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1.
Eur J Pharm Biopharm ; 203: 114465, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39173935

RESUMEN

In the manufacture of soft gelatin capsules using a rotary-die encapsulation machine, the formation of ribbons at the cooling drums and their subsequent mechanical performance are key attributes for a smooth machinability. In this paper we present the results of a comprehensive investigation of the intricate impact of the cooling drum temperature in the range between 5 and 25 °C on the mechanical and the microstructural properties of a highly concentrated gelatin formulation (40% w/w) typically used in soft capsule manufacture. The study demonstrates that the temperature at the cooling drums strongly affects the gelation kinetics, the gel elasticity and the tensile strength of the ribbons. The temperature correlates linearly with the storage modulus G' under low shear deformation, i.e. the lower the temperature of the gel, the higher the gel elasticity. A reverse linear relationship was found for the temperature-dependent ultimate tensile strength (UTS) of the gelatin ribbons, i.e. a higher drum temperature leads to a higher UTS. This inverse effect of the ageing temperature on G' and UTS can be explained by temperature-induced microstructural differences within the gel network, as indicated by FTIR spectroscopy and Differential Scanning Calorimetry (DSC) measurements. Lower ageing temperatures result in a higher number of triple helical junction zones with fewer and/or weaker hydrogen bonds, which translate into a higher gel elasticity under low shear deformation, but a lower resilience of the ribbons against rupture in tensile testing. At higher temperatures, fewer but longer and/or more thermostable triple helical links in the gel network enhance the stability of the ribbons against tensile stress. In summary, the results clearly reveal that a detailed understanding of the complex relationship between the drum temperature, the gel network structure and the mechanical properties of gelatin ribbons is essential for process optimization.


Asunto(s)
Cápsulas , Gelatina , Temperatura , Resistencia a la Tracción , Gelatina/química , Elasticidad , Geles/química , Rastreo Diferencial de Calorimetría , Composición de Medicamentos/métodos , Química Farmacéutica/métodos , Espectroscopía Infrarroja por Transformada de Fourier/métodos
2.
J Mech Behav Biomed Mater ; 157: 106649, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39024732

RESUMEN

Characterizing the ultimate tensile strength (UTS) of the meniscus is critical in studying knee damage and pathology. This study aims to determine the UTS of the meniscus with an emphasis on its heterogeneity and anisotropy. We performed tensile tests to failure on the menisci of six month old Yorkshire pigs at a low strain rate. Specimens from the anterior, middle and posterior regions of the meniscus were tested in the radial and circumferential directions. Then the UTS was obtained for each specimen and the data were analyzed statistically, leading to a comprehensive view of the variations in porcine meniscal strength. The middle region has the highest average strength in the circumferential (43.3 ± 4.7 MPa) and radial (12.6 ± 2.2 MPa) directions. This is followed by the anterior and posterior regions, which present similar average values (about 34.0MPa) in circumferential direction. The average strength of each region in the radial direction is approximately one-fourth to one-third of the value in the circumferential direction. This study is novel as it is the first work to focus on the experimental methods to investigate the heterogeneity and anisotropy only for porcine meniscus.


Asunto(s)
Ensayo de Materiales , Menisco , Resistencia a la Tracción , Animales , Anisotropía , Porcinos , Menisco/fisiología , Estrés Mecánico , Fenómenos Biomecánicos , Meniscos Tibiales/fisiología
3.
J Mech Behav Biomed Mater ; 157: 106643, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38945120

RESUMEN

Recent advancements in biomaterial research conduct artificial intelligence for predicting diverse material properties. However, research predicting the mechanical properties of biomaterial based on amino acid sequences have been notably absent. This research pioneers the use of classification models to predict ultimate tensile strength from silk fiber amino acid sequences, employing logistic regression, support vector machines with various kernels, and a deep neural network (DNN). Remarkably, the model demonstrates a high accuracy of 0.83 during the generalization test. The study introduces an innovative approach to predicting biomaterial mechanical properties beyond traditional experimental methods. Recognizing the limitations of conventional linear prediction models, the research emphasizes the future trajectory toward DNNs that can adeptly capture non-linear relationships with high precision. Moreover, through comprehensive performance comparisons among diverse prediction models, the study offers insights into the effectiveness of specific models for predicting the mechanical properties of certain materials. In conclusion, this study serves as a pioneering contribution, laying the groundwork for future endeavors and advocating for the seamless integration of AI methodologies into materials research.


