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BACKGROUND: Eclampsia and pre-eclampsia rank as the third leading causes of maternal death in Ecuador, following pre-existing chronic diseases and postpartum haemorrhage, as reported by the Ecuadorian National Institute of Statistics and Census (INEC). In contrast, HELLP (Haemolysis, Elevated Liver enzymes, Low Platelet count) syndrome remains underexplored epidemiologically, not only in Latin America but globally. This study marks the first population-based investigation into HELLP syndrome incidence and mortality in Ecuador, examining geographical variations, altitude influences and ethnic backgrounds. METHODS: Conducted as a retrospective population-based cohort study from 2015 to 2017, this research delves into the incidence, risk factors and maternal mortality associated with HELLP syndrome in Ecuador. Utilising data from INEC and the Ecuadorian Ministry of Health, we identified HELLP syndrome cases through ICD-10 (International Classification of Diseases, tenth revision) coding in hospitalised individuals. Logistic regression analysis was employed to explore association, whilst geospatial statistical analysis focused on cantons to identify significant spatial clusters. Primary outcome measures include HELLP syndrome incidence and maternal mortality, supplying crucial insights into the syndrome's impact on maternal health in Ecuador. RESULTS: The incidence of HELLP syndrome is 0.76 (0.69-0.84)/ 1000 deliveries. Afro-Ecuadorian communities have a higher risk (Odds Ratio (OR) = 2.18 (1.03-4.63)) compared to Indigenous Ecuadorian communities. Living at mid-level or high altitude is a significant risk factor OR of 2.79 (2.19-3.55) and an OR 3.61 (2.58-5.03), respectively. Being an older mother was also identified as a risk factor. Women living more than 20 km from the obstetric unit have an OR of 2.55 (2.05-3.18). Moreover, we found that cantons with higher crude HELLP syndrome incidence also have lower numbers of physicians (R = 0.503, p-value < 0.001). The mortality incidence of women with HELLP syndrome is 21.22 (12.05-20.59)/1000 deliveries with HELLP syndrome diagnoses. CONCLUSIONS: High altitude, advanced maternal age and geographical distance between residence and health centres are risk factors for HELLP syndrome. Maternal mortality in women with HELLP syndrome is higher than pre-eclampsia and eclampsia but comparable with previous reports in other countries.

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Introducción: los trastornos mentales comunes pueden tener un impacto significativo en la vida de los indígenas, pueden provocar discapacidad, disminución de la productividad y aumento de la mortalidad. Objetivo: determinar la prevalencia de trastornos mentales comunes en indígenas de cinco departamentos de Paraguay durante el 2022. Metodología: se realizó un estudio observacional, descriptivo de corte transversal en indígenas residentes en los departamentos de Alto Paraguay, Boquerón, Concepción, Caaguazú, Presidente Hayes de Paraguay. Para la recolección de datos se utilizó el Self Reporting Questionnaire (SRQ-20). Este instrumento constó de 20 preguntas de tipo sí/no correspondientes al mes anterior a la entrevista. Resultados: participaron del estudio 779, indígenas de entre 18 a 69 años de edad. El alfa de Cronbach fue de 0,89, la medida de Kaiser-Meyers-Olkin fue 0,88. El SRQ+ fue del 25,80 % (201), el 14,51 % (113) tuvo síntomas de depresión, el 16,17 % (126) tuvo síntomas de ansiedad, y el 12,58 % (98) tuvo síntomas de psicosis. Conclusión: se encontró una alta prevalencia de trastornos mentales comunes, de acuerdo al Self Reporting Questionnaire, siendo el más frecuente al psicosis. Estos hallazgos subrayan la necesidad de mejorar el acceso a los servicios de salud mental para los indígenas de Paraguay.

Introduction: common mental disorders can have a significant impact on the lives of indigenous people, leading to disability, decreased productivity, and increased mortality. Objective: to determine the prevalence of common mental disorders in indigenous people from five departments of Paraguay in 2022. Methods: a cross-sectional, descriptive observational study was conducted in indigenous people residing in the departments of Alto Paraguay, Boquerón, Concepción, Caaguazú, and Presidente Hayes, Paraguay. Data were collected using the Self Reporting Questionnaire (SRQ-20). This instrument consisted of 20 yes/no questions pertaining to the month prior to the interview. Results: a total of 779 indigenous people aged 18-69 years participated in the study. The Cronbach's alpha was 0.89, and the Kaiser-Meyers-Olkin measure was 0.88. The SRQ+ was 25.80 % (201), 14.51 % (113) had symptoms of depression, 16.17 % (126) had symptoms of anxiety, and 12.58 % (98) had symptoms of psychosis. Conclusion: a high prevalence of common mental disorders was found, according to the SRQ, with psychosis being the most common. These findings underscore the need to improve access to mental health services for indigenous people in Paraguay.

