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1.
Artículo en Inglés | MEDLINE | ID: mdl-39145875

RESUMEN

PURPOSE: Laparoscopic cystectomy for ovarian endometriomas and benign ovarian cysts is often conducted through hemostatic methods, with bipolar electrocoagulation as a common approach. This study evaluated the impact of electrocoagulation, primarily through bipolar energy, versus nonthermal hemostatic methods on ovarian reserve in patients undergoing laparoscopic cystectomy for ovarian endometriomas and benign ovarian cysts. METHODS: A systematic review with meta-analysis was conducted by searching the Cochrane Library, PubMed, EMBASE, and Web of Science databases. Randomized controlled trials (RCTs) comparing the impact of nonthermal hemostatic methods and electrocoagulation on the ovarian reserve during laparoscopic cystectomy were included. The Cochrane Risk of Bias Tool for Randomized Controlled Trials (ROB 2.0) was utilized to assess the quality of the included studies. The meta-analysis included 13 RCTs involving 1043 patients. Postoperative serum anti-Müllerian hormone (AMH) levels and antral follicle counts (AFCs) were analyzed using Review Manager ver. 5.4. RESULTS: Compared with the bipolar group, patients with endometriomas in the nonthermal hemostatic group exhibited significantly higher postoperative AMH levels at 1, 3, 6, and 12 months. Conversely, no significant differences in AMH levels were observed in patients with benign ovarian cysts. Similarly, AFCs showed no significant differences, except for lower postoperative AFCs in patients with endometrioma in the electrocoagulation group. CONCLUSION: Nonthermal hemostatic methods are associated with more effective preservation of the ovarian reserve compared with bipolar electrocoagulation in laparoscopic cystectomy for ovarian endometriomas. However, no significant impact of bipolar electrocoagulation on the ovarian reserve was observed in patients with benign ovarian cysts. TRIAL REGISTRATION: Registered in PROSPERO on April 10, 2023; ID # CRD42023413158.

2.
J Menopausal Med ; 29(3): 127-133, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-38230596

RESUMEN

OBJECTIVES: To determine the factors affecting the decline in ovarian reserve following laparoscopic ovarian cystectomy (LOC) in women with ovarian endometriosis. METHODS: This retrospective study included 22 women, aged 25-45 years, with regular menstrual cycles who underwent unilateral LOC and were diagnosed with ovarian endometriosis at a university hospital. Blood samples were collected preoperatively and on the third postoperative day to determine the serum anti-Müllerian hormone (AMH) levels for assessment of the decline in ovarian reserve during the early postoperative period. RESULTS: The preoperative hemoglobin level, white blood cell count, and AMH level were associated with changes in the AMH level after unilateral LOC. Among these parameters, only the preoperative hemoglobin level was correlated with the rate of decline in postoperative AMH levels. The preoperative serum AMH level was correlated with the amount of postoperative AMH change but not with its rate of decline. CONCLUSIONS: Preoperative hemoglobin levels may be associated with the rate of decline in AMH levels in the early postoperative period after unilateral LOC.

