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Memory control (MC) and emotion regulation (ER) are critical cognitive functions for adapting to life's challenges, drawing significant research attention. Accumulating evidence suggests these processes are interrelated, yet a comprehensive discussion of their interplay remains lacking. We introduce an integrative framework exploring the mutual influence between MC and ER, composed of two interrelated branches: first, MC aids in ER through the retrieval of positive memories, intentional forgetting of undesirable content, and the adaptive updating of memory stores. Second, ER impacts MC by upregulating positivity and downregulating negativity in memories. The framework spotlights the need to harness MC-ER interplay for future research. Potential directions include utilizing MC to amplify ER capabilities, training ER skills to refine MC performance, and modulating the cognitive and neural overlapping of both processes to improve both functions. Delving into the MC-ER nexus advances understanding of the intricate emotion-memory relationship and holds great promise for developing novel behavioral interventions.

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The Think/No-Think (TNT) task has just celebrated 20 years since its inception, and its use has been growing as a tool to investigate the mechanisms underlying memory control and its neural underpinnings. Here, we present a theoretical and practical guide for designing, implementing, and running TNT studies. For this purpose, we provide a step-by-step description of the structure of the TNT task, methodological choices that can be made, parameters that can be chosen, instruments available, aspects to be aware of, systematic information about how to run a study and analyze the data. Importantly, we provide a TNT training package (as Supplementary Material), that is, a series of multimedia materials (e.g., tutorial videos, informative HTML pages, MATLAB code to run experiments, questionnaires, scoring sheets, etc.) to complement this method paper and facilitate a deeper understanding of the TNT task, its rationale, and how to set it up in practice. Given the recent discussion about the replication crisis in the behavioral sciences, we hope that this contribution will increase standardization, reliability, and replicability across laboratories.

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Intrusive memories can be downregulated using intentional memory control, as measured via the Think/No-Think paradigm. In this task, participants retrieve or suppress memories in response to an associated reminder cue. After each suppression trial, participants rate whether the association intruded into awareness. Previous research has found that repeatedly exerting intentional control over memory intrusions reduces their frequency. This decrease is often summarised with a linear index, which may miss more complex patterns characterising the temporal dynamics of intrusion control. The goal of this paper is to propose a novel metric of intrusion control that captures those dynamic changes over time as a single index. Results from a mega-analysis of published datasets revealed that the change in intrusion frequencies across time is not purely linear, but also includes non-linear dynamics that seem best captured by a log function of the number of suppression attempts. To capture those linear and non-linear dynamics, we propose the Index of Intrusion Control (IIC), which relies on the integral of intrusion changes across suppression attempts. Simulations revealed that the IIC best captured the linear and non-linear dynamics of intrusion suppression when compared with other linear or non-linear indexes of control, such as the regression slope or Spearman correlation, respectively. Our findings demonstrate how the IIC may therefore act as a more reliable metric to capture individual differences in intrusion control, and examine the role of non-linear dynamics characterizing the conscious access to unwanted memories.

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Structural damage to the hippocampus gives rise to a severe memory deficit for personal experiences known as organic amnesia. Remarkably, such structural damage may not be the only way of creating amnesia; windows of amnesia can also arise when people deliberately disengage from memory via a process known as retrieval suppression. In this review, we discuss how retrieval suppression induces systemic inhibition of the hippocampus, creating "amnesic shadow" intervals in people's memory for their personal experiences. When new memories are encoded or older memories are reactivated during this amnesic shadow, these memories are disrupted, and such disruption even arises when older memories are subliminally cued. Evidence suggests that the systemic inhibition of the hippocampus during retrieval suppression that gives rise to the amnesic shadow may be mediated by engagement of hippocampal GABAergic inhibitory interneurons. Similar amnesic shadow effects are observed during working memory tasks like the n-back, which also induce notable hippocampal downregulation. We discuss our recent proposal that cognitive operations that require the disengagement of memory retrieval, such as retrieval suppression, are capable of mnemonic process inhibition (the inhibition of mnemonic processes such as encoding, consolidation, and retrieval and not simply individual memories). We suggest that people engage mnemonic process inhibition whenever they shift attention from internal processes to demanding perceptual-motor tasks that may otherwise be disrupted by distraction from our inner world. This hitherto unstudied model of inhibition is a missing step in understanding what happens when attentional shifts occur between internally and externally oriented processes to facilitate goal-directed behaviour. This process constitutes an important novel mechanism underlying the forgetting of life events.

