RESUMEN
Anetoderma or macular atrophy is a rare skin condition of unclear pathogenesis, often associated with autoimmune diseases and skin damage from various infections. Human immunodeficiency virus (HIV), syphilis, and poxviruses have been implicated in the development of anetoderma. A 37-year-old male patient with HIV and recent unprotected sexual encounters presented with more than 400 skin lesions, consistent with Mpox. Symptomatic treatment for Mpox resulted in acute symptom resolution. However, 8 months later he developed papular anetoderma lesions in areas previously affected by Mpox. Biopsy confirmed the loss of elastic fibers in the affected skin areas, leading to the diagnosis of Mpox-induced anetoderma. This report presents a unique case of anetoderma following Mpox in an HIV-positive patient.
Asunto(s)
Anetodermia , Infecciones por VIH , Humanos , Masculino , Adulto , Anetodermia/patología , Infecciones por VIH/complicaciones , Infecciones por VIH/tratamiento farmacológico , Combinación Trimetoprim y Sulfametoxazol/efectos adversos , Combinación Trimetoprim y Sulfametoxazol/uso terapéuticoAsunto(s)
Anetodermia/metabolismo , Basófilos/metabolismo , Macrófagos/enzimología , Metaloproteinasa 9 de la Matriz/metabolismo , Anetodermia/patología , Antígenos CD/metabolismo , Antígenos de Diferenciación Mielomonocítica/metabolismo , Niño , Humanos , Macrófagos/metabolismo , Masculino , Factor de Necrosis Tumoral alfa/metabolismoRESUMEN
Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder in which autoantibodies are produced against a variety of phospholipids and phospholipid-binding proteins. The purpose of this article is to review cutaneous findings in patients with APS diagnosis. An overview regarding prevalence, description, pathogenesis and histopathology, are described for cutaneous manifestations of APS.
Asunto(s)
Anticuerpos Antifosfolípidos/inmunología , Síndrome Antifosfolípido/patología , Livedo Reticularis/patología , Enfermedades de la Piel/patología , Vasculitis/patología , Adulto , Anciano , Anetodermia/etiología , Anetodermia/patología , Anticuerpos Anticardiolipina/inmunología , Síndrome Antifosfolípido/diagnóstico , Síndrome Antifosfolípido/epidemiología , Síndrome Antifosfolípido/inmunología , Biopsia , Femenino , Gangrena/etiología , Gangrena/patología , Humanos , Livedo Reticularis/diagnóstico , Livedo Reticularis/etiología , Livedo Reticularis/inmunología , Inhibidor de Coagulación del Lupus/inmunología , Masculino , Papulosis Atrófica Maligna/etiología , Papulosis Atrófica Maligna/patología , Persona de Mediana Edad , Necrosis/diagnóstico , Necrosis/etiología , Prevalencia , Enfermedades de la Piel/inmunología , Úlcera/patología , Vasculitis/etiologíaRESUMEN
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Asunto(s)
Humanos , Femenino , Adulto , Anetodermia/etiología , Síndrome Antifosfolípido/complicaciones , Anetodermia/patología , Extremidad Superior/patología , Biopsia , Lupus Eritematoso Sistémico/complicacionesAsunto(s)
Anetodermia/diagnóstico por imagen , Enfermedades del Cabello/diagnóstico por imagen , Pilomatrixoma/diagnóstico por imagen , Neoplasias Cutáneas/diagnóstico por imagen , Adolescente , Anetodermia/complicaciones , Anetodermia/patología , Dermoscopía , Enfermedades del Cabello/patología , Humanos , Inmunohistoquímica , Masculino , Pilomatrixoma/complicaciones , Pilomatrixoma/patología , Neoplasias Cutáneas/patologíaAsunto(s)
Anetodermia/inducido químicamente , Reacción en el Punto de Inyección/etiología , Neurofibromatosis 1/diagnóstico , Vitamina K 1/efectos adversos , Anetodermia/complicaciones , Anetodermia/diagnóstico , Anetodermia/patología , Biopsia , Diagnóstico Diferencial , Femenino , Humanos , Lactante , Reacción en el Punto de Inyección/diagnóstico , Reacción en el Punto de Inyección/patología , Inyecciones Intramusculares/efectos adversos , Neurofibromatosis 1/complicaciones , Neurofibromatosis 1/genética , Neurofibromatosis 1/patología , Neurofibromina 1/genética , Piel/patología , Vitamina K 1/administración & dosificaciónAsunto(s)
Anetodermia/virología , Molusco Contagioso/complicaciones , Anetodermia/patología , Preescolar , Dermoscopía , Humanos , MasculinoRESUMEN
Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue, resulting in macular atrophy or herniated saclike skin. Some families with hereditary anetoderma have been described, but there have been no reports on Japanese familial anetoderma so far. We herein report two Japanese sibling cases of primary anetoderma. A healthy 13-year-old Japanese girl and a healthy 15-year-old Japanese girl presented to our hospital with a 6-month history of small atrophic pittings on their arms and trunks. All lesions were less than 0.5 cm in diameter, which are relatively small for non-familial anetoderma. Preceding infections or skin lesions were not observed. A skin biopsy revealed a focal, complete loss of elastic tissue in the superficial to mid-dermis which was surrounded by fine, irregular or twisted elastic fibers. Based on these findings, the diagnosis of anetoderma was made. Review of published works demonstrated that the mode of inheritance of familial anetoderma is not simple, suggesting that it is important to survey any family member of the patients with anetoderma.
