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It is increasingly understood that the epilepsies are characterized by network pathology that can span multiple spatial and temporal scales. Recent work indicates that infraslow (<0.2 Hz) envelope correlations may form a basis for distant spatial coupling in the brain. We speculated that infraslow correlation structure may be preserved even with some time lag between signals. To this end, we studied intracranial EEG (icEEG) data collected from 22 medically refractory epilepsy patients. For each patient, we selected hour-long background, awake icEEG epochs before and after antiseizure medication (ASM) taper. For each epoch, we selected 5,000 random electrode contact pairs and estimated magnitude-squared coherence (MSC) below 0.15 Hz of band power time-series in the traditional EEG frequency bands. Using these same contact pairs, we shifted one signal of the pair by random durations in 15-s increments between 0 and 300 s. We aggregated these data across all patients to determine how infraslow MSC varies with duration of lag. We further examined the effect of ASM taper on infraslow correlation structure. We also used surrogate data to empirically characterize MSC estimator and to set optimal parameters for estimation specifically for the study of infraslow activity. Our empirical analysis of the MSC estimator showed that hour-long segments with MSC computed using 3-min windows with 50% overlap was sufficient to capture infraslow envelope correlations while minimizing estimator bias and variance. The mean MSC decreased monotonically with increasing time lag until 105 s of lag, then plateaued between 106 and 300 s. Significantly nonzero infraslow envelope MSC was preserved in all frequency bands until about 1 min of time lag, both pre- and post-ASM taper. We also saw a slight, but significant increase in infraslow MSC post-ASM taper, consistent with prior work. These results provide evidence for the feasibility of examining infraslow activity via its modulation of higher-frequency activity in the absence of DC-coupled recordings. The use of surrogate data also provides a general methodology for benchmarking measures used in network neuroscience studies. Finally, our study points to the clinical relevance of infraslow activity in assessing seizure risk.

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BACKGROUND: The impact of P-wave abnormality in acute anterior MI, where the culprit vessel is the left anterior descending artery, remains undetermined. This study aimed to elucidate the impact of P-wave morphology on clinical outcomes in acute anterior MI. METHODS: Patients undergoing emergent percutaneous coronary intervention for acute anterior MI were enrolled between September 2014 and April 2019 (derivation cohort) and May 2019 through July 2023 (validation cohort). P-wave duration (Pd) and P-wave vector magnitude (Pvm) were measured. The Pvm was calculated as the square root of the sum of the squared P-wave magnitudes in leads II and V6 and one-half of the P-wave amplitude in V2. The patients were categorized into high and low Pd/Pvm groups using a statistically derived cut-off value. The endpoint comprised the composite of heart failure (HF) hospitalization and all-cause death. RESULTS: Consecutive 426 patients were enrolled in this study (derivation cohort, 213 patients; validation cohort, 216 patients). The calculated cut-off value of Pd/Pvm for predicting the clinical endpoint, determined through receiver operating curve analysis, was 793.5 ms/mV (area under the curve [AUC] = 0.85, sensitivity of 73.8 %, and specificity of 94.0 %) in the derivation cohort. Kaplan-Meier analyses revealed a significantly higher risk of the endpoint in patients with high Pd/Pvm than those with low Pd/Pvm in derivation and validation cohorts (Log-rank p < 0.001 and p < 0.001, respectively). Multivariate Cox proportional hazards analysis identified advanced age, elevated Pd/Pvm, and reduced left ventricular ejection fraction as independent and significant factors associated with the endpoint in the validation cohort (p = 0.008, p < 0.001, and p < 0.001, respectively). CONCLUSION: High Pd/Pvm was significantly associated with the composite of HF hospitalization and all-cause death after acute anterior MI.

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In addition to designing certain excitation modulated logic systems, we have created the first-ever genuine molecular 1-bit magnitude comparator, using acid and base guided varied absorption responses at separate channels. Designed and manufactured Bifunctional Bis(indolyl)methane Derivative (1) demonstrates distinct optical responses (in UV-visible and fluorescence mode) to a range of chemical stimuli (acid, base, Hg2+, Cu2+, EDTA, GSH, etc.) in aqueous medium. Intriguingly, the compound's excitation-modulated fluorescence responses appeared to change at different detection channels depending on whether the aforementioned analytes were present or not. We have proposed not only an excitation driven logic system with switchable molecular IMPLICATION and XNOR logic gates, but also a molecular 1-bit magnitude comparator in our proposal. A second excitation driven logic system with switchable molecular COMPLEMENT and NOR logic gates was also designed with two different optical channels and used Hg(II) & Cu(II) as chemical inputs.

