RESUMEN
We report a 25-year-old unmarried girl who developed multiple papular lesions on both labia majora with the past history of documented HPV-6 viral infection in the vulva. A wide local excision was performed and histopathological report confirmed a case of angiokeratoma. To the best of our knowledge this is the first case of angiokeratoma of vulva following chronic HPV infection.
Asunto(s)
Angioqueratoma/virología , Papillomavirus Humano 6/aislamiento & purificación , Infecciones por Papillomavirus/complicaciones , Neoplasias Cutáneas/virología , Vulva , Adulto , Angioqueratoma/cirugía , Femenino , Humanos , Infecciones por Papillomavirus/virología , Neoplasias Cutáneas/cirugíaRESUMEN
A female 8-month-old Simmental calf was presented with a history of a gradually enlarging mass in the ventral abdominal skin since 4 months of age. The mass was well circumscribed, lightly pigmented, and rough surfaced with many fine fissures and was attached to the skin by a relatively broad pedicle. On cut section, there was a border between the reddish-black stroma and overlying epithelium, including hemorrhagic foci of variable sizes. Histologically, the tumor was papillomatous with angiokeratomatous features and irregular hyperplasia with epidermal rete ridges and dilated vascular channels filled with blood in the superficial dermis. In the epidermis, orthokeratotic hyperkeratosis, variably sized keratohyalin granules, and many koilocytes, some of which had papillomavirus (PV) genus-specific structural antigen-positive nuclei, were also observed. Cells lining the dilated vascular spaces were positive for vimentin and alpha-smooth muscle actin but negative for factor VIII-related antigen, desmin, and PV. The lesion was regarded as an angiokeratomatous papilloma and was similar to other angiomatous lesions.