Asunto(s)
Intoxicación por Mercurio , Mercurio/fisiología , Mercurio/toxicidad , Absorción , Acrodinia/inducido químicamente , Administración por Inhalación , Animales , Biotransformación , Encéfalo/metabolismo , Carbono/metabolismo , Sistema Digestivo/efectos de los fármacos , Sistema Digestivo/metabolismo , Desarrollo Embrionario y Fetal/efectos de los fármacos , Contaminantes Ambientales/sangre , Contaminantes Ambientales/toxicidad , Contaminantes Ambientales/orina , Heces , Femenino , Cabello/efectos de los fármacos , Cabello/metabolismo , Humanos , Riñón/efectos de los fármacos , Riñón/metabolismo , Riñón/patología , Lactancia , Pulmón/efectos de los fármacos , Pulmón/metabolismo , Mercurio/análisis , Síndrome Nefrótico/inducido químicamente , Placenta/efectos de los fármacos , Placenta/metabolismo , Embarazo , Insuficiencia Renal/inducido químicamente , Selenio/química , Selenio/metabolismo , Piel/efectos de los fármacos , Piel/metabolismo , Azufre/química , Azufre/metabolismo , Distribución TisularAsunto(s)
Acrodinia/inducido químicamente , Amalgama Dental/efectos adversos , Intoxicación por Mercurio/etiología , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Intercambio Materno-Fetal/efectos de los fármacos , Intercambio Materno-Fetal/fisiología , Mercurio/farmacocinética , Embarazo , Efectos Tardíos de la Exposición PrenatalRESUMEN
1. A survey on the literature concerning the toxicity of amalgam is presented. 2. Opinions from various sources are discussed. It is found that there are no conclusive experimental results of clinical importance. Existing results on adults cannot be applied to children, who are more sensitive to amalgam. 3. Research into the toxicity of amalgam in children has begun. Results are expected later in 1992.
Asunto(s)
Amalgama Dental/efectos adversos , Intoxicación por Mercurio/etiología , Acrodinia/inducido químicamente , Niño , Humanos , Concentración Máxima Admisible , Factores de RiesgoAsunto(s)
Acrodinia/inducido químicamente , Contaminantes Atmosféricos/envenenamiento , Hipertiroidismo/inducido químicamente , Intoxicación por Mercurio/complicaciones , Acrodinia/diagnóstico , Acrodinia/tratamiento farmacológico , Adolescente , Humanos , Hipertiroidismo/diagnóstico , Hipertiroidismo/tratamiento farmacológico , Masculino , Intoxicación por Mercurio/diagnóstico , Intoxicación por Mercurio/tratamiento farmacológico , VolatilizaciónRESUMEN
Two sisters and their brother who had been exposed to mercury vapours from a broken fever thermometer were treated for acrodynia. Their urinary Hg concentrations, as well as the relatively few data that can be found in previous publications, show that the brain of children below the age of 5 years is much more sensitive to chronic mercury intoxication than the cerebrum of adults. Hg concentrations of well below 50 micrograms/l in the urine can be associated with severe symptoms. One of our patients had a mercury concentration of 6.3 micrograms/l. In adults with occupational exposure, urinary mercury concentrations of up to 200 micrograms/l are tolerated and permitted. Acrodynia possibly is not always diagnosed when it is occurring. Normal values for urinary Hg excretion in children under basal conditions and after administration of a chelating agent should be established.
Asunto(s)
Acrodinia/inducido químicamente , Intoxicación por Mercurio/diagnóstico , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Mercurio/farmacocinética , Factores de Riesgo , TermómetrosRESUMEN
A case of acrodynia in an eight-and-a-half-year-old girl is presented whose symptoms--profuse perspiration, swelling, desquamation, pain, itching of the extremities, pinkish color of the nose and cheeks and hypertension--responded sharply to nifedipine therapy.
Asunto(s)
Acrodinia/tratamiento farmacológico , Intoxicación por Mercurio/complicaciones , Nifedipino/uso terapéutico , Acrodinia/inducido químicamente , Acrodinia/patología , Niño , Femenino , HumanosRESUMEN
A 14-month-old girl who presented with multiple systemic complaints was found to have gingivitis, peeling of her palms and soles, and a peculiar acral eruption. A diagnosis of acrodynia, or pink disease, was confirmed by elevated levels of mercury in the urine. The many cutaneous manifestations of this once common disease are discussed.
Asunto(s)
Acrodinia/patología , Intoxicación por Mercurio/patología , Enfermedades de la Piel/inducido químicamente , Acrodinia/inducido químicamente , Femenino , Humanos , Lactante , Intoxicación por Mercurio/complicaciones , Hipotonía Muscular/inducido químicamente , Sialorrea/inducido químicamente , Enfermedades de la Piel/patología , Sudoración/efectos de los fármacosRESUMEN
Medical attention was sought for a 23-month-old toddler because of anorexia, weight loss, irritability, profuse sweating, peeling and redness of his fingers and toes, and a miliarial rash. The diagnosis was mercury poisoning, and an investigation of his environment disclosed that he had been exposed to mercury from broken fluorescent light bulbs. Acrodynia resulting from fluorescent bulbs has not been previously reported.
Asunto(s)
Acrodinia/inducido químicamente , Iluminación , Intoxicación por Mercurio/etiología , Exposición a Riesgos Ambientales , Artículos Domésticos , Humanos , Lactante , MasculinoRESUMEN
Pink disease has virtually disappeared since teething powders were withdrawn. We describe a case in a boy who was exposed to metallic mercury vapour. We discuss the potential health hazard of spilled elemental mercury in the house and the difficulties of removing it from the environment.