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Introduction: Gastric cancer is one of the most prevalent types of cancer worldwide. The World Health Organization (WHO), the International Agency for Research on Cancer (IARC), and the Global Cancer Statistics (GLOBOCAN) reported an age standardized global incidence rate of 9.2 per 100,000 individuals for gastric cancer in 2022, with a mortality rate of 6.1. Despite considerable progress in precision oncology through the efforts of international consortia, understanding the genomic features and their influence on the effectiveness of anti-cancer treatments across diverse ethnic groups remains essential. Methods: Our study aimed to address this need by conducting integrated in silico analyses to identify actionable genomic alterations in gastric cancer driver genes, assess their impact using deleteriousness scores, and determine allele frequencies across nine global populations: European Finnish, European non-Finnish, Latino, East Asian, South Asian, African, Middle Eastern, Ashkenazi Jewish, and Amish. Furthermore, our goal was to prioritize targeted therapeutic strategies based on pharmacogenomics clinical guidelines, in silico drug prescriptions, and clinical trial data. Results: Our comprehensive analysis examined 275,634 variants within 60 gastric cancer driver genes from 730,947 exome sequences and 76,215 whole-genome sequences from unrelated individuals, identifying 13,542 annotated and predicted oncogenic variants. We prioritized the most prevalent and deleterious oncogenic variants for subsequent pharmacogenomics testing. Additionally, we discovered actionable genomic alterations in the ARID1A, ATM, BCOR, ERBB2, ERBB3, CDKN2A, KIT, PIK3CA, PTEN, NTRK3, TP53, and CDKN2A genes that could enhance the efficacy of anti-cancer therapies, as suggested by in silico drug prescription analyses, reviews of current pharmacogenomics clinical guidelines, and evaluations of phase III and IV clinical trials targeting gastric cancer driver proteins. Discussion: These findings underline the urgency of consolidating efforts to devise effective prevention measures, invest in genomic profiling for underrepresented populations, and ensure the inclusion of ethnic minorities in future clinical trials and cancer research in developed countries.

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Resumo Os quilombolas são grupos étnico-raciais de ancestralidade negra e tiveram seus territórios consolidados no Brasil em regiões com acesso difícil e distante dos grandes centros. O objetivo desse estudo é conhecer o itinerário terapêutico (IT) adotado por mulheres quilombolas em comunidades tradicionais localizadas no norte do estado de Minas Gerais. Trata-se de um estudo com abordagem qualitativa com o modelo teórico utilizando o sistema de cuidados à saúde de Arthur Kleinman. O estudo se deu em 23 comunidades quilombolas do norte de Minas Gerais. Foram entrevistadas 40 mulheres quilombolas, com idades entre 25 e 89 anos. A análise dos dados foi realizada seguindo os IT. Emergiram unidades de análise que foram agrupadas em três categorias: as mulheres quilombolas e o significado da saúde e do cuidado; o sistema de cuidado profissional nas comunidades quilombolas; e itinerário de cuidados nas situações vivenciadas pelas mulheres. O itinerário terapêutico das comunidades se mostra relacionado principalmente às ações de medicina popular. Foi possível observar ainda que existem fragilidades em relação à atenção à saúde devido a fatores como dificuldade de acesso aos serviços institucionalizados.

Abstract Quilombolas are ethnic-racial groups, of black ancestry, and had their territories consolidated in Brazil in regions with difficult access and far from large centers. The objective of this study is to know the therapeutic itinerary (IT) adopted by quilombola women in traditional communities located in the North of the state of Minas Gerais. This is a qualitative study with the theoretical model using the Arthur Kleinman health care system. The study scenario was 23 quilombola communities in northern Minas Gerais. Forty quilombola women aged between 25 and 89 years were interviewed. Data analysis was performed following the IT. Units of analysis emerged that were grouped into three categories: quilombola women and the meaning of health and care; the professional care system in quilombola communities; and route of care in situations experienced by women. The therapeutic itinerary of the communities is mainly related to the actions of popular medicine. It was also possible to observe that there are weaknesses in relation to health care due to factors such as difficulty of access to institutionalized services.