3.
J Obstet Gynaecol ; 42(7): 3181-3186, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35950341

RESUMEN

This retrospective, monocentric study quantified hidden blood loss (HBL) and investigated its influencing factors in benign ovarian tumour patients undergoing laparoscopic ovarian cystectomy. Data from 153 patients who underwent laparoscopic ovarian cystectomy were retrospectively reviewed. HBL was calculated using the formula derived from 'Nadler' and 'Cross'. Pearson correlation was carried out to measure the association between HBL and potential risk factors. The average HBL was 280.22 ± 168.42 mL, accounting for 84.13 ± 19.20% of total blood loss (TBL) (347.48 ± 179.05 mL), which was a change of almost fourteen-fold relative to median visible blood loss [20.00 mL (10.00 mL, 57.5 mL)]. Surgical time, number of excisional tumours and preoperative albumin values were risk factors for HBL. HBL represents a large proportion more than 80% of TBL in patients undergoing laparoscopic ovarian cystectomy. Collectively, HBL is helpful for estimating intraoperative blood loss and better guidance of haemostatic agents, which reduces postoperative complications and expedites postoperative recovery. Additionally, the estimation of HBL also contributes to the summary, reflection and improvement of surgical technique.IMPACT STATEMENTWhat is already known on this subject? There has been a growing number of surgical patients with perioperative anaemia, which appears to be inconsistent with measured levels of visible intraoperative blood loss and postoperative drainage. This substantial but easily underestimated blood loss is known as hidden blood loss. To date, no published articles have evaluated HBL and its related risk factors in benign ovarian tumour patients undergoing laparoscopic ovarian cystectomy.What the results of this study add? HBL accounts for a large amount of TBL in laparoscopy for benign ovarian tumours. Surgical time, number of excisional tumours and preoperative albumin values are risk factors for HBL.What the implications are of these findings for clinical practice and/or further research? The management of HBL is important for the administration of perioperative blooding loss. In this context, HBL can be applied to estimate intraoperative blood loss and be better guidance of haemostatic agents to reduce postoperative complications and hasten postoperative rehabilitation. Additionally, the estimation of HBL also contributes to the summary, reflection and improvement of surgical technique.


Asunto(s)
Laparoscopía , Neoplasias Ováricas , Femenino , Humanos , Pérdida de Sangre Quirúrgica , Estudios Retrospectivos , Cistectomía/efectos adversos , Laparoscopía/efectos adversos , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Albúminas , Neoplasias Ováricas/cirugía , Neoplasias Ováricas/etiología
4.
Reprod Biomed Online ; 43(2): 310-318, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34193356

RESUMEN

RESEARCH QUESTION: Is there a difference in the ovarian reserve 1 year post-operatively in those who used a haemostatic sealant or bipolar diathermy for haemostasis during laparoscopic ovarian cystectomy for ovarian endometriomas? DESIGN: This was an extended follow-up observational study of a previous randomized controlled trial where women aged 18 to 40 years with 3-8 cm unilateral or bilateral endometriomas were randomized to receive haemostasis by a haemostatic sealant or bipolar diathermy following ovarian cystectomy. The primary outcome was the ovarian reserve as assessed by antral follicle count (AFC) 1 year post-operatively. Secondary outcomes included the recurrence rate of ovarian endometrioma, the change in anti-Müllerian hormone (AMH) and FSH concentrations, and reproductive outcomes. RESULTS: The significant increase in AFC at 3 months after initial surgery (P = 0.025) in the haemostatic sealant group compared with the diathermy group was sustained at 1 year (P = 0.024) but there was no difference in AMH or FSH concentrations between the groups throughout the follow-up period. The recurrence rate in the FloSeal group was 7.7% (n = 3/39) compared with 22.2% (n = 8/36) in the diathermy group (P = 0.060). The recurrence rate in women who had bilateral lesions was significantly higher than those with unilateral lesions (risk ratio 5.33, interquartile range 1.55-18.38). No difference in reproductive outcomes was found between the two groups. CONCLUSIONS: Applying haemostatic sealant after laparoscopic cystectomy of ovarian endometriomas produces a significantly greater improvement in AFC, which was apparent at 3-month follow-up, and was sustained at 1-year follow-up without compromising the recurrence rate.


Asunto(s)
Diatermia/métodos , Esponja de Gelatina Absorbible/uso terapéutico , Recurrencia Local de Neoplasia , Quistes Ováricos/terapia , Reserva Ovárica , Adolescente , Adulto , Endometriosis/patología , Endometriosis/fisiopatología , Endometriosis/terapia , Femenino , Estudios de Seguimiento , Técnicas Hemostáticas , Hemostáticos/uso terapéutico , Hong Kong , Humanos , Laparoscopía/métodos , Recurrencia Local de Neoplasia/patología , Recurrencia Local de Neoplasia/fisiopatología , Quistes Ováricos/patología , Quistes Ováricos/fisiopatología , Enfermedades del Ovario/patología , Enfermedades del Ovario/fisiopatología , Enfermedades del Ovario/terapia , Reserva Ovárica/efectos de los fármacos , Periodo Posoperatorio , Resultado del Tratamiento , Adulto Joven
5.
Trials ; 22(1): 473, 2021 Jul 21.
Artículo en Inglés | MEDLINE | ID: mdl-34289889

