RESUMEN
Previous observations on a group of exceptionally healthy "Super-Seniors" showed a lower variance of multiple physiological measures relevant for health than did a less healthy group of the same age. The finding was interpreted as the healthier individuals having physiological measurement values closer to an optimal level, or "sweet spot." Here, we tested the generalizability of the sweet-spot hypothesis in a larger community sample, comparing differences in the variance between healthier and less healthy groups. We apply this method to the Canadian Longitudinal Study on Aging (CLSA) comprehensive cohort of 30,097 participants aged 45 to 85 years with deep phenotype data. Data from both sexes and four age ranges were analyzed. Five instruments were used to represent different aspects of health, physical, and cognitive functioning. We tested 231 phenotypic measures for lower variance in the most healthy vs. least healthy quartile of each sex and age group, as classified by the five instruments. Segmented regression was used to determine sex-specific optimal values. One hundred forty-two physiological measures (61%) showed lower variance in the healthiest than in the least healthy group, in at least one sex and age group. The difference in variance was most significant for hemoglobin A1c and was also significant for many body composition measurements, but not for bone mineral density. Ninety-four phenotypes showed a nonmonotonic relationship with health, consistent with the idea of a sweet spot; for these, we determined optimal values and 95% confidence intervals that were generally narrower than the ranges of current clinical reference intervals. These findings for sweet spot discovery validate the proposed approach for identifying traits important for healthy aging.
Asunto(s)
Envejecimiento Saludable , Masculino , Femenino , Humanos , Estudios Longitudinales , Canadá , Envejecimiento/psicología , FenotipoRESUMEN
PURPOSE: Microelectrode recordings (MERs) are a significant clinical indicator for sweet spots identification of implanted electrodes during deep brain stimulation of the subthalamic nucleus (STN) surgery. As 1D MERs signals have the unboundedness, large-range, large-amount and time-dependent characteristics, the purpose of this study is to propose an automatic and precise identification method of sweet spots from MERs, reducing the time-consuming and labor-intensive human annotations. METHODS: We propose an automatic identification method of sweet spots from MERs for electrodes implantation in STN-DBS. To better imitate the surgeons' observation and obtain more intuitive contextual information, we first employ the 2D Gramian angular summation field (GASF) images generated from MERs data to perform the sweet spots determination for electrodes implantation. Then, we introduce the convolutional block attention module into convolutional neural network (CNN) to identify the 2D GASF images of sweet spots for electrodes implantation. RESULTS: Experimental results illustrate that the identification result of our method is consistent with the result of doctor's decision, while our method can achieve the accuracy and precision of 96.72% and 98.97%, respectively, which outperforms state-of-the-art for intraoperative sweet spots determination. CONCLUSIONS: The proposed method is the first time to automatically and accurately identify sweet spots from MERs for electrodes implantation by the combination an advanced time series-to-image encoding way with CBAM-enhanced networks model. Our method can assist neurosurgeons in automatically detecting the most likely locations of sweet spots for electrodes implantation, which can provide an important indicator for target selection while it reduces the localization error of the target during STN-DBS surgery.
Asunto(s)
Estimulación Encefálica Profunda/métodos , Electrodos Implantados , Microelectrodos , Núcleo Subtalámico/diagnóstico por imagen , Algoritmos , Análisis de Fourier , Humanos , Masculino , Persona de Mediana Edad , Enfermedad de Parkinson/cirugía , Reconocimiento de Normas Patrones Automatizadas , Reproducibilidad de los Resultados , Análisis de OndículasRESUMEN
BACKGROUND: The existing environment literature separately emphasizes the importance of neighborhood walkability and greenness in enhancing health and wellbeing. Thus, a desirable neighborhood should ideally be green and walkable at the same time. Yet, limited research exists on the prevalence of such "sweet spot" neighborhoods. We sought to investigate this question in the context of a large metropolitan city (i.e., Sydney) in Australia. METHODS: Using suburb level normalized difference vegetative index (NDVI), percentage urban greenspace, Walk Score® (Walk Score, Seattle, WA, USA), and other data, we explored the global and local relationships of neighborhood-level greenness, urban green space (percent park area) with walkability applying both non-spatial and spatial modeling. RESULTS: We found an overall negative relationship between walkability and greenness (measured as NDVI). Most neighborhoods (represented by suburbs) in Sydney are either walkable or green, but not both. Sweet spot neighborhoods that did exist were green but only somewhat walkable. In addition, many neighborhoods were both less green and somewhat walkable. Moreover, we observed a significant positive relationship between percentage park area and walkability. These results indicate walkability and greenness have inverse and, at best, mixed associations in the Sydney metropolitan area. CONCLUSIONS: Our analysis indicates an overall negative relationship between greenness and walkability, with significant local variability. With ongoing efforts towards greening Sydney and improving walkability, more neighborhoods may eventually be transformed into becoming greener and more walkable.