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Objetivo Este artigo tem como objetivo discutir a abordagem da psicologia indígena no cuidado de estudantes indígenas em contexto universitário. Método Utilizando o método qualitativo, este artigo apresenta um estudo de caso detalhando a trajetória de formação da Rede de Escuta e Desaprendizagens Étnico-Subjetivas, para analisar a aplicação dos pressupostos da psicologia indígena no suporte a estudantes indígenas e seus familiares na Universidade Estadual de Campinas. Resultados Evidenciou-se a necessidade de reconhecer diferentes epistemologias para uma conexão terapêutica respeitosa. Foram observados desafios na aplicação de práticas alinhadas com a psicologia indígena, destacando a coautoria nas sessões, a valorização das perspectivas dos pacientes e as desaprendizagens contínuas. O estudo dos elementos culturais das etnias envolvidas mostrou-se crucial para evitar a patologização das cosmovisões e subjetividades indígenas. Conclusão A psicologia indígena apresenta-se como um vetor de mudança nas disputas de narrativas culturais, destacando a lacuna na abordagem clínica e a necessidade urgente de estudos para desenvolver intervenções personalizadas para o atendimento das diferentes etnias indígenas.

Objective This article aims to discuss the approach of indigenous psychology in the care of indigenous students in a university framework. Method Using a qualitative method, this article presents a case study detailing the formation trajectory of the Rede de Escuta e Desaprendizagens Étnico-Subjetivas (Network of Ethno-Subjective Listen-ing and Unlearning) to review the application of the principles of indigenous psychology in sup-porting indigenous students and their families at Universidade Estadual de Campinas (Unicamp, State University of Campinas), Brazil. Results The study highlighted the need to recognize different epistemologies for respectful therapeutic connections. Challenges were faced in the application of practices aligned with indigenous psychology, emphasizing co-authorship in sessions, valuing patients' perspectives, and continuous unlearning. The study of the cultural elements of the ethnicities involved proved crucial to avoid the pathologization of indigenous worldviews and subjectivities. Conclusion Indigenous psychology presents itself as a tool for the changes in the cultural struggles, highlighting the gap in clinical approaches and the urgent need for further studies to develop personalized interven-tions for the care of the diverse indigenous ethnicities.

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Objetivo Em 2021, povos indígenas Pataxó, Pataxó Hãhãhãe e Tupinambá foram atingidos por inundações intensas na Bahia. A situação exigiu respostas imediatas das equipes locais de saúde, contando com a assessoria de especialistas em desastres e emergências em saúde pública. Esse estudo de caso aborda o processo de construção de linhas de cuidado ao Bem-Viver dos povos originários afetados, por meio do trabalho colaborativo entre etnias indígenas e equipes de políticas públicas de saúde. Método Foram analisados registros de reuniões, um curso de formação para profissionais de saúde indígena e três documentos de referência. Resultados Abordou-se possibilidades e desafios no cuidado ao Bem-Viver na fase de resposta pós-desastres e emergências em saúde pública, com a garantia da especificidade e do protagonismo das comunidades atendidas. Conclusão Foram apresentadas considerações para o processo de construção de linhas de cuidado ao Bem-Viver de povos originários, buscando oferecer subsídios à conformação de políticas públicas consoantes às particularidades sócio-histórico-culturais de cada etnia.

Objective In 2021, the indigenous communities Pataxó, Pataxó Hãhãhãe and Tupinambá, in the state of Bahia, Brazil, were hit by intense floods. The situation required immediate response from local health professionals, with advice from experts in public health disasters and emergencies. This case study focuses on the development of lines of care for the "Buen Vivir" of affected original peoples through collaborative work between indigenous ethnic groups and public health policy professionals. Method Analysis of the records of meetings, a training course for indigenous health professionals and three reference documents was carried out. Results Possibilities and challenges for assuring the "Buen Vivir" in the post-disaster and public health emergency response phase were addressed, guaranteeing the specificity and protagonism of the communities served. Conclusion Contributions were presented along the lines of care construction processes for the "Buen Vivir" of indigenous peoples, pursuing subsidies for public policies in accordance with the socio-historical-cultural particularities of each ethnic group.

