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INTRODUCTION: Deep neural networks (DNNs) have made significant contributions to diagnosing pneumonia from chest X-ray imaging. However, certain aspects of diagnosis and planning can be further enhanced through the implementation of a quantum deep neural network (QDNN). Therefore, we introduced a technique that integrates neural networks with quantum algorithms named the ZFNet-quantum neural network for detecting pneumonia using 5863 X-ray scans with binary cases. METHODS: The hybrid model efficiently pre-processes complex and high-dimensional data by extracting significant features from the ZFNet model. These significant features are given to the quantum circuit algorithm and further embedded into a quantum device. The parameterized quantum circuit algorithm using qubits, superposition theorem, and entanglement phenomena generates 4 features from 4098 features extracted from images via a deep transfer learning model. Moreover, to validate the outcome measures of the proposed technique, we used various PennyLane quantum devices to detect pneumonia and normal control images. By using the Adam optimizer, which exploits an adaptive learning rate that is fixed to 10-6 and six layers of a quantum circuit composed of quantum gates, the proposed model achieves an accuracy of 96.5%, corresponding to 25 epochs. RESULTS: The integrated ZFNet-quantum learning network outperforms the deep transfer learning network in terms of testing accuracy, as the accuracy gained by the convolutional neural network (CNN) is 94%. Therefore, we use a hybrid classical-quantum model to detect pneumonia in which a variational quantum algorithm enhances the outcomes of a ZFNet transfer learning method. CONCLUSION: This approach is an efficient and automated method for detecting pneumonia and could significantly enhance outcome measures related to the speed and accuracy of the network in the clinical and healthcare sectors.

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This paper addresses the significant problem of identifying the relevant background and contextual literature related to deep learning (DL) as an evolving technology in order to provide a comprehensive analysis of the application of DL to the specific problem of pneumonia detection via chest X-ray (CXR) imaging, which is the most common and cost-effective imaging technique available worldwide for pneumonia diagnosis. This paper in particular addresses the key period associated with COVID-19, 2020-2023, to explain, analyze, and systematically evaluate the limitations of approaches and determine their relative levels of effectiveness. The context in which DL is applied as both an aid to and an automated substitute for existing expert radiography professionals, who often have limited availability, is elaborated in detail. The rationale for the undertaken research is provided, along with a justification of the resources adopted and their relevance. This explanatory text and the subsequent analyses are intended to provide sufficient detail of the problem being addressed, existing solutions, and the limitations of these, ranging in detail from the specific to the more general. Indeed, our analysis and evaluation agree with the generally held view that the use of transformers, specifically, vision transformers (ViTs), is the most promising technique for obtaining further effective results in the area of pneumonia detection using CXR images. However, ViTs require extensive further research to address several limitations, specifically the following: biased CXR datasets, data and code availability, the ease with which a model can be explained, systematic methods of accurate model comparison, the notion of class imbalance in CXR datasets, and the possibility of adversarial attacks, the latter of which remains an area of fundamental research.

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In the domain of AI-driven healthcare, deep learning models have markedly advanced pneumonia diagnosis through X-ray image analysis, thus indicating a significant stride in the efficacy of medical decision systems. This paper presents a novel approach utilizing a deep convolutional neural network that effectively amalgamates the strengths of EfficientNetB0 and DenseNet121, and it is enhanced by a suite of attention mechanisms for refined pneumonia image classification. Leveraging pre-trained models, our network employs multi-head, self-attention modules for meticulous feature extraction from X-ray images. The model's integration and processing efficiency are further augmented by a channel-attention-based feature fusion strategy, one that is complemented by a residual block and an attention-augmented feature enhancement and dynamic pooling strategy. Our used dataset, which comprises a comprehensive collection of chest X-ray images, represents both healthy individuals and those affected by pneumonia, and it serves as the foundation for this research. This study delves deep into the algorithms, architectural details, and operational intricacies of the proposed model. The empirical outcomes of our model are noteworthy, with an exceptional performance marked by an accuracy of 95.19%, a precision of 98.38%, a recall of 93.84%, an F1 score of 96.06%, a specificity of 97.43%, and an AUC of 0.9564 on the test dataset. These results not only affirm the model's high diagnostic accuracy, but also highlight its promising potential for real-world clinical deployment.

