RESUMEN
Nature always inspires us to develop advanced materials for diverse applications. The liquid-infused surface (LIS) inspired by Nepenthes pitcher plants has aroused broad interest in fabricating anti-biofouling materials over the past decade. The infused liquid layer on the solid substrate repels immiscible fluids and displays ultralow adhesion to various biomolecules. Due to these fascinating features, bioinspired LIS has been applied in biomedical-related fields. Here, we review the recent progress of LIS in bioengineering, medical devices, and biosensing, and highlight how the infused liquid layer affects the performance of medical materials. The prospects for the future trend of LIS are also presented.
RESUMEN
Amphiphilic surfaces are particularly effective at inhibiting the adhesion of microorganisms (bacteria, cells, microalgae, etc.) in liquid media. The aim of this study is to determine the best hydrophilic linker to promote bonding between poly(ethylene glycol) (PEG) as a hydrophilic additive and poly(dimethyl siloxane) (PDMS) as the hydrophobic matrix. Various parameters have been studied (molecular weight, linker type, and polymer end-group), as well as the efficiency of the linking, the capacity of PEG to access to the surface of the film, and overall film homogeneity. According to the results, a PDMS linker paired with a PEG moiety allows for compatibilization of the compounds during cross-linking. This compatibilization seems to provide a good bonding with the matrix and a good surface access to the hydrophilic moiety. Therefore, this structure comprising a linking function attached to the PDMSâ»PEG copolymer has high potential as a non-releasable additive for amphiphilic coating applications.
RESUMEN
Reducing bacterial adhesion on substrates is fundamental for various industries. In this work, new superhydrophobic surfaces are created by electrodeposition of hydrophobic polymers (PEDOT-F4 or PEDOT-H8) on stainless steel with controlled topographical features, especially at a nano-scale. Results show that anti-bioadhesive and anti-biofilm properties require the control of the surface topographical features, and should be associated with a low adhesion of water onto the surface (Cassie-Baxter state) with limited crevice features at the scale of bacterial cells (nano-scale structures).
Asunto(s)
Interacciones Hidrofóbicas e Hidrofílicas , Listeria monocytogenes/efectos de los fármacos , Nanoestructuras/química , Implantación de Prótesis , Pseudomonas aeruginosa/efectos de los fármacos , Acero Inoxidable/farmacología , Adhesión Bacteriana , Biopelículas/efectos de los fármacos , Compuestos Bicíclicos Heterocíclicos con Puentes/química , Polímeros/química , Acero Inoxidable/química , Propiedades de SuperficieRESUMEN
We present the synthesis and applications of multifunctional hollow porous carbon spheres with well-ordered pore architecture and ability to encapsulate functional nanoparticles. In the present work, the applications of hollow mesoporous carbon capsules (HMCCs) are illustrated in two different contexts. In the first approach, the hollow capsule core is used to encapsulate silver nanoparticles to impart antimicrobial characteristics. It is shown that silver-loaded HMCCs (concentration â¼100 µg/mL) inhibit the growth and multiplication of bacterial colonies of Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) up to 96% and 83%, respectively. In the second part, the fabrication of hierarchical micro- and nanostructured superhydrophobic coatings of HMCCs (without encapsulation with silver nanoparticles) is evaluated for anti-bioadhesion properties. Studies of protein adsorption and microorganism and platelet adhesion have shown a significant reduction (up to 100%) for the HMCC-based superhydrophobic surfaces compared with the control surfaces. Therefore, this unique architecture of HMCCs and their coatings with the ability to encapsulate functional materials make them a promising candidate for a variety of applications.
Asunto(s)
Carbono/química , Antibacterianos , Cápsulas , Nanopartículas del Metal , Porosidad , PlataRESUMEN
Amphiphilic diblock copolymer containing randomly distributed positive and negative charged monomers are synthesized using RAFT polymerization technique to be used as anti-bioadhesion coatings for hydrophobic surfaces. Quaternized 2-(dimethylamino) ethyl methacrylate and potassium 3-sulfopropyl methacrylate (P[qDMAEMA-co-KSPMA]) are randomly polymerized to yield an anti-bioadhesion block which is, in one pot, copolymerized with styrene as an anchoring block. This copolymer has demonstrated high anti-bioadhesion properties to avoid the blood clotting in medical devices through a simple and facile approach to preparation of pseudozwitterionic copolymers.
Asunto(s)
Sangre , Polímeros/química , Adsorción , Materiales Biocompatibles Revestidos , Humanos , Metacrilatos/química , Polimerizacion , Estireno/químicaRESUMEN
A polymeric platform for immunodiagnostic bioassay was constructed based on biostable polymeric support and two functional monomers, low-fouling methacryloyloxyethyl phosphorylcholine (MPC) and acrylic acid (AAc), by a photografting polymerization approach. Covalent binding of antibody to pAAc chains was achieved by activating carboxyl with NHS/EDC partner. The resultant surface showed obvious suppression of nonspecific protein adsorption and platelet adhesion relative to the control sample, exhibiting good anti-bioadhesion performances. Based on the polymer-supported matrix, a highly sensitive antibody-antigen specific recognition was confirmed in both native plasma and diluted human plasma due to the enhanced antibody loading capacity and lowered bioadhesion as compared to the reference.