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ABSTRACT In recent years, the change in the design of video games has become evident, one of them is accessibility for people with different disabilities, despite the laws, which are very limited, there are no standards that require companies, industries and producers from different sectors implement this resource in their projects. From this research, the objective is to investigate the importance that these inclusion games comply with the response to stimuli provided by the industry, in this field, and that the support that the country is giving to this need to be felt is also felt. this visually impaired population. Based on the mixed research methodology, different sources are investigated in order to demonstrate how necessary it is that there are models of inclusion in video games, both entertainment and educational (serious), thus reaching an identity model that. The lack of laws and resources that promote this industry is evidenced. The project made it possible to describe the main strategies and resources that have been proposed and/or implemented in terms of accessibility for people with visual disabilities in Colombia, investigating and comparing the information obtained from the state of the art, and in this way conclude with the impact of these development methods, in the visually impaired population. An important impact has been the technological evolution that other countries have managed to develop for this type of population. As a conclusion, a disparity was found in the development of this project, which is precisely the little accessibility that people with visual disabilities have to video games in Colombia, because beyond the interaction that exists with some, much more access is required. And above all more investment and enactment of laws that support this resource. Using the mixed research methodology, different sources are investigated in order to demonstrate how necessary it is that there are models of inclusion in video games, both entertainment and educational (serious), thus reaching an identity pattern that gives as shows the lack of laws and resources that promote this industry. From this type of research, it was concluded that the lack of resources has been a legible mark that passes through these industries that have the panorama quite compromised by the demands of the market, but that due to this lack of economic resources they cannot reach the levels of implementation. to its mission and vision. Observing what was said above, it becomes complex to be able to carry out a research that clearly defines the inclusion processes for this type of people with said disability in Colombia. Each model of each industry is defined in a different way, since not all of them have this offer in their services. Common to this type of population. What, then, allowed us to conclude this research, finding social differences in each production of a video game? The project allowed us to describe the main strategies that have been proposed and/or implemented in terms of accessibility for people with visual disabilities in Colombia, investigating and comparing the information obtained from the state of the art, as mentioned above. Thus, then, different responses were found to this inclusion, not only in entertainment games but also in educational ones, which in the end are also very important in the classroom, because not only should one think about the distraction game, but also about the playful nature of teaching, thus helping teachers in the development of their classes. In this way, we conclude with the impact of these development methods on the visually impaired population. Another important point that could be evidenced is the evolution of technology, which has brought haptic systems, immersive and dynamic audio, as well as braille itself in digital systems, this, of course, has allowed progress towards much more logical and dynamic resources, but they continue to be limited precisely because they cannot be implemented correctly, due to their high purchasing value. We must think not of people who suffer from visual disabilities, but rather we must think of all social strata with this type of disability who can, with their resources, access this type of technology. Each part of the intervention exercise with state and private companies led to results that concluded in the population with visual disabilities that does not have the possibility of accessing this exercise of inclusion, and beyond the common interest in popularizing these video games, the limitation of certain sectors is seen that do not find in this undertaking a great industry, since the majority assures that it is more lucrative to invest in video games for people without no limitation or disability than investing in this other type of video game In conclusion, the disabled population in Colombia is 3,134,037; this number is very high if we also consider the rural populations that live without any type of resource or technological reach; Due to their socioeconomic condition and location, they are people who have a deterioration in services, then what is the extent of the disabled population in these areas that do not have the support and resources to improve their quality of life? It is almost null, there is no possibility that in the most vulnerable places and far from the reach of the government, inclusion exercises will be carried out with the visually disabled population, because simply in the last population census that was carried out in Colombia in 2018, more than 50% of the population They do not access the Internet, this added to governments that waste state money, it could be said that the level exceeds that percentage. If so, it is very possible that the reach of this population to these technological resources is very bad. A lot of economic investment is required on the part of the state, and for the designers of these technologies to expand to cover their creative enterprises, to the entire population, without the right to exclusion. For this reason, in this project a disparity is evident, which is precisely the little accessibility that people with visual disabilities have to video games in Colombia, not only from entertainment, but from their spaces in the classroom, which is what many demands. academics for their models and resources to work with this population, because beyond the interaction that exists with some (very few), much more access is still required and above all more investment and enactment of laws that support said resource.

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Resumen El duelo por finalización de una relación de pareja puede ser una experiencia que genera diferentes afectaciones, y para lidiar con ello, las personas utilizan diversos recursos de afrontamiento. El presente estudió buscó identificar las diferentes estrategias de afrontamiento que utilizan las personas en duelo de pareja en general y según el tiempo de finalización del vínculo. Esta investigación, de enfoque cuantitativo, alcance descriptivo no experimental y de corte transversal, fue realizada con 172 participantes, elegidos en un muestro a conveniencia. Se evidenció en los resultados que las estrategias que presentaron menor uso fueron la búsqueda de solución de problemas y la reevaluación positiva, y las más utilizadas fueron la búsqueda de apoyo social, la espera, religión, evitación emocional, el apoyo profesional, la reacción agresiva, la evitación cognitiva y la expresión de dificultad de afrontamiento. A nivel del tiempo de la finalización de la relación, se encontró mayor uso de la evitación emocional, reacción agresiva, evitación cognitiva y el apoyo profesional en aquellos con 6 meses de duelo, y menor uso de la reevaluación positiva, búsqueda de apoyo social, solución de problemas, negación, expresión de la dificultad de afrontamiento y autonomía en este periodo de tiempo. En conclusión, se identificó que las estrategias para afrontar el duelo en pareja varían conforme avanza el tiempo de la finalización del vínculo.

