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Se escogieron 30 pacientes tratados en el Servicio de Flebolinfología del INACV en el período de enero de 1997 a mayo de 1999, aquejados de úlceras postrombóticas en los miembros inferiores, divididos en 3 grupos de 10 pacientes cada uno y seleccionados al azar. Se les aplicó tópicamente las cremas de aloe 50(por ciento), sulfadiacina de plata 1(por ciento) y su combinación, indistintamente en un período de 6 semanas. Se les realizó semanalmente mediciones de las lesiones ulcerosas y examen clínico. Se constató reducción del porcentaje de los síntomas subjetivos (dolor, secreción, inflamación y fetidez) con todas las cremas, en primer lugar la sulfadiacina de plata 1(por ciento), luego la de aloe 50(por ciento) y por último la combinación de ambas. En cuanto a los criterios de remisión la sulfadiacina de plata al 1(por ciento) tuvo un 60(por ciento) de remisión total, la de aloe 50(por ciento) un 50(por,ciento) y la combinación de ambas sustancias un 40(por ciento)(AU)

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Antecedentes: Históricamente los pacientes en tratamientos radioterápicos recibían la orden de no usar jabones ni cremas en la zona tratada mientras duraba el tratamiento, por la convicción clínica de que los jabones y las cremas podían crear irritación en la dermis de la zona tratada. Método: Se trataba de un estudio abierto y aleatorio sobre la respuesta dérmica en pacientes en los que se les aplicó Aloe vera frente a otros que no se les aplicó, bajo las mismas condiciones de radiación. Resultados: El uso de Aloe vera al 90 por ciento ha demostrado ser útil para proteger y calmar la piel en pacientes con cáncer de mama sometidos a tratamientos de radioterapia. Conclusiones: Por los resultados de estos estudios se ha demostrado que con los productos adecuados el radiólogo puede cuidar la zona tratada sin menoscabo del tratamiento radioterápico (AU)

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El Aloe barbadensis inyectable (A. barbadensis), es un producto farmacéutico que tiene la propiedad de estimular la cicatrización de heridas. Basado en ello, a un modelo de fractura cerrada de tibia se le administró 3 dosis diferentes de A. barbadensis por vía subcutánea para estudiar su acción sobre el callo óseo. Las dosis de 0,03; 0,1 y 0,18 mg/kg estimularon la cicatrización ósea de forma significativa (p < 0,05). También fue observada una elevación de los valores de hemoglobina además de un descenso de calcio y fósforo sanguíneos en los animales tratados(AU)

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Uma máxima da cultura popular "você é o que você come" vai de encontro com as pesquisas feitas no Laboratório de Produtos Naturais, do Departamento de Farmacologia Básica e Clínica, da Universidade Federal do Rio de Janeiro (UFRJ). Substâncias como ômega 3 e ômega 6 podem ser sintetizadas e compradas em comprimidos, pois säo recomendadas pelos especialistas pela atuaçäo antioxidades, isto é, porque previnem envelhecimento das células e, consequentemente, melhoram a qualidade de vida das pessoas

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PURPOSE/OBJECTIVES: To determine whether the use of mild soap and aloe vera gel versus mild soap alone would decrease the incidence of skin reactions in patients undergoing radiation therapy. DATA SOURCES: Prospective, randomized, blinded clinical trial. SETTING: Radiation therapy outpatient clinic in a cancer center affiliated with a major teaching medical facility. SAMPLE: The mean age of the participants was 56 years. The group consisted of Caucasians (74%) and African Americans (26%). The ethnic mix was non-Hispanic (65%) and Hispanic (35%). METHODS: Prophylactic skin care began on the first day of radiation therapy. Patients cleansed the area with mild, unscented soap. Patients randomized into the experimental arm of the trial were instructed to liberally apply aloe vera gel to the area at various intervals throughout the day. FINDINGS: At low cumulative dose levels < or = 2,700 cGy, no difference existed in the effect of adding aloe. When the cumulative dose was high (> 2,700 cGy), the median time was five weeks prior to any skin changes in the aloe/soap arm versus three weeks in the soap only arm. When the cumulative dose increases over time, there seems to be a protective effect of adding aloe to the soap regimen. IMPLICATIONS FOR NURSING PRACTICE: Skin products used to treat radiation dermatitis vary among institutions. Nurses should be aware that some patients may be predisposed to skin problems. Nurses must be aware of newly developed products and research regarding these products so that effective treatment can be instituted.