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Background: Comorbid anxiety in hypertensive patients yields poor remedy adherence which may additionally restrict treatment choices. Objective: To assess the magnitude and severity of anxiety and risk factors among hypertensive patients attending public hospitals in Arba Minch town, Ethiopia, 2022. Methods: A hospital-based cross-sectional study design was performed from June 1 to July 30/2022. The overall sample size was 336 and a systematic random sampling technique was used to pick out sufferers. Used Epi data version 3.1 for data entry and SPSS version 25 for analysis. Logistic regression analysis was done and variables with p-values less than .25 were taken into multivariable. Statistical significance was declared at a p-value of less than .05 with a 95% confidence interval in the adjusted odds ratio. Result: The magnitude of anxiety among hypertensive patients was 32.1% with 95% CI (26.2%-37.1%). Sex [AOR: 2.25, 95%CI: 1.22-4.13], status of blood pressure [AOR: 0.30, 95%CI: 0.15-0.63], family history of hypertension [AOR: 2.48, 95%CI: 1.20-5.12], family history of mental illness [AOR: 0.19, 95%CI: 0.09-0.39], history of admission [AOR: 5.14, 95%CI: 2.73-9.68], social support status [AOR: 2.96, 95%CI: 1.09-7.97], and current alcohol use [AOR: 0.39, 95%CI: 0.18-0.86] had been notably related. Conclusion: About three in 10 hypertensive patients attending public hospitals in Arba Minch town public hospitals were anxious. Approximately two in 10 hypertensive sufferers had moderate to severe anxiety. Sex, status of blood pressure, family history of hypertension, family history of mental illness, history of admission, social support status, and current alcohol use have been substantially associated with anxiety among hypertensive patients. Therefore, enhancing gender identity, controlling blood pressure, screening and treating a family history of high blood pressure and family history of mental illness, coping with previous admission, improving social help, and cessation of alcohol use might lessen the burden of anxiety among hypertensive sufferers.

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This study investigated whether the electric field magnitude (E-field) delivered to the left dorsolateral prefrontal cortex (L-DLPFC) changes resting-state brain activity and the L-DLPFC resting-state functional connectivity (rsFC), given the variability in tDCS response and lack of understanding of how rsFC changes. Twenty-one healthy participants received either 2 mA anodal or sham tDCS targeting the L-DLPFC for 10 min. Brain imaging was conducted before and after stimulation. The fractional amplitude of low-frequency fluctuation (fALFF), reflecting resting brain activity, and the L-DLPFC rsFC were analyzed to investigate the main effect of tDCS, main effect of time, and interaction effects. The E-field was estimated by modeling tDCS-induced individual electric fields and correlated with fALFF and L-DLPFC rsFC. Anodal tDCS increased fALFF in the left rostral middle frontal area and decreased fALFF in the midline frontal area (FWE p < 0.050), whereas sham induced no changes. Overall rsFC decreased after sham (positive and negative connectivity, p = 0.001 and 0.020, respectively), with modest and nonsignificant changes after anodal tDCS (p = 0.063 and 0.069, respectively). No significant differences in local rsFC were observed among the conditions. Correlations were observed between the E-field and rsFC changes in the L-DLPFC (r = 0.385, p = 0.115), left inferior parietal area (r = 0.495, p = 0.037), and right lateral visual area (r = 0.683, p = 0.002). Single-session tDCS induced resting brain activity changes and may help maintain overall rsFC. The E-field in the L-DLPFC is associated with rsFC changes in both proximal and distally connected brain regions to the L-DLPFC.

