RESUMEN
Importance: Several studies have reported that the progression of coronary atherosclerosis, as measured by serial coronary computed tomographic (CT) angiography, is associated with the risk of future cardiovascular events. However, the cumulative consequences of multiple risk factors for plaque progression and the development of adverse plaque characteristics have not been well characterized. Objectives: To examine the association of cardiovascular risk factor burden, as assessed by atherosclerotic cardiovascular disease (ASCVD) risk score, with the progression of coronary atherosclerosis and the development of adverse plaque characteristics. Design, Setting, and Participants: This cohort study is a subgroup analysis of participant data from the prospective observational Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging (PARADIGM) study, which evaluated the association between serial coronary CT angiography findings and clinical presentation. The PARADIGM international multicenter registry, which includes 13 centers in 7 countries (Brazil, Canada, Germany, Italy, Portugal, South Korea, and the US), was used to identify 1005 adult patients without known coronary artery disease who underwent serial coronary CT angiography scans (median interscan interval, 3.3 years; interquartile range [IQR], 2.6-4.8 years) between December 24, 2003, and December 16, 2015. Based on the 10-year ASCVD risk score, the cardiovascular risk factor burden was classified as low (<7.5%), intermediate (7.5%-20.0%), or high (>20.0%). Data were analyzed from February 8, 2019, to April 17, 2020. Exposures: Association of baseline ASCVD risk burden with plaque progression. Main Outcomes and Measures: Noncalcified plaque, calcified plaque, and total plaque volumes (mm3) were measured. Noncalcified plaque was subclassified using predefined Hounsfield unit thresholds for fibrous, fibrofatty, and low-attenuation plaque. The percent atheroma volume (PAV) was defined as plaque volume divided by vessel volume. Adverse plaque characteristics were defined as the presence of positive remodeling, low-attenuation plaque, or spotty calcification. Results: In total, 1005 patients (mean [SD] age, 60 [8] years; 575 men [57.2%]) were included in the analysis. Of those, 463 patients (46.1%) had a low 10-year ASCVD risk score (low-risk group), 373 patients (37.1%) had an intermediate ASCVD risk score (intermediate-risk group), and 169 patients (16.8%) had a high ASCVD risk score (high-risk group). The annualized progression rate of PAV for total plaque, calcified plaque, and noncalcified plaque was associated with increasing ASCVD risk (r = 0.26 for total plaque, r = 0.23 for calcified plaque, and r = 0.11 for noncalcified plaque; P < .001). The annualized PAV progression of total plaque, calcified plaque, and noncalcified plaque was significantly greater in the high-risk group compared with the low-risk and intermediate-risk groups (for total plaque, 0.99% vs 0.45% and 0.58%, respectively; P < .001; for calcified plaque, 0.61% vs 0.23% and 0.36%; P < .001; and for noncalcified plaque, 0.38%vs 0.22% and 0.23%; P = .01). When further subclassified by noncalcified plaque type, the annualized PAV progression of fibrofatty and low-attenuation plaque was greater in the high-risk group (0.09% and 0.02%, respectively) compared with the low- to intermediate-risk group (n = 836; 0.02% [P = .02] and 0.001% [P = .008], respectively). The interval development of adverse plaque characteristics was greater in the high-risk group compared with the low-risk and intermediate-risk groups (for new positive remodeling, 73 patients [43.2%] vs 151 patients [32.6%] and 133 patients [35.7%], respectively; P = .02; for new low-attenuation plaque, 26 patients [15.4%] vs 44 patients [9.5%] and 35 patients [9.4%]; P = .02; and for new spotty calcification, 37 patients [21.9%] vs 52 patients [11.2%] and 54 patients [14.5%]; P = .002). The progression of noncalcified plaque subclasses and the interval development of adverse plaque characteristics did not significantly differ between the low-risk and intermediate-risk groups. Conclusions and Relevance: Progression of coronary atherosclerosis occurred across all ASCVD risk groups and was associated with an increase in 10-year ASCVD risk. The progression of fibrofatty and low-attenuation plaques and the development of adverse plaque characteristics was greater in patients with a high risk of ASCVD.
Asunto(s)
Enfermedades Cardiovasculares/fisiopatología , Angiografía por Tomografía Computarizada/estadística & datos numéricos , Enfermedad de la Arteria Coronaria/clasificación , Factores de Riesgo , Anciano , Brasil/epidemiología , Enfermedades Cardiovasculares/complicaciones , Enfermedades Cardiovasculares/epidemiología , Estudios de Cohortes , Angiografía por Tomografía Computarizada/métodos , Enfermedad de la Arteria Coronaria/complicaciones , Enfermedad de la Arteria Coronaria/epidemiología , Vasos Coronarios/diagnóstico por imagen , Vasos Coronarios/fisiopatología , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Portugal/epidemiología , Estudios Prospectivos , Quebec/epidemiología , Sistema de Registros/estadística & datos numéricos , República de Corea/epidemiologíaRESUMEN
BACKGROUND: Critically ill patients are at high risk for pulmonary embolism (PE). Specific PE prediction rules have not been validated in this population. The present study assessed the Wells and revised Geneva scoring systems as predictors of PE in critically ill patients. METHODS: Pulmonary computed tomographic angiograms (CTAs) performed for suspected PE in critically ill adult patients were retrospectively identified. Wells and revised Geneva scores were calculated based on information from medical records. The reliability of both scores as predictors of PE was determined using receiver operating characteristic (ROC) curve analysis. RESULTS: Of 138 patients, 42 (30.4%) were positive for PE based on pulmonary CTA. Mean Wells score was 4.3 (3.5) in patients with PE versus 2.7 (1.9) in patients without PE (P < .001). Revised Geneva score was 5.8 (3.3) versus 5.1 (2.5) in patients with versus without PE (P = .194). According to the Wells and revised Geneva scores, 56 (40.6%) patients and 49 (35.5%) patients, respectively, were considered as low probability for PE. Of those considered as low risk by the Wells score, 15 (26.8%) had filling defects on CTA, including 2 patients with main pulmonary artery embolism. The area under the ROC curve was 0.634 for the Wells score and 0.546 for the revised Geneva score. Wells score >4 had a sensitivity of 40%, specificity of 87%, positive predictive value of 59%, and negative predictive value of 77% to predict risk of PE. CONCLUSIONS: In this population of critically ill patients, Wells and revised Geneva scores were not reliable predictors of PE.
