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1.
Cureus ; 16(8): e66860, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-39280561

RESUMEN

Blunt traumatic injury to the chest or abdomen can produce injury to the aorta, which can compromise perfusion to the lower spinal cord. This report presents the case of a seat belt-restrained driver who sustained blunt abdominal trauma and progressive paraplegia. The trauma produced an acute occlusion of the abdominal aorta associated with an L4 Chance fracture and multiple bowel injuries. The Chance fracture occurred two levels below the aortic occlusion. The significant aortic atherosclerosis changes in this patient could have triggered the complete occlusion two levels above the fracture. An aortic injury associated with a vertebral fracture represents a severe and potentially lethal condition. Lower limb ischemia in the setting of a blunt abdominal injury could lead to a high diagnostic suspicion of abdominal aortic injury. Treatment of the vascular injury should be performed without delay to prevent or reduce permanent neurological deficits and ischemic injuries.

2.
Wien Med Wochenschr ; 2024 Sep 13.
Artículo en Inglés | MEDLINE | ID: mdl-39269535

RESUMEN

Very recently, a comprehensive re-evaluation of the medical facts and observations surrounding the death of Empress Elisabeth "Sisi" of Austria (1837-1898) was published. The Empress was assassinated in Geneva by the anarchist Luigi Luccheni or Lucheni (1873-1910). In parallel to this recent publication, our study group came across an almost unknown letter from Dr. Golay, who was one of the examining doctors of Empress Elisabeth. In this publication we add relevant additions based on this letter and provide further insights regarding the attempts at resuscitation.

3.
Evol Comput ; : 1-22, 2024 Aug 02.
Artículo en Inglés | MEDLINE | ID: mdl-39101892

RESUMEN

Chance constrained optimization problems allow to model problems where constraints involving stochastic components should only be violated with a small probability. Evolutionary algorithms have been applied to this scenario and shown to achieve high quality results. With this paper, we contribute to the theoretical understanding of evolutionary algorithms for chance constrained optimization. We study the scenario of stochastic components that are independent and normally distributed. Considering the simple single-objective (1+1) EA, we show that imposing an additional uniform constraint already leads to local optima for very restricted scenarios and an exponential optimization time. We therefore introduce a multi-objective formulation of the problem which trades off the expected cost and its variance. We show that multi-objective evolutionary algorithms are highly effective when using this formulation and obtain a set of solutions that contains an optimal solution for any possible confidence level imposed on the constraint. Furthermore, we prove that this approach can also be used to compute a set of optimal solutions for the chance constrained minimum spanning tree problem. In order to deal with potentially exponentially many trade-offs in the multi-objective formulation, we propose and analyze improved convex multi-objective approaches. Experimental investigations on instances of the NP-hard stochastic minimum weight dominating set problem confirm the benefit of the multi-objective and the improved convex multi-objective approach in practice.

4.
Heliyon ; 10(15): e34857, 2024 Aug 15.
Artículo en Inglés | MEDLINE | ID: mdl-39166002

RESUMEN

This paper presents a mathematical optimization framework for the strategic placement of quasi-dynamic wireless charging (QWC) stations within road networks to address the charging needs of battery electric buses (BEBs). This study evaluates two scenarios for powering the buses. In the first scenario, a grid-connected system is considered. The optimization aims to minimize annual costs related to capital, operation, and energy losses of the electric bus fleet. This involves determining the optimal locations for QWC stations, the length of power transmitters, and the corresponding battery capacities for the BEBs. Using MATLAB-based optimization tools Casadi and Yalmip, with solvers Bonmin and Fmincon, the optimal configuration includes a 13 kWh battery capacity and a 300 m power transmitter distributed across five bus stop areas. The second scenario employs a chance-constrained optimization approach for an isolated solar photovoltaic (PV) and battery energy storage system (BESS). This system is designed to reliably meet the BEBs' energy requirements throughout the day, considering different seasonal data (winter, summer, all seasons/year-round). The optimization results for the PV and BESS capacities vary with the seasons: 394.247 kW and 2012.6 kWh using summer data, 1762.1 kW and 2738.2 kWh using winter data, and 1610.8 kW and 2741.9 kWh using year-round data. Additionally, the paper examines the impact of varying bus fleet sizes on the optimal battery size and power transmitter combination using a real-world example of the bus route between Khalifa City and Abu Dhabi Downtown in the UAE. The findings suggest that larger batteries with fewer or no charging stations are more economical for smaller fleets. Conversely, as the fleet size increases, a combination of smaller battery sizes and a greater number (and length) of QWC (power transmitters) becomes more cost-effective. This research offers significant insights into the efficient deployment of QWC stations and the integration of renewable energy and energy storage for sustainable urban electric bus networks. The proposed optimization models provide a systematic approach to designing and operating charging infrastructure, contributing to sustainable urban transportation systems. Moreover, the study highlights the influence of seasonal data on PV system sizing and costs.