Asunto(s)
Acrodinia/inducido químicamente , Mercurio/efectos adversos , Descontaminación , Exposición a Riesgos Ambientales , Humanos , Lactante , MasculinoRESUMEN
trans-Bis(salicylaldoximato)copper(II) (CuSAO2), the parent compound of a new group of antiproliferative copper(II) complexes, was studied in vivo. It had marked antitumor activity against Ehrlich ascites carcinoma in NMRI mice. Survival was considerably increased, and, in some cases, total cures were encountered. No activity against leukemia L1210 was found in female DBA/2J mice, although CuSAO2 is equally effective against L1210 and Ehrlich carcinoma cells in vitro. The side effects of CuSAO2 included weight loss, weakness, acrodynia, and blindness; all of these side effects were transient.
Asunto(s)
Antineoplásicos , Carcinoma de Ehrlich/tratamiento farmacológico , Cobre/uso terapéutico , Leucemia L1210/tratamiento farmacológico , Compuestos Organometálicos/uso terapéutico , Acrodinia/inducido químicamente , Animales , Ceguera/inducido químicamente , Peso Corporal/efectos de los fármacos , Carcinoma de Ehrlich/patología , Cobre/efectos adversos , Femenino , Leucemia L1210/patología , Ratones , Compuestos Organometálicos/efectos adversos , Factores de TiempoRESUMEN
In a family exposed to metallic mercury vapour two patients had acrodynia, one had the nephrotic syndrome, and one person remained well. Recognition of the variable manifestations of the disease and prevention of further exposure were the most important aspects of management. Recovery appeared to be complete as blood mercury levels fell to normal. Urinary mercury levels were too variable to be reliable as indications of progress.
Asunto(s)
Accidentes Domésticos , Acrodinia/inducido químicamente , Intoxicación por Mercurio/complicaciones , Síndrome Nefrótico/inducido químicamente , Adolescente , Adulto , Niño , Exposición a Riesgos Ambientales , Femenino , Humanos , Masculino , Mercurio/análisis , Mercurio/sangre , Mercurio/orina , Intoxicación por Mercurio/tratamiento farmacológico , Penicilamina/uso terapéutico , Factores de TiempoRESUMEN
A 31 year-old inhabitant of French Guiana was prescribed mercuric iodide per os for two and a half months. Shortly before the end of the treatment he developed fasciculations in the trunk and particularly the lower limb muscles, distal painful paresthesias with vasomotor disorders, episodes of excessive perspiration and palmoplantar erythema, moderate fluctuating hypertension, progressive loss of weight and irritability with insomnia. Clinical and electrical signs of neuropathy were lacking. The clinical picture was that of Morvan's fibrillary chorea with acrodynia, the conditions of onset strongly suggesting a mercurial intoxication. Blood and particularly urine mercury levels were elevated. Administration of dimercaprol (BAL) considerably increased urinary excretion of mercury and there was progressive improvement and finally recovery after two months of BAL treatment. This case exemplifies the possible co-existence of fibrillary chorea and acrodynia. Whereas in many cases of fibrillary chorea a precise etiology cannot be determined, the affection can be induced by mercury as by gold administration. The fact that cases of fibrillary chorea due to mercury poisoning are rarely reported may be the result of individual patient hypersensitivity or particular metabolic absorption and excretion features of mercury. This case cannot be included within the continuous activity syndrome of muscle fibers described by Isaacs, since muscle contractures were absent and there was associated acrodynia. Moreover, there was no latent polyneuropathy, in spite of the intense fasciculations. It must be concluded, therefore, that in spite of its rarity fibrillary chorea should keep its semiologic autonomy.
Asunto(s)
Acrodinia/inducido químicamente , Corea/inducido químicamente , Intoxicación por Mercurio/complicaciones , Acrodinia/diagnóstico , Adulto , Corea/diagnóstico , Humanos , Masculino , Mercurio/metabolismo , Intoxicación por Mercurio/diagnósticoAsunto(s)
Intoxicación por Mercurio , Acrodinia/inducido químicamente , Humanos , Mercurio/metabolismo , Intoxicación por Mercurio/complicaciones , Intoxicación por Mercurio/etiología , Intoxicación por Mercurio/terapia , Trastornos Neuróticos/inducido químicamente , Cuadriplejía/inducido químicamenteAsunto(s)
Anomalías Inducidas por Medicamentos , Talidomida/efectos adversos , Acrodinia/inducido químicamente , Infecciones Bacterianas/tratamiento farmacológico , Niño , Preescolar , Cloranfenicol/efectos adversos , Ectromelia/inducido químicamente , Femenino , Humanos , Hipoglucemiantes/uso terapéutico , Lactante , Recién Nacido , Masculino , Intercambio Materno-Fetal , Mercurio/efectos adversos , Embarazo , Raquitismo/tratamiento farmacológico , Sepsis/tratamiento farmacológico , Vitamina D/uso terapéuticoRESUMEN
Dichloroacetate is known to reduce plasma cholesterol and triglyceride in patients with Fredrickson Types IIb or IV hyperlipoproteinemia. We now report the effects of chronic, oral dichloroacetate administration (as the sodium salt) in two patients with severe homozygous familial hypercholesterolemia. Dichloroacetate markedly reduced serum total and low density lipoprotein cholesterol levels and lowered the low density lipoprotein to high density lipoprotein cholesterol ratio. One patient developed a polyneuropathy while receiving dichloroacetate which resolved following discontinuation of the drug. Because of its apparent toxicity, dichloroacetate cannot be recommended for chronic oral use. Investigation of the mechanism of its lipid-lowering effect, however, may provide insight into the pathogenesis and treatment of hypercholesterolemic disorders.