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Resumo Este artigo apresenta uma perspectiva da saúde mental a partir do estudo dos efeitos dos conflitos pela terra e da organização comunitária na aldeia Tupinambá da Serra do Padeiro, no sul da Bahia. A luta pela terra com a retomada do território destaca-se enquanto força produtora de saúde, com potência de suplantar as agruras vividas em um contexto de ameaças, violências e traumas. Para isso, diferentes saberes, práticas e atores, indígenas e não indígenas, são continuamente articulados. Os modos de organização da comunidade se inserem como elemento-chave para prevenção e recuperação da saúde mental, evitando agravos nos conflitos territoriais e promovendo condições para reabilitação e inserção social. A espiritualidade, o trabalho, a cultura, a coletividade e o diálogo interétnico são aspectos centrais de proteção e promoção da saúde mental.

Abstract This study offers a mental health perspective based on the study of the effects of conflicts over land and community organization at Aldeia Tupinambá in Serra do Padeiro in southern Bahia. The struggle for land with the repossession of the territory stands out as a force that produces health with the power to overcome the hardships experienced in a context of threats, violence, and trauma. For this, Indigenous and non-Indigenous knowledges, practices, and actors are continuously articulated. The community's ways of organizing itself are inserted as a key-element to prevent and recover mental health, avoid injuries in territorial conflicts, and promote conditions for rehabilitation and social insertion. Spirituality, work, culture, community and interethnic dialogue are central aspects of protecting and promoting mental health.

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Purpose: Thiopurine S-methyltransferase (TPMT) is an enzyme that metabolizes purine analogs, agents used in the treatment of acute lymphoblastic leukemia. Improper drug metabolism leads to toxicity in chemotherapy patients and reduces treatment effectiveness. TPMT variants associated with reduced enzymatic activity vary across populations. Therefore, studying these variants in heterogeneous populations, such as Ecuadorians, can help identify molecular causes of deficiency for this enzyme. Methods: We sequenced the entire TPMT coding region in 550 Ecuadorian individuals from Afro-Ecuadorian, Indigenous, Mestizo, and Montubio ethnicities. Moreover, we conducted an ancestry analysis using 46 informative ancestry markers. Results: We identified 8 single nucleotide variants in the coding region of TPMT. The most prevalent alleles were TPMT*3A, TPMT*3B, and TPMT*3C, with frequencies of 0.055, 0.012, and 0.015, respectively. Additionally, we found rare alleles TPMT*4 and TPMT*8 with frequencies of 0.005 and 0.003. Correlating the ancestry proportions with TPMT-deficient genotypes, we observed that the Native American ancestry proportion influenced the distribution of the TPMT*1/TPMT*3A genotype (OR = 5.977, p = 0.002), while the contribution of African ancestral populations was associated with the TPMT*1/TPMT*3C genotype (OR = 9.769, p = 0.003). The rates of TPMT-deficient genotypes observed in Mestizo (f = 0.121) and Indigenous (f = 0.273) groups provide evidence for the influence of Native American ancestry and the prevalence of the TPMT*3A allele. In contrast, although Afro-Ecuadorian groups demonstrate similar deficiency rates (f = 0.160), the genetic factors involved are associated with contributions from African ancestral populations, specifically the prevalent TPMT*3C allele. Conclusion: The distribution of TPMT-deficient variants offers valuable insights into the populations under study, underscoring the necessity for genetic screening strategies to prevent thiopurine toxicity events among Latin American minority groups.

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Resumen Introducción: La paternidad adolescente ha sido considerada un importante problema social que recientemente ha empezado a estudiarse desde la construcción sociocultural de las masculinidades y la desigualdad de género. Este trabajo contribuye a documentar la experiencia de la paternidad adolescente en las comunidades rurales indígenas Ch'oles y Tseltales del estado de Chiapas, México. Metodología: El estudio fue realizado a través de un enfoque cualitativo, la técnica de acopio de información consistió en entrevistas semiestructuradas y la selección de las personas participantes fue mediante la técnica de bola de nieve lineal. Se completó un total de 25 entrevistas. En específico, se entrevistó a 16 personas menores de 20 años que fueron padres o madres en la adolescencia; a cinco varones de 24 a 40 años; y a cuatro varones de 50 años o más. Resultados: La paternidad adolescente se asocia con la construcción de las masculinidades soportada en normas socioculturales tradicionales, como el pago por la novia, la poliginia y el intercambio de mujeres. El embarazo adolescente se asocia con la importancia de la paternidad para los hombres, pese a la resistencia de las mujeres a unirse y embarazarse tempranamente. Conclusiones: Diversas condiciones facilitan la ocurrencia de la paternidad adolescente no como un fenómeno individual, aislado, sino en el contexto de la producción económica de las estructuras familiares y de la subordinación de las mujeres, el cual se ha mantenido más allá de algunos cambios generacionales.