5.
J Environ Manage ; 367: 121986, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39094421

RESUMEN

Modern project managers cope with significant challenges to schedule and control projects considering dynamic environments, frequent uncertainties, strict project deadlines, and stricter sustainable requirements above all. Sustainability taking into account resource utilization has been recently associated with project management. Hence, this paper presents a new mixed-integer linear programming (MILP) model with two objectives for a resource-constrained project scheduling problem (RCPSP) with multiple skills and multiple modes, assuming preemptive and non-preemptive activities in an uncertain environment. Given the importance of sustainable developments in projects, the considered objectives are to maximize job opportunities and minimize project duration, resource costs, and total energy consumption. To deal with the model, an AUGNMECON2VIKOR algorithm is utilized to create Pareto solutions. In this model, project activities can be crashed by allocating extra resources. Furthermore, multi-skill resources are used to perform project activities. This study also investigates the impact of these resources on project scheduling. To deal with uncertain circumstances, a fuzzy chance-constrained programming method is employed to develop a robust possibilistic programming model. With respect to the increasing significance of sustainability in project management, this study pioneers the examination of the impact of sustainable factors on project scheduling. Finally, the proposed formulation is validated using instances from the well-known PSPLIB and MMLIB test sets. Finally, a comparison is drawn between the presented solution method considering AUGMECON2VIKOR and AUGMECON2.


Asunto(s)
Algoritmos , Modelos Teóricos , Conservación de los Recursos Naturales/métodos , Desarrollo Sostenible
6.
Int J Spine Surg ; 18(4): 383-388, 2024 Sep 12.
Artículo en Inglés | MEDLINE | ID: mdl-39025528

RESUMEN

BACKGROUND: Nonoperative management is an appealing option for purely transosseous thoracolumbar flexion-distraction injuries given the prospects of osseous healing and restoration of the posterior tension band complex. This study seeks to examine differences in outcomes following flexion-distraction injuries after operative and nonoperative management. METHODS: This study reviews all patients at a single Level 1 trauma center from 2004 to 2022 with AO Spine B1 thoracolumbar injuries treated operatively vs nonoperatively. Inclusion criteria were age greater than 16 years, computed tomography-confirmed transosseous flexion-distraction injuries, and at least 3 months of follow-up with available imaging. The primary outcome assessed was a change in local Cobb angles, with secondary outcomes consisting of complications, time to return to work, and need for subsequent operative fixation. RESULTS: Initial Cobb angles in the operative (n = 14) vs nonoperative group (n = 13) were -5° and -13°, respectively (P = 0.225), indicating kyphotic alignment in both cohorts. We noted a significant difference in Cobb angles between cohorts at first follow-up (2.6° and -13.9°, P = 0.015) and within the operative cohort from presentation to first follow-up (P = 0.029). At the second follow-up, there was no significant difference in Cobb angles between cohorts (3.6° and -12.6°, P = 0.07). No significant differences were noted in complication rates (P = 1), time to return to work (P = 0.193), or resolution of subjective back pain (P = 0.193). No crossover was noted. CONCLUSIONS: Nonoperative management of minimally displaced transosseous flexion-distraction injuries is a safe alternative to surgery. Patient factors, such as compliance with follow-up, and location of the injury should be factored into the surgeon's management recommendation. CLINICAL RELEVANCE: Overall, no significant differences in outcomes and complications were noted following nonoperative management of AO Spine B1 injuries, indicating the potential for these injuries to be managed conservatively.