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INTRODUCTION: Currently, kidney disease is an increasing major health problem worldwide. It is expected to be the 5th ranked cause of death by 2040. If it is early detected, further complication caused by kidney disease will be minimized. An assessment of impaired glomerular filtration rate (eGFR) has potential aids in early identification and treatment of kidney disease. However, in hospital practice instead of using eGFR, direct measurement of serum creatinine level is used for assessing renal function. Hence, this study is aimed to assess the magnitude and associated factors of impaired glomerular filtration rate among admitted patients in Wolkite University Specialized Teaching Hospital (WKUSTH). OBJECTIVE: To assess the magnitude and associated factors of impaired glomerular filtration rate in WKUSTH, Ethiopia 2023. METHOD: Institutional based cross-sectional study with secondary data was conducted. 338 participants were selected by a convenient sampling technique. Epidata 3.1 version for data entry and SPSS version 20 for data analysis was used. Bivariate analysis was used to screen candidate variables for multivariate analysis. In the multivariate analysis a P-value < 0.05 were considered statistically significant. RESULTS: The study enrolled 338 patients admitted to WUSTH. Seventy (20.7%) (95% CI: 16.6-25.4%) of them had impaired eGFR according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and Modification of Diet in Renal Disease (MDRD-4). older age (AOR 3.38, 95% CI; 1.31, 8.71), hypertension (AOR 17.8, 95% CI; 7.75, 41.22), anemia (AOR 2.51, 95% CI; 1.11, 5.83) DM (AOR 11.2, 95% CI; 4.11, 30.73), and high BMI (AOR 7.56, 95% CI; 3.16, 18.08), were independently associated with impaired eGFR. CONCLUSIONS: The magnitude of impaired eGFR was prevalent among adult patients admitted to WKUSTH medical ward with different medical conditions. Old age, Hypertension, Diabetes, high body mass index, and Anemia were significantly associated with impaired eGFR both in CKD-EPI and MDRD-4 equation. Estimation of GFR for all hospitalized adults with known CKD risk factors might help in early detection of CKD and prevent complications.

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OBJECTIVES: The purposes of this study were (1) to analyze the reliability of direct magnitude estimation (DME) in auditory perceptual assessments measuring dysphonia severity and (2) to analyze the relationship between DME and four acoustic parameters (cepstral peak prominence [CPP], cepstral peak prominence-smoothed [CPPs], Acoustic Voice Quality Index [AVQI], and Acoustic Breathiness Index [ABI]) and (3) to predict dysphonia severity based on DME using four acoustic parameters. STUDY DESIGN: One hundred and sixty-one voice samples for dysphonia patients were used. In this study, we combined sustained vowel samples and connected speech samples using the Praat software to make the concatenated samples for implementing acoustic analysis and auditory perceptual assessments. For acoustic analysis, we analyzed each value of CPP, CPPs, AVQI, and ABI. For auditory perceptual assessments, three speech-language pathologists evaluated dysphonia severity from the concatenated samples. Finally, we performed a stepwise multiple regression analysis to verify which combination of the four acoustic parameters could best predict perceived dysphonia severity based on the DME. RESULTS: DME was found to have high reliability for auditory perceptual assessments measuring dysphonia severity, and there was a significant correlation between DME and four acoustic parameters. Finally, a two-variable model (AVQI and ABI) was useful for predicting perceived dysphonia severity based on the DME. CONCLUSIONS: We verified the usefulness of DME scales in judging the dysphonia severity of dysphonic patients when used with acoustic analysis. Also, the two-variable model was useful to predict perceived dysphonia severity based on the DME.

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Integration of rational number knowledge with prior whole number knowledge has been theorized as critical for mathematical success. Fractions, decimals, and percentages are generally assumed to differ in difficulty based on the degree to which their structure is perceptually similar to whole numbers. Specifically, percentages are viewed as most similar to whole numbers with their fixed unstated denominator of 100. Decimals are often assumed to be easier than fractions because their place-value structure is an extension of the base-ten system for whole numbers, unlike fractions, which have a bipartite structure (i.e., a/b). However, there has been no comprehensive investigation of how fraction, decimal, and percentage knowledge compares with whole number knowledge. To assess understanding of the four notations, we measured within-participants number line estimation of equivalent fractions and decimals with shorter string lengths (e.g., 8/10 and 0.8) and longer string lengths (e.g., 80/100 and 0.80), percentages (e.g., 80%), and proportionally equivalent whole numbers on a 0-100 scale (e.g., 80.0). Middle school students (N = 65; 33 female) generally underestimated all formats relative to their actual values (whole numbers: 3% below; percentages: 2%; decimals: 17%; fractions: 5%). Shorter string-length decimals and fractions were estimated as smaller than equivalent longer string-length equivalents. Overall, percentages were estimated similarly to corresponding whole numbers, fractions had modest string-length effects, and decimals were the most underestimated, especially for single-digit decimals. These results highlight the strengths and weaknesses of children's understanding of each notation's magnitudes and challenge the assumption that decimals are easier than fractions.

