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1.
J Nephrol ; 2024 Sep 18.
Artículo en Inglés | MEDLINE | ID: mdl-39289296

RESUMEN

BACKGROUND: Haemodialysis treatments generate greenhouse gas (GHG) emissions mainly as a result of the equipment, consumables and pharmaceuticals required. An internal audit demonstrated a 33% wastage of acid concentrate when using individual 5.0 L containers at a 1:44 dilution ratio. We therefore investigated whether changing the delivery system for acid concentrate would reduce wastage and any associated greenhouse gas emissions. METHODS: We calculated the difference for a 30-bed dialysis unit between receiving acid concentrate in single-use 5.0 L plastic containers versus bulk delivery for a central acid delivery system connected to the dialysis machines. Estimates of carbon dioxide equivalent (CO2e) emissions were made using the United Kingdom government database and other sources. RESULTS: A 30-station dialysis unit functioning at maximum capacity (3 shifts and 6 days/week), switching to bulk delivery and central acid delivery could realise an approximate total reduction of 33,841 kgCO2e/year; in reduced product wastage, saving 6192 kgCO2e, 5205 kgCO2e from fewer deliveries, and 22,444 kgCO2e saving from a reduction in packaging and waste generated, which equates approximately to a one tonne reduction in CO2e emissions per dialysis station/year. CONCLUSIONS: Switching from delivering acid concentrate in individual 5.0 L containers to a central acid delivery system can result in substantial reductions in CO2e emissions within a dialysis clinic. The emission savings from reducing the single-use plastic packaging greatly outweigh any gains from eliminating wastage of acid concentrate. Dialysis companies and clinicians should consider reviewing the design of current and future dialysis facilities and policies to determine whether reductions in CO2e emissions can be made.

2.
Soft Robot ; 2024 Sep 17.
Artículo en Inglés | MEDLINE | ID: mdl-39288069

RESUMEN

Numerous soft actuators based on pneumatic network (PneuNet) design have already been proposed and extensively employed across various soft robotics applications in recent years. Despite their widespread use, a common limitation of most existing designs is that their action is predetermined during the fabrication process, thereby restricting the ability to modify or alter their function during operation. To address this shortcoming, in this article the design of a Reconfigurable, Transformable Soft Pneumatic Actuator (RT-SPA) is proposed. The working principle of the RT-SPA is analogous to the conventional PneuNet. The key distinction between the two lies in the ability of the RT-SPA to undergo controlled transformations, allowing for more versatile bending and twisting motions in various directions. Furthermore, the unique reconfigurable design of the RT-SPA enables the selection of actuation units with different sizes to achieve a diverse range of three-dimensional deformations. This versatility enhances the RT-SPA's potential for adaptation to a multitude of tasks and environments, setting it apart from traditional PneuNet. The article begins with a detailed description of the design and fabrication of the RT-SPA. Following this, a series of experiments are conducted to evaluate the performance of the RT-SPA. Finally, the abilities of the RT-SPA for locomotion, gripping, and object manipulation are demonstrated to illustrate the versatility of the RT-SPA across different aspects.

3.
Artículo en Inglés | MEDLINE | ID: mdl-39225840

RESUMEN

PURPOSE: Identification of mature sperm at microdissection testicular sperm extraction (mTESE) is a crucial step of sperm retrieval to help patients with non-obstructive azoospermia (NOA) proceed to intracytoplasmic sperm injection. Touch print smear (TPS) cytology allows immediate interpretation and prompt sperm identification intraoperatively. In this study, we leverage machine learning (ML) to facilitate TPS reading and conquer the learning curve for new operators. MATERIALS AND METHODS: One hundred seventy-six microscopic TPS images from the testicular specimen of patients with azoospermia at Taipei Veterans General Hospital were retrospectively collected, including categories of Sertoli cell, primary spermatocytes, round spermatids, elongated spermatids, immature sperm, and mature sperm. Among them, 118 images were assigned as the training set and 29 images as the validation set. RetinaNet (Lin et al. in IEEE Trans Pattern Anal Mach Intell. 42:318-327, 2020), a one-stage detection framework, was adopted for cell detection. The performance was evaluated at the cell level with average precision (AP) and recall, and the precision-recall (PR) curve was displayed among an independent testing set that contains 29 images that aim to assess the model. RESULTS: The training set consisted of 4772 annotated cells, including 1782 Sertoli cells, 314 primary spermatocytes, 443 round spermatids, 279 elongated spermatids, 504 immature sperm, and 1450 mature sperm. This study demonstrated the performance of each category and the overall AP and recall on the validation set, which were 80.47% and 96.69%. The overall AP and recall were 79.48% and 93.63% on the testing set, while increased to 85.29% and 93.80% once the post-meiotic cells were merged into one category. CONCLUSIONS: This study proposed an innovative approach that leveraged ML methods to facilitate the diagnosis of spermatogenesis at mTESE for patients with NOA. With the assistance of ML techniques, surgeons could determine the stages of spermatogenesis and provide timely histopathological diagnosis for infertile males.

