesia , Ratones Endogámicos C57BL , Obesidad , Receptor Nicotínico de Acetilcolina alfa 7 , Animales , Receptor Nicotínico de Acetilcolina alfa 7/metabolismo , Masculino , Ansiedad/etiología , Hiperalgesia/etiología , Hiperalgesia/metabolismo , Benzamidas/farmacología , Benzamidas/administración & dosificación , Obesidad/psicología , Obesidad/metabolismo , Compuestos Bicíclicos con Puentes/farmacología , Ratones , Ingestión de Alimentos/efectos de los fármacos , Conducta Animal/efectos de los fármacos , Aumento de Peso/efectos de los fármacos

RESUMEN

Skeletal Class III malocclusion can significantly impact psychological well-being. Although bimaxillary surgery is a well-established corrective intervention, its psychological effects are not fully understood. This study aims to investigate changes in self-esteem, sensitivity to criticism, and social appearance anxiety following surgery to inform targeted nursing interventions for psychological adaptation. This comparative study included 205 participants: 150 patients with skeletal Class III malocclusion who underwent bimaxillary surgery, and a control group of 55 individuals without malocclusion. The malocclusion group had a mean age of 21.99 ±â€…2.28 years (96 males, 109 females). The control group consisted of department interns with Class I occlusion, normal overjet and overbite, and typical facial appearance, with a mean age of 21.61 ±â€…2.40 years (26 males, 29 females). Psychological assessments, validated for reliability, measured self-esteem, sensitivity to criticism, and social appearance anxiety before and after surgery. Statistical analyses, including independent sample t tests and one-way ANOVA, were performed to compare outcomes between the groups, with a significance level set at P < .05. Preoperative assessments revealed that patients with skeletal Class III malocclusion had significantly lower self-esteem and higher sensitivity to criticism and social appearance anxiety compared to the control group (P < .05). Postoperatively, there were modest improvements in self-esteem and significant reductions in sensitivity to criticism and social appearance anxiety, though levels of social appearance anxiety remained higher than those in the control group (P < .05). No significant differences in self-esteem and sensitivity to criticism were observed between the surgical and control groups postoperatively (P > .05). Within-group comparisons showed significant improvements in all measures after surgery (P < .05). Bimaxillary surgery positively affects the psychological well-being of patients with skeletal Class III malocclusion, enhancing self-esteem and reducing sensitivity to criticism and social appearance anxiety. However, some psychological concerns persist, indicating a need for targeted nursing interventions to further support these patients' psychological well-being.

Asunto(s)

Ansiedad , Maloclusión de Angle Clase III , Procedimientos Quirúrgicos Ortognáticos , Autoimagen , Humanos , Maloclusión de Angle Clase III/cirugía , Maloclusión de Angle Clase III/psicología , Femenino , Masculino , Adulto Joven , Procedimientos Quirúrgicos Ortognáticos/psicología , Ansiedad/psicología , Ansiedad/etiología , Adulto

RESUMEN

OBJECTIVE: To investigate the efficacy and safety of Aviandr in the treatment of anxiety in patients with adjustment disorders after COVID-19. MATERIAL AND METHODS: A multicenter prospective open-label study included 109 patients of both sexes aged 18 to 65 years (70 women, 39 men, average age - 41.4±13.18 years) with a leading complaint of anxiety (Hamilton scale score, HAM-A ≥18 - ≤24), which arose after acute coronavirus infections. Clinical manifestations had to meet the diagnostic criteria F43.2 ICD-10. The drug Aviander was prescribed 20 mg 2 times a day for 4 weeks. At the end of taking the drug, patients were monitored for another 1 week (a delayed follow-up visit). Psychopathological, statistical and parametric research methods were used using standardized HAM-A, Montgomery-Asberg scales (MADRS), visual analog asthenia scale (VASH-A), Sheehan Disability Scale (SDS), digital character substitution test (DSST), general clinical impression scale (CGI). RESULTS: Data from 109\110 patients were analyzed to evaluate efficacy\safety. Aviandr was administered 20 mg 2 times daily for 4 weeks. Patients were followed for 1 week (delayed follow-up visit) at the end of treatment. Reducing the intensity of anxiety on the HAM-A scale was - 14.2±4.92 or 69.4±22.66% by the end of treatment. The response rate to therapy (responders are patients with a decrease in the total score on the HAM-A ≥50%) was 83.49%. Remission was achieved (sum of HAM-A scores ≤7) by the end of treatment 68.81% of patients, and 79.8% of patients at the follow-up visit. Significant changes were obtained on the MADRS, VAS-A, SDS and DSST scales. According CGI 45.9% of patients had «much improved¼ and 43.1% of patients had «very much improved¼ by the end of treatment; 58.7% of patients had «much improved¼ and of 33.9% patients had «very much improved¼ at the follow-up visit. 38 adverse events were reported in 27 (24.55%) patients during the study. A definite association with study drug was reported between 5 mild adverse events in 4 (3.64%) patients. No subjects withdrew from the study due to an adverse event. Positive dynamics (reduction of anxiety symptoms, decrease in asthenia) persisted after discontinuation of the study drug. No cases of withdrawal syndrome were observed. CONCLUSION: According to the results of the study, the anxiolytic, antidepressant, antiasthenic and pro-cognitive effects of Aviandr were observed. An increase in the social activity of patients was observed.