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Depression is associated with general sleep disturbance and abnormalities in sleep physiology. For example, compared with control subjects, depressed patients exhibit lower sleep efficiency, longer rapid eye movement (REM) sleep duration, and diminished slow-wave activity during non-REM sleep. A separate literature indicates that depression is also associated with many distinguishing memory characteristics, including emotional memory bias, overgeneral autobiographical memory, and impaired memory suppression. The sleep and memory features that hallmark depression may both contribute to the onset and maintenance of the disorder. Despite our rapidly growing understanding of the intimate relationship between sleep and memory, our comprehension of how sleep and memory interact in the aetiology of depression remains poor. In this narrative review, we consider how the sleep signatures of depression could contribute to the accompanying memory characteristics.

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It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear. Therefore, this study used two samples to explore the neural mechanisms of motivated forgetting of self-referential memories. Every participant provided 40 life events (20 negative and 20 neutral) from their past personal experience, and then completed the Think/No-Think task while undergoing functional magnetic resonance imaging (fMRI). The first sample showed a significant reduction in recall in the No-Think condition relative to the Think condition. Attempting to exclude negative autobiographical memories from awareness was associated with increased activity in the right MFG, superior frontal gyrus (SFG), and inferior frontal gyrus (IFG), while reduced activity was observed in the bilateral Brodmann areas BA18 and BA19, bilateral medial prefrontal cortex (mPFC), bilateral precuneus, bilateral post cingulate cortex (PCC), the left parahippocampus, and the left hippocampus. Functional connectivity analyses showed that the right MFG projected into the bilateral mPFC, bilateral precuneus, and bilateral middle occipital gyrus (MOG) for negative autobiographical memories. The second sample replicated the results of the first sample at both the behavioral and brain levels. These results suggest that retrieval suppression of autobiographical memories involve the pathway between the MFG and the mPFC and precuneus to exclude self-referential memories. These results reveal how people engage in motivated forgetting of negative events in their daily lives.

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Prior studies explored the early development of memory monitoring and control. However, little work has examined cross-cultural similarities and differences in metacognitive development in early childhood. In the present research, we investigated a total of 100 Japanese and German preschool-aged children's memory monitoring and control in a visual perception task. After seeing picture items, some of which were repeated, children were presented with picture pairs, one of which had been presented earlier and the other was a novel item. They then were asked to identify the previously presented picture. Children were also asked to evaluate their confidence about their selection, and to sort the responses to be used for being awarded with a prize at the end of the test. Both groups similarly expressed more confidence in the accurately remembered items than in the inaccurately remembered items, and their sorting decision was based on their subjective confidence. Japanese children's sorting more closely corresponded to memory accuracy than German children's sorting, however. These findings were further confirmed by a hierarchical Bayesian estimation of metacognitive efficiency. The present findings therefore suggest that early memory monitoring and control have both culturally similar and diverse aspects. The findings are discussed in light of broader sociocultural influences on metacognition.

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Retrieval-induced forgetting (RIF) is the phenomenon whereby remembering a subset of learned items can reduce memory for other related items. There are two main explanations for this effect: the competition account and the inhibition account. Most research to date has favoured the inhibition account, though two potential confounds have been identified in the evidence for key predictions of the account: (1) Using binary measures of accuracy may make it difficult to detect correlations between the magnitude of RIF and the increase in recall for practised items that is predicted by the competition account (strength dependence), and (2) typical non-competitive restudy may be too weak a form of practice to elicit detectible RIF effects. The present study aimed to test these contentions by adapting the RIF paradigm to allow a more graded measurement of memory strength and a more active form of non-competitive practice. We trained participants (N = 87) to draw sets of novel shapes from memory, using colour as a category cue and overlaid patterns as individual item recall cues. Responses were graded based on the number of features present and items underwent retrieval practice, copying practice (as a more effective form of restudy), or no practice. The results demonstrated RIF in the retrieval practice condition, but no evidence of RIF in the restudy condition, despite a large memory gain for practised items, supporting the notion of retrieval specificity. There was no evidence of strength dependence in any condition. Our results are consistent with the forgetting in this experiment being driven by inhibition.

