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Introduction: Mechanical damage significantly reduces the market value of fruits, making the early detection of such damage a critical aspect of agricultural management. This study focuses on the early detection of mechanical damage in blueberries (variety: Sapphire) through a non-destructive method. Methods: The proposed method integrates hyperspectral image fusion with a multi-strategy improved support vector machine (SVM) model. Initially, spectral features and image features were extracted from the hyperspectral information using the successive projections algorithm (SPA) and Grey Level Co-occurrence Matrix (GLCM), respectively. Different models including SVM, RF (Random Forest), and PLS-DA (Partial Least Squares Discriminant Analysis) were developed based on the extracted features. To refine the SVM model, its hyperparameters were optimized using a multi-strategy improved Beluga Whale Optimization (BWO) algorithm. Results: The SVM model, upon optimization with the multi-strategy improved BWO algorithm, demonstrated superior performance, achieving the highest classification accuracy among the models tested. The optimized SVM model achieved a classification accuracy of 95.00% on the test set. Discussion: The integration of hyperspectral image information through feature fusion proved highly efficient for the early detection of bruising in blueberries. However, the effectiveness of this technology is contingent upon specific conditions in the detection environment, such as light intensity and temperature. The high accuracy of the optimized SVM model underscores its potential utility in post-harvest assessment of blueberries for early detection of bruising. Despite these promising results, further studies are needed to validate the model under varying environmental conditions and to explore its applicability to other fruit varieties.

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High-grade serous ovarian cancer has a high degree of malignancy, and at detection, it is prone to infiltration of surrounding soft tissues, as well as metastasis to the peritoneum and lymph nodes, peritoneal seeding, and distant metastasis. Whether recurrence occurs becomes an important reference for surgical planning and treatment methods for this disease. Current recurrence prediction models do not consider the potential pathological relationships between internal tissues of the entire ovary. They use convolutional neural networks to extract local region features for judgment, but the accuracy is low, and the cost is high. To address this issue, this paper proposes a new lightweight deep learning algorithm model for predicting recurrence of high-grade serous ovarian cancer. The model first uses ghost convolution (Ghost Conv) and coordinate attention (CA) to establish ghost counter residual (SCblock) modules to extract local feature information from images. Then, it captures global information and integrates multi-level information through proposed layered fusion Transformer (STblock) modules to enhance interaction between different layers. The Transformer module unfolds the feature map to compute corresponding region blocks, then folds it back to reduce computational cost. Finally, each STblock module fuses deep and shallow layer depth information and incorporates patient's clinical metadata for recurrence prediction. Experimental results show that compared to the mainstream lightweight mobile visual Transformer (MobileViT) network, the proposed slicer visual Transformer (SlicerViT) network improves accuracy, precision, sensitivity, and F1 score, with only 1/6 of the computational cost and half the parameter count. This research confirms that the proposed algorithm model is more accurate and efficient in predicting recurrence of high-grade serous ovarian cancer. In the future, it can serve as an auxiliary diagnostic technique to improve patient survival rates and facilitate the application of the model in embedded devices.

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Named entity recognition is a critical task in the electronic medical record management system for rehabilitation robots. Handwritten documents often contain spelling errors and illegible handwriting, and healthcare professionals frequently use different terminologies. These issues adversely affect the robot's judgment and precise operations. Additionally, the same entity can have different meanings in various contexts, leading to category inconsistencies, which further increase the system's complexity. To address these challenges, a novel medical entity recognition algorithm for Chinese electronic medical records is developed to enhance the processing and understanding capabilities of rehabilitation robots for patient data. This algorithm is based on a fusion classification strategy. Specifically, a preprocessing strategy is proposed according to clinical medical knowledge, which includes redefining entities, removing outliers, and eliminating invalid characters. Subsequently, a medical entity recognition model is developed to identify Chinese electronic medical records, thereby enhancing the data analysis capabilities of rehabilitation robots. To extract semantic information, the ALBERT network is utilized, and BILSTM and MHA networks are combined to capture the dependency relationships between words, overcoming the problem of different meanings for the same entity in different contexts. The CRF network is employed to determine the boundaries of different entities. The research results indicate that the proposed model significantly enhances the recognition accuracy of electronic medical texts by rehabilitation robots, particularly in accurately identifying entities and handling terminology diversity and contextual differences. This model effectively addresses the key challenges faced by rehabilitation robots in processing Chinese electronic medical texts, and holds important theoretical and practical value.