RESUMEN

BACKGROUND: Endometriosis (EMS) can be implanted everywhere, especially in pelvic organs. EMS can be asymptomatic, but it can result in pelvic pain and infertility by inducing local inflammation and pelvic adhesion. The prevalence of EMS is about 10% in reproductive-age women and higher in women with pelvic pain or infertility. For young patients with ovarian EMS, laparoscopic ovarian cystectomy is effective in relieving pelvic pain and preventing local recurrence. However, there is a concern that the ovarian reserve would decrease after the operation because of the removal of a part of the normal ovarian tissue and thermal damage during hemostasis, which depends on the types of hemostasis such as bipolar electrocoagulation, suturing, and the use of a hemostatic agent. In this study, we aim to evaluate the protective effect for the ovarian reserve and hemostasis between a hemostatic agent and suturing during laparoscopic ovarian cystectomy for patients with ovarian EMS. METHODS: This study is a randomized controlled, non-inferiority trial, where a total of 90 patients with ovarian EMS will be randomly assigned to the experimental (hemostatic agent) and control (suturing) groups. In the control group, a barbed suture will be applied for hemostasis, whereas a hemostatic agent will be applied in the experimental group. If two methods are insufficient, bipolar electrocoagulation will be applied for complete hemostasis. As the primary endpoint, the reduction rate of serum anti- Müllerian hormone (AMH) levels reflecting the ovarian reserve will be compared between the two groups 12 weeks after surgery. As secondary endpoints, we will compare the reduction rate of AMH level 48 weeks after surgery, the time required to complete hemostasis, the success rate of hemostasis within 10 min, and adverse events associated with operation. DISCUSSION: We expect that the protective effect for the ovarian reserve and hemostasis may be comparable between the two methods, suggesting that a hemostatic agent may be preferred considering that it is easy to use during laparoscopic ovarian cystectomy. TRIAL REGISTRATION: ClinicalTrials.gov NCT04643106 . Registered on 22 November 2020.


Asunto(s)
Endometriosis , Hemostáticos , Laparoscopía , Reserva Ovárica , Hormona Antimülleriana , Cistectomía , Endometriosis/diagnóstico , Endometriosis/cirugía , Femenino , Hemostasis , Hemostáticos/efectos adversos , Humanos , Laparoscopía/efectos adversos , Recurrencia Local de Neoplasia , Ensayos Clínicos Controlados Aleatorios como Asunto , Suturas
6.
J Pak Med Assoc ; 71(Suppl 9)(12): S8-S11, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35130252

RESUMEN

OBJECTIVE: To study the effects of laparoscopic surgical resection of ovarian endometrioma on ovarian reserve. METHODS: The prospective cohort study was conducted from March 2014 to March 2019 at private clinics and hospitals in the Kerbala province of Iraq, and comprised women aged 19-42 years complaining of chronic pelvic pain, dysmenorrhea and dyspareunia. The measurement of serum anti-Müllerian hormone and follicular stimulating hormone was done preoperatively on the third day of the menstrual cycle. The levels were compared to those at 1 week and then 3 months postoperatively. Data was analysed using SPSS 20. RESULTS: Of the 332 women with a mean age of 31.36±6.28 years, 9(2.7%) had minimal endometriosis, 23(6.9%) mild, 120(36.1%) moderate and 180(54.2%) had severe endometriosis. There was a significant decrease in serum anti-Müllerian hormone level and increase in follicular stimulating hormone level 1 week postoperatively (p<0.0001) and also at 3 months postoperatively (p<0.0001) compared to the baseline. There was a significant difference between the two cut-off points for both the markers (p≤0.001) postoperatively. CONCLUSIONS: Laparoscopic resection of ovarian endometrioma led to decrease in serum anti-Müllerian hormone level at one week postoperatively then there was gradual increase 3 months postoperatively. The increment serum follicular stimulating hormone level continued even three months postoperatively.