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In this paper, we propose an attention-enhanced architecture for improved pneumonia detection in chest X-ray images. A unique attention mechanism is integrated with ResNet to highlight salient features crucial for pneumonia detection. Rigorous evaluation demonstrates that our attention mechanism significantly enhances pneumonia detection accuracy, achieving a satisfactory result of 96% accuracy. To address the issue of imbalanced training samples, we integrate an enhanced focal loss into our architecture. This approach assigns higher weights to minority classes during training, effectively mitigating data imbalance. Our model's performance significantly improves, surpassing that of traditional approaches such as the pretrained ResNet-50 model. Our attention-enhanced architecture thus presents a powerful solution for pneumonia detection in chest X-ray images, achieving an accuracy of 98%. By integrating enhanced focal loss, our approach effectively addresses imbalanced training sample. Comparative analysis underscores the positive impact of our model's spatial and channel attention modules. Overall, our study advances pneumonia detection in medical imaging and underscores the potential of attention-enhanced architectures for improved diagnostic accuracy and patient outcomes. Our findings offer valuable insights into image diagnosis and pneumonia prevention, contributing to future research in medical imaging and machine learning.

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Pneumonia is a disease caused by bacteria, viruses, and fungi that settle in the alveolar sacs of the lungs and can lead to serious health complications in humans. Early detection of pneumonia is necessary for early treatment to manage and cure the disease. Recently, machine learning-based pneumonia detection methods have focused on pneumonia in adults. Machine learning relies on manual feature engineering, whereas deep learning can automatically detect and extract features from data. This study proposes a deep learning feature extraction-based hybrid approach that combines deep learning and machine learning to detect pediatric pneumonia, which is difficult to standardize. The proposed hybrid approach enhances the accuracy of detecting pediatric pneumonia and simplifies the approach by eliminating the requirement for advanced feature extraction. The experiments indicate that the hybrid approach using a Medium Neural Network based on AlexNet feature extraction achieved a 97.9% accuracy rate and 98.0% sensitivity rate. The results show that the proposed approach achieved higher accuracy rates than state-of-the-art approaches.

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A disease is an abnormal condition that negatively impacts the functioning of the human body. Pathology determines the causes behind the disease and identifies its development mechanism and functional consequences. Each disease has different identification methods, including X-ray scans for pneumonia, covid-19, and lung cancer, whereas biopsy and CT-scan can identify the presence of skin cancer and Alzheimer's disease, respectively. Early disease detection leads to effective treatment and avoids abiding complications. Deep learning has provided a vast number of applications in medical sectors resulting in accurate and reliable early disease predictions. These models are utilized in the healthcare industry to provide supplementary assistance to doctors in identifying the presence of diseases. Majorly, these models are trained through secondary data sources since healthcare institutions refrain from sharing patients' private data to ensure confidentiality, which limits the effectiveness of deep learning models due to the requirement of extensive datasets for training to achieve optimal results. Federated learning deals with the data in such a way that it doesn't exploit the privacy of a patient's data. In this work, a wide variety of disease detection models trained through federated learning have been rigorously reviewed. This meta-analysis provides an in-depth review of the federated learning architectures, federated learning types, hyperparameters, dataset utilization details, aggregation techniques, performance measures, and augmentation methods applied in the existing models during the development phase. The review also highlights various open challenges associated with the disease detection models trained through federated learning for future research.