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Verifying the speaker of a speech fragment can be crucial in attributing a crime to a suspect. The question can be addressed given disputed and reference speech material, adopting the recommended and scientifically accepted likelihood ratio framework for reporting evidential strength in court. In forensic practice, usually, auditory and acoustic analyses are performed to carry out such a verification task considering a diversity of features, such as language competence, pronunciation, or other linguistic features. Automated speaker comparison systems can also be used alongside those manual analyses. State-of-the-art automatic speaker comparison systems are based on deep neural networks that take acoustic features as input. Additional information, though, may be obtained from linguistic analysis. In this paper, we aim to answer if, when and how modern acoustic-based systems can be complemented by an authorship technique based on frequent words, within the likelihood ratio framework. We consider three different approaches to derive a combined likelihood ratio: using a support vector machine algorithm, fitting bivariate normal distributions, and passing the score of the acoustic system as additional input to the frequent-word analysis. We apply our method to the forensically relevant dataset FRIDA and the FISHER corpus, and we explore under which conditions fusion is valuable. We evaluate our results in terms of log likelihood ratio cost (Cllr) and equal error rate (EER). We show that fusion can be beneficial, especially in the case of intercepted phone calls with noise in the background.

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By integrating the thermal characteristics from thermal-infrared remote sensing with the physiological and structural information of vegetation revealed by multispectral remote sensing, a more comprehensive assessment of the crop soil-moisture-status response can be achieved. In this study, multispectral and thermal-infrared remote-sensing data, along with soil-moisture-content (SMC) samples (0~20 cm, 20~40 cm, and 40~60 cm soil layers), were collected during the flowering stage of soybean. Data sources included vegetation indices, texture features, texture indices, and thermal-infrared vegetation indices. Spectral parameters with a significant correlation level (p < 0.01) were selected and input into the model as single- and fuse-input variables. Three machine learning methods, eXtreme Gradient Boosting (XGBoost), Random Forest (RF), and Genetic Algorithm-optimized Backpropagation Neural Network (GA-BP), were utilized to construct prediction models for soybean SMC based on the fusion of UAV multispectral and thermal-infrared remote-sensing information. The results indicated that among the single-input variables, the vegetation indices (VIs) derived from multispectral sensors had the optimal accuracy for monitoring SMC in different soil layers under soybean cultivation. The prediction accuracy was the lowest when using single-texture information, while the combination of texture feature values into new texture indices significantly improved the performance of estimating SMC. The fusion of vegetation indices (VIs), texture indices (TIs), and thermal-infrared vegetation indices (TVIs) provided a better prediction of soybean SMC. The optimal prediction model for SMC in different soil layers under soybean cultivation was constructed based on the input combination of VIs + TIs + TVIs, and XGBoost was identified as the preferred method for soybean SMC monitoring and modeling, with its R2 = 0.780, RMSE = 0.437%, and MRE = 1.667% in predicting 0~20 cm SMC. In summary, the fusion of UAV multispectral and thermal-infrared remote-sensing information has good application value in predicting SMC in different soil layers under soybean cultivation. This study can provide technical support for precise management of soybean soil moisture status using the UAV platform.