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Coherence Therapy is an empirically derived experiential psychotherapy based on Psychological Constructivism. Symptoms are viewed as necessary output from an implicit model of the world. The therapist curates experiences and directs attention toward discovering the model. Rendered explicit, the model is juxtaposed with contradictory knowledge driving memory re-consolidation with resolution of the symptom. The Bayesian Brain views perception and action as inferential processes. Prior beliefs are combined in a generative model to explain the hidden causes of sensations through a process of Active Inference. Prior beliefs that are poor fits to the real world are suboptimal. Suboptimal priors with optimal inference produce Bayes Optimal Pathology with behavioral symptoms. The Active Inference Model of Coherence Therapy posits that Coherence Therapy is a dyadic act of therapist guided Active Inference that renders the (probable) hidden causes of a client's behavior conscious. The therapist's sustained attention on the goal of inference helps to overcome memory control bias against retrieval of the affectively charged suboptimal prior. Serial experiences cue memory retrieval and re-instantiation of the physiological/affective state that necessitates production of the symptom in a particular context. As this process continues there is a break in modularity with assimilation into broader networks of experience. Typically, the symptom produced by optimal inference with the suboptimal prior is experienced as unnecessary/inappropriate when taken out of the particular context. The implicit construct has been re-represented and rendered consciously accessible, by a more complex but more accurate model in which the symptom is necessary in some contexts but not others. There is an experience of agency and control in symptom creation, accompanied by the spontaneous production of context appropriate behavior. The capacity for inference has been restored. The Active Inference Model of Coherence Therapy provides a framework for Coherence Therapy as a computational process which can serve as the basis for new therapeutic interventions and experimental designs integrating biological, cognitive, behavioral, and environmental factors.

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Recent research has shown that providing a cue to selectively forget one subset of previously learned facts may result in specific forgetting of this information. Behavioral evidence suggests that this selective directed forgetting effect relies on executive control and is a direct consequence of active, rather than passive, mechanisms. To date, however, no previous research has addressed the neural underpinnings of selective directed forgetting. Since the lateral prefrontal cortex is thought to mediate motivated forgetting by exerting top-down control over the brain structures that underpin memory representations, the present study aimed to test the hypothesis that selective directed forgetting is prefrontally driven. Specifically, we used transcranial direct current stimulation to disrupt activity in the dorsolateral prefrontal cortex, using a stimulation protocol that has already been shown to be effective in this regard. Our results reveal that, in contrast to sham stimulation, real stimulation abolished selective directed forgetting. Additionally, real stimulation hindered performance in an updating working memory task thought to recruit the lateral prefrontal cortex. These findings, complementing others obtained with a variety of memory control tasks, support the hypothesis that memory downregulation is achieved by control processes mediated by the right lateral prefrontal cortex.

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Although negative life events are a risk factor for developing depression, cognitive control can help maintain one's mental health. However, whether thought-control ability (TCA) can alleviate the adverse effects of negative life events on depression is unclear. Therefore, two studies were conducted to test if it does, by having participant's complete measures of negative life events, TCA, and depression. Study 1, which included 140 healthy young adults, showed TCA mediated the relationship between negative life events and depressive symptoms, and that TCA also moderated the relationship between negative life events and depressive symptoms. Study 2 recruited patients with major depressive disorder (MDD) to test whether the findings could be generalized to individuals with MDD. Study 2 found TCA also mediated the relationship between negative life events and symptoms of MDD. Suggesting that improving the ability to control negative thoughts in daily life help maintain mental health and prevent depressive symptoms.

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Models of posttraumatic stress disorder (PTSD) suggest that the hippocampus is key to the persistence of traumatic memory. Yet very little is known about the precise changes that take place in this structure, nor their relation with PTSD symptoms. Previous studies have mostly used magnetic resonance imaging (MRI) at low resolutions, making it impossible to identify sensitive anatomical landmarks, or compared groups often unequally matched in terms of traumatic exposure. The present cross-sectional study included 92 individuals who had all been exposed to the terrorist attacks in Paris on November 13, 2015 (53 of whom subsequently developed PTSD) and 56 individuals who had not been exposed. Hippocampal subfield volumes were estimated using cross-validated automatic segmentation of high-resolution MRI images. Results revealed changes in CA1 and CA2-3/dentate gyrus (DG) volumes in individuals with PTSD, but not in resilient (i.e., exposed but without PTSD) individuals, after controlling for potential nuisance variables such as previous traumatic exposure and substance abuse. In line with current models of hippocampal subfield functions, CA1 changes were linked to the uncontrollable re-experiencing of intrusive memories, while CA2-3/DG changes, potentially exacerbated by comorbid depression, fostered the overgeneralization of fear linked to avoidance and hypervigilance behaviors. Additional analyses revealed that CA1 integrity was linked to optimum functioning of the memory control network in resilient individuals. These findings shed new light on potential pathophysiological mechanisms in the hippocampus subtending the development of PTSD and the failure to recover from trauma.