7.
Clin Ter ; 175(Suppl 1(4)): 56-58, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39054983

RESUMEN

Background: The concept of damages for loss of chance originated in France in 1877 and was adapted to healthcare in 1962. In Italy, it was first introduced in healthcare liability in 2004, with Civil Court of Cassation decision No. 4400. Italian jurisprudence recognizes the loss of chance as an independent, legally and economically assessable damage, distinct from the actual outcome lost. The landmark St. Martin Judgments of 2019 further established that such damages can be claimed if they involve appreciable, serious, and consistent values. This requires proving a causal link between the conduct and the lost chance, based on established civil law criteria. Case report: 1) a 71-year-old man whose lung carcinoma was not diagnosed in time, leading to a significant reduction in survival chances. 2) a woman whose breast cancer diagnosis was delayed, resulting in a more advanced stage and decreased survival prospects. Discussion: In medical professional liability, the Supreme Court requires a high probability or certainty of causation for recognizing the causal link between wrongful conduct and damage. The assessment involves proving both the causal link and the reasonable probability of a lost opportunity's realization. Hypothetical damage is insufficient for compensation. Conclusions: The compensability of loss of chance relies on proving the causal link between the negligent act and the uncertain event, where the impact on the patient's non-pecuniary sphere is significant. Medicolegal practice faces challenges in distinguishing between causality and damage, which can lead to confusion between biological damage and damage from loss of opportunity.


Asunto(s)
Neoplasias de la Mama , Responsabilidad Legal , Neoplasias Pulmonares , Mala Praxis , Anciano , Humanos , Femenino , Masculino , Incertidumbre , Italia , Mala Praxis/legislación & jurisprudencia , Compensación y Reparación/legislación & jurisprudencia
8.
J Stroke ; 26(2): 231-241, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38836270

RESUMEN

BACKGROUND AND PURPOSE: Non-high-density lipoprotein cholesterol (non-HDL-C), which represents the total cholesterol content of all pro-atherogenic lipoproteins, has recently been included as a new target for lipid-lowering therapy in high-risk atherosclerotic patients in multiple guidelines. Herein, we aimed to explore the relationship between non-HDL-C level and the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin in preventing stroke recurrence. METHODS: This study comprised a post hoc analysis of the CHANCE-2 (Ticagrelor or Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events II) trial, from which 5,901 patients with complete data on non-HDL-C were included and categorized by median non-HDL-C levels, using a cutoff of 3.5 mmol/L. The primary efficacy and safety outcomes were recurrent stroke and severe or moderate bleeding within 90 days. RESULTS: Ticagrelor-aspirin significantly reduced the risk of recurrent stroke in patients with low non-HDL-C (71 [4.8%] vs. 119 [7.7%]; adjusted hazard ratio [HR] 0.54; 95% confidence interval [CI], 0.40-0.74), but not in those with high non-HDL-C (107 [7.3%] vs. 108 [7.6%]; adjusted HR, 0.88; 95% CI, 0.67-1.16), compared with clopidogrel-aspirin (P for interaction=0.010). When analyzed as a continuous variable, the benefit of ticagrelor-aspirin for recurrent stroke decreased as non-HDL-C levels increased. No significant differences in the treatment assignments across the non-HDL-C groups were observed in terms of the rate of severe or moderate bleeding (5 [0.3%] vs. 8 [0.5%] in the low non-HDL-C group; 4 [0.3%] vs. 2 [0.1%] in the high non-HDL-C group; P for interaction=0.425). CONCLUSION: CHANCE-2 participants with low non-HDL-C levels received more clinical benefit from ticagrelor-aspirin versus clopidogrel-aspirin compared to those with high non-HDL-C, following minor ischemic stroke or transient ischemic attack.

9.
J Environ Manage ; 363: 121309, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38848638

RESUMEN

Multiple uncertainties such as water quality processes, streamflow randomness affected by climate change, indicators' interrelation, and socio-economic development have brought significant risks in managing water quantity and quality (WQQ) for river basins. This research developed an integrated simulation-optimization modeling approach (ISMA) to tackle multiple uncertainties simultaneously. This approach combined water quality analysis simulation programming, Markov-Chain, generalized likelihood uncertainty estimation, and interval two-stage left-hand-side chance-constrained joint-probabilistic programming into an integration nonlinear modeling framework. A case study of multiple water intake projects in the Downstream and Delta of Dongjiang River Basin was used to demonstrate the proposed model. Results reveal that ISMA helps predict the trend of water quality changes and quantitatively analyze the interaction between WQQ. As the joint probability level increases, under strict water quality scenario system benefits would increase [3.23, 5.90] × 109 Yuan, comprehensive water scarcity based on quantity and quality would decrease [782.24, 945.82] × 106 m3, with an increase in water allocation and a decrease in pollutant generation. Compared to the deterministic and water quantity model, it allocates water efficiently and quantifies more economic losses and water scarcity. Therefore, this research has significant implications for improving water quality in basins, balancing the benefits and risks of water quality violations, and stabilizing socio-economic development.