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BACKGROUND:  Pneumonia is an infectious disease that is especially harmful to those with weak immune systems, such as children under the age of 5. While radiologists' diagnosis of pediatric pneumonia on chest radiographs (CXRs) is often accurate, subtle findings can be missed due to the subjective nature of the diagnosis process. Artificial intelligence (AI) techniques, such as convolutional neural networks (CNNs), can help make the process more objective and precise. However, off-the-shelf CNNs may perform poorly if they are not tuned to their appropriate hyperparameters. Our study aimed to identify the CNNs and their hyperparameter combinations (dropout, batch size, and optimizer) that optimize model performance. METHODOLOGY:  Sixty models based on five CNNs (VGG 16, VGG 19, DenseNet 121, DenseNet 169, and InceptionResNet V2) and 12 hyperparameter combinations were tested. Adam, Root Mean Squared Propagation (RmsProp), and Mini-Batch Stochastic Gradient Descent (SGD) optimizers were used. Two batch sizes, 32 and 64, were utilized. A dropout rate of either 0.5 or 0.7 was used in all dropout layers. We used a deidentified CXR dataset of 4200 pneumonia (Figure 1a) and 1600 normal images (Figure 1b). Seventy percent of the CXRs in the dataset were used for training the model, 20% were used for validating the model, and 10% were used for testing the model. All CNNs were trained first on the ImageNet dataset. They were then trained, with frozen weights, on the CXR-containing dataset.  Results: Among the 60 models, VGG-19 (dropout of 0.5, batch size of 32, and Adam optimizer) was the most accurate. This model achieved an accuracy of 87.9%. A dropout of 0.5 consistently gave higher accuracy, area under the receiver operating characteristics curve (AUROC), and area under the precision-recall curve (AUPRC) compared to a dropout of 0.7. The CNNs InceptionResNet V2, DenseNet 169, VGG 16, and VGG 19 significantly outperformed the DenseNet121 CNN in accuracy and AUROC. The Adam and RmsProp optimizer had improved AUROC and AUPRC compared to the SGD optimizer. The batch size had no statistically significant effect on model performance. CONCLUSION:  We recommend using low dropout rates (0.5) and RmsProp or Adam optimizer for pneumonia-detecting CNNs. Additionally, we discourage using the DenseNet121 CNN when other CNNs are available. Finally, the batch size may be set to any value, dependent on computational resources.

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Background: According to the World Health Organization (WHO), pneumonia is the leading infectious cause of death in children below 5 years old. Hence, the early detection of pediatric pneumonia is crucial to reduce its morbidity and mortality rates. Even though chest radiography is the most commonly employed modality for pneumonia detection, recent studies highlight the existence of poor interobserver agreement in the chest X-ray interpretation of healthcare practitioners when it comes to diagnosing pediatric pneumonia. Thus, there is a significant need for automating the detection process to minimize the potential human error. Since Artificial Intelligence tools such as Deep Learning (DL) and Machine Learning (ML) have the potential to automate disease detection, many researchers explored how such tools can be implemented to detect pneumonia in chest X-rays. Notably, the majority of efforts tackled this problem from a DL point of view. However, ML has shown a higher potential for medical interpretability while being less computationally demanding than DL. Objective: The aim of this paper is to automate the early detection process of pediatric pneumonia using ML as it is less computationally demanding than DL. Methods: The proposed approach entails performing data augmentation to balance the classes of the utilized dataset, optimizing the feature extraction scheme, and evaluating the performance of several ML models. Moreover, the performance of this approach is compared to a TL benchmark to evaluate its candidacy. Results: Using the proposed approach, the Quadratic SVM model yielded an accuracy of 97.58%, surpassing the accuracies reported in the current ML literature. In addition, this model classification time was significantly smaller than that of the TL benchmark. Conclusion: The results strongly support the candidacy of the proposed approach in reliably detecting pediatric pneumonia.

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Binary classification and anomaly detection face the problem of class imbalance in data sets. The contribution of this paper is to provide an ensemble model that improves image binary classification by reducing the class imbalance between the minority and majority classes in a data set. The ensemble model is a classifier of real images, synthetic images, and metadata associated with the real images. First, we apply a generative model to synthesize images of the minority class from the real image data set. Secondly, we train the ensemble model jointly with synthesized images of the minority class, real images, and metadata. Finally, we evaluate the model performance using a sensitivity metric to observe the difference in classification resulting from the adjustment of class imbalance. Improving the imbalance of the minority class by adding half the size of the majority class we observe an improvement in the classifier's sensitivity by 12% and 24% for the benchmark pre-trained models of RESNET50 and DENSENet121 respectively.