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The concept of zero is challenging for many children. This study investigated conceptions of zero in fifth- through seventh-grade children (N = 72) in the United States and examined how children's conceptions of zero related to other aspects of their integer knowledge. At the outset of the study, many participants held a null conception of zero (i.e., zero as "nothing"), and some participants held a conception of zero as the symmetry point between the positive and negative integers. Participants in higher grades were more likely to hold a symmetry conception. We hypothesized that participants' conceptions of zero would be related to other aspects of their integer knowledge. Relative to participants who held a null conception of zero, participants who held a symmetry conception demonstrated greater knowledge of the additive inverse principle (for every number x, there exists an inverse, -x, such that the two numbers sum to zero) and greater integer arithmetic skill. Conceptions of zero were not related to integer magnitude understanding. We also examined whether a brief lesson focusing on zero as the symmetry point would lead to shifts in participants' conceptions of zero and gains in understanding of the additive inverse principle. Participants were randomly assigned to receive a lesson about zero as null or zero as the symmetry point between positive and negative integers. Relative to the lesson about zero as null, the lesson about zero as the symmetry point did not lead to substantial changes in conceptions of zero or additive inverse knowledge.

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Language understanding and mathematics understanding are two fundamental forms of human thinking. Prior research has largely focused on the question of how language shapes mathematical thinking. The current study considers the converse question. Specifically, it investigates whether the magnitude representations that are thought to anchor understanding of number are also recruited to understand the meanings of graded words. These are words that come in scales (e.g., Anger) whose members can be ordered by the degree to which they possess the defining property (e.g., calm, annoyed, angry, furious). Experiment 1 uses the comparison paradigm to find evidence that the distance, ratio, and boundary effects that are taken as evidence of the recruitment of magnitude representations extend from numbers to words. Experiment 2 uses a similarity rating paradigm and multi-dimensional scaling to find converging evidence for these effects in graded word understanding. Experiment 3 evaluates an alternative hypothesis - that these effects for graded words simply reflect the statistical structure of the linguistic environment - by using machine learning models of distributional word semantics: LSA, word2vec, GloVe, counterfitted word vectors, BERT, RoBERTa, and GPT-2. These models fail to show the full pattern of effects observed of humans in Experiment 2, suggesting that more is needed than mere statistics. This research paves the way for further investigations of the role of magnitude representations in sentence and text comprehension, and of the question of whether language understanding and number understanding draw on shared or independent magnitude representations. It also informs the role of machine learning models in cognitive psychology research.

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Organic carbon (C) and CO2 pools are closely interactive in aquatic environments. While there are strong indications linking freshwater CO2 to dissolved organic matter (DOM), the specific mechanisms underlying their common pathways remain unclear. Here, we present an extensive investigation from 20 subtropical lakes in China, establishing a comprehensive conceptual framework for identifying CO2 drivers and retrieving CO2 magnitude through co-trajectories of DOM evolution. Based on this framework, we show that lake CO2 during wet period is constrained by a combination of biogeochemical processes, while photo-mineralization of activated aromatic compounds fuels CO2 during dry period. We clearly determine that biological degradation of DOM governs temporal variations in CO2 rather than terrestrial C inputs within the subtropical lakes. Specifically, our results identify a shared route for the uptake of atmospheric polycyclic aromatic compounds and CO2 by lakes. Using machine learning, in-lake CO2 levels are well modelled through DOM signaling regardless of varying CO2 mechanisms. This study unravels the mechanistic underpinnings of causal links between lake CO2 and DOM, with important implications for understanding obscure aquatic CO2 drivers amidst the ongoing impacts of global climate change.

