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1.
Artículo en Inglés | MEDLINE | ID: mdl-39171438

RESUMEN

PURPOSE: The aberrant anterior tibial artery (ATA) runs along the posterior surface of the tibial cortex making it, particularly, at risk during high tibial osteotomy (HTO). This study aimed to analyze the prevalence of the ATA according to global morphotype and its anatomical features in consideration of knee surgery. METHODS: This retrospective study included 1589 knees on magnetic resonance imaging (MRI) studies with long-leg radiographs. The anatomical characteristics of the ATA, its distance in surgical areas at risk and its lumen were defined on MRI. Its presence according to the patient's morphotype (varus, valgus or neutral) was assessed using a χ2 test. RESULTS: The ATA was present in 33 of 1589 knees, resulting in a prevalence of 2.1%. The anteroposterior distance of the ATA to the tibial head was 6.6 ± 2.5 mm at the height of the tibial plateau, 2.7 ± 1.6 mm at the footprint of the posterior cruciate ligament and 1.0 ± 0.6 mm under the top of the fibula (p < 0.01). For these three levels, the ratio between the distance from the ATA to the lateral tibial border and the total tibial width decreases progressively (p < 0.001). The mean lumen area of the ATA was 4.2 ± 2.5 mm2, and the lumen of the popliteal artery was 9.2 ± 3.6 mm2, representing a ratio of 49.4 ± 27.0%. The prevalence of ATA was similar between varus and valgus patients (n.s). CONCLUSION: The presence of an ATA is rare, found in one out of 50 cases, but can be easily identified on MRI in patients before knee surgery, especially before HTO. The patient's morphotype did not influence its presence, the lumen diameter is highly variable and its clinical impact has yet to be determined. STUDY DESIGN: Cross-sectional study. LEVEL OF EVIDENCE: Level 3.

2.
Surg Radiol Anat ; 46(10): 1633-1642, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39102042

RESUMEN

PURPOSE: A translation of the initial observation of vertebral arteria lusoria reported by Hyrtl in 1859 is followed by a review of all cases published until May 2023 to identify the anatomical and clinical features characterizing the typical form of this rare variant. METHODS: PubMed, Google Scholar, and Google queries were performed with "vertebral arteria lusoria", "retroesophageal vertebral artery", and "aberrant vertebral artery" as keywords (in English, German, and French). A feature was considered typical when present in at least 75% of analyzed cases. A case of incidentally discovered vertebral arteria lusoria illustrates the typical form of the variant. RESULTS: The analysis of 56 publications yielded 66 observations of right-sided vertebral arteria lusoria published between 1859 and May 2023. A small caliber, a retro-esophageal location, and passage through the foramen transversarium of C7 were typical. There was no evidence of association with clinical symptoms or other cardiovascular anomalies. CONCLUSION: A typical vertebral arteria lusoria is an incidentally discovered nondominant aberrant right VA originating from the proximal descending aorta and following a retro-esophageal course to enter the C7 foramen transversarium, without associated aortic arch branching anomalies or congenital cardiovascular pathologies.


Asunto(s)
Arteria Vertebral , Humanos , Arteria Vertebral/anomalías , Arteria Vertebral/diagnóstico por imagen , Historia del Siglo XIX , Masculino , Variación Anatómica , Arteria Subclavia/anomalías , Arteria Subclavia/diagnóstico por imagen , Femenino , Hallazgos Incidentales , Aorta Torácica/anomalías , Aorta Torácica/diagnóstico por imagen , Persona de Mediana Edad
3.
J Ultrasound ; 27(3): 635-643, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38910220

RESUMEN

PURPOSE: Central venous catheterization (CVC) carries inherent risks which can be mitigated through the use of appropriate ultrasound-guidance during needle insertion. This study aims to comprehensively understand patient anatomy as it is visualized during CVC by employing a semi-automated image analysis method to track the internal jugular vein and carotid artery throughout recorded ultrasound videos. METHODS: The ultrasound visualization of 50 CVC procedures were recorded at Penn State Health Milton S. Hershey Medical Center. The developed algorithm was used to detect the vessel edges, calculating metrics such as area, position, and eccentricity. RESULTS: Results show typical anatomical variations of the vein and artery, with the artery being more circular and posterior to the vein in most cases. Notably, two cases revealed atypical artery positions, emphasizing the algorithm's precision in detecting anomalies. Additionally, dynamic vessel properties were analyzed, with the vein compressing on average to 13.4% of its original size and the artery expanding by 13.2%. CONCLUSION: This study provides valuable insights which can be used to increase the accuracy of training simulations, thus enhancing medical education and procedural expertise. Furthermore, the novel approach of employing automated data analysis techniques to clinical recordings showcases the potential for continual assessment of patient anatomy, which could be useful in future advancements.


