1.
Chemistry
; 22(44): 15629-15633, 2016 Oct 24.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27595239
RESUMEN
A new transfer hydrofunctionalization strategy to turnover H-MII -X complexes has enabled both intra- and intermolecular Mizoroki-Heck (MH)-type reactions of aryl cyanides that are challenging to realize under traditional, basic conditions. Initially, a cascade carbonickelation/MH reaction of 2-cyanostyrenes was achieved using a key alkyne transfer hydrocyanation step. Mechanistic experiments supported the proposed catalytic cycle, including the turnover-enabling transfer hydrocyanation step. The reactivity was then extended to the intermolecular MH reaction of benzonitriles and styrenes.