Asunto(s)
Aprendizaje Automático , Seda , Resistencia a la Tracción , Seda/química , Animales , Ensayo de Materiales , Redes Neurales de la Computación
4.
Artículo en Inglés | MEDLINE | ID: mdl-38532601

RESUMEN

AIM: This article describes the use of graphite(Gr) and boron carbide (B4C) as multiple nanoparticle reinforcements in LM25 aluminum alloy. Because boron carbide naturally absorbs neutron radiation, aluminium alloy reinforced with boron carbide metal matrix composite has gained interest in nuclear shielding applications. The primary goal of the endeavor is to create composite materials with high wear resistance, high microhardness, and high ultimate tensile strength for use in nuclear applications. BACKGROUND: Science and Technology have brought a vast change to human life. The human burden has been minimized by the use of innovation in developing new and innovative technologies. To improve the quality of human life, fresh, lightweight, and creative materials are being used, which play a vital role in science and technology and reduce the human workload. Composite materials made of metal are being used because they are lightweight. Neutron absorption, high ultimate strength, high wear resistance, high microhardness, high thermal and electrical conductivity, high vacuum environmental resistance, and low coefficient of thermal expansion under static and dynamic conditions are all demands for the hybrid metal matrix composites utilized in nuclear applications. OBJECTIVE: • Stir casting is used to create the novel LM 25 aluminum alloy/graphite and boron carbide hybrid nanocomposites. • The mechanical properties such as ultimate tensile strength, yield strength, percentage of elongation, microhardness, and wear behavior are calculated. • Three analyses are performed: microstructure, worn surface analysis, and fracture analysis of the tensile specimen. METHOD: • Stir casting process< • Tensile, Hardness, Wear Test • Materials Characterization - FESEM, Optical Microscopy, EDS< Results: The mechanical properties values are 308.76 MPa, 293.51 MPa, 7.8, 169.2 VHN, and 0.01854mm3/m intended for ultimate tensile strength, yield strength, percentage of elongation, microhardness, and wear behavior, respectively. This implies that the synthesized composite may be used in nuclear applications successfully. CONCLUSION: The subsequent explanation was drawn from this investigative work: • The LM 25/B4C/Gr hybrid nanocomposite was successfully manufactured by employing the stir casting technique. For nuclear shielding applications, these composites were prepared with three different weight percentages of nanoparticle reinforcements in 2,4,6% Boron carbide and constant 4 wt.% graphite. • The microhardness values of the three-hybrid nanocomposite fabricated castings were determined to be 143.4VHN, 156.7VHN, and 169.2VHN, respectively. • The hybrid nano composite's microstructure revealed that the underlying LM 25 aluminum alloy matrix's finegrained, evenly dispersed nanoparticles of graphite and boron carbide were present.

• The microtensile test was carried out and it was found that the ultimate tensile strength, yield strength and percentage of elongation values are 281.35MPa, 296.52MPa, 308.76MPa, 269.43, 274.69, 293.51 and 3.4, 5.7, 7.8 respectively.

• Deformation caused the hybrid LM 25/B4C/Gr nanocomposite to fracture in ductile mode. Dimples and cavities are seen in the fracture because of the nanoparticle reinforcements and the matrix's tight connection.

• The wear loss of nanocomposite based on the input parameter applied load, sliding velocity and sliding distance values are 0.02456, 0.02189, 0.01854, 0.02892, 0.02586, 0.02315 and 0.02682, 0.02254, 0.02015 mm3/m, respectively.

• The LM 25 alloy's elemental analysis displays the aluminum alloy phase as the largest peak and the remaining elements as smaller peaks; also, the spectral analysis reveals the presence of boron (B), graphite (C), silicon, and ferrous in the aluminum alloy LM 25.

• Through worn surface FESEM investigation, it was shown that under sliding and high load situations, debris, delamination, and groove develop. Further rupture, fine, and continuous grooves were seen when low stress and sliding circumstances were applied to the LM 25/B4C/Gr and stir cast specimen. This result implies the presence of mild adhesive and delamination wear processes.

.