Asunto(s)
Arterias Carótidas , Cateterismo Venoso Central , Procesamiento de Imagen Asistido por Computador , Venas Yugulares , Humanos , Venas Yugulares/diagnóstico por imagen , Venas Yugulares/anatomía & histología , Arterias Carótidas/diagnóstico por imagen , Arterias Carótidas/anatomía & histología , Procesamiento de Imagen Asistido por Computador/métodos , Femenino , Cateterismo Venoso Central/métodos , Masculino , Algoritmos , Adulto , Ultrasonografía Intervencional/métodos , Ultrasonografía/métodos , Persona de Mediana Edad , Anciano
4.
JPRAS Open ; 40: 253-258, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38694442

RESUMEN

Hand amputation is a devastating, usually accidental, injury. Re-implantation of the severed hand is a challenging procedure that requires careful planning, precise microsurgical techniques, and adequate vascular supply. Successful surgical reimplantation therefore requires foresight into unique variant neurovascular anatomy that could be encountered and how these would pose challenges during the procedure. We report the case of a successful complex re-implantation of a distal forearm traumatic amputation, sustained from a chaff cutter, in a 5-year-old male Kenyan patient. The case presented with unique variant anatomy including a persistent dominant median artery, with absent ulnar artery and superficial and deep palmar arches. The ulnar nerve also had a variant coarse that was difficult to locate. We discuss the importance of adjusting surgical approaches for optimal outcomes and highlight the challenges involved in such a complex procedure.

5.
Acta Vet Scand ; 66(1): 10, 2024 Mar 07.
Artículo en Inglés | MEDLINE | ID: mdl-38454467

RESUMEN

BACKGROUND: The white rhinoceros (Ceratotherium simum) is close to extinction, listed as "Near Threatened", with a decreasing population on the Red List of Threatened Species of the International Union for Conservation of Nature. In at least 50% of the specimens in captivity, podiatric diseases, such as osteitis, osteomyelitis, chip fractures, enthesophytes, fractures and osteoarthritis were found during necropsy. These osteal deformations cause further pathogenic alterations in the soft tissues, particularly in the digital cushion. The literature provides good description of the skeleton of the rhino's limbs, but similar for the vascular system is non-existent. In order to recognize the symptoms in an early state and for a successful surgical treatment, precise knowledge of the vascular anatomy is essential. The purpose of our study was to provide detailed anatomical description of the blood supply of the digits and that of the digital cushion. RESULTS: The blood supply of the distal foot, digits and digital cushions were perfectly visible on the reconstructed and coloured 3D models. The deep palmar arch provided not only the blood supply to the digits but had a palmaro-distal running branch which developed a trifurcation proximal to the proximal sesamoid bones of the third digit. Two of its branches participated in the blood supply of the digits' proximal palmar surface, while the major branch supplied the digital cushion from proximal direction. CONCLUSIONS: Our findings show a unique blood supply: the main vessels of the digital cushion stem both directly from the deep palmar arch and from the digits' own arteries. The detailed description of vessels may be useful in planning surgery of the region and also in cases where the veins of the ear are not accessible.


Asunto(s)
Imagenología Tridimensional , Perisodáctilos , Animales , Imagenología Tridimensional/veterinaria , Perisodáctilos/anatomía & histología , Tomografía Computarizada por Rayos X
6.
Updates Surg ; 76(3): 933-941, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38526696

RESUMEN

Colorectal cancer, the third most common cancer worldwide, affects 40-45% of patients on the right side. Surgery, especially minimally invasive methods such as laparoscopic and robotic procedures, is the preferred treatment. However, these techniques present technical complications. The anatomical complexity and variations in vessel branching patterns pose challenges, particularly for less experienced surgeons. The CoDIG 2 is a nationwide observational study involving 76 specialized Italian general surgery departments focused on colorectal surgery. The centres were directed to maintain their standard surgical and clinical practices. The aim of this study was to analyse the intraoperative vascular anatomy of Italian patients who underwent laparoscopic right colectomy and explore the ligature techniques used by Italian surgeons. Surgeons reported information about vascularization of the right colon for 616 patients and about surgical anatomy of RCA for 368 patients. Fifty-three patients (10.8%) showed no RCA intraoperatively. The right colic artery (RCA) was categorized according to the Yada classification (types 1-4) during evaluation, and intraoperative assessments revealed that Yada type 1 was the most common type (55.2%), while radiologic evaluations revealed a higher prevalence of type 2. Furthermore, compared with the superior mesenteric vein (SMV), the RCA is more often located anteriorly according to intraoperative and contrast-enhanced CT examination; 59.9% were found in the anterior position during intraoperative examination, while 40.1% were found in the same position on preoperative contrast-enhanced CT. Vascularization of the right colon, including missing branches, additional branches, shared trunks, and retro-superior courses of the mesenteric vein, exhibited notable variations. To understand vascular variations, a preoperative radiological study is necessary; although there was no concordance between the intraoperative and radiological evaluations, this is a limitation of preinterventional radiological evaluation (PII) because it is always needed for oncological staging. This approach is especially critical for inexperienced surgeons to avoid potential complications, such as problematic bleeding.