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The main aim of this study is to critically evaluate the influence of pressure, working memory and attention on the overall sports performance in the context of the sports sector in China. To fulfill that aim, game or job pressure is studied as an independent variable, sports performance as a dependent variable, while working memory capacity, working memory control and attention act as mediators within this research study. Authentic and first-hand sources of data collection were used for the purposes of this study wherein different online surveys were conducted to study the performance of Chinese athletes. For this purpose, relevant respondents i.e. athletes, coaches, management and related experienced stakeholders were considered for accurate data collection. After this, the confirmatory factor analysis and the structural equation modeling based authentic statistical tests have been performed whose outcomes justified the proposed hypothesis of this research. According to the SEM-based authentic outcomes, the game/ job pressure caused a negative significant impact on working memory capacity, working memory control, attention, and the overall sports performance of Chinese athletes. While, the mediators i.e. working memory capacity, working memory control and attention caused a positive significant impact on the sports performance within the context of this study. Overall, it’s an important source of information for the Chinese sports community, their coaches, trainers, decision-makers and other related ones to utilize its authentic data in their upcoming sports-related activities. Also, upcoming scholars can utilize this authentic data in their own research studies. This research also carries some contextual, theoretical, and methodological gaps that can be overcome by future researchers and scholars(AU)

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BACKGROUND: Memory control (MC) ability is critical for people's mental and physical health. Previous research had conceptually demonstrated that MC ability has close relationship with reappraisal. However, experimental evidence supporting the relationship was limited. Thus, in the present study, we investigated how MC and reappraisal are linked, both in behavior and in the brain. METHODS: The habitual use of reappraisal was assessed by Emotion Regulation Questionnaire, and memory control ability was measured through directed forgetting task. Resting-state functional magnetic resonance imaging was used to test the seed-based functional connectivity in 181 healthy subjects. RESULTS: Behavioral results revealed that more frequent reappraisal was associated with an enhanced ability to control negative memories. Resting-state seed-based functional connectivity showed that habitual use of reappraisal was positively related to the strength of functional connectivity between the right ventrolateral prefrontal cortex (VLPFC) and right insula. Most importantly, this functional connectivity mediated the effect of habitual use of reappraisal on control over negative memories. LIMITATIONS: Present results mainly showed the habitual use of reappraisal was related with MC ability in negative items. Future study could further explore the relationship between MC ability of different categories of negative emotional memories and other kinds of ER strategies. CONCLUSIONS: Our results support the notion that reappraisal provides opportunities for individuals to practice and enhance inhibitory control-a relationship underpinned by connectivity between the right VLPFC and right insula.

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We propose a framework in which top-down inhibitory control networks are impaired by sleep deprivation, giving rise to intrusive thoughts and, consequently, emotion dysregulation. This process leads to a vicious cycle of sleeplessness, persistent unwanted thoughts, and heightened anxiety, ultimately increasing the risk of mental illness.

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Unwanted memories often enter conscious awareness when individuals confront reminders. People vary widely in their talents at suppressing such memory intrusions; however, the factors that govern suppression ability are poorly understood. We tested the hypothesis that successful memory control requires sleep. Following overnight sleep or total sleep deprivation, participants attempted to suppress intrusions of emotionally negative and neutral scenes when confronted with reminders. The sleep-deprived group experienced significantly more intrusions (unsuccessful suppressions) than the sleep group. Deficient control over intrusive thoughts had consequences: Whereas in rested participants suppression reduced behavioral and psychophysiological indices of negative affect for aversive memories, it had no such salutary effect for sleep-deprived participants. Our findings raise the possibility that sleep deprivation disrupts prefrontal control over medial temporal lobe structures that support memory and emotion. These data point to an important role of sleep disturbance in maintaining and exacerbating psychiatric conditions characterized by persistent, unwanted thoughts.