5.
Heliyon ; 10(5): e26777, 2024 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-38495197

RESUMEN

Fused Deposition Modeling (FDM) 3D printing creates components by layering extruded material. Printer parameters such as layer height and infill density can greatly impact the mechanical properties and quality of the printed parts. One critical factor to be considered in analysis is the anisotropy nature of printed components, considering all cross-sectional area (CSA) profiles for less than 100% infill density. This paper investigates the effect of the anisotropy nature of 3D printed CSA has on stress calculations and hence mechanical properties of the specimen through Design of Experiment (DOE). Analysis of variance (ANOVA) is utilised to evaluate the results. Printed specimens were tensile tested as per ASTM D638-14. Raw data was analysed using various CSA profiles, taking changes in infill density and layer height into account. Fixed parameter such as shell count, top and bottom layers, nozzle diameter, Hexagonal pattern were defined. Specimens Ultimate Tensile Strength (UTS) values increased on average by 30% using average profile CSA data compared to using external specimen dimensions. Further analysis assessing printer parameters affect on recycled Polyethylene Terephthalate (rPET) specimen's Young's Modulus (YM) and UTS was studied. One significant finding from this study suggests that the thickness of each layer has the most significant impact on the material properties of 3D printed rPET, as observed through the analysis of tensile test data obtained from 3D printed samples. A 3D printed rPET specimen with 30% infill density and 0.25 mm layer height has a higher YM (1175 MPa) and UTS (39 MPa) compared to a specimen with 75% infill density and 0.1 mm layer height (1159 MPa, 31 MPa). However careful interpretation of the results is required because for the same 30% infill parameter at 0.2 mm layer height the YM (936 MPa) and UTM (28 MPa) are significantly lower than at 0.25 mm layer height. If a higher value of YM and UTS is required an infill setting of 50% and layer height of 0.25 mm gave the highest values, YM (1330 MPa) and UTS (43 MPa).

6.
Heliyon ; 10(1): e23920, 2024 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-38234921

RESUMEN

Structural components are generally composed of material discontinuities, including open holes, which are considered stress concentrators in engineering components. In view of this, assessing the influence of open holes on the tensile properties is crucial to determine the sensitivity and tensile strength of a particular material. Nevertheless, investigation of the impact of open holes on the tensile properties of SS400 steel sheets is very limited and yet to be explored. Therefore, this study was performed to optimize the effects of open holes on the tensile properties of SS400 sheet specimens based on a Full Factorial Design (FFD) experiment. Four input parameters that represent various hole configurations, which include the hole diameter, location of the hole, number of holes, and hole shape, were considered in this study to develop the experimental-based prediction models to optimize the output performance, namely yield strength, ultimate tensile strength, and ultimate elongation, commonly denoted as YS, UTS, and UE respectively. A total of 10 additional experimental trials were then utilized to verify the constructed models. In addition, the weight fractions for YS, UTS, and UE were identified using the Criteria Importance Through Inter-Criteria Correlation (CRITIC) method. Subsequently, the Desirability Function Analysis (DFA) is utilized to pinpoint the optimal parameter conditions for maximizing the tensile properties. Based on the results, all four parameters showed significant effects on the response variables, except the number of holes for UTS and hole location for UE. The diameter also recorded the highest contribution toward UTS and UE, followed by the hole shape. Regarding YS, hole diameter takes precedence, with the number of holes as the second most influential factor. Furthermore, the average absolute percent deviation for the prediction responses of 10 experimental cases were 1.06 %, 0.90 %, and 0.85 % for YS, UTS, and UE, respectively, confirming the validity of the constructed models. Meanwhile, the CRITIC method estimated the weight fractions for YS, UTS and UE from the experimental data, which were 0.3825, 0.2559, and 0.3616, respectively. The DFA-derived composite desirability, rated at 0.9820, suggests optimal conditions: a 1 mm hole diameter, centered hole location, three holes, and a hexagonal shape. The minimal deviations between predicted and experimental values affirm the robustness of the models. Overall, this investigation yields important insights for optimizing open holes and elevating the tensile performance of SS400 sheet specimens.