Asunto(s)
Colectomía , Laparoscopía , Arteria Mesentérica Superior , Humanos , Colectomía/métodos , Laparoscopía/métodos , Estudios Prospectivos , Italia/epidemiología , Femenino , Masculino , Arteria Mesentérica Superior/anatomía & histología , Arteria Mesentérica Superior/diagnóstico por imagen , Arteria Mesentérica Superior/cirugía , Anciano , Persona de Mediana Edad , Bases de Datos Factuales , Colon/cirugía , Colon/irrigación sanguínea , Neoplasias Colorrectales/cirugía , Adulto , Anciano de 80 o más Años , Variación Anatómica , Periodo Intraoperatorio
7.
Medicina (Kaunas) ; 60(2)2024 Feb 14.
Artículo en Inglés | MEDLINE | ID: mdl-38399613

RESUMEN

Background and Objectives: As the oblique lateral interbody fusion at L5/S1 (OLIF51) and the lateral corridor approach (LCA) have gained popularity, an understanding of the precise vascular structure at the L5/S1 level is indispensable. The objectives of this study were to investigate the vascular anatomy at the L5/S1 level, and to compare the movement of vascular tissue between the supine and lateral decubitus positions using intraoperative enhanced CT and MRI. Materials and Methods: A total of 43 patients who underwent either OLIF51 or LCA were investigated with an average age at surgery of 60.4 (37-80) years old. The preoperative MRI was taken to observe the axial and sagittal anatomy of the vascular position under the supine position. The intraoperative vein-enhanced CT was taken just before incision in the right decubitus position, and compared to supine MRI anatomy. Iliolumbar vein appearance and its types were also classified. Results: The average vascular window allowed for OLIF51 was 22.8 mm and 34.1 mm at either the L5 caudal endplate level or the S1 cephalad endplate level, respectively. The LCA was 14.2 mm and 12.6 mm at either level, respectively. The left common iliac vein moved 3.8 mm and 6.9 mm to the right direction at either level from supine to the right decubitus position, respectively. The bifurcation moved 6.3 mm to the caudal direction from supine to right decubitus. The iliolumbar vein was located at 31 mm laterally from the midline, and the MRI detection rate was 52%. Conclusions: The precise measurement of vascular anatomy indicated that the OLIF51 approach was the standard minimally invasive anterior approach for the L5/S1 disc level compared to LCA; however, there were many variations in quantitative anatomy as well as significant vascular movements between the supine and right decubitus positions. In the clinical setting of OLIF51 and LCA surgeries, careful preoperative evaluation and intraoperative 3D imaging are recommended for safe and accurate surgery.


Asunto(s)
Disco Intervertebral , Fusión Vertebral , Humanos , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Fusión Vertebral/métodos , Imagen por Resonancia Magnética , Vértebras Lumbares/cirugía , Tomografía Computarizada por Rayos X
8.
J Clin Med ; 13(2)2024 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-38256659

RESUMEN

Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical implantation and its implementation is progressively increasing worldwide. We routinely perform pre-procedural aortic angiography CT to assess aortic dimensions and vascular anatomy. This study aims to evaluate the image quality of CTA for TAVI planning using dual-layer spectral CT, with virtual monoenergetic image reconstructions at 40 keV. Thirty-one patients underwent a CTA protocol with the injection of 20 mL of contrast media. Image quality was assessed by measuring the mean density in Hounsfield Units (HU), the signal-to-noise ratio, and the contrast-to-noise ratio in VMI reconstructions. Additionally, a blinded subjective analysis was conducted by two observers. The results showed significant enhancement at all sampled vascular levels with a gradual decrease in HU from proximal to distal regions. Favourable subjective ratings were given for all parameters, with greater variability in the evaluation of iliac axes. A significant negative correlation (p < 0.05) was observed between BMI and CA at all vascular levels, indicating reduced contrast enhancement with increasing BMI. Spectral CT, along with reducing iodine load, allows for obtaining high-quality images without a significant increase in noise. The reduction in iodine load can have positive implications in clinical practice, improving patient safety and resource efficiency.