Abstract Introduction: Teenage paternity has been considered an important social problem that has been recently studied from the sociocultural construction of masculinities and gender inequality. This work contributes to documenting the experience of adolescent fatherhood in two Ch'ol and Tseltal indigenous rural communities in the state of Chiapas, Mexico. Methodology: The study was conducted through a qualitative approach, the data collection technique consisted of semi structured interviews and the selection of participants was through the linear snowball technique. Twenty-five complete interviews were carried out in two stages, 13 in each locality, of which 16 were with children under 20 years of age who were fathers and mothers in adolescence, five with men between 24 and 40 years old, and four with men aged 50 and over. Results: Adolescent fatherhood is associated with the construction of masculinities, supported by traditional sociocultural norms such as payment for the bride, polygyny, and the traffic of women. Teenage pregnancy is associated with the importance of fatherhood for men despite the resistance of women to unite and get pregnant early. Conclusions: There are some conditions that facilitate the occurrence of adolescent fatherhood, but not as an individual, isolated phenomenon, but rather in the context of economic production, family structures and the subordination of women, which have remained despite some generational social changes.

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Background: Despite improvements in health insurance coverage, out-of-pocket (OOP) health spending remains a public health issue in Peru, and OOP payment has implications for disease treatment in ethnic minorities. We aimed to analyze the ethnic disparities in the OOP payment and estimate the gaps related to observable risk factors in the OOP payment on medicines by ethnic conditions during 2014-2016 in Peru. Study design: cross-sectional study. Methods: We conducted a secondary data analysis using the National Health User Satisfaction Survey. The outcome was the participants' OOP payment in self-reported medications. Ethnic minorities were considered participants who habitually spoke a language other than Spanish at home. Crude and adjusted linear regression models were performed, and the Oaxaca-Blinder decomposition method was used to assess the OPP payment differential by ethnic minority condition, explained by their individual and sociodemographic characteristics. Results: We analyzed 11,346 surveyed, the mean age was 40.78 years, and 57.67 % were women. There was lower OOP payment in medications among ethnic minorities in the adjusted analysis (Beta coefficient [ß]: -0.11; 95 % confidence interval [95%CI]: -0.21 to -0.01; p = 0.043). In the Oaxaca-Blinder decomposition analysis, a gap of 0.19 USD in the OOP payment in medicines among ethnic minorities was found (p < 0.001), and the explained component by the variables measured in this research only represents 40.5 % of the gap (p = 0.001). Conclusion: There was less OOP expenditure on medicines in ethnic minorities. However, the measured variables explain only 40.5 % of these gaps. Therefore, we recommend future research that measures other variables that explain aspects of OOP spending on medicines not identified in this research. Likewise, our findings can be used to establish policies with an intercultural approach that adapt health documents to native languages or are disseminated by trained people from their communities.

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Quilombola communities are descended from African slaves who escaped in resistance to imperial rule in Brazil. Today, these communities suffer from inadequate health care and health promotion programs due to socioeconomic, geographic, and political factors. This generates greater vulnerability among these groups because they have limited information about prevention to improve their quality of life. This research aimed to analyze the sexuality of young quilombola adults and the impact on their quality of life through an observational, cross-sectional, quantitative study with descriptive and inferential analyses. Our study is the first to address these issues among quilombolas in the Eastern Amazon region. The participants were 79 individuals of both sexes, aged between 18 to 35 years, belonging to seven communities in the state of Pará. The questionnaires were designed to assess sexual behavior and satisfaction, values and beliefs about sexuality, prejudice regarding sexual and gender diversity, knowledge about sexually transmitted infections (STIs), beliefs about maternity, and quality of life. Women reported greater sexual dissatisfaction and lower quality of life than men. Men reported no dysfunctions; however, they were highly prejudiced towards sexual and gender diversity. Low education negatively impacts the health of quilombola populations, as knowledge about STIs and values and beliefs influence sexual behavior, exposing individuals to diseases. The research also confirms that, both among quilombolas and other groups, factors such as sexual satisfaction, values and beliefs about reproduction, and affectivity directly influence the quality of life.

