RESUMEN
Spectral preprocessing is frequently required to render Raman spectra useful for further processing and analyses. The various preprocessing steps, individually and sequentially, are increasingly being automated to cope with large volumes of data from, for example, hyperspectral imaging studies. Full automation of preprocessing is especially desirable when it produces consistent results and requires minimal user input. It is therefore essential to evaluate the "quality" of such preprocessed spectra. However, relatively few methods exist to evaluate preprocessing quality, and fully automated methods for doing so are virtually non-existent. Here we provide a brief overview of fully automated spectral preprocessing and fully automated quality assessment of preprocessed spectra. We follow this with the introduction of fully automated methods to establish figures-of-merit that encapsulate preprocessing quality. By way of illustration, these quantitative methods are applied to simulated and real Raman spectra. Quality factor and quality parameter figures-of-merit resulting from individual preprocessing step quality tests, as well as overall figures-of-merit, were found to be consistent with the quality of preprocessed spectra.