7.
Adv Mater ; 36(5): e2306513, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37823403

RESUMEN

For decades, mechanical resonators with high sensitivity have been realized using thin-film materials under high tensile loads. Although there are remarkable strides in achieving low-dissipation mechanical sensors by utilizing high tensile stress, the performance of even the best strategy is limited by the tensile fracture strength of the resonator materials. In this study, a wafer-scale amorphous thin film is uncovered, which has the highest ultimate tensile strength ever measured for a nanostructured amorphous material. This silicon carbide (SiC) material exhibits an ultimate tensile strength of over 10 GPa, reaching the regime reserved for strong crystalline materials and approaching levels experimentally shown in graphene nanoribbons. Amorphous SiC strings with high aspect ratios are fabricated, with mechanical modes exceeding quality factors 108 at room temperature, the highest value achieves among SiC resonators. These performances are demonstrated faithfully after characterizing the mechanical properties of the thin film using the resonance behaviors of free-standing resonators. This robust thin-film material has significant potential for applications in nanomechanical sensors, solar cells, biological applications, space exploration, and other areas requiring strength and stability in dynamic environments. The findings of this study open up new possibilities for the use of amorphous thin-film materials in high-performance applications.

8.
J Mech Behav Biomed Mater ; 150: 106295, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38096611

RESUMEN

OBJECTIVE: To evaluate the effect of ions released from surface pre-reacted glass-ionomer (S-PRG) filler on collagen morphology, remineralization, and ultimate tensile strength (UTS) of demineralized dentin. MATERIALS AND METHODS: Bovine incisor root dentins were demineralized with EDTA and divided into three treatment groups: 1) water (control); 2) S-PRG filler eluate; 3) 125 ppm sodium fluoride (NaF). After a 3-min treatment, the specimens were stored in simulated body fluid (SBF) for 3 months. Collagen morphology and remineralization were assessed using transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR). Additionally, ultimate tensile strength (UTS) was measured. RESULTS: TEM and SEM demonstrated that S-PRG induced more effective remineralization compared to NaF, while the control group exhibited faint mineral deposition with collagen degradation. S-PRG displayed the most homogenous mineral deposition in collagen fibrils, along with closure of interfibrillar spaces. Extensive mineral precipitation was observed within dentinal tubules in the S-PRG group. In addition, S-PRG filler eluate demonstrated significantly higher phosphate-to-amide ratio and UTS compared to NaF and control groups (p < 0.05). CONCLUSIONS: Ion released from S-PRG filler positively influenced collagen morphology, remineralization, and ultimate tensile strength of demineralized dentin. CLINICAL SIGNIFICANCE: S-PRG filler enhances remineralization and improve the biomechanics of demineralized dentin.


Asunto(s)
Dentina , Dióxido de Silicio , Animales , Bovinos , Resistencia a la Tracción , Colágeno/farmacología , Iones/farmacología , Cementos de Ionómero Vítreo/química
9.
Membranes (Basel) ; 13(8)2023 Aug 14.
Artículo en Inglés | MEDLINE | ID: mdl-37623792

RESUMEN

An extreme ultraviolet (EUV) pellicle is an ultrathin membrane at a stand-off distance from the reticle surface that protects the EUV mask from contamination during the exposure process. EUV pellicles must exhibit high EUV transmittance, low EUV reflectivity, and superior thermomechanical durability that can withstand the gradually increasing EUV source power. This study proposes an optimal range of optical constants to satisfy the EUV pellicle requirements based on the optical simulation results. Based on this, zirconium disilicide (ZrSi2), which is expected to satisfy the optical and thermomechanical requirements, was selected as the EUV pellicle candidate material. An EUV pellicle composite comprising a ZrSi2 thin film deposited via co-sputtering was fabricated, and its thermal, optical, and mechanical properties were evaluated. The emissivity increased with an increase in the thickness of the ZrSi2 thin film. The measured EUV transmittance (92.7%) and reflectivity (0.033%) of the fabricated pellicle satisfied the EUV pellicle requirements. The ultimate tensile strength of the pellicle was 3.5 GPa. Thus, the applicability of the ZrSi2 thin film as an EUV pellicle material was verified.