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BACKGROUND: The prevalence of Human Papillomavirus (HPV) infection in the general population is widely known, however, there are still few studies related to this infection in minority groups, Thus, the objective is to analyze the frequency of human papillomavirus and associated factors in quilombola and gypsy women. METHODS: Cross-sectional research with 145 quilombola and gypsy women from Caxias, Maranhão. Two Pap smear collections were performed and a questionnaire with 46 questions was applied between January, 2020 and March, 2021. Descriptive analysis and Odds Ratio with 95% confidence interval were performed. The research was approved by the ethics committee. RESULTS: There were 09 cases of atypia. The frequency of human papillomavirus was 41.37%, with a higher risk in quilombolas 55 (91.70%). Multiple infections were prevalent (53%) with high-risk genotypes 21 (35%). Types 16 and 18 together accounted for 42.85% of cases. CONCLUSIONS: The frequency of human papillomavirus infection was higher than those recorded in the Northeast and Brazil, and therefore type 16 predominated. Due to limitations, the virus lineages and sublineages were not evaluated. Quilombola women had a higher rate of infection than gypsies.

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This research aimed to understand the role of after-school sports programs in social inclusion processes in culturally diverse contexts through a multicase study within two locations. The first location was in Spain where immigrant and Spanish students were enrolled, and the other was in Chile with Mapuche-Huilliche students, immigrant and Chilean students. The implemented programs at both sites were similar in their educational focus on socio-educational values, and teaching models (hybridization of teaching games for understanding and cooperative learning) that enhance social inclusion. Using individual and group interviews with teachers, sports coordinators, parents, and students, a qualitative approach was used to identify the factors that facilitate or hinder the social inclusion processes. In addition, the researchers used qualitative observations of the programs over six months using "notes logbook" to record their impressions during the observation process. Results indicated that the implemented sports programs successfully facilitated social inclusion processes, enabling the development of interpersonal skills and relationships between students from different cultural backgrounds. The previous training and experiences of teachers in culturally diverse contexts, and incorporation of traditional sporting games from all cultures, seems to be an important facilitator factor for the inclusion potential of the implemented programs.

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Objetivo: Determinar la autopercepción del estado nutricional y el riesgo cardiovascular (RCV) de los grupos étnicos de La Guajira colombiana. Materiales y métodos: Estudio descriptivo-transversal en 233 individuos adultos de zonas urbanas en tres municipios de La Guajira. Se evaluó la autopercepción del estado nutricional, la intención de realizar actividad física (AF), estado nutricional, calculando el índice de masa corporal (IMC) y el riesgo cardiovascular a través del índice cintura-cadera [Ci/Ca]), estas se relacionaron con el grupo étnico (afrocolombiano, indígena y no étnico) y el estrato socioeconómico (1, 2 y >3). Se calcularon Odd Ratios (OR) para determinar la relación entre el RCV y el resto de las variables. Resultados: El 56,7 % de la muestra fueron mujeres, un 38,2 % afrocolombianos, un 32,2 % conformado por población indígena. El 65,2 % no contemplaba realizar AF y el 58,4 % presentó una autopercepción de su estado nutricional normal. Se encontró además que solo un 39,5 % presentó un IMC normal; un 48,5 % presentó un alto RCV. Se observó un alto RCV en mujeres afro-colombianas (OR= 3,22; IC 95 % 1,3-7,8) e indígenas (OR= 4,35; IC 95 % 1,7-10,9) en comparación con mujeres no étnicas (OR= 1, condición de referencia); así mismo, un mayor RCV en mujeres y hombres con sobrepeso y obesidad (p < 0,05). Conclusiones: Existe una alta prevalencia de RCV en la población de La Guajira, especialmente en las mujeres afrocolombianas e indígenas, siendo el IMC un indicador asociado al RCV en ellas.

Objective: To determine the self-perception of nutritional status and cardiovascular risk (CVR) of ethnic groups in La Guajira, Colombia. Materials and methods: Descriptive-cross-sectional study in 233 adult individuals from urban areas in three municipalities of La Guajira. Self-perception of nutritional status, intention to engage in physical activity (PA), nutritional status, calculating body mass index (BMI) and cardiovascular risk through waist-hip index [Ci/Ca]) were evaluated, these were related to ethnic group (Afro-Colombian, indigenous and non-ethnic) and socioeconomic stratum (1, 2 and >3). Odd Ratios (OR) were calculated to determine the relationship between CVR and the rest of the variables. Results: 56.7% of the sample were women, 38.2% were Afro-Colombian, 32.2% were indigenous population. 65.2 % did not consider doing PA and 58.4 % presented a self-perception of their nutritional status as normal. It was also found that only 39.5 % had a normal BMI; 48.5 % had a high CVR. A high CVR was observed in Afro-Colombian (OR= 3.22; 95 % CI 1.3-7.8) and indigenous women (OR= 4.35; 95 % CI 1.7-10.9) compared to non-ethnic women (OR= 1, reference condition); likewise, a higher CVR in overweight and obese women and men (p < 0.05). Conclusions: there is a high prevalence of CVR in the population of La Guajira, especially in Afro-Colombian and indigenous women, with BMI being an indicator associated with CVR in them.

