1.
Methods Enzymol
; 299: 300-6, 1999.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9916209
2.
Determination of noscapine, hexylresorcinol and anethole in cough lozenges by liquid chromatography.
Boll Chim Farm
; 135(6): 387-90, 1996 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-8942066
RESUMEN
A liquid chromatographic method was developed for the simultaneous separation and determination of noscapine hydrochloride, hexylresorcinol and anethole in cough lozenges. Analysis was performed on a phenyl column with phosphate buffer- acetonitrile as mobile phase and the separated components were detected at 282 mm. Recoveries obtained for the analytes were of 94.6% for noscapine hydrochloride, 99.1% for hexylresorcinol and 96.3% for anethole. The values of the relative standard deviation were 0.8% for noscapine hydrochloride, 1.5% for hexylresorcinol and 1.1% for anethole. The analytical method was validated and a system suitability test was accomplished for the chromatographic method.