10.
Materials (Basel) ; 16(14)2023 Jul 23.
Artículo en Inglés | MEDLINE | ID: mdl-37512454

RESUMEN

To study the effects of Fe content and cold drawing strain on the microstructure and properties, Cu-Fe alloys were prepared via powder metallurgy and hot extrusion. Scanning electron microscopy was applied to observe the Fe phase, and the ultimate tensile strength was investigated using a universal material testing machine. Alloying with an Fe content below 10 wt.% formed a spherically dispersed Fe phase via the conventional nucleation and growth mechanism, whereas a higher Fe content formed a water-droplet-like Fe phase via the spinodal decomposition mechanism in the as-extruded Cu-Fe alloy. Further cold drawing induced the fiber structure of the Fe phase (fiber strengthening), which could not be destroyed by subsequent annealing. As the Fe content increased, the strength increased but the electrical conductivity decreased; as the cold drawing strain increased, both the strength and the electrical conductivity roughly increased, but the elongation roughly decreased. After thermal-mechanical processing, the electrical conductivity and strength of the Cu-40Fe alloy could reach 51% IACS and 1.14 GPa, respectively. This study can provide insight into the design of high-performance Cu-Fe alloys by tailoring the size and morphology of the Fe phase.

11.
Materials (Basel) ; 16(11)2023 06 05.
Artículo en Inglés | MEDLINE | ID: mdl-37297323

RESUMEN

The use of materials for computer-aided design/computer-aided manufacturing (CAD/CAM) has been rapidly increasing in daily practice. However, one of the main issues regarding modern CAD/CAM materials is their aging in the oral environment, which may lead to significant changes in their overall properties. The aim of this study was to compare the flexural strength, water sorption, cross-link density (softening ratio%), surface roughness, and SEM analysis of three modern CAD/CAM "multicolor" composites. Grandio (Grandio disc multicolor-VOCO GmbH, Cuxhaven, Germany), Shofu (Shofu Block HC-Shofu Inc., Kyoto, Japan), and Vita (Vita Enamic multiColor-Vita Zahnfabrik, Bad Sackingen, Germany) were tested in this study. They were prepared in stick-shaped specimens and submitted to different tests after several aging protocols, such as thermocycling and mechanical cycle loading challenge. Further disc-shaped specimens were also created and tested for water sorption, cross-link density, surface roughness, and SEM ultramorphology, before and after storage in an ethanol-based solution. For flexural strength and ultimate tensile strength, Grandio showed the greatest values both at baseline and after aging (p < 0.05). Grandio and Vita Enamic presented the highest modulus of elasticity and the lowest water sorption (p < 0.05). A significant reduction (p < 0.05) in microhardness after ethanol storage (softening ratio%) was observed especially in Shofu. Grandio had the lowest roughness parameters compared to the other tested CAD/CAM materials, while ethanol storage significantly increased the Ra and RSm values in Shofu (p < 0.05). Despite the comparable modulus of elasticity of Vita and Grandio, this latter showed greater flexural strength and ultimate tensile strength both at baseline and after aging. Hence, Grandio and Vita Enamic may be employed for the anterior teeth and for those restorations requiring load-bearing capacity. Conversely, aging seems to affect several properties of Shofu, so its use for permanent restorations should be well-pondered based on the clinical situation.

12.
Materials (Basel) ; 16(5)2023 Mar 03.
Artículo en Inglés | MEDLINE | ID: mdl-36903195

RESUMEN

Post weld heat treatment, or PWHT, is often used to improve the mechanical properties of materials that have been welded. Several publications have investigated the effects of the PWHT process using experimental designs. However, the modeling and optimization using the integration of machine learning (ML) and metaheuristics have yet to be reported, which are fundamental steps toward intelligent manufacturing applications. This research proposes a novel approach using ML techniques and metaheuristics to optimize PWHT process parameters. The goal is to determine the optimal PWHT parameters for both single and multiple objective perspectives. In this research, support vector regression (SVR), K-nearest neighbors (KNN), decision tree (DT), and random forest (RF) were ML techniques employed to obtain a relationship model between PWHT parameters and mechanical properties: ultimate tensile strength (UTS) and elongation percentage (EL). The results show that the SVR demonstrated superior performance among ML techniques for both UTS and EL models. Then, SVR is used with metaheuristics such as differential evolution (DE), particle swarm optimization (PSO), and genetic algorithms (GA). SVR-PSO shows the fastest convergence among other combinations. The final solutions of single-objective and Pareto solutions were also suggested in this research.