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Printed Circuit Boards (PCBs) are the foundational component of electronic devices, and the detection of PCB defects is essential for ensuring the quality control of electronic products. Aiming at the problem that the existing PCB plug-in solder defect detection algorithms cannot meet the requirements of high precision, low false alarm rate, and high speed at the same time, this paper proposes a method based on spatial convolution pooling and information fusion. Firstly, on the basis of YOLOv3, an attention-guided pyramid structure is used to fuse context information, and multiple convolutions of different size are used to explore richer high-level semantic information; Secondly, a coordinated attention network structure is introduced to calibrate the fused pyramidal feature information, highlighting the important feature channels, and reducing the adverse impact of redundant parameters generated by feature fusion; Finally, the ASPP (Atrous Spatial Pyramid Pooling) structure is implemented in the original Darknet53 backbone feature extraction network to acquire multi-scale feature information of the detection targets. With these improvements, the average detection accuracy of the enhanced network has been elevated from 94.45 to 96.43%. This experiments shows that the improved network is more suitable for PCB plug-in solder defect detection applications.

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Prediction of Remaining Useful Life (RUL) for Rolling Element Bearings (REB) has attracted widespread attention from academia and industry. However, there are still several bottlenecks, including the effective utilization of multi-sensor data, the interpretability of prediction models, and the prediction across the entire life cycle, which limit prediction accuracy. In view of that, we propose a knowledge-based explainable life-cycle RUL prediction framework. First, considering the feature fusion of fast-changing signals, the Pearson correlation coefficient matrix and feature transformation objective function are incorporated to an Improved Graph Convolutional Autoencoder. Furthermore, to integrate the multi-source signals, a Cascaded Multi-head Self-attention Autoencoder with Characteristic Guidance is proposed to construct health indicators. Then, the whole life cycle of REB is divided into different stages based on the Continuous Gradient Recognition with Outlier Detection. With the development of Measurement-based Correction Life Formula and Bidirectional Recursive Gated Dual Attention Unit, accurate life-cycle RUL prediction is achieved. Data from self-designed test rig and PHM 2012 Prognostic challenge datasets are analyzed with the proposed framework and five existing prediction models. Compared with the strongest prediction model among the five, the proposed framework demonstrates significant improvements. For the data from self-designed test rig, there is a 1.66 % enhancement in Corrected Cumulative Relative Accuracy (CCRA) and a 49.00 % improvement in Coefficient of Determination (R2). For the PHM 2012 datasets, there is a 4.04 % increase in CCRA and a 120.72 % boost in R2.

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Developing a convenient detection method is important for diagnosing and treating obstructive sleep apnea. Considering availability and medical reliability, we established a deep-learning model that uses single-lead electrocardiogram signals for obstructive sleep apnea detection and severity assessment. The detection model consisted of signal preprocessing, feature extraction, time-frequency domain information fusion, and classification segments. A total of 375 patients who underwent polysomnography were included. The single-lead electrocardiogram signals obtained by polysomnography were used to train, validate and test the model. Moreover, the proposed model performance on a public dataset was compared with the findings of previous studies. In the test set, the accuracy of per-segment and per-recording detection were 82.55% and 85.33%, respectively. The accuracy values for mild, moderate and severe obstructive sleep apnea were 69.33%, 74.67% and 85.33%, respectively. In the public dataset, the accuracy of per-segment detection was 91.66%. A Bland-Altman plot revealed the consistency of true apnea-hypopnea index and predicted apnea-hypopnea index. We confirmed the feasibility of single-lead electrocardiogram signals and deep-learning model for obstructive sleep apnea detection and severity evaluation in both hospital and public datasets. The detection performance is high for patients with obstructive sleep apnea, especially those with severe obstructive sleep apnea.

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Network traffic anomaly detection, as an effective analysis method for network security, can identify differentiated traffic information and provide secure operation in complex and changing network environments. To avoid information loss caused when handling traffic data while improving the detection performance of traffic feature information, this paper proposes a multi-information fusion model based on a convolutional neural network and AutoEncoder. The model uses a convolutional neural network to extract features directly from the raw traffic data, and a AutoEncoder to encode the statistical features extracted from the raw traffic data, which are used to supplement the information loss due to cropping. These two features are combined to form a new integrated feature for network traffic, which has the load information from the original traffic data and the global information of the original traffic data obtained from the statistical features, thus providing a complete representation of the information contained in the network traffic and improving the detection performance of the model. The experiments show that the classification accuracy of network traffic anomaly detection using this model outperforms that of classical machine learning methods.