Asunto(s)
Ríos , Calidad del Agua , Incertidumbre , Abastecimiento de Agua , Modelos Teóricos , Cambio Climático
10.
Hum Nat ; 35(2): 89-113, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38816642

RESUMEN

Chance-based gambling has been a recurrent cultural activity throughout history and across many diverse human societies. In this paper, I combine quantitative and qualitative data and present a cultural evolutionary framework to explain why the odds in games of chance in premodern China appeared "designed" to ensure a moderate yet favorable house advantage. This is especially intriguing since extensive research in the history of probability has shown that, prior to the development of probability theory, people had very limited understanding of the nature of random events and were generally disinclined to think mathematically about the frequency of their occurrence. I argue that games of chance in the context of gambling may have culturally evolved into their documented forms via a process of selective imitation and retention, and neither the customers nor the gambling houses understood the probability calculus involved in these games.


Asunto(s)
Evolución Cultural , Juego de Azar , Humanos , China/etnología , Pueblos del Este de Asia , Juego de Azar/etnología , Juego de Azar/historia , Probabilidad
11.
J Belg Soc Radiol ; 108(1): 37, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38618146

RESUMEN

Chest compressions, used in cardiopulmonary resuscitation (CPR), cause rib and sternum fractures in around 79% and 54% of patients, respectively. Spinal fractures resulting from CPR are far rarer. We present the case of a 70-year-old man who underwent mechanical CPR after choking whilst eating. The patient received a cerebral and thoracic CT scan upon arrival to the hospital. The cerebral scan was normal, but the chest CT scan revealed signs of ankylosing spondylitis and an unstable Chance fracture of the 12th thoracic vertebra. The patient was hospitalised but passed away. This case highlights the need for awareness of uncommon spine fractures due to the high associated morbidity. Teaching point: In patients who have undergone thoracic compressions, one should not only search for rib fractures but also for spine fractures, which, though uncommon, have a far greater impact on the patient's morbidity, especially in patients with predisposing spine conditions.

12.
Ann Agric Environ Med ; 31(1): 131-137, 2024 Mar 25.
Artículo en Inglés | MEDLINE | ID: mdl-38549487

RESUMEN

INTRODUCTION AND OBJECTIVE: Patella dislocation represents 3.3% of all knee injuries often leading to persistent instability. Medial patello-femoral ligament(MPFL) reconstruction is the standard method of treatment in the patellar instability. Rehabilitation after MPFL-R is a long and demanding procedure. The hypothesis presented reflects the idea that despite relatively good access to hospital care and surgical options, the post-operative rehabilitation care system is still inferior in rural areas versus the one offered in major cities and towns. MATERIAL AND METHODS: Between January 2015 - January 2018, 47 patients met the study inclusion criteria, diagnosed and operated on due to patellar instability. 8 patients were lost for full follow-up. Finally, 39 patients were included, divided into two groups - group A (19 from cities), group B (20 from rural area). Prospective KOOS and Kujala scales assessments were conducted: preoperative, 6 and 12 months after surgery. Knee isokinetic muscle strength was measured at 3 stages; prior to surgery, 6 and 12 months after reconstruction. RESULTS: All patients showed significant improvement measured in the KOOS and Kujala scales after the procedure, compared to the pre-operational results. Despite equal clinical improvement, patients from Group A(city) achieved better functional outcomes as presented in the results of knee extensor functional tests using a Biodex dynamometer. CONCLUSIONS: Rehabilitation after MPFL reconstruction improves muscle strength and clinical outcome. Patients from rural areas had inferior functional results in comparison to the patients from major cities, even 12 months after surgical patella stabilization. Despite the development of roads and transport according to the EU cohesion policy, there are still differences in rehabilitation results between rural and city areas.