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The objective of this study was to better understand human variation by comparing cone-beam computed tomography-based cranial measurements between both sexes of individuals from two distinct populations: Brazilian and Dutch. Cone-beam computed tomography volumes of 311 patients between 20 and 60 years from Brazil and The Netherlands were selected. Two radiologists performed 16 linear measurements in the maxillary sinuses and mandibular canal. Kruskall-Wallis test compared measurements of the two cranial structures between male and female for the two populations and four age ranges (20-30, 31-40, 41-50, 51-60). Mann-Whitney test compared individual measurements obtained from the cranial structures between male and female for each population, and between both populations for both sexes. Intra- and inter-observer reliability was assessed by intraclass correlation test (α = 0.05). No significant differences were found in the linear measurements among the experimental groups including sex, population and age group for both cranial structures (p > 0.05). Most of the cranial linear measurements were significantly higher for male than those for female irrespective of the population (p ≤ 0.05). When the populations were compared regardless of sex, Brazilians presented four significantly higher measurements, and Dutch presented seven significantly higher measurements (p ≤ 0.05). The assessed cranial structures did not differ between Brazilian and Dutch populations for both sexes and four age ranges. Multiple linear measurements differed between both populations with a predominance of larger dimensions for the Dutch population.

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RESUMEN Objetivo Analizar la asociación entre la etnicidad y la gravedad de la infección por el virus del dengue en población mexicana. Materiales y Métodos Se analizaron de manera retrospectiva los datos registrados por el Gobierno Federal de México con respecto a los casos confirmados de dengue. El análisis se realizó desde el 3 de enero hasta el 29 de noviembre de 2021. Se realizó un análisis exploratorio para evaluar la asociación de la etnicidad con la necesidad de hospitalización y muerte utilizando Chi-cuadrado. También se utilizaron modelos de regresión logística para evaluar otros indicadores de gravedad. Resultados Se evaluaron 5 759 pacientes; la media de edad fue 27 años y el 1,9 % era indígena. No se observó una asociación significativa entre la etnicidad y la gravedad del dengue tras analizar el porcentaje de muertes y hospitalizaciones. En el modelo crudo se encontró que los factores asociados a hospitalización fueron ser menor de edad (OR: 2,48; p<0,001), vivir en una entidad de alta marginación (OR: 2,06; p<0,001), tener cirrosis hepática (OR: 5,71; p=0,033), enfermedad renal crónica (OR: 4,76; p=0,008) o hipertensión (OR: 2,57, p<0,001). La asociación se mantuvo en la mayoría de variables evaluadas en el modelo ajustado. Conclusiones No fue posible demostrar asociación entre la etnicidad y la gravedad de la infección por el virus del dengue en el presente estudio. Son necesarios estudios prospectivos con la inclusión de una mayor cantidad de pacientes de etnia indígena.

ABSTRACT Objective The purpose of this study was to explore the association between ethnicity and severity of dengue infection in the Mexican population. Materials and Methods We analyzed a national database of confirmed patients with dengue; data was collected between January 3 to November 29, 2021. We extracted the following information: demographics, ethnicity, associated comorbidities and outcomes of interest (need for hospitalization and death). Exploratory analysis using Chi-square was undertaken to examine the relationship between dengue severity and ethnicity. Other covariates were also included in logistic regression models (unadjusted and adjusted). Results 5 759 patients were included in our analysis; the mean age was 27 years and 1,9% were indigenous people. There was no association between ethnicity and severity of dengue infection as measured by the percentage of people who died or required inpatient care. In the unadjusted model, we found an association between the following risk factors and need for hospitalization: age under 18 (OR: 2,48; p<0,001), living in rural areas (OR: 2,06; p<0,001), cirrhosis (OR: 5,71; p=0,033), chronic kidney disease (OR: 4,76; p=0,008) and arterial hypertension (OR: 2,57, p<0,001). In the adjusted model, chronic kidney disease, diabetes mellitus and arterial hypertension were found to be associated with hospitalization. Conclusions In this retrospective cohort study of patients with dengue, we could not find and association between ethnicity and severity of dengue infection. Prospective studies that consider ethnicity are urgently needed.

