RESUMEN
In recent years, there have been increasing reports of embolism or thrombosis in children with Mycoplasma pneumoniae pneumonia, and in severe cases, it can lead to disability or even endanger life.The coagulation dysfunction and thrombosis caused by Mycoplasma pneumoniae infection affect multiple organs, so it is necessary to pay attention to the early warning role of coagulation related indicators in severe and suspected cases.This article mainly summarizes the progress on coagulation abnormalities and thrombosis caused by Mycoplasma pneumoniae pneumonia both domestically and internationally in recent years.It reviews the coagulation abnormalities and blood related indicators caused by Mycoplasma pneumoniae pneumonia, with the aim of early detection and treatment, preventing related complications, and improving the quality of life in children.
RESUMEN
Protein C (PC) deficiency is an inherited thrombotic disorder with a prevalence of 0.19% among the general population. PC deficiency is associated with an increased risk of thrombosis when other risk factors are present, such as trauma, surgery, or infection, and is an important cause of mechanical valve thrombosis. We performed tricuspid valve replacement with a 29mm Carpentier-Edwards Perimount valve in a 20-year-old man with PC deficiency. The patient had corrected transposition of the great vessels with severe tricuspid insufficiency, as well as a history of cerebral infarction. In the perioperative period, we used only heparin sodium as the anticoagulant. When we restarted administration of warfarin, changing over from heparin, transient increases of serum plasmin inhibitor-plasmin complex (PIC) and thrombin antithrombin complex (TAT) levels were observed. Despite an increased dose of heparin, an appropriate activated partial thromboplastin time (APTT) was not obtained. This suggested a hypercoagulatory state, but the postoperative course was uneventful. Management of perioperative anticoagulation, prevention of late thrombotic events, and prosthetic valve selection in this particular situation are discussed.