Asunto(s)
Anetodermia/diagnóstico , Anamnesis , Herencia Multifactorial , Enfermedades Raras/diagnóstico , Adolescente , Anetodermia/genética , Anetodermia/patología , Biopsia , Femenino , Humanos , Japón , Enfermedades Raras/genética , Enfermedades Raras/patología , Piel/patologíaRESUMEN
A 15-month-old boy presented with 1-4 cm, pink edematous plaques with overlying round erosions and hemorrhagic bullae in the setting of a gastrointestinal illness and was ultimately diagnosed with bullous-type Sweet syndrome. Despite appropriate treatment with oral steroids, the patient's cutaneous lesions healed with secondary anetoderma. This case should prompt practitioners to be aware of bullous-type Sweet syndrome and the possibility of lesions healing with postinflammatory scarring.
Asunto(s)
Anetodermia/etiología , Síndrome de Sweet/diagnóstico , Anetodermia/patología , Glucocorticoides/uso terapéutico , Humanos , Lactante , Masculino , Prednisolona/uso terapéutico , Piel/patología , Síndrome de Sweet/complicaciones , Síndrome de Sweet/tratamiento farmacológico , Cicatrización de HeridasRESUMEN
Along with collagen, elastic fibers are integral components of cutaneous connective tissue. A decrease in elastic fibers or loss thereof has been described in a number of clinically distinct skin diseases, both hereditary and acquired. In disorders associated with inflammation, elastophagocytosis is an important histological hallmark. Treatment is generally difficult.
Asunto(s)
Tejido Elástico/patología , Enfermedades de la Piel/patología , Piel/patología , Anetodermia/diagnóstico , Anetodermia/patología , Anetodermia/terapia , Cutis Laxo/diagnóstico , Cutis Laxo/patología , Cutis Laxo/terapia , Granuloma de Células Gigantes , Humanos , Queratodermia Palmoplantar/diagnóstico , Queratodermia Palmoplantar/patología , Queratodermia Palmoplantar/terapia , Linfoma Cutáneo de Células T/diagnóstico , Linfoma Cutáneo de Células T/patología , Linfoma Cutáneo de Células T/terapia , Seudoxantoma Elástico , Enfermedades de la Piel/diagnóstico , Enfermedades de la Piel/terapia , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapiaAsunto(s)
Anetodermia/diagnóstico , Pilomatrixoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Neoplasias Torácicas/diagnóstico , Pared Torácica , Adolescente , Anetodermia/patología , Anetodermia/cirugía , Diagnóstico Diferencial , Humanos , Masculino , Pilomatrixoma/patología , Pilomatrixoma/cirugía , Piel/patología , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/cirugía , Neoplasias Torácicas/patología , Neoplasias Torácicas/cirugía , UltrasonografíaRESUMEN
Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature, the pathogenesis is still poorly determined. Anetoderma in syphilis is rare, and occurs even in the most uncommon cutaneous manifestations of the disease, such as the nodular form. In order to better understand the changes that lead to elastolysis, we propose a better correlation with the histopathological findings of the lesions that precede it. We present two cases of anetoderma secondary to syphilis, whose clinical aspects resembled the pattern of their initial secondary syphilis rash.
Asunto(s)
Anetodermia/tratamiento farmacológico , Anetodermia/etiología , Tejido Elástico/patología , Penicilina G Benzatina/uso terapéutico , Sífilis/complicaciones , Adulto , Anetodermia/diagnóstico , Anetodermia/patología , Biopsia , Femenino , Humanos , Penicilina G Benzatina/efectos adversos , Piel/patología , Enfermedades de la Piel , Sífilis/patología , TerapéuticaRESUMEN
Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue due to unknown mechanisms. Primary anetoderma develops on clinical normal skin, without any preceding dermatosis and it can be associated with autoimmune conditions. Secondary anetoderma develops on the same area of a previous disorder, such as infectious, neoplastic or inflammatory diseases. A 37-year-old female patient noticed for 4 years circumscribed, normochromic, asymptomatic herniated plaques on the trunk and upper limbs. Family history was negative. Only a positive antinuclear factor (ANF) test, with titer of 1:160 and nuclear homogeneous pattern was found. Light microscopy with Weigert staining showed a lessening of elastic fibers with fragmentation; the oxytalanic fibers were also affected or absent. Transmission electron microscopy showed fragmentation and granular degeneration of elastic fibers. With greater magnification, fragments similar to those seen with optical microscopy were identified. The collagen fibers did not present any alteration. The examination of the dermis with scanning electron microscopy also identified fragmentation and significant fissures of the elastic tissue, granular degeneration was also observed. With greater magnification fragmented elastic fibers were seen.