Asunto(s)
Angiografía por Tomografía Computarizada/estadística & datos numéricos , Cuidados Críticos/normas , Embolia Pulmonar/diagnóstico , Medición de Riesgo/normas , Índice de Severidad de la Enfermedad , Anciano , Área Bajo la Curva , Cuidados Críticos/métodos , Enfermedad Crítica , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Embolia Pulmonar/etiología , Curva ROC , Reproducibilidad de los Resultados , Estudios RetrospectivosRESUMEN
INTRODUCCIÓN: La coronariografia convencional sigue siendo el patrón de referencia para cuantificar y guiar el tratamiento en la enfermedad coronaria sin embargo con la introducción de la angiotomografía coronaria multidetector en la valoración de placas ateromatosas coronarias y con esto la exposición a la radiación ha permanecido como área de constante preocupación. En la práctica diaria se recomienda basarse en lo que se conoce como As Low As Reasonably Achievable que significa optimizar la radiación sin perjuicio de la calidad del estudio. MÉTODOS: Se trata de un estudio descriptivo retrospectivo en el Hospital de Especialidades José Carrasco Arteaga de Cuenca Ecuador, durante el periodo de tiempo comprendido entre el 01 enero del 2013 y 31 diciembre del 2015. Para este estudio se incluyeron todos los pacientes a quienes se les realizó angiotomografía coronaria multidetector, se recolectaron los datos clínicos y la dosis efectiva de radiación de cada paciente. RESULTADOS: La edad promedio fue de 63.2 años. Con una probabilidad pre-test intermedia-baja para enfermedad coronaria en más del 94 % de los pacientes, de los cuales el promedio de dosis de radiación efectiva en angiotomografía coronaria multidetector es de 13.0276 mSv (0.9002 20.657).CONCLUSION: Se trata del primer estudio en el medio donde investiga la dosis de radiación utilizada en angiotomografía coronaria multidetector permitiendo conocer la media de dosis efectiva y así optimizar la misma mediante técnicas de reducción.
INTRODUCTION: The conventional coronography continues to be the standard used to quantify and manage the treatment of coronary disease. However, with the introduction of the multidetector coronary angiothomography in the evaluation of coronary atheromatous plaque, the exposure to radiation has continued to be an area of constant concern. It is recommended that in daily practice the As Low as Reasonably Achievable guidelines be used, which means optimizing the amount of radiation without affecting the quality of the study. METHOD: This a descriptive retrospective study that took place at the José Carrasco Arteaga Specialties Hospital in Cuenca Ecuador, covering the time period between January 1, 2013 from December 31, 2015. The clinical data and effective dose of radiation of each patient who underwent a multidetector coronary angiothomography during this time span were included in the study. RESULTS: The average age was 63.2 years, with a low to intermediate pre-test probability of coronary disease in over 94 % of the patients. The average dose of effective radiation in multidetector coronary angiothomography was of 13.0276 mSv (0.9002-20.657). CONCLUSIONS: This is the first study in our area where the dose of radiation used in multidetector coronary angiothomography has been investigated, making it possible to identify the effective half dose, in this way optimizing the same through the use of reduction techniques.
Asunto(s)
Humanos , Enfermedad Coronaria/diagnóstico por imagen , Angiografía por Tomografía Computarizada/estadística & datos numéricos , Radiación , Factores de RiesgoRESUMEN
OBJECTIVE: The objective of our study was to determine the impact of embedding a pretest probability rule that is required during the computerized physician order-entry (CPOE) process on the appropriateness of CT angiography (CTA) of the pulmonary arteries for the diagnosis of pulmonary embolism (PE) in the emergency department (ED). MATERIALS AND METHODS: Data were obtained from the electronic medical records of all adults who visited the ED from October 17, 2010, through October 17, 2012 (n = 96,507). The primary outcome was the appropriateness of pulmonary CTA. Logistic regression was used to test whether rates of appropriate use, overuse, and underuse of pulmonary CTA improved significantly after the implementation of the decision support tool when controlling for other patient characteristics. RESULTS: Pulmonary CTA was appropriately used in 67.2% of patients with a modified Wells score of ≥ 4, a positive d-dimer test result, or both. CTA was overused in 19.3% of patients and underused in 13.5% of patients. Each additional month after the start of the intervention was associated with a 4-percentage point increase in the odds that the modified Wells score would indicate CTA had been used appropriately (odds ratio [OR] = 1.04; 95% CI, 1.01-1.07) and significantly lowered the odds of overuse of CTA (OR = 0.93; 95% CI, 0.90-0.96) based on the modified Wells score. These changes were not associated with any significant alteration in the level of CTA utilization or the positivity rate. CONCLUSION: The addition of a mandatory field in the CPOE record was associated with a significant improvement in the appropriate ordering of pulmonary CTA but did not change the PE positive rate or CTA utilization. It seems likely that physicians gradually inflated the modified Wells scores in spite of the fact that a threshold modified Wells score was not required to perform pulmonary CTA.