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In complex environments a single visible image is not good enough to perceive the environment, this paper proposes a novel dual-stream real-time detector designed for target detection in extreme environments such as nighttime and fog, which is able to efficiently utilise both visible and infrared images to achieve Fast All-Weatherenvironment sensing (FAWDet). Firstly, in order to allow the network to process information from different modalities simultaneously, this paper expands the state-of-the-art end-to-end detector YOLOv8, the backbone is expanded in parallel as a dual stream. Then, for purpose of avoid information loss in the process of network deepening, a cross-modal feature enhancement module is designed in this study, which enhances each modal feature by cross-modal attention mechanisms, thus effectively avoiding information loss and improving the detection capability of small targets. In addition, for the significant differences between modal features, this paper proposes a three-stage fusion strategy to optimise the feature integration through the fusion of spatial, channel and overall dimensions. It is worth mentioning that the cross-modal feature fusion module adopts an end-to-end training approach. Extensive experiments on two datasets validate that the proposed method achieves state-of-the-art performance in detecting small targets. The cross-modal real-time detector in this study not only demonstrates excellent stability and robust detection performance, but also provides a new solution for target detection techniques in extreme environments.

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The accurate detection of electrical equipment states and faults is crucial for the reliable operation of such equipment and for maintaining the health of the overall power system. The state of power equipment can be effectively monitored through deep learning-based visual inspection methods, which provide essential information for diagnosing and predicting equipment failures. However, there are significant challenges: on the one hand, electrical equipment typically operates in complex environments, thus resulting in captured images that contain environmental noise, which significantly reduces the accuracy of state recognition based on visual perception. This, in turn, affects the comprehensiveness of the power system's situational awareness. On the other hand, visual perception is limited to obtaining the appearance characteristics of the equipment. The lack of logical reasoning makes it difficult for purely visual analysis to conduct a deeper analysis and diagnosis of the complex equipment state. Therefore, to address these two issues, we first designed an image super-resolution reconstruction method based on the Generative Adversarial Network (GAN) to filter environmental noise. Then, the pixel information is analyzed using a deep learning-based method to obtain the spatial feature of the equipment. Finally, by constructing the logic diagram for electrical equipment clusters, we propose an interpretable fault diagnosis method that integrates the spatial features and temporal states of the electrical equipment. To verify the effectiveness of the proposed algorithm, extensive experiments are conducted on six datasets. The results demonstrate that the proposed method can achieve high accuracy in diagnosing electrical equipment faults.

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Motor imagery (MI) stands as a powerful paradigm within Brain-Computer Interface (BCI) research due to its ability to induce changes in brain rhythms detectable through common spatial patterns (CSP). However, the raw feature sets captured often contain redundant and invalid information, potentially hindering CSP performance. Methodology-wise, we propose the Information Fusion for Optimizing Temporal-Frequency Combination Pattern (IFTFCP) algorithm to enhance raw feature optimization. Initially, preprocessed data undergoes simultaneous processing in both time and frequency domains via sliding overlapping time windows and filter banks. Subsequently, we introduce the Pearson-Fisher combinational method along with Discriminant Correlation Analysis (DCA) for joint feature selection and fusion. These steps aim to refine raw electroencephalogram (EEG) features. For precise classification of binary MI problems, an Radial Basis Function (RBF)-kernel Support Vector Machine classifier is trained. To validate the efficacy of IFTFCP and evaluate it against other techniques, we conducted experimental investigations using two EEG datasets. Results indicate a notably superior classification performance, boasting an average accuracy of 78.14% and 85.98% on dataset 1 and dataset 2, which is better than other methods outlined in this article. The study's findings suggest potential benefits for the advancement of MI-based BCI strategies, particularly in the domain of feature fusion.