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Everything in our environment moves through both space and time, and to effectively act we must be aware of both spatial and temporal elements in relation to our own bodies. Thus, perceptions of space and time have an intimate relationship. Walsh's a theory of magnitude (ATOM) suggests that space and time perception rely on a general magnitude system and their relationship should be roughly symmetrical. Alternatively, metaphor theory, which is based on the philosophical work of Lakoff and Johnson, argues that we represent time using a spatial metaphor and thus the relationship should be asymmetrical (with space influencing time more than time influences space). A compelling line of evidence for metaphor theory comes from the work of Casasanto & Boroditsky. Cognition, 106(2), 579-593. (2008) who experimentally demonstrated this asymmetric effect. However, in our previous unpublished online replication attempt of this work, we found a roughly symmetrical relationship between space and time, more in line with the theoretical predictions of ATOM. Given this, we performed a registered replication of Casasanto & Boroditsky. Cognition, 106(2), 579-593. (2008) in both an online and laboratory environment.

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This study investigated the relationship between semantic numerical magnitudes and motor magnitudes. We asked whether the processing of numbers can affect motor behavior such as the size of numbers affecting the size of motor actions. For this, we recorded continuous grip force fluctuations from 43 healthy adults during a symbolic magnitude comparison task. We found that numbers induced spontaneous grip force fluctuations during number processing. Smaller numbers induced lower grip forces, whereas larger numbers induced larger forces. This result constitutes strong behavioral support for a generalized magnitude processing by continuously quantifying the response that challenges binary accounts of cross-domain interactions.

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Delay discounting, the decrease in outcome value as a function of delay to receipt, is an extensive area of research. How delays are framed (i.e., temporal framing), as well as the sign and magnitude of an outcome, produce important effects on the degree to which outcomes are discounted. Here, we examined how recent experience (i.e., order of presentation) modifies these well-known findings. Experiment 1 examined the effects of temporal framing across gains and losses. Regardless of outcome sign, the order of task presentation affected the effect of temporal framing. In particular, when typical delay frames (e.g., 1 week) preceded delays framed as actual dates (e.g., February 15), discounting was less in the date-framed task. However, when dates were followed by the delay frame, there was no difference in the degree of discounting. The experience of date-framed delays persisted or carried over to the delay-framed task. Experiment 2 examined recent experience and the magnitude effect. In particular, $10 and $100 were discounted similarly between-subjects when it was the first task completed. However, once participants completed the second magnitude task, the magnitude effect was present both within-subjects and across subjects. Furthermore, $10 was discounted more steeply when it followed $100, and $100 was discounted less steeply when it followed $10. The impact of recent experience on delay discounting has important implications for understanding mechanisms that may contribute to delay discounting. Recent experience should be considered when designing delay discounting experiments as well as when implementing interventions to reduce steep delay discounting.

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Heart Rate Variability (HRV) refers to the capability of the heart rhythm to vary at different times, typically reflecting the regulation of the heart by the autonomic nervous system. In recent years, with advancements in Electrocardiogram (ECG) signal processing technology, HRV features reflect various aspects of cardiac activity, such as variability in heart rate, cardiac health status, and responses. We extracted key features of HRV and used them to develop and evaluate an automatic recognition model for cardiac diseases. Consequently, we proposed the HRV Heart Disease Recognition (HHDR) method, employing the Spectral Magnitude Quantification (SMQ) technique for feature extraction. Firstly, the HRV signals are extracted through electrocardiogram signal processing. Then, by analyzing parts of the HRV signal within various frequency ranges, the SMQ method extracts rich features of partial information. Finally, the Random Forest (RF) classification computational method is employed to classify the extracted information, achieving efficient and accurate cardiac disease recognition. Experimental results indicate that this method surpasses current technologies in recognizing cardiac diseases, with an average accuracy rate of 95.1% for normal/diseased classification, and an average accuracy of 84.8% in classifying five different disease categories. Thus, the proposed HHDR method effectively utilizes the local information of HRV signals for efficient and accurate cardiac disease recognition, providing strong support for cardiac disease research in the medical field.