4.
Clin Dermatol ; 2024 Sep 09.
Artículo en Inglés | MEDLINE | ID: mdl-39260461

RESUMEN

Fingerprints are created by elevations and depressions on the fingertip pads. Each person has their own unique fingerprints which can be used in the identification of that individual when alive, during the immediate postmortem period, or even after the digits have become mummified. Mummification can occur naturally; it can be partial (such as localized to only the hands and feet, extensive, or complete. Obtaining fingerprints after the skin has become mummified can be attempted while the digits remaining intact with the hand; however, the digits may need to be removed from the hand and the finger pads may also need to be separated from the underlying bone to secure an adequate fingerprint. Frequently, the mummified tissue needs to be rehydrated; numerous solutions have been used that increase the turgor of the digits, provide softening and pliability of the tissue, and enhance the details of the finger pad ridges. An aqueous solution of sodium carbonate (either combined with acetic acid or combined with 95 percent ethanol and distilled water) was found to be most effective for rehydration. Thereafter, various techniques can be attempted to obtain the fingerprint. These include the traditional method of inking and rolling of the finger or photographing the finger. Powders (such as aluminum powder, black fingerprint powder, white cornstarch-based powder, or fluorescent powder) can be used to enhance the ridge features; adhesive tape can be pressed against the powdered digit and the print pattern preserved by applying the adhesive tape to a clear transparency sheet. In addition, molds (using modeling clay or silicone rubber) and casts (using plaster of Paris, dental casting materials, or putty) can be made of the digits; either the molds or the casts or both can be photographed with or without prior application of fingerprint powder. Transillumination, using a fiber optic light source to illuminate the epidermis and underlying remaining dermis of a scraped and defleshed finger pad can be used to demonstrate the finger ridge pattern when the photographing the tip of the digit. In summary, forensic dermatology can have an integral role in obtaining fingerprints from mummified digits, which can be successfully used for the identification of the decedent.

5.
Polymers (Basel) ; 16(17)2024 Sep 06.
Artículo en Inglés | MEDLINE | ID: mdl-39274161

RESUMEN

Polymer additive manufacturing has advanced from prototyping to producing essential parts with improved precision and versatility. Despite challenges like surface finish and wear resistance, new materials and metallic reinforcements in polymers have expanded its applications, enabling stronger, more durable parts for demanding industries like aerospace and structural engineering. This research investigates the tribological behaviour of FFF surfaces by integrating copper and aluminium reinforcement particles into a PLA (polylactic acid) matrix. Pin-on-disc tests were conducted to evaluate friction coefficients and wear rates. Statistical analysis was performed to study the correlation of the main process variables. The results confirmed that reinforced materials offer interesting characteristics despite their complex use, with the roughness of the fabricated parts increasing by more than 300%. This leads to an increase in the coefficient of friction, which is related to the variation in the material's mechanical properties, as the hardness increases by more than 75% for materials reinforced with Al. Despite this, their performance is more stable, and the volume of material lost due to wear is reduced by half. These results highlight the potential of reinforced polymers to improve the performance and durability of components manufactured through additive processes.

6.
Wiad Lek ; 77(8): 1623-1626, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39231335

RESUMEN

Orbital fractures, constituting 10-25% of facial traumas, result from diverse mechanisms such as traffic accidents and assaults. These fractures present with characteristic symptoms like edema, diplopia, and infraorbital paraesthesia. Timely diagnosis and surgical intervention are paramount to mitigate long-term complications. Recent advancements in materials science and surgical methodologies have ushered in innovative approaches including 3D printing and computer-aided design implants. This article details a case study of successful reconstructive orbital surgery in a patient following a traumatic incident where a car accident caused extensive facial fractures. Leveraging 3D printing technology, a precisely tailored titanium mesh aided in the meticulous restoration of the orbital floor. During surgery, entrapped soft tissues were released, and the zygomatic-maxillary complex was carefully repositioned. Postoperative evaluation revealed promising outcomes, affirming the efficacy of contemporary surgical strategies. This case highlights the evolving role of 3D printing in enhancing the accuracy, cost-effectiveness, and accessibility of orbital reconstruction procedures, demonstrating its potential for broader clinical applications.