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Neurodegenerative diseases involve progressive neuronal death. Traditional treatments often struggle due to solubility, bioavailability, and crossing the Blood-Brain Barrier (BBB). Nanoparticles (NPs) in biomedical field are garnering growing attention as neurodegenerative disease drugs (NDDs) carrier to the central nervous system. Here, we introduced computational and experimental analysis. In the computational study, a specific IFPTML technique was used, which combined Information Fusion (IF) + Perturbation Theory (PT) + Machine Learning (ML) to select the most promising Nanoparticle Neuronal Disease Drug Delivery (N2D3) systems. For the application of IFPTML model in the nanoscience, NANO.PTML is used. IF-process was carried out between 4403 NDDs assays and 260 cytotoxicity NP assays conducting a dataset of 500,000 cases. The optimal IFPTML was the Decision Tree (DT) algorithm which shown satisfactory performance with specificity values of 96.4% and 96.2%, and sensitivity values of 79.3% and 75.7% in the training (375k/75%) and validation (125k/25%) set. Moreover, the DT model obtained Area Under Receiver Operating Characteristic (AUROC) scores of 0.97 and 0.96 in the training and validation series, highlighting its effectiveness in classification tasks. In the experimental part, two samples of NPs (Fe3O4_A and Fe3O4_B) were synthesized by thermal decomposition of an iron(III) oleate (FeOl) precursor and structurally characterized by different methods. Additionally, in order to make the as-synthesized hydrophobic NPs (Fe3O4_A and Fe3O4_B) soluble in water the amphiphilic CTAB (Cetyl Trimethyl Ammonium Bromide) molecule was employed. Therefore, to conduct a study with a wider range of NP system variants, an experimental illustrative simulation experiment was performed using the IFPTML-DT model. For this, a set of 500,000 prediction dataset was created. The outcome of this experiment highlighted certain NANO.PTML systems as promising candidates for further investigation. The NANO.PTML approach holds potential to accelerate experimental investigations and offer initial insights into various NP and NDDs compounds, serving as an efficient alternative to time-consuming trial-and-error procedures.

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The museum system is exposed to a high risk of seismic hazards. However, it is difficult to carry out seismic hazard prevention to protect cultural relics in collections due to the lack of real data and diverse types of seismic hazards. To address this problem, we developed a deep-learning-based multi-source feature-fusion method to assess the data on seismic damage caused by collected cultural relics. Firstly, a multi-source data-processing strategy was developed according to the needs of seismic impact analysis of the cultural relics in the collection, and a seismic event-ontology model of cultural relics was constructed. Additionally, a seismic damage data-classification acquisition method and empirical calculation model were designed. Secondly, we proposed a deep learning-based multi-source feature-fusion matching method for cultural relics. By constructing a damage state assessment model of cultural relics using superpixel map convolutional fusion and an automatic data-matching model, the quality and processing efficiency of seismic damage data of the cultural relics in the collection were improved. Finally, we formed a dataset oriented to the seismic damage risk analysis of the cultural relics in the collection. The experimental results show that the accuracy of this method reaches 93.6%, and the accuracy of cultural relics label matching is as high as 82.6% compared with many kinds of earthquake damage state assessment models. This method can provide more accurate and efficient data support, along with a scientific basis for subsequent research on the impact analysis of seismic damage to cultural relics in collections.