10.
Rev. argent. neurocir ; 37(4): 227-231, dic. 2023. ilus
Artículo en Español | LILACS, BINACIS | ID: biblio-1563273

RESUMEN

Introducción. La arteria cerebelosa posteroinferior (ACPI) nace de la arteria vertebral en la cara anterolateral del tronco cerebral, generalmente a la altura de la oliva inferior, transcurriendo en forma rostral a través de las raíces de los nervios glosofaríngeo, vago y accesorio. El objetivo del trabajo es determinar la prevalencia del nacimiento de la arteria cerebelosa postero inferior a nivel extracraneano, la presencia de bucle caudal extracraneano y las relaciones con estructuras oseas adyacentes, en una población estudiada por angiografía de vasos supraaórticos. Material y métodos. Estudio prospectivo, descriptivo, de una muestra consecutiva realizada durante un año (septiembre 2021 a agosto 2022) de todos los pacientes a los que se les realizó un cateterismo de vasos de cuello y cerebrales en Neurointervencionismo del Hospital de Alta Complejidad en Red "El Cruce", Buenos Aires, Argentina.Los estudios se realizaron en dos angiógrafos digitales en forma indistinta en incidencia perfil, con y sin digitalización de imagen, focalizadas en la unión craneo-cervical en todos los pacientes estudiados entre 18 y 80 años. Se objetivó el lugar de nacimiento de las arterias ACPI y la presencia de bucles extracraneanos por visión directa en los estudios sin y con sustracción. Se definió como bucle o loop extracraneano a la presencia de un segmento curvo de la arteria con dirección caudal que se extiende por debajo del foramen magno. Se buscó la concordancia interobservador entre 2 profesionales en forma independiente. Resultados. De los 404 procedimientos realizados en el período estudiado ingresaron 288 pacientes al estudio, de los cuales 152 fueron mujeres. La edad promedio fue de 49,2 años. Se analizaron 422 ACPI, 214 derechas y 208 izquierdas. Se observaron un total de 102 ACPI con bucles extracraneanos, representando un 24,1% del total: 49 derechos (48%) y 53 izquierdos (52%). En relación a arterias con origen extracraneal, se observaron en total 58 (13,7%) de las cuales 29 fueron derechas (50%). En 10 casos se observó en la misma arteria nacimiento y loop extracraneano (10%) y en dos casos nacimiento y loop extracraneano bilateral (3.9%). En 13 casos la arteria vertebral fue terminal en ACPI, de las cuales 5 presentaron un loop extracraneano, representando el 38,5 % de su población, siendo en su totalidad del territorio derecho. Conclusión. La prevalencia del nacimiento extracraneano de la ACPI en la población estudiada por angiografía fue de 13,7% y la prevalencia de bucle extracraneano fue del 24%. Ambos porcentajes se encuentran dentro de los resultados hallados en estudios previos, anatómicos y por imágenes: 0,7 al 20% y 9,5 al 35% respectivamente. La prevalencia de bucle extracraneano en arterias vertebrales con terminación en ACPI fue del 38,5%, siendo significativamente superior a los estudios reportados


Background. The posteroinferior cerebellar artery (PICA) arises from the vertebral artery on the anterolateral aspect of the brain stem, generally at the level of the inferior olive, running rostrally through the roots of the glossopharyngeal, vagus and accessory nerves. The objective of the work is to determine the prevalence of the origin of the posterior inferior cerebellar artery at the extracranial level, the presence of an extracranial caudal loop and the relationships with adjacent bone structures, in a population studied by angiography of supra-aortic vessels. Methods. Prospective, descriptive study of a consecutive sample carried out for one year (September 2021 to August 2022) of all patients who underwent catheterization of neck and cerebral vessels in the "Hospital de Alta Complejidad en Red El Cruce", Buenos Aires, Argentina. The studies were carried out in two digital angiographers indistinctly in profile incidence, with and without image digitization, focused on the cranio-cervical junction in all patients studied between 18 and 80 years of age. The birthplace of the ACPI arteries and the presence of extracranial loops were observed by direct vision in the studies without and with subtraction. An extracranial loop was defined as the presence of a curved segment of the artery with a caudal direction that extends below the foramen magnum. Interobserver agreement was sought between 2 professionals independently. Results. Of the 404 procedures performed in the studied period, 288 patients entered the study, of which 152 were women. The average age was 49,2 years; 422 PICA were analyzed, 214 right and 208 left. A total of 102 PICA with extracranial loops were observed, representing 24.1% of the total: 49 right (48%) and 53 left (52%). In relation to arteries with extracranial origin, a total of 58 (13.7%) were observed, of which 29 were right (50%). In 10 cases birth and extracranial loop were observed in the same artery (10%) and in two cases birth and bilateral extracranial loop (3.9%). In 13 cases the vertebral artery was terminal in PICA, of which 5 presented an extracranial loop, representing 38.5% of its population, being entirely in the right territory. Conclusions. The prevalence of extracranial origin of the PICA in the population studied by angiography was 13.7% and the prevalence of extracranial loop was 24%. Both percentages are within the results found in previous anatomical and imaging studies: 0.7 to 20% and 9.5 to 35% respectively. The prevalence of extracranial loop in vertebral arteries ending in PICA was 38.5%, being significantly higher than the reported studies