Asunto(s)
Fracturas Orbitales , Procedimientos de Cirugía Plástica , Impresión Tridimensional , Humanos , Fracturas Orbitales/cirugía , Procedimientos de Cirugía Plástica/métodos , Masculino , Órbita/cirugía , Órbita/lesiones , Adulto , Accidentes de Tránsito , Mallas Quirúrgicas
7.
Angle Orthod ; 94(4): 375-382, 2024 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-39229951

RESUMEN

OBJECTIVES: To determine the impact of build orientation, increased layer thickness, and dental crowding on the trueness of three-dimensional (3D)-printed models, and to evaluate how these parameters affect the fit of thermoformed appliances. MATERIALS AND METHODS: Ninety-six dental models were printed horizontally and vertically on the building platform using different 3D-printing technologies: (1) a stereolithography (SLA) printer with layer thicknesses of 160 µm and 300 µm and (2) a digital light processing (DLP) printer with layer thicknesses of 100 µm and 200 µm. Each printed model was digitalized and superimposed on the corresponding source file using 3D rendering software, and deviations were quantified by the root mean square values. Subsequently, a total of 32 thermoformed appliances were fabricated on top of the most accurate 3D-printed models, and their fit was evaluated by digital superimposition and inspection by three blinded orthodontists. Paired t-tests were used to analyze the data. RESULTS: Significant differences (P < .05) between printing technologies used were identified for models printed horizontally, with the SLA system achieving better trueness, especially in crowded dentitions. No significant differences between technology were found when models were printed vertically. The highest values of deviation were recorded in appliances fabricated on top of DLP-printed models. The results of the qualitative evaluation indicated that appliances fabricated on top of SLA models outperformed the DLP-modeled appliances. CONCLUSIONS: Three-dimensional printing with increased layer height seems to produce accurate working models for orthodontic applications.


Asunto(s)
Modelos Dentales , Impresión Tridimensional , Humanos , Estereolitografía , Diseño de Aparato Ortodóncico , Diseño Asistido por Computadora , Ortodoncia/métodos , Ortodoncia/instrumentación
8.
Phys Imaging Radiat Oncol ; 31: 100629, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-39257571

RESUMEN

Background and purpose: Brachytherapy is treatment of choice for early stage nasal vestibule cancer. Over the years improvements were achieved by means of image guided target definition, interstitial implant techniques and also individual mold techniques. The aim of this study was to improve the technique of the implant so that the need for interstitial catheters can be limited by making use of patient individualized 3D-printed applicators. Materials and Methods: In 19 patients 3D-printed applicators were used to deliver pulse dose rate (PDR) brachytherapy. All patients underwent computed tomography (CT) and magnetic resonance imaging (MRI). A pre-plan with tumor delineation and manually optimized catheter positions to achieve tumor coverage was made. Based on the pre-plan a 3D-printed applicator was manufactured. Dose was evaluated by several indices: Conformity Index, Healthy Tissues Conformity Index, Dose Homogeneity Index, Dose non-uniformity ratio, Conformal index and high dose (HD) index. Results: A high target coverage was achieved, with a median V100%CTV of 99.1 % (range, 81.8-100 %) and median CI of 0.99 (range, 0.82-1.00), as well as a median V0.7GyGTV of 100 % (range, 93.0-100 %). The median HD was 0.39 (range, 0.20-0.83). Interstitial catheters were needed in 12 patients. None of the patients developed grade ≥ II toxicity within the median follow up of 18 months. Conclusions: This study shows that using 3D-printed applicators limits the need for interstitial catheters and also limits the high doses in normal tissue.