Asunto(s)
Inestabilidad de la Articulación , Articulación Patelofemoral , Humanos , Rótula/cirugía , Articulación Patelofemoral/lesiones , Articulación Patelofemoral/cirugía , Inestabilidad de la Articulación/cirugía , Estudios Prospectivos , Población Urbana
13.
J Endocrinol Invest ; 47(10): 2499-2505, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-38526836

RESUMEN

PURPOSE: Graves' disease (GD) is an auto-immune cause of hyperthyroidism. First-line treatment often consists of a 12-18 month course of antithyroid drugs (ATD). After discontinuation of ATD, GD relapses in approximately 50% of patients. The 'Graves recurrent event after therapy+ ' (GREAT+) score may predict individual relapse chances after ATD discontinuation more accurately based on clinical and laboratory parameters at diagnosis. We investigated the need for the GREAT+ score through an online questionnaire among GD patients and physicians treating GD. METHODS: An anonymous online questionnaire was distributed to patients and physicians between June 2022 and August 2023. RESULTS: The questionnaire was completed by 532 patients and 44 physicians. Results showed that 94% of patients were interested in knowing their GREAT+ score at the start of treatment. 55% would consider definite treatment (radioiodine/thyroidectomy) as first-line treatment in case of a high relapse chance. 98% of the physicians indicated the GREAT + score would support patient counseling. 84% may change their advice for first-line treatment if a patient has a high relapse chance based on the score. CONCLUSION: Patients and physicians considered the GREAT+ score as a valuable addition to the current available information which could change treatment decisions. Therefore, external validation of the GREAT+ score is justified to implement this score in clinical practice.


Asunto(s)
Antitiroideos , Enfermedad de Graves , Medicina Interna , Recurrencia , Humanos , Enfermedad de Graves/diagnóstico , Enfermedad de Graves/terapia , Encuestas y Cuestionarios , Femenino , Masculino , Medicina Interna/métodos , Persona de Mediana Edad , Adulto , Antitiroideos/uso terapéutico , Pronóstico , Anciano , Adulto Joven
14.
Clin Podiatr Med Surg ; 41(2): 281-290, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38388125

RESUMEN

A well-conducted prospective cohort study has the potential to change the way in which surgeons practice. However, not all are equal. In this article, we provide many of the tools needed to critically appraise this powerful study design. We advocate for using a 3-step approach that centers on understanding the study's generalizability, results, and validity. We illustrate how this process is applied into practice regularly at our hospital section's journal club sessions.


Asunto(s)
Internado y Residencia , Humanos , Estudios Prospectivos , Estudios de Cohortes
15.
Hum Reprod ; 39(1): 130-138, 2024 Jan 05.
Artículo en Inglés | MEDLINE | ID: mdl-37976406