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Se realizó un experimento in vitro e in vivo utilizando el virus salvaje de la hepatitis B y ratones balb/c transgénicos para evaluar la acción antiviral del Aloe barbadensis Miller (sábila). Se trabajó con concentraciones de Aloe b. M de 0,1; 0,2 y 0,3 mg/mL que se enfrentaron a una concentración fija del estándar de antígeno del virus de la hepatitis B de 83,75 Ng/mL durante 24, 48, 72 h; 7, 14 y 21 d. Las cuantificaciones del antígeno se realizaron por un ensayo inmunoenzimático (ELISA) tipo sandwich. Se comprobó que la mejor actividad antiviral se obtuvo a los 21 d, se utilizó una concentración de 0,3 mg/mL por lo que se aplicó al grupo de ratones transgénicos y se obtuvo una disminución de la expresión antigénica del virus comparado con el grupo de transgénicos que se trató con agua bidestilada(AU)

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PURPOSE: To determine if Biafine compared to Best Supportive Care (BSC) is effective in minimizing or preventing radiation-induced dermatitis in women undergoing breast irradiation. METHODS AND MATERIALS: Patients were randomized between Biafine (n = 83) vs. BSC (n = 89). The institutions identified preference for BSC at the time of randomization. A no-treatment arm was allowed (16% received no treatment). Patients were instructed to apply randomized product three times a day, but not within 4 h of their daily RT session. Application began following their first radiation treatment and continued 2 weeks postradiation. Skin dermatitis was scored weekly utilizing the RTOG and ONS (Oncology Nursing Society) skin toxicity scales, a weekly patient satisfaction and quality-of-life questionnaire. RESULTS: Using the RTOG toxicity scale there was no overall difference for maximum dermatitis during RT between Biafine and BSC (p = 0.77). There was no difference in maximum toxicity by arm or breast size. There was an interaction between breast size and toxicity, with large-breasted women exhibiting more toxicity. Large-breasted women receiving Biafine were more likely to have no toxicity 6 weeks post RT. CONCLUSION: There was no overall difference between BSC and Biafine in the prevention, time to, or duration of radiation-induced dermatitis.

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Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented. Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development as pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies.

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Objetivo: Comunicar la experiencia obtenida al tratar úlceras venosas con apósitos de hidrogel de polimanosa comparándola con un grupo control. Antecedentes: La frecuencia de presentación de úlceras venosas es muy alta y requieren tratamiento local efectivo para lograr su cicatrización. Un producto natural derivado del ALOE-VERA cuyo principio activo es la polimanosa, parece que favorece y acelera la cicatrización. Material y métodos: Se estudiaron 40 pacientes divididos en 2 grupos, 20 tratados con apósitos de hidrogel de polimanosa y 20 tratados sólo con solución físiológica y jabón a los cuales se les hizo seguimiento por 16 semanas y se valoró la velocidad de cicatrización. Resultados: El grupo tratado con polimanosa cicatrizó en un 50 por ciento más rápido que el tratado con agua y jabón. Conclusión: El hidrogel de polimanosa aumenta el doble la velocidad de cicatrización de las úlceras venosas comparado con la curación con solución fisiológica y jabón.

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BACKGROUND: To evaluate the efficacy of a new bioadhesive patch, Aloe vera hydrogel, for the treatment of aphthous stomatitis. METHODS: An open, not controlled study was performed in 31 pediatric out-patients, aged 6-14 years, affected by mouth ulcers were enrolled consecutively in the 3 Gps Depts+ of San Marino Republic. For each case, data on case history and clinical profile, patterns of the lesion, presence of spontaneous or provoked pain were collected at baseline, and a bioadhesive patch ("Alovex patch") was administered on the basis of a daily regimen of < or = 3 patches for 4 days. Data on modification of the above-mentioned parameters, with patients and physicians opinion on the therapeutical efficacy, were collected during a control visit (4 days later). Moreover, by means of a daily diary, patients recorded information on the course of the symptoms during the 4 days and were also asked to compare the current treatment with other previous therapies. RESULTS: At the control visit 77% of the patients have shown a marked resolution of spontaneous pain, while in the other patients, pain was significantly decreased to a "mild" or "moderate" level. No one child declared to suffer from severe pain. Also provoked pain resulted to be significantly decreased after treatment Global efficacy was judged positively, being the therapeutical effect in more than 80% of cases "evident or of absolute improvement" both by physicians and patients opinion. A positive improvement of symptomatology started within the 2nd day of treatment in 74% of the patients. The compliance (adhesivity, acceptability and palatability) of the formulation was judged largely favourable in more than 90% of the patients. CONCLUSIONS: The results of this study underline the good efficacy and compliance of the patch for the treatment of the aphtous stomatitis; also the limit of topical available therapies, linked to the "contact time", to develop their therapeutical action, seems not to be evinced on the basis of this study, so the application of this patch seems to be more easy and beneficial.