Asunto(s)
Arterias Cerebrales
11.
Transl Cancer Res ; 12(10): 2946-2951, 2023 Oct 31.
Artículo en Inglés | MEDLINE | ID: mdl-37969404

RESUMEN

Background: Extensive and dense pleural adhesion is a serious challenge in video-assisted thoracoscopic surgery (VATS), in which identification of vessels and their anatomical spaces is difficult. Once critical vessel is damaged while dissecting adhesion in VATS, leading to fatal hemorrhage, the surgeon will have to switch to thoracotomy. This is the first report of a case in which intraoperative indocyanine green (ICG) fluorescence imaging was used to identify critical vessels in severe pleural adhesions in uniportal VATS. Case Description: The patient (67-year-old male) with an 8-year history of tuberculosis and severe mixed ventilation dysfunction underwent a standardized wedge resection due to chest computed tomography (CT) scan that revealed a 2.6-cm nodule in the right upper lung. Intraoperatively, the superior vena cava and azygos vein were successfully identified and safely dissected using ICG fluorescence imaging in the presence of extensive and dense pleural adhesions. The chest drainage tube was removed on postoperative day (POD) 3, and patient was released from hospital on POD 5. The patient recovered well and no complication was observed in the follow-up. Conclusions: The ICG fluorescence imaging is used to illustrate the vessels and help to dissect them safely, which is a feasible, visualizable, and user-friendly method in severe pleural adhesions in uniportal VATS.

12.
Int J Surg Case Rep ; 113: 108997, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37952491

RESUMEN

INTRODUCTION: The normal anatomy of the celiac trunk (CT) is characterized by splitting into three branches in approximately 80 % of cases. In other cases, multiple anatomical variations can be observed. The purpose of this study was to review the clinical case featuring an extremely rare location of common hepatic artery (CHA) and to emphasize the importance of being familiar with possible anatomical variations of the hepatic artery through preoperative imaging in preparation for oncological surgery. PRESENTATION OF CASE: A 71-year-old patient presented with Siewert III cardioesophageal junction cancer with liver metastases (T2N2M1, stage IV). Preoperative contrast-enhanced computed tomography (CECT) showed that the CHA branched from the AA. The operation included the proximal resection of the stomach and abdominal esophagus, D2 lymph nodes dissection, peritumoral liver resection, and extramucosal pyloroplasty. DISCUSSION: We report a rare anatomical variation of replaced common hepatic artery, when it is located as VI type of Hiatt's classification - CHA branching from abdominal aorta (AA). It was discovered during contrast-enhanced computed tomography and illustrated by 3D reconstruction of vascular architectonics of the celiac trunk. CONCLUSION: This case shows the importance of preoperative preparation using CECT to identify anatomical variations of the CHA, particularly for patients with locally advanced and metastatic cancer.

13.
Interv Radiol (Higashimatsuyama) ; 8(3): 118-129, 2023 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-38020459

RESUMEN

The caudate lobe is located between the bilateral hepatic lobes and is divided into three subsegments: the Spiegel lobe, paracaval portion, and caudate process. The caudate artery arises from various sites of the bilateral hepatic arteries as an independent branch, common trunk, or arcade. Extrahepatic arteries can enter the caudate lobe mainly by the right inferior phrenic artery. The caudate artery also supplies the main bile duct and posterior aspect of segment IV. Although catheterization into the caudate artery is occasionally difficult because of its small size and sharp angulation, selective embolization of a tumor feeder is a significant prognostic factor in patients with hepatocellular carcinoma originating there. Therefore, we should recognize the peculiarity of its vascular anatomy and should be familiar with catheterization and embolization techniques.