13.
J Mech Behav Biomed Mater ; 138: 105617, 2023 02.
Artículo en Inglés | MEDLINE | ID: mdl-36543085

RESUMEN

Despite of its assumed role to mitigate brain tissue response under dynamic loading conditions, the human dura mater is frequently neglected in computational and physical human head models. A reason for this is the lack of load-deformation data when the dura mater is loaded dynamically. To date, the biomechanical characterization of the human dura mater predominantly involved quasi-static testing setups. This study aimed to investigate the strain rate-dependent mechanical properties of the human dura mater comparing three different velocities of 0.3, 0.5 and 0.7 m/s. Samples were chosen in a perpendicular orientation to the visible main fiber direction on the samples' surface, which was mostly neglected in previous studies. The elastic modulus of dura mater significantly increased at higher velocities (5.16 [3.38; 7.27] MPa at 0.3 m/s versus 44.38 [35.30; 74.94] MPa at 0.7 m/s). Both the stretch at yield point λf (1.148 [1.137; 1.188] for 0.3 m/s, 1.062 [1.054; 1.066] for 0.5 m/s and 1.015 [1.012; 1.021] for 0.7 m/s) and stress at yield point σf of dura mater (519.14 [366.74; 707.99] kPa for 0.3 m/s versus 300.52 [245.31; 354.89] kPa at 0.7 m/s) significantly decreased with increasing velocities. Conclusively, increasing the load application velocity increases stiffness and decreases tensile strength as well as straining potential of human dura mater between 0.3 and 0.7 m/s. The elastic modulus of human dura mater should be adapted to the respective velocities in computational head impact simulations.


Asunto(s)
Encéfalo , Duramadre , Humanos , Resistencia a la Tracción , Duramadre/fisiología , Módulo de Elasticidad/fisiología , Fenómenos Biomecánicos
14.
Sci Prog ; 105(4): 368504221126795, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36222014

RESUMEN

The tensile strength and corrosion behavior of dissimilar welded joints are currently a subject of concern. In this work, gas metal arc welding (GMAW) and distinct welding parameters (welding current, arc voltage, and welding speed) were used to join 304 stainless steel (SUS304) and SS400 low carbon steel, and the ultimate tensile strength (UTS) of the dissimilar welded joints was investigated. A corrosion test was conducted by immersion in 3.5 wt.% sodium chloride (NaCl) solution for 7, 14, and 21 days. Based on tensile strength and Tafel testing, the welding parameters "Item 4" (welding current: 170 A, arc voltage: 20 V, welding speed: 40 cm/min) yielded good mechanical strength and low corrosion characteristics. The microstructure characterization showed that the area around the welded joints and SUS304 had more granular corrosion and corrosion tubercles with increasing immersion time. The chromium content gradually decreased. When exposed to the chloride environment, these welded joints easily underwent corrosion due to the loss of passivity. However, high-velocity oxygen-fuel (HVOF) spray used on the welded joints reduced the corrosion current density. Compared with the non-thermal spray sample (corrosion current density:7.49e - 05 A/cm2) while the corrosion current density (7.89e - 10 A/cm2) is five orders of magnitude lower. This spray effectively slowed down the corrosion rate of the welded joints and gave the structural objects good protection in the sodium chloride solution.

15.
Membranes (Basel) ; 12(9)2022 Aug 24.
Artículo en Inglés | MEDLINE | ID: mdl-36135845

RESUMEN

The production of medical devices follows strict guidelines where bio- and hemocompatibility, mechanical strength, and tear resistance are important features. Segmented polyurethanes (PUs) are an important class of polymers that fulfill many of these requirements, thus justifying the investigation of novel derivatives with enhanced properties, such as modulated carbon dioxide and oxygen permeability. In this work, three segmented polyurethane-based membranes, containing blocks of hard segments (HSs) dispersed in a matrix of soft segment (SS) blocks, were prepared by reacting a PU prepolymer (PUR) with tris(hydroxymethyl)aminomethane (TRIS), Congo red (CR) and methyl-ß-cyclodextrin (MBCD), rendering PU/TRIS, PU/CR and PU/MBCD membranes. The pure (control) PU membrane exhibited the highest degree of phase segregation between HSs and SSs followed by PU/TRIS and PU/MBCD membranes, and the PU/CR membrane displayed the highest degree of mixing. Pure PU and PU/CR membranes exhibited the highest and lowest values of Young's modulus, tangent moduli and ultimate tensile strength, respectively, suggesting that the introduction of CR increases molecular mobility, thus reducing stiffness. The CO2 permeability was highest for the PU/CR membrane, 347 Barrer, and lowest for the pure PU membrane, 278 Barrer, suggesting that a higher degree of mixing between HSs and SSs leads to higher CO2 permeation rates. The permeability of O2 was similar for all membranes, but ca. 10-fold lower than the CO2 permeability.