RESUMEN

STUDY QUESTION: How well informed are Australian women who undergo IVF about their chances of having a baby? SUMMARY ANSWER: Only one in four women estimated their individual chance of success with IVF accurately, with most women overestimating their chance. WHAT IS KNOWN ALREADY: Limited knowledge about infertility and infertility treatment in the general population is well-documented. The few studies that have investigated patients' knowledge about the chance of IVF success suggest that while IVF patients are aware of average success rates, they tend to be unrealistic about their own chance of success. STUDY DESIGN, SIZE, DURATION: We conducted an anonymous online survey of 217 women who had started IVF since 2018 in Australia. The survey was advertised on social media, enabling women from across Australia to participate. Responses were collected in June 2021. PARTICIPANTS/MATERIALS, SETTING, METHODS: The survey included questions on demographic characteristics and IVF history. It asked what participants thought their chance of having a baby from one IVF treatment cycle was, how they rated their knowledge about chance of success, and about their experience of receiving IVF-related information. Participants' estimations of their chance of success were compared with their chance as calculated by the Society for Assisted Reproductive Technology's (SART) online calculator. Responses to a free-text question about what information women wished they had been given when they started treatment were analysed thematically. MAIN RESULTS AND THE ROLE OF CHANCE: Only about a quarter (58/217, 27%) of participants accurately estimated their chance of having a baby within 20% relative to their SART calculated chance, with more than half (118/217, 54%) overestimating their chance. Ninety percent of women indicated that their preferred source of treatment information was a consultation with their doctor, despite less than half (44%) reporting that doctors explained the probability of having a baby with IVF well (mean 5.9/10). In free-text responses, many women also reported that they wished they had been given more realistic information about IVF and their chance of success. LIMITATIONS, REASONS FOR CAUTION: The dissemination method precludes calculation of response rate, and it is not possible to know if participants are representative of all women undergoing IVF. Additionally, we only surveyed women undergoing IVF, while those who decided not to have IVF were not included. Therefore, women who overestimated their chance may have been overrepresented. There is also inherent imprecision in the way understanding of chance of success was estimated. The potential impact of recall bias could neither be quantified nor excluded. It is difficult to determine to what extent women's lack of understanding of what is possible with IVF is due to poor information-provision by clinicians and the clinic, and how much can be explained by optimism bias. WIDER IMPLICATIONS OF THE FINDINGS: The finding of poor understanding of personal chance of success amongst women undergoing IVF in Australia requires further investigation to determine potential reasons for this. The findings can be used by clinics to develop strategies for improvement in the information-provision process to ensure that women can make informed decisions about their fertility treatment. STUDY FUNDING/COMPETING INTEREST(S): This study received no external funding. S.L. is supported by a NHMRC Investigator Grant (APP1195189). R.W. is supported by a NHMRC Investigator Grant (APP2009767). B.W.M. is supported by a NHMRC Investigator Grant (GNT1176437). B.W.M. reports consultancy for Merck and ObsEva and has received research funding and travel funding from Merck. The other authors have no conflicts of interest. TRIAL REGISTRATION NUMBER: N/A.


Asunto(s)
Tasa de Natalidad , Infertilidad , Humanos , Femenino , Embarazo , Australia , Fertilización In Vitro/métodos , Infertilidad/terapia , Probabilidad , Índice de Embarazo
16.
J Gambl Stud ; 40(3): 1517-1537, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38148441

RESUMEN

Games for mobiles present strategies to monetize not only from selling a title but from financial exchanges that take place in the game. Those microtransactions motivate players to purchase random or surprise items (known as loot boxes) to customize game features or to overcome narrative obstacles necessary to progress to new levels. Researchers associate the practice with gambling if completing the transaction does not mean the acquisition of an item but the chance to receive it. This research quantified gambling-like features in games available for free, classified by Apple's marketplace as suitable for children from 4 to 8 years old, and from the top-downloaded list. The findings reveal normalization traces of chance-based mechanisms in most of the games. According to the research literature, early exposure to such features may result in problem gambling in adult life. This paper concluded that legal changes and more information provided by the marketplaces are needed to raise awareness of gambling-like practices in mobile games.


Asunto(s)
Juego de Azar , Humanos , Niño , Juego de Azar/psicología , Femenino , Masculino , Preescolar , Juegos de Video/psicología , Conducta Infantil/psicología , Motivación , Aplicaciones Móviles
17.
EClinicalMedicine ; 67: 102357, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-38125963

RESUMEN

Background: The atherogenicity of remnant cholesterol (RC), a contributor to residual risk of cardiovascular events, has been underlined by recent guidelines. We aimed to evaluate the relationship between RC levels and the efficacy and safety of genotype-guided dual antiplatelet therapy in the CHANCE-2 trial. Methods: This post-hoc study used data from the CHANCE-2 trial, which was a randomised, double-blind, placebo-controlled trial of 6412 patients (aged >40 years) enrolled from 202 hospitals in China, between Sept 23, 2019, and March 22, 2021, who carried CYP2C19 loss-of-function alleles and had either an acute minor stroke or high-risk transient ischaemic attack (TIA), and could start treatment within 24 h of symptom onset. Participants received either (1:1) ticagrelor plus aspirin (control) or clopidogrel plus aspirin (intervention) and the effect of reducing the 3-month risk of any new stroke was assessed (ischemic or haemorrhagic, primary outcome). From the CHANCE-2 study population, we enrolled 5890 patients with complete data on RC. The cutoff point of RC for distinguishing patients with greater benefit from ticagrelor-aspirin versus clopidogrel-aspirin was determined with subpopulation treatment effect pattern plot. The primary efficacy and safety outcome was recurrent stroke and severe or moderate bleeding within 90 days, respectively. CHANCE-2 is registered with ClinicalTrials.gov, NCT04078737. Findings: The cutoff to define elevated RC was 0.91 mmol/L. Ticagrelor-aspirin versus clopidogrel-aspirin was associated with a reduced risk of recurrent stroke in patients with non-elevated RC levels (122 [5.3%] versus 179 [7.8%]; hazard ratio [HR], 0.68; 95% confidence interval [CI], 0.54-0.85), but this benefit was absent in those with elevated RC levels (58 [8.4%] versus 48 [7.3%]; HR, 1.10; 95% CI, 0.73-1.65; P-interaction = 0.03). When analyzed as a continuous variable, the benefit of ticagrelor-aspirin on recurrent stroke decreased as RC levels increased. The rates of severe or moderate bleeding between treatment groups were similar across RC categories (0.3% versus 0.3%, P-interaction = 0.95). Interpretation: Our post-hoc findings suggest that RC could be a potential biomarker to discriminate patients who received more benefits from ticagrelor-aspirin versus clopidogrel-aspirin therapy in CYP2C19 loss-of-function carriers with minor stroke or TIA. These findings need to be validated in an independent study. Funding: The National Key Research and Development Program of China, Beijing Natural Science Foundation Haidian original innovation joint fund, Fund for Young Talents of Beijing Medical Management Center, the high-level public health talents, Training Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University; and Salubris.