14.
iScience ; 26(10): 108010, 2023 Oct 20.
Artículo en Inglés | MEDLINE | ID: mdl-37829206

RESUMEN

Astrocytes interact with not only synapses but also brain blood vessels through perivascular astrocyte endfeet (PV-AEF) to form the neurovascular unit (NVU). However, PV-AEF components have not been fully identified. Here, we biochemically isolated blood vessels from mouse brain homogenates and purified PV-AEF. The purified PV-AEF were observed in different sizes, similar to PV-AEF on brain blood vessels. Mass spectrometry analysis identified 9,762 proteins in the purified PV-AEF, including cell adhesion molecules, nectin-2δ, Kirrel2, and podoplanin. Immunofluorescence microscopic analysis revealed that nectin-2δ and podoplanin were concentrated mainly in arteries/arterioles and veins/venules of the mouse brain, whereas Kirrel2 was mainly in arteries/arterioles. Nectin-2α/δ, Kirrel2, and podoplanin were preferentially observed in large sizes of the purified PV-AEF. Furthermore, Kirrel2 potentially has cell adhesion activity of cultured astrocytes. Collectively, these results indicate that PV-AEF have heterogeneity in sizes and molecular components, implying different roles of PV-AEF in NVU function depending on vascular regions.

15.
iScience ; 26(9): 107455, 2023 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-37680481

RESUMEN

Type H vessels couple angiogenesis with osteogenesis, while sympathetic cues regulate vascular and skeletal function. The crosstalk between sympathetic nerves and type H vessels in bone remains unclear. Here, we first identify close spatial connections between sympathetic nerves and type H vessels in bone, particularly in metaphysis. Sympathoexcitation, mimicked by isoproterenol (ISO) injection, reduces type H vessels and bone mass. Conversely, beta-2-adrenergic receptor (ADRB2) deficiency maintains type H vessels and bone mass in the physiological condition. In vitro experiments reveal indirect sympathetic modulation of angiogenesis via paracrine effects of mesenchymal stem cells (MSCs), which alter the transcription of multiple angiogenic genes in endothelial cells (ECs). Furthermore, Notch signaling in ECs underlies sympathoexcitation-regulated type H vessel formation, impacting osteogenesis and bone mass. Finally, propranolol (PRO) inhibits beta-adrenergic activity and protects type H vessels and bone mass against estrogen deficiency. These findings unravel the specialized neurovascular coupling in bone homeostasis and regeneration.

16.
Rev. argent. coloproctología ; 34(3): 10-16, sept. 2023. ilus, tab, graf
Artículo en Español | LILACS | ID: biblio-1552469

RESUMEN

Introducción: La escisión completa del mesocolon con linfadenectomía D3 (CME-D3) mejora los resultados de los pacientes operados por cáncer del colon. Reconocer adecuadamente la anatomía vascular es fundamental para evitar complicaciones. Objetivo: El objetivo primario fue determinar la prevalencia de las variaciones anatómicas de la arteria mesentérica superior (AMS) y sus ramas en relación a la vena mesentérica superior (VMS). El objetivo secundario fue evaluar la asociación entre las distintas variantes anatómicas y el sexo y la etnia de lo pacientes. Diseño: Estudio de corte transversal. Material y métodos: Se incluyeron 225 pacientes con cáncer del colon derecho diagnosticados entre enero 2017 y diciembre de 2020. Dos radiólogos independientes describieron la anatomía vascular observada en las tomografías computadas. Según la relación de las ramas de la AMS con la VMS, la población fue dividida en 2 grupos y subdividida en 6 (1a-c, 2a-c). Resultados: La arteria ileocólica fue constante, transcurriendo en el 58,7% de los casos por la cara posterior de la VMS. La arteria cólica derecha, presente en el 39,6% de los pacientes, cruzó la VMS por su cara anterior en el 95,5% de los casos. La variante de subgrupo más frecuente fue la 2a seguida por la 1a (36,4 y 24%, respectivamente). No se encontró asociación entre las variantes anatómicas y el sexo u origen étnico. Conclusión: Las variaciones anatómicas de la AMS y sus ramas son frecuentes y no presentan un patrón predominante. No hubo asociación entre las mismas y el sexo u origen étnico en nuestra cohorte. El reconocimiento preoperatorio de estas variantes mediante angiotomografía resulta útil para evitar lesiones vasculares durante la CME-D3. (AU)