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Although the U-shape networks have achieved remarkable performances in many medical image segmentation tasks, they rarely model the sequential relationship of hierarchical layers. This weakness makes it difficult for the current layer to effectively utilize the historical information of the previous layer, leading to unsatisfactory segmentation results for lesions with blurred boundaries and irregular shapes. To solve this problem, we propose a novel dual-path U-Net, dubbed I2U-Net. The newly proposed network encourages historical information re-usage and re-exploration through rich information interaction among the dual paths, allowing deep layers to learn more comprehensive features that contain both low-level detail description and high-level semantic abstraction. Specifically, we introduce a multi-functional information interaction module (MFII), which can model cross-path, cross-layer, and cross-path-and-layer information interactions via a unified design, making the proposed I2U-Net behave similarly to an unfolded RNN and enjoying its advantage of modeling time sequence information. Besides, to further selectively and sensitively integrate the information extracted by the encoder of the dual paths, we propose a holistic information fusion and augmentation module (HIFA), which can efficiently bridge the encoder and the decoder. Extensive experiments on four challenging tasks, including skin lesion, polyp, brain tumor, and abdominal multi-organ segmentation, consistently show that the proposed I2U-Net has superior performance and generalization ability over other state-of-the-art methods. The code is available at https://github.com/duweidai/I2U-Net.

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Dempster-Shafer evidence theory, as a generalization of probability theory, is a powerful tool for dealing with a variety of uncertainties, such as incompleteness, ambiguity, and conflict. Because of its advantages in information fusion compared with traditional probability theory, it is widely used in various fields. However, the classic Dempster's combination rule assumes that evidences are independent of each other, which is difficult to satisfy in real life. Ignoring the dependence among the evidences will lead to unreasonable fusion results, and even wrong conclusions. Considering the limitations of D-S evidence theory, this paper proposed a new evidence fusion model based on principal component analysis (PCA) to deal with the dependence among evidences. First, the approximate independent principal components of each information source were obtained based on principal component analysis. Second, the principal component data set was used as a new information source for evidence theory. Third, the basic belief assignments (BBAs) were constructed. As the fundamental construct of evidence theory, a BBA is a probabilistic function corresponding to each hypothesis, quantifying the belief assigned based on the evidence at hand. This function facilitates the synthesis of disparate evidence sources into a mathematically coherent and unified belief structure. After constructing the BBAs, the BBAs were fused and a conclusion was drawn. The case study verified that the proposed method is more robust than several traditional methods and can deal with redundant information effectively to obtain more stable results.

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Aiming at the shortcomings of single-sensor sensing information characterization ability, which is easily interfered with by external environmental factors, a method of intelligent perception is proposed in this paper. This method integrates multi-source and multi-level information, including spindle temperature field, spindle thermal deformation, operating parameters, and motor current. Firstly, the internal and external thermal-error-related signals of the spindle system are collected by sensors, and the feature parameters are extracted; then, the radial basis function (RBF) neural network is utilized to realize the preliminary integration of the feature parameters because of the advantages of the RBF neural network, which offers strong multi-dimensional solid nonlinear mapping ability and generalization ability. Thermal-error decision values are then generated by a weighted fusion of different pieces of evidence by considering uncertain information from multiple sources. The spindle thermal-error sensing experiment was based on the spindle system of the VMC850 (Yunnan Machine Tool Group Co., LTD, Yunnan, China) vertical machining center of the Yunnan Machine Tool Factory. Experiments were designed for thermal-error sensing of the spindle under constant speed (2000 r/min and 4000 r/min), standard variable speed, and stepped variable speed conditions. The experiment's results show that the prediction accuracy of the intelligent-sensing model with multi-source information fusion can reach 98.1%, 99.3%, 98.6%, and 98.8% under the above working conditions, respectively. The intelligent-perception model proposed in this paper has higher accuracy and lower residual error than the traditional BP neural network perception and wavelet neural network models. The research in this paper provides a theoretical basis for the operation, maintenance management, and performance optimization of machine tool spindle systems.