9.
Cognition ; 251: 105905, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39094254

RESUMEN

Regular print exposure is thought to benefit reading and language processes: those who read more have a larger vocabulary and better spelling and comprehension skills. Yet, there is little or no direct evidence that exposure to print facilitates reading. Here, we used an ecologically valid design to test the impact of print exposure on the early stages of reading in skilled adult readers. Participants read a novel at their own pace. Reading was followed by a lexical decision task, in which the positive trials were words that were exposed in the novel, and matched controls not exposed in the novel. If exposure during reading had a positive impact on subsequent word recognition, exposed words would be processed more efficiently than not-exposed words (exposure effect). This effect was obtained in three experiments. In addition, the effect was not modulated by the amount of exposure (1 vs. 3 occurrences in the text; Experiment 1), or the timing between reading and the exposure test (immediately after reading vs. on the following day; Experiment 3). However, the effect was present only in low-frequency words (Experiment 3). Interpretations of the exposure effect in terms of activation threshold and lexical quality are discussed.


Asunto(s)
Lectura , Humanos , Masculino , Femenino , Adulto , Adulto Joven , Reconocimiento en Psicología/fisiología , Vocabulario , Comprensión/fisiología , Libros , Adolescente
10.
Dent Mater ; 2024 Aug 07.
Artículo en Inglés | MEDLINE | ID: mdl-39117501

RESUMEN

OBJECTIVES: 3D printing found its way into various medical applications and could be particularly beneficial for dentistry. Currently, materials for 3D printing of occlusal splints lack mechanical strength compared to polymethyl methacrylate (PMMA) used for standard milling of occlusal splints. It is known that print orientation and graphene nanoplatelets (GNP) can increase biaxial strength in a variety of materials. Thus, the aim of this study was to assess if adjustment of print orientation and addition of GNP improve biaxial strength and if they affect cytotoxicity of a 3D printable resin for occlusal splints. METHODS: Specimens were printed vertically and horizontally with a stereolithography (SLA) printer and multilayered GNP powder was added to the resin at different concentrations. Printed specimens were characterized by Raman spectroscopy, optical profilometer analysis and scanning electron microscopy. Biaxial strength was evaluated by biaxial flexural testing. Cytotoxicity of specimens on L929 and gingival stromal cells (GSC) was assessed by the toxdent test, the resazurin-based toxicity assay and live-dead staining. RESULTS: Horizontally printed specimens showed significantly higher biaxial strength and lower deformation. GNP did not improve biaxial strength and material deformation of 3D-printed resins. None of the specimens were cytotoxic to L929 cells or GSC. SIGNIFICANCE: Print orientation in SLA printing has a significant impact on biaxial strength and material deformation. 3D printable materials can reach comparable or even improved biaxial strength compared to PMMA when using the optimal print orientation while GNP has no beneficial effects on the biaxial strength of resins for 3D printing of occlusal splints.

11.
Clin Case Rep ; 12(9): e9271, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39210933

RESUMEN

Key Clinical Message: In the anatomically complex terrain of the head and neck, the use of 3D intraoperative models serves as an effective verification tool, determining the size, shape, and number of foreign bodies. This allows the main operator to maximize their capacities for careful wound revision and receive real-time information about the remaining content of the sought-after bodies. Abstract: Penetrating foreign bodies of various origins in the head and neck are uncommon, but potentially hazardous injuries. Complete removal of foreign bodies from soft tissues is essential for optimal healing, minimizing complications, and significantly reducing the risk of the need for reoperation. Despite various technological systems and safeguards available, unintentionally retained surgically placed foreign bodies remain difficult to eliminate completely. A 34-year-old female patient with a cut on the right side of her face who was initially treated with sutures at a general surgical clinic presented for a follow-up examination. A foreign body was verified subcutaneously on the anterior-posterior x-ray image on the right side. Computed tomography confirmed a total of 7 foreign bodies with a density corresponding to dental enamel, distributed subcutaneously, subfascially, and intramuscularly in the right temporal region. As part of the preoperative preparation and analysis, the bone segment of the right temporal fossa with the zygomatic bone and the glass fragments were segmented from the CT data and printed on an SLA printer. The physical 3D models were autoclave sterilized and present during surgery. The position, shape, and number of each individual glass fragment was compared with 3D-printed one. The benefits of producing 3D models of foreign bodies are undeniable, particularly in their perioperative comparison with the removed foreign bodies from wounds.