Background: Complete mesocolic excision with D3 lymphadenectomy (CME-D3) improves the outcomes of patients operated on for colon cancer. Proper recognition of vascular anatomy is essential to avoid complications. Aim: Primary outcome was to determine the prevalence of anatomical variations of the superior mesenteric artery (SMA) and its branches in relation to the superior mesenteric vein (SMV). Secondary outcome was to evaluate the association between these anatomical variations and sex and ethnicity of the patients. Design: Cross-sectional study. Material and methods: Two hundred twenty-fivepatients with right colon cancer diagnosed between January 2017 and December 2020 were included. Two independent radiologists described the vascular anatomy of computed tomography scans. The population was divided into 2 groups and subdivided into 6 groups (1a-c, 2a-c), according to the relationship of the SMA and its branches with the SMV. Results: The ileocolic artery was constant, crossing the SMV posteriorly in 58.7% of the cases. The right colic artery, present in 39.6% of the patients, crossed the SMV on its anterior aspect in 95.5% of the cases. The most frequent subgroup variant was 2a followed by 1a (36.4 and 24%, respectively). No association was found between anatomical variants and gender or ethnic origin. Conclusions: The anatomical variations of the SMA and its branches are common, with no predominant pattern. There was no association between anatomical variations and gender or ethnic origin in our cohort. Preoperative evaluation of these variations by computed tomography angi-ography is useful to avoid vascular injuries during CME-D3. (AU)


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Neoplasias del Colon/cirugía , Colon Ascendente/anatomía & histología , Colon Ascendente/irrigación sanguínea , Escisión del Ganglio Linfático , Mesocolon/cirugía , Argentina , Tomografía Computarizada por Rayos X/métodos , Estudios Transversales , Arteria Mesentérica Superior/anatomía & histología , Distribución por Sexo , Colectomía/métodos , Distribución por Etnia , Variación Anatómica , Venas Mesentéricas/anatomía & histología
17.
Handb Clin Neurol ; 196: 305-346, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37620077

RESUMEN

Stroke is the leading cause of neurological disability in the United States and worldwide. Remarkable advances have been made over the past 20 years in acute vascular treatments to reduce infarct size and improve neurological outcome. Substantially less progress has been made in the understanding and clinical approaches to neurological recovery after stroke. This chapter reviews the epidemiology, bedside examination, localization approaches, and classification of stroke, with an emphasis on motor stroke presentations and management, and promising research approaches to enhancing motor aspects of stroke recovery.


Asunto(s)
Accidente Cerebrovascular , Humanos , Adulto , Niño , Progresión de la Enfermedad , Accidente Cerebrovascular/epidemiología , Accidente Cerebrovascular/terapia
18.
Rev. cir. (Impr.) ; 75(4)ago. 2023.
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1515244

RESUMEN

Objetivo: Identificar los patrones de distribución vascular del ángulo esplénico del colon (AEC) en la población chilena para su comparación con la literatura oriental (Fukuoka). Materiales y Métodos: Estudio descriptivo, transversal. Se caracterizó la irrigación del AEC de imágenes con protocolo Urotac realizadas en Clínica INDISA entre el año 2020 y 2021 (n = 127), clasificándolas dentro de 6 tipos descritos por Fukuoka. Se evaluaron características demográficas y comorbilidades. Las variables fueron analizadas utilizando estadística descriptiva y la significancia mediante la prueba Chi2. Resultados: Existen diferencias en los tipos irrigación del AEC entre la serie local y Fukuoka, la irrigación tipo 3 fue la que presentó mayor variación (p < 0,05). El tipo 1 es la más frecuente (34,7%), sin casos del Tipo 4. No se identificó diferencia entre los distintos tipos de irrigación con relación a las variables demográficas y comorbilidades. Discusión: Al comparar nuestra serie con la oriental se evidenció similar frecuencia en tipos 1 y 6, mayor en tipos 3 y 5, y tipos 2 y 4 con menor representación. Se identificó un mayor aporte en la irrigación del AEC por la arteria cólica izquierda (ACI) en la población estudiada (64,6%). Conclusión: Nuestra población tiene mayor participación de ACI en irrigación del AEC que orientales (64,6% vs 49,6%), los tipos más frecuentes son 1, 3 y 6, el Tipo 1 es la forma más frecuente de irrigación, similar a Fukuoka (34,7% vs 39,7%), Tipo 3 tiene mayor representación en nuestra población que en la oriental (29,9% vs 9,9%).


Objective: To identify the vascular distribution patterns of the splenic flexure of the colon (AEC) in the Chilean population for comparison with the oriental literature (Fukuoka). Methods: Descriptive, cross-sectional study. The irrigation of the AEC of images with the Urotac protocol performed at the INDISA Clinic between 2020 and 2021 (n = 127) was characterized, classifying them into 6 types described by Fukuoka. Demographic characteristics and comorbidities were evaluated. Variables were analyzed using descriptive statistics and significance using the Chi2 test. Results: There are differences in the types of irrigation of the AEC between the local series and Fukuoka, irrigation type 3 was the one that presented the greatest variation (p < 0.05). Type 1 is the most frequent (34.7%), with no cases of Type 4. No difference was identified between the different types of irrigation in relation to demographic variables and comorbidities. Discussion: When comparing our series with the eastern one, a similar frequency was found in types 1 and 6, higher in types 3 and 5, and types 2 and 4 with less representation. A greater contribution was identified in the irrigation of the AEC by the left colic artery (ICA) in the population studied (64.6%). Conclusion: Our population has a greater participation of ICA in AEC irrigation than Orientals (64.6% vs 49.6%), the most frequent types are 1, 3 and 6, Type 1 is the most frequent form of irrigation, similar to Fukuoka (34.7% vs 39.7%), Type 3 is more represented in our population than in the eastern one (29.9% vs 9.9%).