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BACKGROUND: Child mortality is one of the key indicators of the Sustainable development goals. The Ethiopian healthcare system in general and Tigray's healthcare system in particular has shown a remarkable progress in terms of reducing maternal, neonatal, and under-five mortality in the last couple of decades. However, the war erupted in November 2020 caused the healthcare system to collapse and little is known about the status of child mortality in Tigray. Thus, this study aimed to examine the magnitude and causes of under-five child mortality in the embattled Tigray region was conducted from October 2020 - May 2022. METHODS: A cross-sectional community-based survey was employed. The study included all zones except the western zone and some areas of eastern and north western Tigray bordering Eritrea. These areas were skipped for security reasons. Based on multistage cluster sampling, 121 tabiyas in districts were selected. Census was conducted to survey 189,087 households in the 121 Tabiyas. A locally developed household screening tool and the latest world health organization verbal autopsy instrument were used. The Verbal Autopsy data was processed using the Inter-VA-5.1 (probabilistic modeling) to assign the cause of death. Under-five mortality rate (U5MR) was calculated per 1000 live births with a 95% confidence interval (CI). RESULTS: In the present study, out of 29,761 live births, 1761 under-five children died giving an under-five mortality rate of 59(95% CI, 57-62) per 1000 live births. Deaths in the neonatal period and post-neonatal period accounted for 60% and 19.9% of the deaths respectively. Overall, the top 3 causes of under-five child mortality in the present study were: Perinatal asphyxia (n = 277,18%,) prematurity (n = 235,16%) and diarrheal diseases (n = 162, 12.5%). In those who died after first month of life, diarrheal diseases, lower respiratory tract infection, sever acute malnutrition and HIV were the main causes of death. Concerning the place of death, 61.6% of the children died at home. CONCLUSION: The present study revealed the doubling of under-five mortality in Tigray from where the figure stood in the pre-war period. The leading causes of death in under-five mortality are potentially preventable in situation where the healthcare system is functioning. Restoring the healthcare system and its apparatus, improving access to skilled institutional delivery, smooth perinatal transition, improving nutrition status of children, access to full course of vaccines could ameliorate the staggering under-five mortality rate in the war in Tigray.

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Background: Hypothermia is characterized by a drop in core body temperature of less than 36°C. It occurs frequently throughout the operating period and affects surgical patient outcomes differently in terms of morbidity and mortality. Because of coagulopathy, metabolic acidosis, multiple organ failure, hemodynamic instability, and infections, a core temperature below 34°C is strongly associated with mortality. Objective: This study aimed to assess the magnitude and associated factors of intraoperative hypothermia in pediatric patients undergoing elective surgery at the Ayder Comprehensive Specialized Hospital. Method: A prospective observational cross-sectional study was conducted on 399 pediatric patients undergoing elective surgery at Ayder Comprehensive Specialized Hospital in Tigray, Ethiopia, from 1 May 2023, to 30 July 2023. Participants in the study were selected by a systematic random sampling technique. The data collection procedure was chart review and intraoperative temperature measurement, and the collected data were analyzed by SPSS version 23. The independent variables were analyzed using binary and multi-logistic regression. The odds ratio, 95% CI, and p value of less than 0.05 were considered statistical significance. Result: The magnitude of intraoperative hypothermia was 52.9%. Neonate and infant [adjusted odds ratio (AOR): 6, 95% CI: 3.7, 9.8], (AOR=4.5, 95% CI: 2.9, 7) respectively, volume of fluid administered greater than half-liter [AOR: 4.37, (95% CI, 3, 6.4)], patients who underwent surgery during the morning [AOR: 5.3, (95% CI: 3.8, 7.4)], and duration of surgery and anesthesia greater than 120 minutes [AOR: 2.7, (95% CI, 1.8, 4)] and (AOR=3.4, 95% CI, 2.4, 4.9], respectively, were factors significantly associated with intraoperative hypothermia. Conclusion and recommendation: This study revealed a high magnitude of intraoperative hypothermia among pediatric patients. Being neonates and infants, having a cold volume of IV fluid administered greater than half a liter, entering surgery during the morning, the duration of surgery, and the anesthesia time were significantly associated with intraoperative hypothermia. The authors would like to advise anesthetists to use warm intravenous fluids, calculate IV fluids, and maintain room temperature.