Asunto(s)
Endometriosis , Laparoscopía , Quistes Ováricos , Reserva Ovárica , Adulto , Cistectomía , Endometriosis/cirugía , Femenino , Humanos , Quistes Ováricos/cirugía , Estudios Prospectivos , Adulto Joven
7.
BJOG ; 126(10): 1267-1275, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31038276

RESUMEN

OBJECTIVE: To evaluate the effect of haemostatic sealant compared with bipolar coagulation on ovarian reserve after laparoscopic cystectomy for ovarian endometriomas. DESIGN: Patient-blinded, randomised controlled trial. SETTING: University-affiliated tertiary hospital. POPULATION: Women aged 18-40 years with 3-8 cm unilateral or bilateral endometriomas. METHODS: Ninety-four patients were randomised to receive haemostasis by the application of haemostatic sealant (n = 47) or standard care (n = 47). MAIN OUTCOME MEASURES: Primary outcome was the effect on the antral follicular count 3 months after the operation as it captures the effect on the ovary subjected to treatment. Secondary outcomes included the change in anti-Mullerian hormone, follicular-stimulating hormone and peri-operative outcomes including haemostasis, complications, pain, and satisfaction scores. RESULTS: A total of 94 patients aged 32.36 ± 4.92 years underwent laparoscopic cystectomy for ovarian endometriomas. The average diameter of the endometrioma was 4.21 ± 1.38 cm. The increase in antral follicle count of the affected ovaries at 3 months in the intervention group (+2.36 ± 0.37) was significantly (P = 0.013) higher than that in the control group (+1.08 ± 0.36). Repeated measures analysis of variance revealed significant effect with time (P < 0.001) and of interaction of group × time (P = 0.029) for affected ovary antral follicle count. No significant difference was noted between the two groups with regard to follicular-stimulating hormone, anti-Mullerian hormone, and other secondary outcomes. CONCLUSIONS: Applying haemostatic sealant after laparoscopic cystectomy of ovarian endometriomas produced a greater increase in antral follicle count 3 months after surgery compared with the control group. TWEETABLE ABSTRACT: RCT: Haemostatic sealant in laparoscopic cystectomy of endometriomas increase in the antral follicle count after surgery.


Asunto(s)
Cistectomía , Electrocoagulación , Preservación de la Fertilidad/métodos , Hemostasis/efectos de los fármacos , Laparoscopía , Neoplasias Ováricas/cirugía , Teratoma/cirugía , Adhesivos Tisulares/uso terapéutico , Adulto , Femenino , Humanos , Neoplasias Ováricas/patología , Reserva Ovárica , Teratoma/patología , Resultado del Tratamiento , Adulto Joven
8.
Exp Ther Med ; 17(4): 2689-2693, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30906458

RESUMEN

Impact of hemostatic methods, electrocoagulation versus suture, on ovarian reserve and fertility in laparoscopic ovarian cystectomy was investigated. Eighty patients with bilateral ovarian cysts who underwent laparoscopic ovarian cystectomy were randomly divided into 2 groups based on the hemostatic methods: 40 in suture group and another 40 in electrocoagulation group. Blood samples were drawn from all patients at roughly three time points: Before the surgery, 1 month and 6 months after the surgery. Radioimmunoassay was performed to measure the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-Mullerian hormone (AMH). Moreover, the vaginal ultrasound examination was performed to obtain the ovarian size, peak systolic velocity (PSV) of ovarian stromal blood flow, and antral follicle count (AFC). In terms of postoperative ovarian reserve, the levels of E2 and AMH slightly decreased while the FSH level slightly increased in the suture group at both 1 and 6 months after surgery. In the electrocoagulation group, however, the levels of E2 and AMH decreased significantly while the FSH level increased significantly at 1 month after surgery. Six months after surgery, these levels all returned slightly showing some recovery of ovarian reserve. In comparison between the suture group and the electrocoagulation group, the differences in levels of E2, FSH and AMH were all statistically significant at both 1 and 6 months after surgery (P<0.05). Six months after surgery, the differences in AFC and PSV between the suture group and the electrocoagulation group were statistically significant (P<0.05). In laparoscopic ovarian cystectomy, hemostatic electrocoagulation had a more negative impact on ovarian reserve than hemostatic suture. The use of electrocoagulation for hemostasis should be minimized during the operation, and the suture method should be adopted for hemostasis and shaping of the ovarian wound.