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Extracts of Aloe vera Linne have been found to exhibit cytotoxicity against human tumour cell lines. This study examines the anti-tumour effects of di(2-ethylhexyl)phthalate (DEHP) isolated from Aloe vera Linne, in human and animal cell lines. Its anti-mutagenic effects were examined using Salmonella typhimurium TA98 and TA100 strains. Growth inhibition was specifically exerted by DEHP against three leukaemic cell lines at concentrations below 100 microg mL(-1). At 100 microg mL(-1) DEHP, K562, HL60 and U937 leukaemic cell lines showed growth inhibition of 95, 97 and 95%, respectively. DEHP exhibited an inhibitory activity of 74, 83 and 81%, respectively, in K562, HL60 and U937 cell lines at a concentration of 10 microg mL(-1). At a concentration of 1 microg mL(-1), DEHP exerted an inhibitory activity of 50, 51 and 52%, respectively, in K562, HL60 and U937. In a normal cell line, MDBK, DEHP exerted 30% growth inhibition at a concentration of 100 microg mL(-1), and showed no inhibitory activity at concentrations below 50 microg mL(-1). It was found that DEHP exerted anti-mutagenic activity in the Salmonella mutation assay. The number of mutant colonies of Salmonella typhimurium strain TA98 upon exposure to AF-2 (0.2 microg/plate) decreased in a concentration-dependent manner in the presence of different DEHP concentrations (decreasing to 90.4, 83.9, 75.4, 69.6 and 46.9%, respectively, for DEHP concentrations of 100, 50, 10, 5 and 1 microg/plate). In the case of Salmonella typhimurium strain TA100, DEHP reduced AF-2-induced mutagenicity at 1, 5, 10, 50 and 100 microg/plate to 57.4, 77.5, 80.0, 89.0 and 91.5%, respectively. The isolated compound from Aloe vera Linne, DEHP, was considered to be the active principle responsible for anti-leukaemic and anti-mutagenic effects in-vitro.

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OBJECTIVE: To demonstrate the microcirculatory and wound healing effects of Aloe vera on induced second degree burn wounds in rats. METHOD: A total of 48 male Wistar rats were equally divided into 4 groups as follows: sham controls, untreated burn-wound rats, those treated with once-daily application of normal saline (NSS) and those treated with once-daily application of lyophilized Aloe vera gel. The animals in each group were equally subdivided into 2 subgroups for the study of cutaneous microcirculation and wound healing on day 7 and 14 after burn. Dorsal skinfold chamber preparation and intravital fluorescence microscopic technique were performed to examine dermal microvascular changes, including arteriolar diameter, postcapillary venular permeability and leukocyte adhesion on postcapillary venules. RESULTS: On day 7, the vasodilation and increased postcapillary venular permeability as encountered in the untreated burn were found to be reduced significantly (p < 0.05) in both the NSS- and Aloe vera-treated groups, but to a greater extent in the latter. Leukocyte adhesion was not different among the untreated, NSS- and Aloe vera-treated groups. On day 14, vasoconstriction occurred after the wound had been left untreated. Only in the Aloe vera-treated groups, was arteriolar diameter increased up to normal condition and postcapillary venular permeability was not different from the sham controls. The amount of leukocyte adhesion was also less observed compared to the untreated and NSS- treated groups. Besides, the healing area of the Aloe vera-treated wound was better than that of the untreated and NSS- treated groups during 7 and 14 days after burn. CONCLUSION: Aloe vera could exhibit the actions of both anti-inflammation and wound healing promotion when applied on a second degree burn wound.

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Herbs have been used in clinical medicine for thousands of years. However, it is only in recent times that we have been able to employ scientific methods to prove the efficacy of many of these herbs and to give us a better understanding of their mechanisms of action. This article will focus on the use of herbs in various dermatological conditions characterized by inflammation and pruritus. Topical preparations of many of these herbs are more commonplace in Europe. However, their availability is increasing in the US. As this is occurring we are witnessing a growing marriage between alternative and traditional medicines.