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Pneumonia is among the common symptoms of the virus that causes COVID-19, which has turned into a worldwide pandemic. It is possible to diagnose pneumonia by examining chest radiographs. Chest x-ray (CXR) is a fast, low-cost, and practical method widely used in this field. The fact that different pathogens other than COVID-19 also cause pneumonia and the radiographic images of all are similar make it difficult to detect the source of the disease. In this study, automatic detection of COVID-19 cases over CXR images was tried to be performed using convolutional neural network (CNN), a deep learning technique. Classifications were carried out using six different architectures on the dataset consisting of 15,153 images of three different types: healthy, COVID-19, and other viral-induced pneumonia. In the classifications performed with five different state-of-art models, ResNet18, GoogLeNet, AlexNet, VGG16, and DenseNet161, and a minimal CNN architecture specific to this study, the most successful result was obtained with the ResNet18 architecture as 99.25% accuracy. Although the minimal CNN model developed for this study has a simpler structure, it was observed that it has a success to compete with more complex models. The performances of the models used in this study were compared with similar studies in the literature and it was revealed that they generally achieved higher success. The model with the highest success was transformed into a test application, tested by 10 volunteer clinicians, and it was concluded that it provides 99.06% accuracy in practical use. This result reveals that the conducted study can play the role of a successful decision support system for experts.

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Pneumonia is one of the main causes of child mortality in the world and has been reported by the World Health Organization (WHO) to be the cause of one-third of child deaths in India. Designing an automated classification system to detect pneumonia has become a worthwhile research topic. Numerous deep learning models have attempted to detect pneumonia by applying convolutional neural networks (CNNs) to X-ray radiographs, as they are essentially images and have achieved great performances. However, they failed to capture higher-order feature information of all objects based on the X-ray images because the topology of the X-ray images' dimensions does not always come with some spatially regular locality properties, which makes defining a spatial kernel filter in X-ray images non-trivial. This paper proposes a principal neighborhood aggregation-based graph convolutional network (PNA-GCN) for pneumonia detection. In PNA-GCN, we propose a new graph-based feature construction utilizing the transfer learning technique to extract features and then construct the graph from images. Then, we propose a graph convolutional network with principal neighborhood aggregation. We integrate multiple aggregation functions in a single layer with degree-scalers to capture more effective information in a single layer to exploit the underlying properties of the graph structure. The experimental results show that PNA-GCN can perform best in the pneumonia detection task on a real-world dataset against the state-of-the-art baseline methods.

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It became apparent that mankind has to learn to live with and adapt to COVID-19, especially because the developed vaccines thus far do not prevent the infection but rather just reduce the severity of the symptoms. The manual classification and diagnosis of COVID-19 pneumonia requires specialized personnel and is time consuming and very costly. On the other hand, automatic diagnosis would allow for real-time diagnosis without human intervention resulting in reduced costs. Therefore, the objective of this research is to propose a novel optimized Deep Learning (DL) approach for the automatic classification and diagnosis of COVID-19 pneumonia using X-ray images. For this purpose, a publicly available dataset of chest X-rays on Kaggle was used in this study. The dataset was developed over three stages in a quest to have a unified COVID-19 entities dataset available for researchers. The dataset consists of 21,165 anterior-to-posterior and posterior-to-anterior chest X-ray images classified as: Normal (48%), COVID-19 (17%), Lung Opacity (28%) and Viral Pneumonia (6%). Data Augmentation was also applied to increase the dataset size to enhance the reliability of results by preventing overfitting. An optimized DL approach is implemented in which chest X-ray images go through a three-stage process. Image Enhancement is performed in the first stage, followed by Data Augmentation stage and in the final stage the results are fed to the Transfer Learning algorithms (AlexNet, GoogleNet, VGG16, VGG19, and DenseNet) where the images are classified and diagnosed. Extensive experiments were performed under various scenarios, which led to achieving the highest classification accuracy of 95.63% through the application of VGG16 transfer learning algorithm on the augmented enhanced dataset with freeze weights. This accuracy was found to be better as compared to the results reported by other methods in the recent literature. Thus, the proposed approach proved superior in performance as compared with that of other similar approaches in the extant literature, and it made a valuable contribution to the body of knowledge. Although the results achieved so far are promising, further work is planned to correlate the results of the proposed approach with clinical observations to further enhance the efficiency and accuracy of COVID-19 diagnosis.