16.
Mater Today Bio ; 16: 100368, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35937578

RESUMEN

Implantation of cardiovascular stents is an important therapeutic method to treat coronary artery diseases. Bare-metal and drug-eluting stents show promising clinical outcomes, however, their permanent presence may create complications. In recent years, numerous preclinical and clinical trials have evaluated the properties of bioresorbable stents, including polymer and magnesium-based stents. Three-dimensional (3D) printed-shape-memory polymeric materials enable the self-deployment of stents and provide a novel approach for individualized treatment. Novel bioresorbable metallic stents such as iron- and zinc-based stents have also been investigated and refined. However, the development of novel bioresorbable stents accompanied by clinical translation remains time-consuming and challenging. This review comprehensively summarizes the development of bioresorbable stents based on their preclinical/clinical trials and highlights translational research as well as novel technologies for stents (e.g., bioresorbable electronic stents integrated with biosensors). These findings are expected to inspire the design of novel stents and optimization approaches to improve the efficacy of treatments for cardiovascular diseases.

17.
Rev.chil.ortop.traumatol. ; 63(2): 83-86, ago.2022. ilus, graf
Artículo en Español | LILACS | ID: biblio-1436080

RESUMEN

OBJETIVO Determinar la resistencia máxima a la tracción (RMT) de la continuación prepatelar del cuádriceps (CPC).MATERIALES Y MÉTODOS Se realizó un estudio en cadáveres humanos. Fueron incluidos diez especímenes, en los cuales se utilizaron los tercios proximal y medial de la cortical anterior de la patela para evaluar las propiedades mecánicas de la CPC. En cada espécimen, se estudió un área de sección transversal de 0,2 cm2 (A1) y 1 cm2 (A2). Se aplicó una carga gradual para determinar la RMT.RESULTADOS La mediana de la RMT en el A1 fue de 232,56 N (rango: 141,23 N a 295,33 N) y en el A2 fue de 335,30 N (rango: 216,45 N a 371,40 N). El incremento en la TMR fue significativo entre las 2 áreas (p = 0,006).CONCLUSIÓN El ignificado clínico de este estudio es que la CPC es un tejido fuerte que puede servir de anclaje seguro para reconstrucciones alrededor de la patela. Un área relativamente pequeña tolera al menos 140 N y, a medida que crece el área, también aumenta la RMT.


OBJETIVE To determine the ultimate tensile strength (UTS) of the prepatellar quadriceps continuation (PQC). MATERIALS AND METHODS A human cadaveric study was performed. Ten fresh-frozen specimens were used. The proximal and medial thirds of the anterior cortex of the patella were used to assess the mechanical properties of the PQC. In each specimen, transverse section areas measuring 0.2 cm2 (A1) and 1 cm2 (A2) were studied. A gradual load was applied to determine the UTS. RESULTS The median UTS of A1 was of 232.56 N (range: 141.23 N to 295.33 N), and that of A2 was of 335.30 N (range: 216.45 N to 371.40 N). The increment in UTS was significant between the 2 areas (p » 0.006). CONCLUSION The clinical significance of the present study lies in the fact that it shows that the PQC is a strong tissue that can be a safe anchor for reconstruction around the patella. A relatively small area supports at least 140 N, and, as the area grows, the UTS increases as well.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Resistencia a la Tracción , Músculo Cuádriceps/fisiopatología , Fenómenos Biomecánicos , Articulación de la Rodilla/fisiopatología
18.
Materials (Basel) ; 15(7)2022 Mar 27.
Artículo en Inglés | MEDLINE | ID: mdl-35407798