9.
Gynecol Endocrinol ; 35(6): 494-497, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30732484

RESUMEN

OBJECTIVE: To investigate temporary or long-term changes of AMH after laparoscopic endometrioma cystectomy and its dependency on characteristics of endometriomas. METHODS: One hundred and seventy-one women, open-labeled prospective study; five groups divided according age ≤/> 35, uni-/bilateral, cyst ≤/> 7 cm, coagulation/suture surgery, stage III/IV; between- and within-group analyses after 1, 3, 6, and 12 months. RESULTS: After 12 months, compared to pretreament, AMH decreased significantly for patients with bilateral cysts, cyst size >7 cm and endometriosis stage IV. In the between-group analysis all comparisons were significant, with exception of the surgery type. However, this was different performing the multiple linear regression analysis suggesting lower postoperative decrease using suturing technique. This analysis also showed higher age at pretreatment and bilateral cysts as risk factor for AMH decline. CONCLUSIONS: Effects of endometrioma cystectomy on AMH are dependent on characteristics of the endometrioma, showing long-term a decrease in patients with larger, bilateral cysts and in stage IV endometriosis, but only short-time decrease in smaller, unilateral cysts and stage III which sometimes also can fully recover in AMH production within one year. In our study suture compared to coagulation surgery was protective, i.e. may lead to lower postoperative AMH decline.


Asunto(s)
Hormona Antimülleriana/sangre , Endometriosis/cirugía , Procedimientos Quirúrgicos Ginecológicos/métodos , Laparoscopía/métodos , Quistes Ováricos/cirugía , Enfermedades del Ovario/cirugía , Adulto , Endometriosis/sangre , Femenino , Humanos , Quistes Ováricos/sangre , Enfermedades del Ovario/sangre , Reserva Ovárica/fisiología
10.
Saudi J Biol Sci ; 24(8): 1771-1775, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29551921