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Currently, surface EMG signals have a wide range of applications in human-computer interaction systems. However, selecting features for gesture recognition models based on traditional machine learning can be challenging and may not yield satisfactory results. Considering the strong nonlinear generalization ability of neural networks, this paper proposes a two-stream residual network model with an attention mechanism for gesture recognition. One branch processes surface EMG signals, while the other processes hand acceleration signals. Segmented networks are utilized to fully extract the physiological and kinematic features of the hand. To enhance the model's capacity to learn crucial information, we introduce an attention mechanism after global average pooling. This mechanism strengthens relevant features and weakens irrelevant ones. Finally, the deep features obtained from the two branches of learning are fused to further improve the accuracy of multi-gesture recognition. The experiments conducted on the NinaPro DB2 public dataset resulted in a recognition accuracy of 88.25% for 49 gestures. This demonstrates that our network model can effectively capture gesture features, enhancing accuracy and robustness across various gestures. This approach to multi-source information fusion is expected to provide more accurate and real-time commands for exoskeleton robots and myoelectric prosthetic control systems, thereby enhancing the user experience and the naturalness of robot operation.

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The identification of key points in the human body is vital for sports rehabilitation, medical diagnosis, human-computer interaction, and related fields. Currently, depth cameras provide more precise depth information on these crucial points. However, human motion can lead to variations in the positions of these key points. While the Mediapipe algorithm demonstrates effective anti-shake capabilities for these points, its accuracy can be easily affected by changes in lighting conditions. To address these challenges, this study proposes an illumination-adaptive algorithm for detecting human key points through the fusion of multi-source information. By integrating key point data from the depth camera and Mediapipe, an illumination change model is established to simulate environmental lighting variations. Subsequently, the fitting function of the relationship between lighting conditions and adaptive weights is solved to achieve lighting adaptation for human key point detection. Experimental verification and similarity analysis with benchmark data yielded R2 results of 0.96 and 0.93, and cosine similarity results of 0.92 and 0.90. With a threshold range of 8, the joint accuracy rates for the two rehabilitation actions were found to be 89% and 88%. The experimental results demonstrate the stability of the proposed method in detecting key points in the human body under changing illumination conditions, its anti-shake ability for human movement, and its high detection accuracy. This method shows promise for applications in human-computer interaction, sports rehabilitation, and virtual reality.

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Accurate identification of potential drug-target pairs is a crucial step in drug development and drug repositioning, which is characterized by the ability of the drug to bind to and modulate the activity of the target molecule, resulting in the desired therapeutic effect. As machine learning and deep learning technologies advance, an increasing number of models are being engaged for the prediction of drug-target interactions. However, there is still a great challenge to improve the accuracy and efficiency of predicting. In this study, we proposed a deep learning method called Multi-source Information Fusion and Attention Mechanism for Drug-Target Interaction (MIFAM-DTI) to predict drug-target interactions. Firstly, the physicochemical property feature vector and the Molecular ACCess System molecular fingerprint feature vector of a drug were extracted based on its SMILES sequence. The dipeptide composition feature vector and the Evolutionary Scale Modeling -1b feature vector of a target were constructed based on its amino acid sequence information. Secondly, the PCA method was employed to reduce the dimensionality of the four feature vectors, and the adjacency matrices were constructed by calculating the cosine similarity. Thirdly, the two feature vectors of each drug were concatenated and the two adjacency matrices were subjected to a logical OR operation. And then they were fed into a model composed of graph attention network and multi-head self-attention to obtain the final drug feature vectors. With the same method, the final target feature vectors were obtained. Finally, these final feature vectors were concatenated, which served as the input to a fully connected layer, resulting in the prediction output. MIFAM-DTI not only integrated multi-source information to capture the drug and target features more comprehensively, but also utilized the graph attention network and multi-head self-attention to autonomously learn attention weights and more comprehensively capture information in sequence data. Experimental results demonstrated that MIFAM-DTI outperformed state-of-the-art methods in terms of AUC and AUPR. Case study results of coenzymes involved in cellular energy metabolism also demonstrated the effectiveness and practicality of MIFAM-DTI. The source code and experimental data for MIFAM-DTI are available at https://github.com/Search-AB/MIFAM-DTI.