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BACKGROUND AND OBJECTIVES: Pneumonia is a disease that affects the lungs, making breathing difficult. Nowadays, pneumonia is the disease that kills the most children under the age of five in the world, and if no action is taken, pneumonia is estimated to kill 11 million children by the year 2030. Knowing that rapid and accurate diagnosis of pneumonia is a significant factor in reducing mortality, acceleration, or automation of the diagnostic process is highly desirable. The use of computational methods can decrease specialists' workload and even offer a second opinion, increasing the number of accurate diagnostics. METHODS: This work proposes a method for constructing a specific convolutional neural network architecture to detect pneumonia and classify viral and bacterial types using Bayesian optimization from pre-trained networks. RESULTS: The results obtained are promising, in the order of 0.964 accuracy for pneumonia detection and 0.957 accuracy for pneumonia type classification. CONCLUSION: This research demonstrated the efficiency of CNN architecture estimation for detecting and diagnosing pneumonia using Bayesian optimization. The proposed network proved to have promising results, despite not using common preprocessing techniques such as histogram equalization and lung segmentation. This fact shows that the proposed method provides efficient and high-performance neural networks since image preprocessing is unnecessary.

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Coronavirus disease 2019 (COVID-19) is an infectious disease with first symptoms similar to the flu. COVID-19 appeared first in China and very quickly spreads to the rest of the world, causing then the 2019-20 coronavirus pandemic. In many cases, this disease causes pneumonia. Since pulmonary infections can be observed through radiography images, this paper investigates deep learning methods for automatically analyzing query chest X-ray images with the hope to bring precision tools to health professionals towards screening the COVID-19 and diagnosing confirmed patients. In this context, training datasets, deep learning architectures and analysis strategies have been experimented from publicly open sets of chest X-ray images. Tailored deep learning models are proposed to detect pneumonia infection cases, notably viral cases. It is assumed that viral pneumonia cases detected during an epidemic COVID-19 context have a high probability to presume COVID-19 infections. Moreover, easy-to-apply health indicators are proposed for estimating infection status and predicting patient status from the detected pneumonia cases. Experimental results show possibilities of training deep learning models over publicly open sets of chest X-ray images towards screening viral pneumonia. Chest X-ray test images of COVID-19 infected patients are successfully diagnosed through detection models retained for their performances. The efficiency of proposed health indicators is highlighted through simulated scenarios of patients presenting infections and health problems by combining real and synthetic health data.

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Pneumonia is responsible for high infant morbidity and mortality. This disease affects the small air sacs (alveoli) in the lung and requires prompt diagnosis and appropriate treatment. Chest X-rays are one of the most common tests used to detect pneumonia. In this work, we propose a real-time Internet of Things (IoT) system to detect pneumonia in chest X-ray images. The dataset used has 6000 chest X-ray images of children, and three medical specialists performed the validations. In this work, twelve different architectures of Convolutional Neural Networks (CNNs) trained on ImageNet were adapted to operate as the resource extractors. Subsequently, the CNNs were combined with consolidated learning methods, such as k-Nearest Neighbor (kNN), Naive Bayes, Random Forest, Multilayer Perceptron (MLP), and Support Vector Machine (SVM). The results showed that the VGG19 architecture with the SVM classifier using the RBF kernel was the best model to detect pneumonia in these chest radiographs. This combination reached 96.47%, 96.46%, and 96.46% for Accuracy, F1 score, and Precision values, respectively. Compared to other works in the literature, the proposed approach had better results for the metrics used. These results show that this approach for the detection of pneumonia in children using a real-time IoT system is efficient and is, therefore, a potential tool to aid in medical diagnoses. This approach will allow specialists to obtain faster and more accurate results and thus provide the appropriate treatment.

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Pneumonia is a severe health problem causing millions of deaths every year. The aim of this study was to develop an advanced deep learning-based architecture to detect pneumonia using chest X-ray images. We utilized a convolutional neural network (CNN) based on VGG16 architecture consisting of 16 fully connected convolutional layers. A total of 5856 high-resolution frontal view chest X-ray images were used for training, validating, and testing the model. The model achieved an accuracy of 96.6%, sensitivity of 98.1%, specificity of 92.4%, precision of 97.2%, and a F1 Score of 97.6%. This indicates that the model has an excellent performance in classifying pneumonia cases and normal cases. We believe, the proposed model will reduce physician workload, expand the performance of pneumonia screening programs, and improve healthcare service.

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