19.
Anticancer Res ; 43(7): 3295-3303, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37351991

RESUMEN

BACKGROUND/AIM: This study aimed to evaluate the extent of lymph node dissection (LND) determined using preoperative Three-dimensional computed tomographic angiography (3D-CTA), in the management of splenic flexure colon cancer (SFC). PATIENTS AND METHODS: In this retrospective, observational study, 61 patients who underwent preoperative 3D-CTA and laparoscopic complete mesocolic excision for SFC between December 2011 and December 2021 were identified at a tertiary care center in Japan. Preoperative 3D-CTA was used to confirm the feeding arteries, following which the extent of LND was determined. Left hemicolectomy was performed in cases requiring LND in the domains of the middle colic artery and left colic artery. In other cases, a partial colectomy (PC) that was defined as a segmental resection of the splenic flexure with LND in the domains of the feeding arteries was performed. Surgical and oncological outcomes were compared between PC and left hemicolectomy. RESULTS: Preoperative 3D-CTA enabled the evaluation of the feeding artery in all patients. PC was performed in 51 patients (83.6%). Patients who underwent PC had a shorter operative time (p=0.03) and less blood loss (p=0.01). There was no difference in complications between the two groups. There was also no significant difference in 5-year overall survival, nor 3-year disease free survival. CONCLUSION: Preoperative simulation using 3D-CTA has the potential to be useful in the identification of feeding arteries and determination of the oncologically adequate extent of LND for each patient.


Asunto(s)
Colon Transverso , Neoplasias del Colon , Laparoscopía , Humanos , Colon Transverso/diagnóstico por imagen , Colon Transverso/cirugía , Colon Transverso/irrigación sanguínea , Angiografía por Tomografía Computarizada , Estudios Retrospectivos , Neoplasias del Colon/diagnóstico por imagen , Neoplasias del Colon/cirugía , Escisión del Ganglio Linfático/métodos , Colectomía/métodos , Arteria Mesentérica Superior , Laparoscopía/métodos
20.
Acta Neurochir (Wien) ; 165(7): 1807-1819, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-37162608

RESUMEN

BACKGROUND: Since the medullary arteries are of a great neurologic and neurosurgical significance, the aim was to perform a detailed microanatomic study of these vessels, as well as of the medullary infarctions in a group of patients. METHODS: The arteries of 26 halves of the brain stem were injected with India ink and gelatin, microdissected and measured with an ocular micrometer. Neurologic and magnetic resonance imaging (MRI) examinations were performed in 11 patients. RESULTS: The perforating medullary arteries, averaging 6.7 in number and 0.26 mm in diameter, most often originated from the anterior spinal artery (ASA), and rarely from the vertebral (VA) (38.5%) and the basilar artery (BA) (11.6%). They supplied the medial medullary region. The anterolateral arteries, 4.8 in number and 0.2 mm in size, most often arose from the ASA and PerfAs, and nourished the anterolateral region. The lateral arteries, 2.2 in number and 0.31 mm in diameter, usually originated from the VA and the posterior inferior cerebellar artery (PICA). They supplied the lateral medullary region. The dorsal arteries, which mainly arose from the PICA and the posterior spinal artery (PSA), nourished the dorsal region, including the roof of the 4th ventricle. The anastomotic channels, averaging 0.3 mm in size, were noted in 42.3%. Among the medullary infarctions, the lateral ones were most frequently present (72.8%). CONCLUSION: The obtained anatomic data, which can explain the medullary infarctions symptomatology, are also important in order to avoid damage to the medullary arteries during neurosurgical and neuroradiologic interventions.


Asunto(s)
Relevancia Clínica , Arteria Vertebral , Humanos , Arteria Vertebral/diagnóstico por imagen , Arteria Vertebral/cirugía , Arteria Vertebral/anatomía & histología , Bulbo Raquídeo/diagnóstico por imagen , Bulbo Raquídeo/cirugía , Tronco Encefálico , Infarto , Cerebelo/irrigación sanguínea
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