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Cognitive and neurofeedback training (NFT) studies have demonstrated that training-induced alterations of frontal-midline (FM) theta activity (4-8 Hz) transfer to cognitive control processes. Given that FM theta oscillations are assumed to provide top-down control for episodic memory retrieval, especially for source retrieval, that is, accurate recollection of contextual details of prior episodes, the present study investigated whether FM theta NFT transfers to memory control processes. It was assessed (1) whether FM theta NFT improves source retrieval and modulates its underlying EEG characteristics and (2) whether this transfer extends over two posttests. Over seven NFT sessions, the training group who trained individual FM theta activity showed greater FM theta increase than an active control group who trained randomly chosen frequency bands. The training group showed better source retrieval in a posttraining session performed 13 days after NFT and their performance increases from pre- to both posttraining sessions were predicted by NFT theta increases. Thus, training-induced enhancement of memory control processes seems to protect newly formed memories from proactive interference of previously learned information. EEG analyses revealed that during pretest both groups showed source memory specific theta activity at frontal and parietal sites. Surprisingly, training-induced improvements in source retrieval tended to be accompanied by less prestimulus FM theta activity, which was predicted by NFT theta change for the training but not the control group, suggesting a more efficient use of memory control processes after training. The present findings provide unique evidence for the enhancement of memory control processes by FM theta NFT.

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Inhibitory control is crucial for regulating emotions and may also enable memory control. However, evidence for their shared neurobiological correlates is limited. Here, we report meta-analyses of neuroimaging studies on emotion regulation, or memory control and link neural commonalities to transcriptional commonalities using the Allen Human Brain Atlas (AHBA). Based on 95 functional magnetic resonance imaging studies, we reveal a role of the right inferior parietal lobule embedded in a frontal-parietal-insular network during emotion regulation and memory control, which is similarly recruited during response inhibition. These co-activation patterns also overlap with the networks associated with 'inhibition', 'cognitive control' and 'working memory' when consulting the Neurosynth. Using the AHBA, we demonstrate that emotion regulation- and memory control-related brain activity patterns are associated with transcriptional profiles of a specific set of 'inhibition-related' genes. Gene ontology enrichment analysis of these 'inhibition-related' genes reveal associations with the neuronal transmission and risk for major psychiatric disorders as well as seizures and alcoholic dependence. In summary, this study identified a neural network and a set of genes associated with inhibitory control across emotion regulation and memory control. These findings facilitate our understanding of the neurobiological correlates of inhibitory control and may contribute to the development of brain stimulation and pharmacological interventions.

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The causal influence of the dorsolateral prefrontal cortex (DLPFC) in voluntary forgetting remains unclear. Here, we employed repetitive transcranial magnetic stimulation (rTMS) over the right DLPFC to temporarily disrupt function of this brain region and examined its influence on an item-method directed forgetting (DF) task with both neutral and negative emotional memories. Participants were assigned to either an active or a sham rTMS group, in which we administered stimulation for 20 min before the DF task. We then examined the explicit and implicit DF effects with an explicit recognition and an implicit word completion test. We found that while participants in the sham group showed the classic DF effects in both explicit and implicit memory tests, temporally disrupting activity of the right DLPFC selectively reduced the DF effect on explicit recognition, but not on implicit word completion test. Our findings provide novel evidence that the right DLPFC plays a causal role in voluntary forgetting and support the direct inhibition account of voluntary memory control. Intriguingly, preserved implicit DF effects in the active stimulation group suggest that unintentional expressions of unwanted memories may be more sensitive to DF and less dependent on the right DLPFC.

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Directed forgetting in rats, to elucidate active control of memory rehearsal processes while controlling for nonmemorial artifacts, was examined using an eight-arm radial maze. To-be-remembered and to-be-forgotten items were presented at different arms in the same trial. A trial consisted of learning and test phases. Rats needed to remember win or loss of a food pellet presented in the middle of the arms, signaling presence or absence of a large reward there in the subsequent test phase. Two other qualitatively different foods placed at the end of the arms served as remember (R) or forget (F) cues, signaling whether those arms would be presented in the test phase. Compared with the normal test, rats' performance deteriorated significantly if the arms previously marked by F-cues in the preceding learning phase were actually used in the test phase, showing reliable directed forgetting in rats. Rats were also tested in a condition in which F-cues were not presented at all, and thus rats had to remember all the arms. Although positive evidence of reduction of memory load in working memory by utilizing F-cues was not demonstrated, analysis of individual data suggested that utilization of R-cues and F-cues interfered with the main task of remembering win/lose information.

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