RESUMEN

In a further exploration of idiosyncratic reactions to injections of contrast media, a systematic study of immediate or delayed hypersensitivity in guinea pigs injected with contrast media analogs was performed. No evidence of immediate or delayed hypersensitivity could be ascertained to either contrast media analogs alone, or analogs bound to protein carriers. This does not represent conclusive evidence against the notion of antibody formation as a factor in the production of some adverse reactions, but makes such a pathogenesis less likely.

Asunto(s)

Ácido Acetrizoico/inmunología , Formación de Anticuerpos , Diatrizoato/inmunología , Hipersensibilidad Tardía/inmunología , Hipersensibilidad Inmediata/inmunología , Yodobenzoatos/inmunología , Ácido Metrizoico/inmunología , Animales , Especificidad de Anticuerpos , Complejo Antígeno-Anticuerpo , Antígenos , Medios de Contraste/efectos adversos , Cobayas , Masculino , Ovalbúmina , Anafilaxis Cutánea Pasiva , Albúmina Sérica Bovina , Pruebas Cutáneas