RESUMEN

Friction Stir Welding (FSW) is a solid-state bonding technique. There are many direct and indirect factors affecting the mechanical and microstructural properties of the FSW joints. Tool offset, tilt angle, and plunge depth are determinative tool positioning in the FSW process. Investigating the effect of these factors simultaneously with other parameters such as process speeds (rotational speed and translational speed) and tool geometry leads to a poor understanding of the impact of these factors on the FSW process. Because the three mentioned parameters have the same origin, they should be studied separately from other process parameters. This paper investigates the effects of tilt angle, plunge depth, and tool offset on Ultimate Tensile Stress (UTS) of joints between AA6061-T6 and AA7075-T6. To design the experiments, optimization, and statistical analysis, Response Surface Methodology (RSM) has been used. Experimental tests were carried out to find the maximum achievable UTS of the joint. The optimum values were determined based on the optimization procedure as 0.7 mm of tool offset, 2.7 degrees of tilt angle, and 0.1 mm of plunge depth. These values resulted in a UTS of 281 MPa. Compared to the UTS of base metals, the joint efficiency of the optimized welded sample was nearly 90 percent.

19.
Polymers (Basel) ; 13(19)2021 Oct 08.
Artículo en Inglés | MEDLINE | ID: mdl-34641261

RESUMEN

The aim of the current study was to evaluate the dimensional changes and ultimate tensile strength in three polyamide materials for denture bases fabrication through injection molding, subjected to artificial aging and different storage conditions. A total of 333 test specimens fabricated from Biosens (BS; Perflex, Netanya, Israel), Bre.flex 2nd edition (BF; Bredent, Senden, Germany) and ThermoSens (TS; Vertex Dental B.V., Soesterberg, The Netherlands)-n = 111 per material-were equally divided into three groups (n = 37) based on different treatments and storage conditions. Test samples allocated to the "Control group" were not artificially aged and stored in water for 24 h. Both "Treatment 1 group" and "Treatment 2 group" were subjected to thermocycling, the former dehydrated and the latter stored in water between cycle-sets. Linear changes and ultimate tensile strength were measured and analyzed for storage condition and material influence on the outcome variables. A Welch ANOVA test with Games-Howell post-hoc analysis was used to compare the influence of treatments across different materials. Significant differences were found for all three included materials with p values ranging from <0.05 to <0.001 for linear dimensional changes. The magnitude of alterations varied and was large for BS (Perflex, Israel) (ω2 = 0.62) and BF (Bredent, Germany) (ω2 = 0.47) and small but significant for TS (Vertex Dental B.V., The Netherlands) (ω2 = 0.05). However, results seem to fall into clinically acceptable range. Significant differences were also observed for the ultimate tensile strength test with the same range of p-values. All three materials showed different initial ultimate tensile strengths and varying reaction to artificial aging and storage with the lowest alterations observed for BF (Bredent, Germany) (ω2 = 0.05). Within the limitation of this study, it can be concluded that all three materials show different dimensional and mechanical properties when subjected to artificial aging and different storage. Although linear dimensions show significant changes, they seem to be clinically irrelevant, whereas the change in ultimate tensile strength after only 6-month equivalent clinical use was substantial for BS (Perflex, Israel) and TS (Vertex Dental B.V., The Netherlands).

20.
Materials (Basel) ; 14(18)2021 Sep 13.
Artículo en Inglés | MEDLINE | ID: mdl-34576483

RESUMEN

This work mainly focuses on increasing the mechanical strength and improving the corrosion resistance of an aluminum alloy hybrid matrix. The composites are prepared by the stir casting procedure. For this work, aluminum alloy 8079 is considered as a base material and titanium nitride and zirconium dioxide are utilized as reinforcement particles. Mechanical tests, such as the ultimate tensile strength, wear, salt spray corrosion test and microhardness test, are conducted effectively in the fabricated AA8079/TiN + ZrO2 composites. L9 OA statistical analysis is executed to optimize the process parameters of the mechanical and corrosion tests. ANOVA analysis defines the contribution and influence of each parameter. In the tensile and wear test, parameters are chosen as % of reinforcement (3%, 6% and 9%), stirring speed (500, 550 and 600 rpm) and stirring time (20, 25 and 30 min). Similarly, in the salt spray test and microhardness test, the selected parameters are: percentage of reinforcement (3%, 6% and 9%), pH value (3, 6 and 9), and hang time (24, 48 and 72 h). The percentage of reinforcement highly influenced the wear and microhardness test, while the stirring time parameter extremely influenced the ultimate tensile strength. From the corrosion test, the hang time influences the corrosion rate. The SEM analysis highly reveals the bonding of each reinforcement particle to the base material.

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