RESUMEN
PURPOSE: To analyze structural and vascular changes of the retina and choroid in pediatric patients with coronavirus disease 2019 (COVID-19) using optical coherence tomography (OCT)/OCT angiography (OCTA). METHODS: This comparative cross-sectional study consists of the COVID-19 group including pediatric COVID-19 patients and the control group including healthy children. Vessel density (VD), central macular thickness,, and choroidal thickness (ChT) measurements were performed using swept-source OCT/OCTA 12 weeks after the recovery from COVID-19. RESULTS: The mean VD measurements in the central fovea and nasal quadrants of all three retinal layers and choriocapillaris showed insignificantly lower values in the COVID-19 group when compared to the control group (0:002 < p < 0:05 for all). Similar to VD measurements, insignificant lower ChT measurements were obtained in the central fovea and nasal points in the COVID-19 group. CONCLUSION: OCTA can be used as a non-invasive and valid biomarker in the assessment of early microvascular dysfunction associated with COVID-19.
Asunto(s)
Angiografía , COVID-19 , Microcirculación , Microvasos , Tomografía de Coherencia Óptica , Niño , Humanos , COVID-19/diagnóstico por imagen , Tomografía de Coherencia Óptica/métodos , Microvasos/diagnóstico por imagen , Microvasos/fisiopatología , Estudios Transversales , Estudios de Casos y Controles , Angiografía/métodos , Coroides/diagnóstico por imagen , Fóvea Central/diagnóstico por imagen , Biomarcadores , Reproducibilidad de los ResultadosRESUMEN
The choroid is one of the most vascularized regions of the human body. Therefore, various local and systemic physiologic/pathologic conditions and environmental factors have effects on choroidal thickness.