RESUMEN
BACKGROUND: Hydrops fetalis (HF) is fluid accumulation in fetus body cavities and subcutaneous tissue. The condition has been described in various farm and companion animal species, including dogs. Most of cases result from a heart defect. Exact nature of this defect is rarely clarified. CASE PRESENTATION: A newborn, male French bulldog puppy with severe HF underwent a full anatomopathological examination to diagnose the primary cause of HF. Based on the anatomopathological examination, fetal ultrasound, and micro-computed tomography, transposition of the great arteries with hypoplasia of the ascending aorta, aortic arch interruption, ostium secundum atrial septal defect, severe tricuspid valve dysplasia, as well as hypoplasia of pulmonary vessels and lungs were diagnosed. CONCLUSIONS: This is the first report of HF caused by severe, complex congenital heart defects with concurrent pulmonary vessel and lung hypoplasia.
Asunto(s)
Enfermedades de los Perros , Cardiopatías Congénitas , Hidropesía Fetal , Pulmón , Microtomografía por Rayos X , Animales , Hidropesía Fetal/veterinaria , Hidropesía Fetal/diagnóstico por imagen , Masculino , Pulmón/diagnóstico por imagen , Pulmón/irrigación sanguínea , Pulmón/patología , Pulmón/anomalías , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/congénito , Enfermedades de los Perros/patología , Perros , Cardiopatías Congénitas/veterinaria , Cardiopatías Congénitas/diagnóstico por imagen , Cardiopatías Congénitas/complicaciones , Microtomografía por Rayos X/veterinaria , Animales Recién NacidosRESUMEN
A 5-year-old healthy pluriparous pregnant Flat-coated Retriever bitch was monitored by ultrasound on post-ovulation days 30 and 57: no deviation from normality picture were observed. On day 60, one of the three most caudal fetuses showed ultrasonographic signs of fetal anasarca: subcutaneous edema and anechoic fluid in thoracic and abdominal cavities. There was an increased volume of extra-fetal fluids. On day 64 a Cesarean section was performed and one of the seven pups that were delivered, a female, showed generalized subcutaneous edema and died soon after birth. She weighed 660 g, compared to a mean of 472 g for the other 6 normal fetuses. A total of 295, 40 and 27.5 mL of liquid were collected from subcutaneous tissue, abdominal and thoracic cavity, respectively. Liver showed sub-glissonian necrotic areas. Molecular analyses with PCR method for canine Herpesvirus, Parvovirus, Adenovirus, Leptospira interrogans, Chlamydia spp., Neospora caninum and Toxoplasma gondii from pools of organs (spleen, kidney and brain) and pleural effusion tested negative. This is the first reported case of fetal anasarca with a rapid onset diagnosed on day 60 post-ovulation just three days after observing a normal ultrasonographic pattern in Flat-coated Retriever. Ultrasonographic diagnosis of fetal anasarca is of primary importance when assisting parturition, due to its inherent risk of dystocia. Ultrasonographic monitoring in the immediate prepartum period may be useful in all breeds as it may help to detect ultrasonographic alterations occurring right before term such as anasarca.
Asunto(s)
Enfermedades de los Perros , Infecciones por Parvoviridae , Animales , Cesárea/efectos adversos , Cesárea/veterinaria , Enfermedades de los Perros/diagnóstico por imagen , Perros , Edema/complicaciones , Edema/diagnóstico por imagen , Edema/veterinaria , Femenino , Feto/diagnóstico por imagen , Infecciones por Parvoviridae/veterinaria , Embarazo , UltrasonografíaRESUMEN
We report a case of intrauterine premature closure of the ductus arteriosus diagnosed in an anasarca fetus associated with major heart failure following mother's ingestion of non-steroidal anti-inflammatory drugs (NSAID). Second trimester obstetric ultrasound allowed detection of an asymmetry of the cardiac chambers. Caesarean section was perfomed at 30 weeks of pregnancy to remove anasarca fetus with major heart failure due to prenatal closure of the ductus arteriosus. Based upon this case, we conducted a literature review to highlight potential fetal and neonatal complications resulting from early closure of the ductus arteriosus secondary to NSAID use during pregnancy.