RESUMEN

OBJECTIVE: To investigate the effect of dexmedetomidine at maintenance dose on the postoperative function of elder patients after general anesthesia for laparoscopic ovarian cystectomy. METHODS: We enrolled a total of 96 elder patients who were admitted to this hospital for laparoscopic ovarian cystectomy under general anesthesia between March 2015 and March 2017, and divided them into two groups, Group A (n = 48) and B (n = 48). Patients in both groups received the same methods for anesthesia induction and maintenance drugs. At the beginning of operation, patients in Group A received the intravenous injection of dexmedetomidine (0.8 µg/kg) followed by maintenance dose [0.5 µg/(kg h)] to the end of operation, while those in Group B underwent intravenous injection of 0.9% normal saline at the same rate, during which blood pressure, heart rate, oxyhemoglobin saturation and dosage of anesthetics at T1 (5 min after being delivered into the operation room), T2 (immediately after anesthesia induction), T3 (immediately after intubation), T4 (immediately after operation), T5 (immediately after end of operation) and T6 (immediately after extubation). Then, the levels of NSE, IL-6, CRP and HMGB1 were compared between two groups at 24 h before the operation, at the end, 24 h, 3 d and 7 d after operation. Besides, we also compared the postoperative cognitive functions and incidence of adverse reactions at 1 d before, 1, 2, 3 and 7 d after operation through MOCA scales. RESULTS: At T3, T4 and T6, comparisons of the average arterial pressure and heart rate showed that the differences between the two groups had statistical significance (p < .05). At the end of operation, and at 24 h, 3 d and 7 d after operation, we found that the levels of IL-6 and CRP in patients of two groups were all significantly elevated when compared with those before operation; at the end of operation and at 24 h and 3 d after operation, the levels of IL-6 and CRP in the Group B were higher than those in the Group A, and the differences had statistical significance (p < .05). At the end of operation and at 24 h and 3 d after operation, the levels of NSE and HMGB1 in two group were higher than those before operation, and a more significant elevation was identified in Group B with statistically significant differences (p < .05); at 7 d after operation, a decreasing trend was found in the level of HMGB1, which, however, remained higher than the preoperative level, and the level in Group B was still higher than that in Group A with statistically significant differences (p < .05). At 2 d after operation, we found that the scores of MOCA in the Group B were remarkably decreased in comparison with the scores in Group A with a statistically significant difference (p < .05). Moreover, the incidence rate of postoperative cognitive dysfunction (POCD) in the Group A was significantly lower than that in the Group B, and the difference had statistical significance (p < .05). CONCLUSION: Dexmedetomidine can ameliorate the postoperative cognitive functions of elder patients who received the laparoscopic ovarian cystectomy under general anesthesia, and effectively decrease the incidence rate of POCD without any obvious or severe adverse reaction. Thus, it can serve as a kind of adjuvant drug for general anesthesia in clinical practice.

11.
Taiwan J Obstet Gynecol ; 55(5): 641-645, 2016 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-27751408

RESUMEN

OBJECTIVE: To evaluate the change of ovarian reserve after unilateral laparoscopic ovarian cystectomy (LOC) in the early postoperative period between patients divided according to histologic diagnosis of cyst type. MATERIALS AND METHODS: Sixty-five patients who were undergoing unilateral LOC for benign ovarian disease were included in this study. All participants were divided into three groups according to histologic diagnosis: endometrioma (n=26), mature teratoma (n=24), and other benign cyst (n=15). Serum samples were collected preoperatively and 3-days postoperatively and assayed for antiMüllerian hormone (AMH) levels, and the changes between the two samples were analyzed. RESULTS: Preoperative AMH levels were not significantly different between the three groups. On postoperative Day 3 AMH levels of all three groups were significantly reduced compared with preoperative AMH levels. The rates of decline of AMH levels after LOC in patients with endometrioma (26.37±20.70%) and in those with teratoma (28.25±22.16%) were both significantly higher than those with other benign cyst (12.03±18.56%). No statistically significant differences were found in the rate of decline of AMH levels between patients with endometrioma and teratoma. Decline of AMH after LOC was not significantly correlated with age, body mass index, the size of cyst, or preoperative AMH levels. CONCLUSION: Our results suggest that ovarian reserve is reduced after unilateral LOC in the early postoperative period, and that the postoperative decline of AMH levels after LOC is similar between patients with endometrioma and those with mature teratoma.


Asunto(s)
Hormona Antimülleriana/sangre , Laparoscopía/métodos , Quistes Ováricos/cirugía , Ovariectomía/métodos , Ovario/diagnóstico por imagen , Adolescente , Adulto , Biomarcadores/sangre , Endosonografía/métodos , Femenino , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Quistes Ováricos/sangre , Quistes Ováricos/diagnóstico , Periodo Posoperatorio , Pronóstico , Estudios Prospectivos , Recto , Vagina , Adulto Joven
12.
Artículo en Chino | WPRIM (Pacífico Occidental) | ID: wpr-514135