12.
Materials (Basel) ; 17(16)2024 Aug 14.
Artículo en Inglés | MEDLINE | ID: mdl-39203211

RESUMEN

This article deals with the possibility of using 3D-printed models as an input for the production of a mould for cast iron castings. This new progressive process is significantly faster (with sufficient accuracy) compared to the current way of making models for moulds. The need to create a wooden model is removed by this process. The quality of this wooden model was highly dependent on the experience and qualifications of the worker. This article describes the manufacturing process of the model and mould in detail. The key dimensions of the final parts are compared with the model and, thus, the accuracy of the chosen procedure is verified. A 3D-printing technology known as Multi Jet Fusion (MJF) was used to produce the model. The material used for the production of the model is polyamide PA12 with 40% glass fibre filling. This material has sufficient structural and strength properties to be used for the given application. Taking into account the dimensions of the part and the printing space of the printer, it was necessary to structurally modify and divide the part. The inlet cone of a turbine is used as an example This cone is produced from grey cast iron as standard.

13.
Neurophotonics ; 11(3): 036601, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-39193445

RESUMEN

Accurate sensor placement is vital for non-invasive brain imaging, particularly for functional near-infrared spectroscopy (fNIRS) and diffuse optical tomography (DOT), which lack standardized layouts such as those in electroencephalography (EEG). Custom, manually prepared probe layouts on textile caps are often imprecise and labor intensive. We introduce a method for creating personalized, 3D-printed headgear, enabling the accurate translation of 3D brain coordinates to 2D printable panels for custom fNIRS and EEG sensor layouts while reducing costs and manual labor. Our approach uses atlas-based or subject-specific head models and a spring-relaxation algorithm for flattening 3D coordinates onto 2D panels, using 10-5 EEG coordinates for reference. This process ensures geometrical fidelity, crucial for accurate probe placement. Probe geometries and holder types are customizable and printed directly on the cap, making the approach agnostic to instrument manufacturers and probe types. Our ninjaCap method offers 2.7 ± 1.8 mm probe placement accuracy. Over the last five years, we have developed and validated this approach with over 50 cap models and 500 participants. A cloud-based ninjaCap generation pipeline along with detailed instructions is now available at openfnirs.org. The ninjaCap marks a significant advancement in creating individualized neuroimaging caps, reducing costs and labor while improving probe placement accuracy, thereby reducing variability in research.

14.
Forensic Sci Int ; 361: 112139, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38971142

RESUMEN

During routine casework, fingerprint examiners are required to make decisions pertaining to the sufficiency of friction ridge skin impressions. Prior experimental research has established that differences of opinion between examiners are expected, though it is uncertain if these findings are representative of the decisions made during casework. In this study, 5000 job-cards completed by fingerprint experts of the NSW Police Force were scrutinised to track the differences of opinion that occurred between examiners. Experts recorded 19,491 casework decisions, which resulted in 8964 reported identification and inconclusive determinations. Expert decision making was found to be unanimous in 94.8 % of these determinations; 4.6 % involved one expert-to-expert disagreement; and 0.5 % involved two expert-to-expert disagreements. Nil determinations featured more than two expert-to-expert disagreements. Expert-to-expert disagreements occurred in 3.7 % of all identification and inconclusive casework verification decisions. However, verifying experts were more likely to agree with a prior expert's identification decision, than a prior expert's inconclusive decision. The observed expert-to-expert identification disagreement rate was 2.0 %, whereas the observed expert-to-expert inconclusive disagreement rate was 12.5 %. Overall, most casework disagreements arose due to subjective differences concerning the suitability of friction ridge skin information for comparison or sufficiency for identification. Experts were more concordant in their decision-making with other experts than with trainees, and approximately three times more likely to disagree with a prior trainees' identification or inconclusive decision than a prior experts' identification or inconclusive decision. We assume these differences reflect trainees' developing proficiencies in assessing the suitability or sufficiency of friction ridge skin impression information. Differences of opinion in casework are expected, which exposes the subjective nature of fingerprint decision-making. Computer-based quality metric and likelihood ratio tools should be considered for use in casework to guide examiner evaluations and mitigate examiner disagreements.


Asunto(s)
Dermatoglifia , Variaciones Dependientes del Observador , Humanos , Toma de Decisiones , Disentimientos y Disputas
15.
Sci Rep ; 14(1): 17295, 2024 07 27.
Artículo en Inglés | MEDLINE | ID: mdl-39068274