18.
Trauma Case Rep ; 48: 100968, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-38078062

RESUMEN

Chance fractures are rare lesions but are often associated with abdominal injuries. We present a case of a 21-year-old patient who sustained a delayed type of abdominal injury associated with a bonny Chance fracture of lumbar 2nd following a traffic accident. Initial X-rays and computed tomography (CT) scans showed a Chance fracture with subtle bowel images, evading the prompt diagnosis of bowel injuries. However, the toxic signs were presented after 17h of stay in intensive care unit, and hollow visceral perforation was diagnosed in the re-do abdominal CT scanning. The laparostomy with primary anastomosis was performed for complete transection of the middle part of the jejunum. After a follow-up period of 20 days, the patient underwent kyphoplasty, accompanied by posterior fusion of the L1-L3 vertebrae and was found well recovered at 2 weeks follow-up. Clinicians should realize the subtle but meaningful imaging signs to allow prompt diagnosis as well as management when meeting patients with seatbelt sign associated with Chance fracture after a traffic accident.

19.
Clin Neuropsychol ; : 1-17, 2023 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-38041021

RESUMEN

Objective: To determine if similar levels of performance on the Overall Test Battery Mean (OTBM) occur at different forced choice test (FCT) p-value score failures. Second, to determine the OTBM levels that are associated with failures at above chance on various performance validity (PVT) tests. Method: OTBMs were computed from archival data obtained from four practices. We calculated each examinee's Estimated Premorbid Global Ability (EPGA) and OTBM. The sample size was 5,103 examinees with 282 (5.5%) of these scoring below chance at p ≤ .20 on at least one FCT. Results: The OTBM associated with a failure at p ≤ .20 was equivalent to the OTBM that was associated with failing 6 or more PVTs at above-chance cutoffs. The mean OTBMs relative to increasingly strict FCT p cutoffs were similar (T scores in the 30s). As expected, there was an inverse relationship between the number of PVTs failed and examinees' OTBMs. Conclusions: The data support the use of p ≤ .20 as the probability level for testing the significance of below chance performance on FCTs. The OTBM can be used to index the influence of invalid performance on outcomes, especially when an examinee scores below chance.

20.
Trauma Case Rep ; 48: 100950, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37915536

RESUMEN

Pediatric pure discoligamentous Chance-type injury is relatively rare and the appropriate surgical method has not yet been established, particularly, whether spinal fixation with fusion or without fusion is more effective. This case report describes a 10-year-old-boy who sustained an L2-3 pure discoligamentous Chance-type injury following a car accident and underwent an L2-3 posterior fixation without fusion. The implants were removed after eight months of an uneventful postoperative course. However, four months later, the kyphotic deformity recurred. Although the deformity gradually progressed over nine months, the patient remained neurologically intact and asymptomatic. This report suggests that fixation without fusion may not be appropriate in pediatric patients with pure discoligamentous Chance-type injuries. Spinal fixation with fusion may be recommended to prevent loss of correction and ensure secure stabilization.

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