Asunto(s)

COVID-19 , Humanos , Femenino , Masculino , Adulto , Persona de Mediana Edad , COVID-19/complicaciones , COVID-19/psicología , Estudios Prospectivos , Anciano , Adulto Joven , Resultado del Tratamiento , Trastornos de Adaptación/tratamiento farmacológico , Adolescente , Ansiedad/tratamiento farmacológico , Ansiedad/etiología , SARS-CoV-2 , Trastornos de Ansiedad/tratamiento farmacológico , Ansiolíticos/uso terapéutico , Ansiolíticos/efectos adversos

RESUMEN

Patients with ITP have been reported to experience higher levels of depression and anxiety than their healthy counterparts. The limited research conducted on this subject in the pediatric age group has demonstrated that patients have psychosocial difficulties, and their quality of life is adversely affected. The correlation of depressive symptoms with disease characteristics of cITP has never been investigated. This was a cross-sectional study in patients being treated for cITP. Communication with participants was done during routine outpatient visits or by telephone or e-mail, and a survey about demographics and the Children's Depression Inventory (CDI) and the Social Anxiety Scale for Children-Revised (SAS-CR) was administered prospectively. A total of 56 children with cITP were recruited. The mean CDI score was 17 (SD: ± 9.44). Approximately half of the patients had higher CDI scores than healthy Turkish children. Older age, time since diagnosis, a number of hospitalizations (both total and within the last year) were positively correlated with CDI scores. There was no significant correlation between SAS-CR scores and disease characteristics. Depressive symptom scores were higher in children with cITP compared with healthy children in this study. Psychological needs may be overlooked in the medical management of children with cITP.

Asunto(s)

Ansiedad , Depresión , Púrpura Trombocitopénica Idiopática , Humanos , Estudios Transversales , Niño , Depresión/etiología , Depresión/diagnóstico , Masculino , Femenino , Adolescente , Púrpura Trombocitopénica Idiopática/psicología , Púrpura Trombocitopénica Idiopática/diagnóstico , Ansiedad/etiología , Preescolar , Calidad de Vida , Enfermedad Crónica

RESUMEN

OBJECTIVE: Although breast magnetic resonance imaging (MRI) is a valuable screening tool, breast MRI testing burden was associated with cancer worry and quality of life. We aimed to develop and validate the MRI-related distress scale (MRI-DS) to assess comprehensive distress specifically related to breast MRI. METHODS: We enrolled women aged above 18 years, diagnosed breast cancer, had MRI examination at least one time, and who could speak and read Korean in phase I and enrolled women aged above 18 years, visited outpatient clinic of breast general surgery, had undergone MRI examination at least once, and could speak and read Korean in phase II. We excluded patients who had any physical or psychiatric conditions in both phases. We recruited from a tertiary university-based hospital in South Korea between April and August 2023. RESULTS: All 18 items had acceptable levels of item correlation (≥0.30) in the explanatory factor analysis with a four-factor solution. The fit indices for the four-factor solution model were good. The discriminant validity of the MRI-DS had a moderate correlation with general anxiety or quality of life. In the known-group analysis, those who reported MRI as the most burden breast examination had higher total scores. CONCLUSION: The validity of the MRI-DS has been confirmed as a scale for measuring the specific distress caused by breast MRI. The MRI-DS is recommended to health professional to communicate with patients with MRI. CLINICAL IMPLICATIONS: It can be used to assess the distress associated with MRI screening in breast cancer patients. Physician could use MRI-DS to discuss the reasons for distress caused by breast MRI screening and to address specific sources of discomfort associated with it.

