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1.
Infect Dis (Lond) ; 55(9): 591-598, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37317789

RESUMEN

OBJECTIVES: Blood culture is a key method for diagnosing bloodstream infections. In this prospective study, we aimed to investigate whether blood cultures collected with the one-puncture method results in fewer contaminants, i.e. microorganisms from the skin or the environment, and the same detection of relevant pathogens compared to the two-puncture method. Further, we aimed to investigate if the time to blood culture positivity could be useful in evaluating contaminants. METHODS: Patients planned for blood cultures were asked to participate in the study. From each recruited patient, six blood culture bottles were drawn, bottles 1-4 from the first venipuncture and bottles 5-6 from the second venipuncture. Within each patient, bottles 1-4 were compared to bottles 1, 2, 5, and 6 for contaminants and relevant pathogens. A sub-analysis was conducted on patients admitted to the ICU and those in the haematology department. We also assessed time-to-positivity for coagulase-negative staphylococci. RESULTS: In the final analysis, 337 episodes from 312 patients were included. Relevant pathogens were identified in 62/337 (18.4%) episodes in both methods. Contaminants were detected in 12 (3.6%) and 19 episodes (5.6%) using the one-puncture and two-puncture method (p = .039), respectively. Corresponding results were observed in the sub-analysis. Notably, relevant coagulase-negative staphylococci demonstrated a shorter time-to-positivity compared to contaminant coagulase-negative staphylococci. CONCLUSION: Blood cultures obtained using the one-puncture method resulted in significantly fewer contaminants and detected relevant pathogens equally to the two-puncture method. Time-to-positivity may be a useful additive indicator for predicting coagulase-negative staphylococci contamination in blood cultures.


Asunto(s)
Bacteriemia , Enfermedades Transmisibles , Hematología , Infecciones Estafilocócicas , Humanos , Flebotomía , Cultivo de Sangre , Estudios Prospectivos , Bacteriemia/diagnóstico , Coagulasa , Staphylococcus , Unidades de Cuidados Intensivos , Infecciones Estafilocócicas/diagnóstico
2.
Front Microbiol ; 7: 697, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27242721

RESUMEN

Bloodstream infection (BSI) is a major cause of death in developed countries and the detection of microorganisms is essential in managing patients. Despite major progress has been made to improve identification of microorganisms, blood culture (BC) remains the gold standard and the first line tool for detecting BSIs. Consensus guidelines are available to ensure optimal BSI procedures, but BC practices often deviate from the recommendations. This review provides an update on clinical and technical issues related to blood collection and to BC performance, with a special focus on the blood sample strategy to optimize the sensitivity and specificity of BCs.

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