RESUMEN

In this retrospective cohort study the survival rate, clinical parameters, patient satisfaction with aesthetics and oral health-related quality of life of 3D printed temporary crowns were evaluated. Temporary crowns were 3D printed with a Form3B out of Permanent Crown Resin (Formlabs GmbH). Anonymized data for the restorations' survival (in-situ) was evaluated retrospectively for 98 temporary crowns of 63 patients fabricated within 19 months. Among these restorations, further analysis was conducted for 42 temporary crowns of 24 patients regarding clinical parameters (modified USPHS criteria), patient satisfaction with aesthetics and impact on oral health-related quality of life (OHRQoL) (OHIP 14). Descriptive statistical analysis (significance level of α = 0.05) included a Kaplan-Meier curve for survival analysis, a Kolmogorov-Smirnov test for USPHS, aesthetics and OHIP data, followed by a Wilcoxon test for USPHS and OHIP data and Chi-squared test for aesthetics data. Cronbach's alpha was calculated for OHIP data. The average observation period for survival analysis was 256 days. The survival rate was satisfactory at 98% and n = 2 catastrophic failures (i.e. fracture) occurred. Total OHIP scores, with good reliabilities, improved from 6.63 to 2.21 significantly (p = 0.005) and patient satisfaction with aesthetics (p < 0.001) as well. Clinical analysis with modified USPHS criteria revealed encouraging results.


Asunto(s)
Coronas , Satisfacción del Paciente , Impresión Tridimensional , Calidad de Vida , Humanos , Estudios Retrospectivos , Femenino , Masculino , Adulto , Persona de Mediana Edad , Estética Dental , Anciano , Restauración Dental Provisional , Adulto Joven , Salud Bucal
16.
Clin Exp Optom ; : 1-8, 2024 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-38951809

RESUMEN

CLINICAL RELEVANCE: Children with vision impairment can have difficulty accessing classroom reading material and knowledge of which students are likely to have improved performance reading performance with reverse polarity would be of value to educators. BACKGROUND: Printed material is typically presented as black text on a white background; however, reversing the polarity to white text on a black background may improve the reading speed for children with vision impairment. This study sought to identify the visual function or pathological features of children with vision impairment where reversing the polarity of text would improve their reading performance. METHODS: Forty-eight vision-impaired participants (27 male), aged 5-18 years with binocular visual acuities between 0.18-1.52 logMAR, were included. Reading performance was assessed by changes in Critical Print Size (ΔCPS), Maximum Reading Speed (ΔMRS) in normal and reverse polarity digital print, and numeric reading speed (ΔNRS) with normal and reverse polarity fonts. Correlations were made with 30 Hz flicker electroretinogram amplitude and high/low contrast acuity. Paired nonparametric tests evaluated significance in pathological condition groups. RESULTS: Significant negative correlations were only found between the 30 Hz flicker amplitude and ΔMRS (r = -.42, p = .028) and ΔNRS (r = -.46, p = .027). Follow-up pairwise comparisons based on pathology group only showed a significant effect of the retinal dystrophy group and CPS (n = 12, z = -2.24, p = .025). All other pairwise comparisons based on group were non-significant (p > .05). CONCLUSIONS: This study did not identify a specific pathological group or visual functional measure that could be used as a clinical marker to predict the impact of reversing polarity. However, significant improvements could be made in reading performance for some children and so a reading performance assessment is recommended for all children with vision impairment.

17.
Adv Funct Mater ; 34(21)2024 May 22.
Artículo en Inglés | MEDLINE | ID: mdl-38952568

RESUMEN

Embedded bioprinting overcomes the barriers associated with the conventional extrusion-based bioprinting process as it enables the direct deposition of bioinks in 3D inside a support bath by providing in situ self-support for deposited bioinks during bioprinting to prevent their collapse and deformation. Embedded bioprinting improves the shape quality of bioprinted constructs made up of soft materials and low-viscosity bioinks, leading to a promising strategy for better anatomical mimicry of tissues or organs. Herein, the interplay mechanism among the printing process parameters toward improved shape quality is critically reviewed. The impact of material properties of the support bath and bioink, printing conditions, cross-linking mechanisms, and post-printing treatment methods, on the printing fidelity, stability, and resolution of the structures is meticulously dissected and thoroughly discussed. Further, the potential scope and applications of this technology in the fields of bioprinting and regenerative medicine are presented. Finally, outstanding challenges and opportunities of embedded bioprinting as well as its promise for fabricating functional solid organs in the future are discussed.

