RESUMEN
ETHNOPHARMACOLOGICAL RELEVANCE: Tropaeolum majus L. (Tropaeolaceae) is a medicinal herb popularly used in Brazil for treatment of inflammatory and cardiovascular diseases. Despite some published data on its efficacy, there are still few toxicological data describing the safety of this plant. The aim of this study was to evaluate the (anti)estrogenic and (anti)androgenic activity of the hydroethanolic extract obtained from Tropaeolum majus L. (HETM), as well as its possible effects on uterine contractility. MATERIALS AND METHODS: Three experimental protocols were performed, (a) uterotrophic assay, (b) Hershberger assay and (c) an ex vivo test to investigate the effects of maternal administration of HETM on uterine contractility at the end of pregnancy. In all protocols three doses of the HETM were administered to Wistar rats: 3, 30 and 300mg/kg. RESULTS: In vivo tests for detection of (anti)androgenic and (anti)estrogenic activities did not show any significant alterations. Similarly, no alterations were observed on uterine contractility induced by oxytocin and arachidonic acid. CONCLUSIONS: HETM was unable to produce (anti)estrogenic or (anti)androgenic activities in the short-term in vivo screening assays performed. In addition, there was no evidence that HETM can affect uterine contractility following gestational exposure of rats.
Asunto(s)
Antagonistas de Andrógenos/farmacología , Andrógenos/farmacología , Moduladores de los Receptores de Estrógeno/farmacología , Estrógenos/farmacología , Extractos Vegetales/farmacología , Tropaeolaceae , Contracción Uterina/efectos de los fármacos , Antagonistas de Andrógenos/administración & dosificación , Antagonistas de Andrógenos/aislamiento & purificación , Andrógenos/administración & dosificación , Andrógenos/aislamiento & purificación , Animales , Moduladores de los Receptores de Estrógeno/administración & dosificación , Moduladores de los Receptores de Estrógeno/aislamiento & purificación , Estrógenos/administración & dosificación , Estrógenos/aislamiento & purificación , Etanol/química , Femenino , Edad Gestacional , Masculino , Exposición Materna , Orquiectomía , Oxitócicos/farmacología , Pene/efectos de los fármacos , Pene/crecimiento & desarrollo , Fitoterapia , Extractos Vegetales/administración & dosificación , Extractos Vegetales/aislamiento & purificación , Plantas Medicinales , Embarazo , Próstata/efectos de los fármacos , Próstata/crecimiento & desarrollo , Ratas , Ratas Wistar , Vesículas Seminales/efectos de los fármacos , Vesículas Seminales/crecimiento & desarrollo , Solventes , Tropaeolaceae/química , Útero/efectos de los fármacos , Útero/crecimiento & desarrolloRESUMEN
As doenças prostáticas constituem um problema comum em cães adultos e idosos. Uma das afecções mais freqüentes é a hiperplasia prostática benigna (HPB) que, tanto no cão como no homem, está associada ao avanço da idade e ao desequilíbrio hormonal. No presente trabalho foram mensurados hormônios andrógenos, estrógeno, fosfatase ácida prostática (PAP) e antígeno prostático específico (PSA) de 37 cães com idade superior a três anos, em função do aspecto microscópico da próstata. Encontraram-se baixos níveis de estrógeno e altas concentrações de PSA nos animais com algum tipo de hiperplasia. Os valores de PAP sérico e urinário também foram maiores nos cães com hiperplasia.
Prostatic diseases have been a common problem in middle age and older intact male dogs. Among these, benign prostatic hyperplasia (BHP) is the most frequent, age-related and hormonal-dependent condition of human and canine prostate. Blood samples were collected from 37 male intact dogs, tree years old dogs or more to determine androgens, estrogen, prostatic acid phosphatase (PAP) and prostatic specific antigen (PSA) according to histopathological aspects. Low levels of estrogen and high levels of prostatic specific antigen (PSA) were founded in dogs with BHP, respectively. Seric and urinary PAP levels were high in dogs with hyperplasia.
Asunto(s)
Animales , Masculino , Andrógenos/aislamiento & purificación , Antígeno Prostático Específico/aislamiento & purificación , Perros , Estrógenos/aislamiento & purificación , Hiperplasia Prostática/diagnóstico , Hiperplasia Prostática/prevención & control , Hiperplasia Prostática/veterinaria , Próstata/anatomía & histologíaRESUMEN
As doenças prostáticas constituem um problema comum em cães adultos e idosos. Uma das afecções mais freqüentes é a hiperplasia prostática benigna (HPB) que, tanto no cão como no homem, está associada ao avanço da idade e ao desequilíbrio hormonal. No presente trabalho foram mensurados hormônios andrógenos, estrógeno, fosfatase ácida prostática (PAP) e antígeno prostático específico (PSA) de 37 cães com idade superior a três anos, em função do aspecto microscópico da próstata. Encontraram-se baixos níveis de estrógeno e altas concentrações de PSA nos animais com algum tipo de hiperplasia. Os valores de PAP sérico e urinário também foram maiores nos cães com hiperplasia.(AU)
Prostatic diseases have been a common problem in middle age and older intact male dogs. Among these, benign prostatic hyperplasia (BHP) is the most frequent, age-related and hormonal-dependent condition of human and canine prostate. Blood samples were collected from 37 male intact dogs, tree years old dogs or more to determine androgens, estrogen, prostatic acid phosphatase (PAP) and prostatic specific antigen (PSA) according to histopathological aspects. Low levels of estrogen and high levels of prostatic specific antigen (PSA) were founded in dogs with BHP, respectively. Seric and urinary PAP levels were high in dogs with hyperplasia.(AU)