RESUMEN

Casimiroa edulis La Llave is known to contain unusual 5,6-dimethoxyflavones bearing a variously oxygenated B-ring. Phytochemical investigation of the leaves and the roots of C. edulis achieved the isolation of two new methoxylated flavones, named casedulones A (1) and B (2), together with 12 known analogues. Their unique structures were established with the aid of spectral analyses and total syntheses. Pre-treatment with 20 µM of 1 and 2 suppressed MMP-9 expression in LPS-mediated THP-1 cells, indicating that the characteristic flavonoids in C. edulis could be potential anti-angiogenics for cancer prevention.

Asunto(s)

Casimiroa , Flavonas , Casimiroa/química , Flavonas/química , Metaloproteinasa 9 de la Matriz , Extractos Vegetales/química , Hojas de la Planta/química , Flavonoides/farmacología , Flavonoides/análisis