RESUMEN

Objective To investigate the effects of preoperative anxiety on the recovery of anesthesia and postoperative analgesia in patients undergoing elective laparoscopic ovarian cystectomy.Methods A total of 87 patients were enrolled who were undergoing elective laparoscopic ovarian cystectomy during July 2015 to June 2016.State-Trait Anxiety Inventory-1 was administered to the patients:patients with anxiety were included in the high-anxiety group (Group H) and patients witouth anxiety were included in the low-anxiety group (Group L) We observed the recovery of anesthesia and postoperative analgesia of the patients in two groups.Results In group H,the extubation time,the time for the Aldrete score to reach 9,were significantly longer;more agitation were found;and more fentanyl and parecoxib were needed.The difference was statistically significant (P<0.05).The age,BMI,operation time,anesthesia time of the patients in the two groups had no statistically significant differences (P>0.05).Conclusion High anxiety has a negative effect on recovery from anesthesia and on postoperative pain control in patients undergoing elective laparoscopic ovarian cystectomy.

13.
J Minim Invasive Gynecol ; 22(6): 997-1003, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25960025

RESUMEN

STUDY OBJECTIVE: This study was conducted to determine the changes in ovarian reserve markers after laparoscopic ovarian cystectomy (LOC). DESIGN: Prospective cohort study (Canadian Task Force classification II-2). SETTING: University teaching hospital. PATIENTS: Fifty 50 patients who underwent LOC were prospectively examined to determine the changes in serum markers of ovarian reserve, starting from 1 month before and 3 months after consecutive operations. INTERVENTIONS: Changes in serum markers were compared between the following groups: endometrioma cysts (n = 26) versus nonendometrioma cysts (n = 24), unilateral cystectomy (n = 38) versus bilateral cystectomy (n = 12), and bilateral endometrioma extirpation (n = 10) versus other cystectomy operations (n = 40). MEASUREMENTS AND MAIN RESULTS: A significant change was noticed between the preoperative and postoperative antimüllerian hormone (AMH) levels (2.67 ± 2.67 ng/mL vs 1.84 ± 1.72 ng/mL, p < .0001). Serum AMH levels were found to be significantly decreased in endometrioma (p = .002), nonendometrioma (p = .019), unilateral cystectomy (p = .001), bilateral cystectomy (p = .005), bilateral endometrioma (p = .011), and cysts other than bilateral endometrioma (p = .000) groups. CONCLUSION: The ovarian reserve was found to be diminished after LOC regardless of the presence of endometrioma that could be distinguishable by serum AMH levels.


Asunto(s)
Hormona Antimülleriana/sangre , Quistes/cirugía , Endometriosis/cirugía , Laparoscopía/efectos adversos , Quistes Ováricos/cirugía , Reserva Ovárica , Ovariectomía/efectos adversos , Adulto , Biomarcadores/sangre , Endometriosis/sangre , Femenino , Humanos , Persona de Mediana Edad , Quistes Ováricos/sangre , Periodo Posoperatorio , Estudios Prospectivos
14.
J Obstet Gynaecol ; 34(8): 718-20, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-24922340

RESUMEN

Laparoscopic surgery is the preferred approach in women with ovarian cysts and a low risk of malignancy, and the aim in young women should be to preserve the ovary. We are not aware of any data on the success of conservative surgery in preserving the affected ovary and this is the reason why we decided to investigate the incidence of unplanned oophorectomy, when a woman is originally scheduled for laparoscopic ovarian cystectomy for clinically benign cysts. We reviewed the medical notes of the 123 women who underwent surgery for clinically benign ovarian cysts between November 2004 and May 2012. The operative procedures performed were ovarian cystectomies (n = 119), salpingo-oophorectomy (n = 2) and fenestration (n = 2). In total, 61 women underwent a concomitant procedure. In our study, we found that planned laparoscopic cystectomy was mostly successful, with only 1.6% of patients in our series requiring unplanned oophorectomy.


Asunto(s)
Quistes Ováricos/cirugía , Ovariectomía/estadística & datos numéricos , Adolescente , Adulto , Femenino , Humanos , Laparoscopía , Persona de Mediana Edad , Estudios Retrospectivos , Riesgo , Adulto Joven
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