Asunto(s)

Neoplasias de la Mama , Imagen por Resonancia Magnética , Calidad de Vida , Humanos , Femenino , Imagen por Resonancia Magnética/métodos , Neoplasias de la Mama/psicología , Neoplasias de la Mama/diagnóstico por imagen , Persona de Mediana Edad , Adulto , República de Corea , Distrés Psicológico , Estrés Psicológico , Psicometría , Ansiedad/psicología , Ansiedad/etiología , Anciano , Medición de Resultados Informados por el Paciente , Reproducibilidad de los Resultados , Encuestas y Cuestionarios

Asunto(s)

Ansiedad , Humanos , Femenino , Adulto , Diagnóstico Diferencial , Ansiedad/etiología , Periodo Posparto/psicología , Trastornos Puerperales/psicología , Trastornos Puerperales/diagnóstico , Razonamiento Clínico

RESUMEN

To investigate the classification of anxiety based on potential category analysis in gestational diabetes mellitus (GDM) patients and the associated factors. This questionnaire-based, cross-sectional study was conducted on GDM patients admitted to a Grade III-A general hospital using convenience sampling between March and November 2021. Latent class analysis was utilized for classification. Multivariate logistic regression analysis was performed to identify factors associated with anxiety. A total of 215 valid questionnaires were collected, yielding a response rate of 99%. GDM patients were classified into 4 potential categories: low anxiety (54%), high anxiety (21%), worried about the fetus (11%), and worried about delivery (14%). Multivariate logistic regression analysis showed that, compared with low anxiety, education level, family history of diabetes, blood glucose changes, delivery mode schedule, knowledge score of GDM, and marital relationship scale score were independently associated with anxiety (P < .05). The number of births, education level, blood glucose changes, delivery mode schedule, and marital relationship scale score were independently associated with being worried about the fetus (P < .05). Education level, family history of diabetes, blood glucose changes, delivery mode schedule, knowledge score of GDM, and marital relationship scale score were independently associated with being worried about delivery (P < .05). Anxiety in GDM patients was categorized by latent class analysis into low anxiety (54%), high anxiety (21%), worried about the fetus (11%), and worried about delivery (14%). Education level, family history of diabetes, blood glucose changes, delivery mode schedule, GDM knowledge score, and marital relationship scale score might be associated with anxiety.

Asunto(s)

Ansiedad , Diabetes Gestacional , Análisis de Clases Latentes , Humanos , Diabetes Gestacional/psicología , Femenino , Embarazo , Estudios Transversales , Adulto , Ansiedad/epidemiología , Ansiedad/psicología , Ansiedad/diagnóstico , Ansiedad/etiología , Encuestas y Cuestionarios , Glucemia/análisis , Modelos Logísticos

RESUMEN

INTRODUCTION: Baduanjin was also called Eight Brocades (EB), a branch of Qigong exercise, is classified as a mild-to-moderate intensity aerobic exercise. It has been theorized that regular practice of EB can alleviate anxiety and depression in patients undergoing chemotherapy; however, there are currently no comprehensive quantitative reviews on the efficacy of EB for this population. Therefore, this meta-analysis aims to investigate the effects of EB on chemotherapy-treated patients. METHODS: Eight electronic databases were searched from their inception until February 15, 2024, to identify relevant studies. The inclusion and exclusion criteria were applied to filter the retrieved studies. Outcomes were various quantitative assessments. This systematic review was registered in the PROSPERO Registry (registration number CRD42023466630). RESULTS: Nine randomized controlled trials (RCTs) met eligibility criteria (n = 704). The meta-analysis results demonstrated that EB significantly reduced levels of anxiety and depression. Subgroup analysis revealed that the intervention frequency of 1 time/day had a greater effect on the improvement of negative emotions, compared with 2 times/day and 5 times/week. The intervention duration of 4 weeks showed more efficacy in reducing depression scores than 12 weeks or 16 weeks; however, no statistical difference was observed for anxiety scores. CONCLUSION: EB exercise can reduce depression and anxiety symptoms in chemotherapy-treated patients. However, the results should be interpreted with caution as existing methodological limitations. The findings provided insights into the development of public health initiatives to improve the negative emotion among chemotherapy-treated patients by EB exercise.

Asunto(s)

Ansiedad , Depresión , Neoplasias , Qigong , Ensayos Clínicos Controlados Aleatorios como Asunto , Humanos , Neoplasias/tratamiento farmacológico , Neoplasias/psicología , Qigong/métodos , Depresión/etiología , Ansiedad/etiología , Antineoplásicos/uso terapéutico , Antineoplásicos/efectos adversos , Emociones