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Se presenta un total de 60 y 52 pacientes portadores de brote hemorroidal agudo y fisura anal, respectivamente, tratados en el Servicio de coloproctología del Hospital Docente General "Orlando Pantoja Tamayo" de Contramaestre, Santiago de Cuba, con ungüento rectal de sábila. Se comprobó por simple inspección, evaluación periódica y confirmación estadística posterior las propiedades terapéuticas de la sábila en el tratamiento de las entidades antes mencionadas. Fue demostrada la acción antiinflamatoria de la sábila en el brote hemorroidal agudo, así como, cicatrizante y resolutiva en la fisura anal (AU)

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Se evaluó las propiedades farmacológicas y terapéuticas de la Aloe vera L. (sábila) en el tratamiento de las crisis de colitis ulcerativa idiopática (CUI) y en el tratamiento de la prevención de las recaídas durante el período de remisión de la enfermedad en pacientes portadores de dicha entidad atendidos en el Hospital Docente General "Orlando Pantoja Tamayo" en Contramaestre, Santiago de Cuba. Se comprobó mediante anamnesis, evaluación endoscópica periódica, así como confirmación estadística posterior, las propiedades terapéuticas de la planta en los períodos de crisis de la enfermedad donde casi la totalidad de los casos curaron en un período no mayor de 7 d y el resto no sobrepasó los 15 d de evolución. Así también se observó la poca influencia sobre la prolongación de los períodos de remisión y la aparición de recaídas. Los resultados arrojados fueron comparados con los obtenidos por el tratamiento convencional con Azulfidina, medicamento de elección en el tratamiento de esta entidad (AU)

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Se evaluó las propiedades farmacológicas y terapéuticas de la Aloe vera L. (sábila) en el tratamiento de las crisis de colitis ulcerativa idiopática (CUI) y en el tratamiento de la prevención de las recaídas durante el período de remisión de la enfermedad en pacientes portadores de dicha entidad atendidos en el Hospital Docente General "Orlando Pantoja Tamayo" en Contramaestre, Santiago de Cuba. Se comprobó mediante anamnesis, evaluación endoscópica periódica, así como confirmación estadística posterior, las propiedades terapéuticas de la planta en los períodos de crisis de la enfermedad donde casi la totalidad de los casos curaron en un período no mayor de 7 d y el resto no sobrepasó los 15 d de evolución. Así también se observó la poca influencia sobre la prolongación de los períodos de remisión y la aparición de recaídas. Los resultados arrojados fueron comparados con los obtenidos por el tratamiento convencional con Azulfidina, medicamento de elección en el tratamiento de esta entidad

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Se presenta un total de 60 y 52 pacientes portadores de brote hemorroidal agudo y fisura anal, respectivamente, tratados en el Servicio de coloproctología del Hospital Docente General "Orlando Pantoja Tamayo" de Contramaestre, Santiago de Cuba, con ungüento rectal de sábila. Se comprobó por simple inspección, evaluación periódica y confirmación estadística posterior las propiedades terapéuticas de la sábila en el tratamiento de las entidades antes mencionadas. Fue demostrada la acción antiinflamatoria de la sábila en el brote hemorroidal agudo, así como, cicatrizante y resolutiva en la fisura anal

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The separation and partial purification of two lectins from the leaf pulp of Aloe vera L. (=barbadensis Miller) is presented. The fraction showing haemagglutinating activity was precipitated at 50% ammonium sulphate concentration from the crude leaf pulp extract. The precipitate thus obtained, after dialysis, was applied to a hydroxylapatite column. Stepwise elution resulted in two peaks showing haemagglutinating activity eluted with 5 mM (Aloctin I) and 20 mM (Aloctin II) phosphate buffers. Haemagglutinating activity was estimated visually by adding a 4% rabbit erythrocyte suspension to serial two-fold dilutions of the lectins in microtitration plates. None of the 20 sugars tested inhibited haemag--glutinating activity of Aloctin I up a concentration of 500 mM. Aloctin II was inhibited by N-acetyl-D--galactosamine at 250 mM concentration. Of 10 metal ions tested, only Al(3+) salts were found to activate Aloctin I and II. On the other hand, it was shown that neither lectin possessed any alpha- and beta- galactosidase or alpha- and beta- glucosidase activity. The lectins were of glycoprotein structure containing approximately 5% neutral sugar. The specificity of the lectins towards human and rat erythrocytes was investigated.

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Used for centuries as folk remedies, herbs are enjoying a surge of public interest. Some empiric findings have been supported by formal research results. In order to advise patients about such preparations, physicians need to be aware of the indications, contraindications, drug interactions, and potential side effects. Eight popular herbs are reviewed.

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