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Objetivo. Analizar la relación de las condiciones sociolaborales con el cuidado de la salud ante la COVID-19 entre la población jornalera en dos municipios de Sonora, México. Metodología. A través de entrevistas semiestructuradas y observaciones de campo, se evaluaron las prácticas de cuidado y las disposiciones sanitarias implementadas por los centros de trabajo agrícola. Se realizaron 22 entrevistas, 18 en el municipio de Hermosillo, y 4 en San Miguel de Horcasitas. Resultados. Las actividades agrícolas en México no cesaron, las personas continuaron sus labores en un contexto diverso de medidas preventivas. Encontramos una disparidad en las distintas unidades productivas, las cuales llevaron a cabo protocolos orientados al cuidado de la cosecha, pero en detrimento de la salud humana. El medio de transporte agrícola y la práctica de pagos en las localidades carecieron de acciones suficientes para prevenir el contagio. Conclusiones. Las condiciones sociolaborales obstaculizan la mitigación de la pandemia. Bajo ese panorama, necesariamente las autoridades competentes deben homogeneizar los protocolos sanitarios ante la COVID-19.

Objective: To analyze the relationship between socio-labor conditions and health care in the face of COVID-19 among the farmworkers in two municipalities of Sonora, Mexico. Method: . Through semi-structured interviews and field observations, the care practices and health provisions implemented by the agricultural work centers were analyzed. Twenty-two interviews were conducted, 18 in the municipality of Hermosillo and 4 in San Miguel de Horcasitas. Results: Agricultural activities in Mexico did not cease and farmworkers continued their work in a diverse context of prevention measures. We found a disparity between the different productive units, which carried out protocols oriented to the care of the harvest to the detriment of human health. The means of agricultural transport lacked sufficient attention in terms of contagion prevention. The practice of payments in the localities without a sanitary protocol was evident. Conclusion: The intervention of the health authorities is necessary to homogenize the prevention protocols in the face of COVID-19. Socio-labor conditions are an obstacle to pandemic mitigation.

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Mexico has a population of 129 million and is considered one of the most unequal countries in the world, suffering from widespread health disparities. There is a pressing need to strengthen epidemiologic capacity in Mexico, to help solve the complex health problems the country faces and to reduce health inequities. However, the representation of Mexican epidemiologists in the largest epidemiologic society in North America is low, despite the short distance to the United States. In this commentary, we discuss the barriers to higher representation of Mexican epidemiologists within the Society for Epidemiologic Research (SER), including language barriers, costs, and regional necessities. We also discuss opportunities to expand Mexican SER representation and collaboration. Overall, we hope that this is a call towards expanding SER global participation and starting a conversation on a common agenda for epidemiologic research.

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Dihydropyrimidine dehydrogenase is one of the main pharmacological metabolizers of fluoropyrimidines, a group of drugs widely used in clinical oncology. Around 20 to 30% of patients treated with fluoropyrimidines experience severe toxicity caused by a partial or total decrease in enzymatic activity. This decrease is due to molecular variants in the DPYD gene. Their prevalence and allelic frequencies vary considerably worldwide, so their description in heterogeneous groups such as the Ecuadorian population will allow for the description of pharmacogenetic variants and proper characterization of this population. Thus, we genotyped all the molecular variants with a predictive value for DPYD in a total of 410 Ecuadorian individuals belonging to Mestizo, Afro-Ecuadorian, and Indigenous ethnic groups. Moreover, we developed a genetic ancestry analysis using 46 autosomal ancestry informative markers. We determined 20 genetic variations in 5 amplified regions, including 3 novel single nucleotide variants. The allele frequencies for DPYD variants c.1627G>A (*5, rs1801159), c.1129-15T>C (rs56293913), c.1218G>A (rs61622928), rs1337752, rs141050810, rs2786783, rs2811178, and g.97450142G>A (chr1, GRCh38.p13) are significantly related to Native American and African ancestry proportions. In addition, the FST calculated from these variants demonstrates the closeness between Indigenous and Mestizo populations, and evidences genetic divergence between Afro-Ecuadorian groups when compared with Mestizo and Indigenous ethnic groups. In conclusion, the genetic variability in the DPYD gene is related to the genetic component of ancestral populations in different Ecuadorian ethnic groups. The absence and low frequency of variants with predictive value for fluoropyrimidine toxicity such as DPYD *2A, HapB3, and c.2846A>T (prevalent in populations with European ancestry) is consistent with the genetic background found.