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PURPOSE: Fluid-sensitive turbo spin echo (TSE) MRI with short-TI inversion-recovery preparation for fat suppression (STIR) plays a critical role in the diagnostics of the musculoskeletal system (e.g., close to metal implants). Potential advantages of 3D acquisitions, however, are difficult to exploit due to long acquisition times. Shortening the TR incurs a signal loss, and a driven-equilibrium (DE) extension reduces fluid signal even further. METHODS: The phase of the flip-back pulse was changed by 180° relative to the conventional implementation (i.e., 90° along the positive x-axis (90°x) instead of -90°x). After signal modeling and numerical simulations, the modification was implemented in STIR-TSE sequences and tested on a clinical 3T system. Imaging was performed in the lumbar spine, and long-TR images without DE were acquired as reference. CSF SNR and fluid-muscle contrast were measured and compared between the sequences. Imaging was repeated in a metal implant phantom. RESULTS: A shortening of TR by 43%-57% reduced the CSF SNR by 39%-59%. A conventional DE module further reduced SNR to 26%-40%, whereas the modified DE recovered SNR to 59%-108% compared with the long-TR acquisitions. Fluid-tissue contrast was increased by about 340% with the modified DE module compared with the conventional extension. Similar results were obtained in implant measurements. CONCLUSIONS: The proposed DE element for TSE-STIR sequences has the potential to accelerate the acquisition of fluid-sensitive images. DE-STIR may work most efficiently for 3D acquisitions, in which no temporo-spatial interleaving of inversion and imaging pulses is possible.

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BACKGROUND: Previous studies have produced conflicting results concerning the extent of magnitude representation deficit and its relationship with arithmetic achievement in children with 22q11.2 deletion syndrome. More specifically, it remains unclear whether deficits are restricted to visuospatial content or are more general and whether they could explain arithmetical impairment. METHODS: Fifteen 5- to 12-year-old children with 22q11.2 deletion syndrome and 23 age-matched healthy controls performed a non-symbolic magnitude comparison task. Depending on the trial, participants had to compare stimuli with high or low visuospatial load (visuospatial stimuli or temporal sequence of visual stimuli). The participants also completed a battery of arithmetic skills (ZAREKI-R) and a battery of global cognitive functioning (WISC-V or WPPSI-IV), from which working memory and visuospatial indices were derived. RESULTS: Children with 22q11.2DS responded as fast as healthy controls did but received fewer correct responses, irrespective of visuospatial load. In addition, their performance in the non-symbolic magnitude comparison task did not correlate with the ZAREKI total score, while the working memory index did. CONCLUSION: Children with 22q11.2DS might suffer from a global magnitude representation deficit rather than a specific deficit due to visuospatial load. However, this deficit alone does not seem to be related to arithmetic achievement. Working memory might be a better concern of interest in favoring arithmetic skills in patients with 22q11.2 deletion syndrome. TRIAL REGISTRATION: Clinicaltrials, NCT04373226 . Registered 16 September 2020.

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Background: Medicines are kept unused at home for many therapeutic reasons. Conversely, unused medication and subsequent wastage can be attributed to several primary factors such as medication change, death, and non-adherence. This study aimed to assess the magnitude and associated factors of unused medication storage practice among households in Jimma City, southwest Ethiopia. Methods: A community-based cross-sectional study design was conducted among households (n = 397) in Jimma Town from July to August 2021. The data were collected using the pre-tested and interviewer-administered questionnaire. SPSS version 21.0 was used for data analysis. The multivariate logistic regression was used to determine the factors associated with the storage of unused medicine at a 5% level of significance. Results: Out of 397 households that responded, (n = 90, 23%) of households were found to have unused medicine at home. This study showed that the majority of households dispose of unused drugs by burning them (32.2%) and burying them in the ground (29%). Antibiotics were the most (6.3%) unused medicines stored while the anti-diabetics (1.3%) were the least unused drugs stored among households. The presence of family members working in the health sector (AOR: 0.402, 95%, CI: 0.202, 0.800) and family size in households (AOR: 2.325, 95%, CI: 1.045, 5.174) were significantly associated with the magnitude of unused medicine storage. Conclusion: The magnitude and improper disposal of unused medicines storage among households were significant in the study area. Therefore, it is important to educate the community and encourage health professionals to understand their role in problems and solutions.