RESUMEN
OBJECTIVE: The aim: To investigate the prevalence of computer games among student athletes and the impact of computer game addiction on their lifestyle and cognitive functions. PATIENTS AND METHODS: Materials and methods: 125 students (age 17 to 26) took part in the study. Students were divided into groups: e-sportsmen (12 people), who have played for an average of 4,592 hours; athletes of various sports (31 people), who are fond of computer games; athletes (82 people), who do not play computer games. A lifestyle questionnaire and attention research methods based on Landolt rings (E. Landolt) were used. RESULTS: Results: We did not set the task of finding reliable differences between groups, but to find out general tendencies. Athletes, who indicated, that they are fond of computer games, show a lower level of weekly motoric activity compared to athletes, who are not fond of computer games. Cyber-sportsmen demonstrated insufficient physical activity in order to maintain physical fitness and a healthy lifestyle, 17% of cyber-sportsmen did not have any physical activity, that lasted for half an hour or more at any time of the week. Cyber-athletes showed a general tendency towards worsening of indicators of quality of life (sleep duration, insomnia, headaches), deterioration of attention, if compared to the athletes of other sports. CONCLUSION: Conclusions: Studies have shown that students, who combine computer games with a sufficient amount of motoric activity, have a tendency to better con-centration of attention. Studies of the necessary parameters of motoric activity and the alternation of mental, physical activity and rest for e-athletes should be prospective.
Asunto(s)
Calidad de Vida , Juegos de Video , Humanos , Adolescente , Adulto Joven , Adulto , Estudios Prospectivos , Atletas/psicología , Estudiantes , AtenciónRESUMEN
The application of pyriproxyfen (PPF) to drinking water and constant exposure of the whole population to this insecticide is an unprecedented action on a world scale and presents a new and serious challenge for toxicology. The aim of the study was to evaluate the potential effect of PPF on the intestine muscle activity. The experiments were performed on isolated duodenum and jejunum strips of rat, in isometric conditions. Doses of PPF in the range of 0.032-100⯵M were used in the experiments. The obtained results indicate that PPF affected significantly the spontaneous activity of duodenum and jejunum strips, PPF caused the muscle relaxation when used in the concentration of 0.8⯵M and higher. The reaction to acetylcholine (ACh) when PPF preceded or followed ACh application was also reduced. It is demonstrated that the reduction of the contraction caused by ACh was stronger when duodenum strips were preincubated in the presence of PPF solution than in case of ACh-precontracted strips. The first significant reaction of duodenal strips appeared in the presence of PPF in a dose of 0.16⯵M and 0.8⯵M when the insecticide application preceded and followed ACh treatment, respectively. Besides, the duodenum turned out to be much more susceptible to the tested insecticide than jejunum. Taking into account PPF kinetic data obtained in animals, the observed disturbances were caused by the insecticide used in relatively high concentrations. However, the full risk estimation requires the kinetic data obtained in human, especially from monitoring studies on general population after long-term exposure to PPF.
Asunto(s)
Insecticidas/toxicidad , Actividad Motora/efectos de los fármacos , Piridinas/toxicidad , Animales , Humanos , Intestinos , Masculino , Contracción Muscular , Ratas , Pruebas de ToxicidadRESUMEN
The study was aimed at evaluating the effect of Roundup, polyoxyethylene tallow amine (POEA) and mixture of glyphosate and POEA in different levels on the motoric activity of jejunum strips. The incubation in the Roundup solutions caused a significant, mostly miorelaxant, reversible reaction of smooth muscle; only in the highest tested dose which is equivalent to the agricultural concentration (1% corresponding to 1.7g glyphosate/L) there was an irreversible disturbance of the spontaneous contractility and reactivity. The incubation in POEA solutions in the range of low doses (0.256; 1.28; 6.4mg/L) resulted in a biphasic muscle reaction (relaxation and contraction); whereas in the range of high doses, i.e. 32; 160 and 800mg/L (agricultural spray concentrations) induced only a miorelaxant, irreversible response. The results indicate very high toxicity of POEA which exceeds the toxicity of the commercial formulations. Besides, it is postulated that glyphosate and POEA may display antagonistic interaction towards the motoric activity of gastrointestinal tract.
Asunto(s)
Glicina/análogos & derivados , Herbicidas/toxicidad , Yeyuno/efectos de los fármacos , Polietilenglicoles/toxicidad , Animales , Glicina/toxicidad , Yeyuno/fisiología , Masculino , Músculo Liso/efectos de los fármacos , Músculo Liso/fisiología , Ratas Wistar , GlifosatoRESUMEN
Glyphosate is an active substance of the most popular herbicides worldwide. Its common use results from the belief that it affects exclusively plants. However, studies on glyphosate and its trade formulations reveal that it causes numerous morphological, physiological and biochemical disturbances in cells and organisms of animals, including mammals. Due to the fact that shortly after oral exposure glyphosate is detected in the highest amount in small intestine, the aim of this study was to evaluate the effect of this compound on the spontaneous motoric activity of intestine under in vitro conditions. The experiments were conducted on rat jejunum strips under isotonic conditions. The strips were incubated in buffered (pH 7.35) and non-buffered (pH 5.2) glyphosate solutions ranged from 0.003 to 1.7 g/L. The results indicate that glyphosate applied in buffered solution affects significantly the spontaneous motoric activity of rat isolated jejunum strips. The muscle response is biphasic (miorelaxation accompanied by contraction). The contraction is observed already at a dose of 0.003 g/L and the first significant biphasic reaction at a dose of 0.014 g/L. The incubation of jejunum strips with glyphosate in non-buffered solution (pH 5.2) results in a different reaction. The smooth muscle undergoes only persistent relaxation, which is stronger than the response to glyphosate solution in pH 7.35. Motility disturbances are also observed after glyphosate removal from the incubation solution. The gathered data suggests that glyphosate impairs gastrointestinal strips' motility at concentration that are noticed in human exposed to non-toxic doses of glyphosate.