18.
Polymers (Basel) ; 16(13)2024 Jun 27.
Artículo en Inglés | MEDLINE | ID: mdl-39000677

RESUMEN

3D printing technology is becoming a widely adopted alternative to traditional polymer manufacturing methods. The most important advantage of 3D printing over traditional manufacturing methods, such as injection molding or extrusion, is the short time from the creation of a new design to the finished product. Nevertheless, 3D-printed parts generally have lower strength and lower durability compared to the same parts manufactured using traditional methods. Resistance to the environmental conditions in which a 3D-printed part operates is important to its durability. One of the most important factors that reduces durability and degrades the mechanical properties of 3D-printed parts is temperature, especially rapid temperature changes. In the case of inhomogeneous internal geometry and heterogeneous material properties, rapid temperature changes can have a significant impact on the degradation of 3D-printed parts. This degradation is more severe in high-humidity environments. Under these complex service conditions, information on the strength and fatigue behavior of 3D-printed polymers is limited. In this study, we evaluated the effects of high humidity and temperature changes on the durability and strength properties of 3D-printed parts. Samples made of commonly available materials such as ABS (Acrylonitrile Butadiene Styrene), ASA (Acrylonitrile-Styrene-Acrylate), HIPS (High-Impact Polystyrene), and PLA (Poly(lactic acid)) were subjected to temperature cycling, from an ambient temperature to -20 °C, and then were heated to 70 °C. After thermal treatment, the samples were subjected to cyclic loading to determine changes in their fatigue life relative to non-thermally treated reference samples. The results of cyclic testing showed a decrease in durability for samples made of ASA and HIPS. The ABS material proved to be resistant to the environmental effects of shocks, while the PLA material exhibited an increase in durability. Changes in the internal structure and porosity of the specimens under temperature changes were also evaluated using microcomputed tomography (microCT). Temperature changes also affected the porosity of the samples, which varied depending on the material used.

19.
Polymers (Basel) ; 16(13)2024 Jun 27.
Artículo en Inglés | MEDLINE | ID: mdl-39000682

RESUMEN

Continuous carbon fiber-reinforced (CCFR) thermoset composites have received significant attention due to their excellent mechanical and thermal properties. The implementation of 3D printing introduces cost-effectiveness and design flexibility into their manufacturing processes. The light-assisted 3D printing process shows promise for manufacturing CCFR composites using low-viscosity thermoset resin, which would otherwise be unprintable. Because of the lack of shape-retaining capability, 3D printing of various shapes is challenging with low-viscosity thermoset resin. This study demonstrated an overshoot-associated algorithm for 3D printing various shapes using low-viscosity thermoset resin and continuous carbon fiber. Additionally, 3D-printed unidirectional composites were mechanically characterized. The printed specimen exhibited tensile strength of 390 ± 22 MPa and an interlaminar strength of 38 ± 1.7 MPa, with a fiber volume fraction of 15.7 ± 0.43%. Void analysis revealed that the printed specimen contained 5.5% overall voids. Moreover, the analysis showed the presence of numerous irregular cylindrical-shaped intra-tow voids, which governed the tensile properties. However, the inter-tow voids were small and spherical-shaped, governing the interlaminar shear strength. Therefore, the printed specimens showed exceptional interlaminar shear strength, and the tensile strength had the potential to increase further by improving the impregnation of polymer resin within the fiber.

20.
Polymers (Basel) ; 16(13)2024 Jul 04.
Artículo en Inglés | MEDLINE | ID: mdl-39000768

RESUMEN

Large-format additive manufacturing (LFAM) is used to print large-scale polymer structures. Understanding the thermal and mechanical properties of polymers suitable for large-scale extrusion is needed for design and production capabilities. An in-house-built LFAM printer was used to print polyethylene terephthalate glycol with 30% carbon fiber (PETG CF30%) samples for thermomechanical characterization. Thermogravimetric analysis (TGA) shows that the samples were 30% carbon fiber by weight. X-ray microscopy (XRM) and porosity studies find 25% voids/volume for undried material and 1.63% voids/volume for dry material. Differential scanning calorimetry (DSC) shows a glass transition temperature (Tg) of 66 °C, while dynamic mechanical analysis (DMA) found Tg as 82 °C. The rheology indicated that PETG CF30% is a good printing material at 220-250 °C. Bending experiments show an average of 48.5 MPa for flexure strength, while tensile experiments found an average tensile strength of 25.0 MPa at room temperature. Comparison with 3D-printed PLA and PETG from the literature demonstrated that LFAM-printed PETG CF30% had a comparative high Young's modulus and had similar tensile strength. For design purposes, prints from LFAM should consider both material choice and print parameters, especially when considering large layer heights.

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