Abstract Grieving duel to the end of a relationship can be an experience that generates different effects and, to deal with it, people use various coping resources. The present study sought to identify the different coping strategies used by bereaved couples in general and according to the time the relationship ended. This research with a quantitative approach, non-experimental and cross-sectional descriptive scope, was carried out with 172 subjects chosen in a convenience sample. The results showed that the strategies that were least used were the search for problem solutions and positive reappraisal and the most used were the search for social support, waiting, religion, emotional avoidance, professional support, aggressive reaction, cognitive avoidance and the expression of coping difficulty. At the time of the end of the relationship, greater use of emotional avoidance, aggressive reaction, cognitive avoidance and professional support was found in those with 6 months of grief and less use of positive reappraisal, search for social support, solution of problems, denial, expression of coping difficulty and autonomy in this period of time. In conclusion, it was identified that the strategies for coping with grief as a couple vary as the time of the end of the relationship progresses.

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BACKGROUND: Matrix Support (MS) is a strategy that can be used to improve integration between Primary Health Care (PHC) and other levels of care. OBJECTIVE: The aim of this study was to investigate the association between MS carried out in Brazilian Dental Specialty Centers (CEOs) (secondary level of oral health care) and aspects of the integrated work process with PHC, as well as contextual variables. METHODS: A quantitative cross-sectional study was conducted using data from the Program for Quality Improvement and Access to CEOs (PMAQ-CEO). Secondary data from the External Evaluation of the second cycle of PMAQ-CEO were analyzed, including contextual variables obtained from sources such as the Unified Health System (SUS) and official research institutions. Descriptive analyses were performed, and four multiple models were adjusted to investigate the association between the variables. RESULTS: The results showed that about half of the CEOs did not carry out therapeutic projects developed with the oral health teams of PHC. It was found that the lack of therapeutic projects developed with the teams was associated with the lack of discussion of complex cases by the team, lack of discussion of individual therapeutic project, absence of joint continuing education activities, lack of construction and discussion of clinical protocols, and lack of belief in the importance of planning and periodic evaluation. The results suggest that the articulation between PHC and secondary oral health care still presents weaknesses within the scope of SUS. Comprehensive care needs to be strengthened, requiring greater intervention from management. CONCLUSION: It was concluded that the individual factors of CEOs, related to the work process, have a greater influence on the lack of integration with oral health teams of PHC, compared to the contextual variables of municipalities.

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Cancer therapy is constantly evolving, with a growing emphasis on targeted and efficient treatment options. In this context, graphene quantum dots (GQDs) have emerged as promising agents for precise drug and gene delivery due to their unique attributes, such as high surface area, photoluminescence, up-conversion photoluminescence, and biocompatibility. GQDs can damage cancer cells and exhibit intrinsic photothermal conversion and singlet oxygen generation efficiency under specific light irradiation, enhancing their effectiveness. They serve as direct therapeutic agents and versatile drug delivery platforms capable of being easily functionalized with various targeting molecules and therapeutic agents. However, challenges such as achieving uniform size and morphology, precise bandgap engineering, and scalability, along with minimizing cytotoxicity and the environmental impact of their production, must be addressed. Additionally, there is a need for a more comprehensive understanding of cellular mechanisms and drug release processes, as well as improved purification methods. Integrating GQDs into existing drug delivery systems enhances the efficacy of traditional treatments, offering more efficient and less invasive options for cancer patients. This review highlights the transformative potential of GQDs in cancer therapy while acknowledging the challenges that researchers must overcome for broader application.

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The tropical maize breeding for low-P tolerance and good performance under low-P stress environments can be achieved through selection based on root morphology traits at seedling stage. Here, we assessed the genotypic variation and genetic diversity of a panel of 151 tropical maize inbred lines for root and shoot seedling traits, investigated the relationship among traits and selected a set of promising inbred lines for low-P tolerance and performance. We evaluated the inbred lines at seedling stage in a greenhouse experiment under two conditions: applied P (AP) and non-applied P (NAP). A mixed model approach was used to estimate variance components and predict the genotypic values of each inbred line. The genetic diversity among inbred lines based on root and shoot traits was assessed, and correlations were estimated between tested traits under AP and NAP. Our panel of inbred lines showed huge genetic variability for all traits and presented large genetic diversity under both P conditions. Variance components due to the inbred line × P condition interaction were also highly significant (P < 0.01) for all traits. Root dry weight (RDW) was positively associated with stalk dimeter (SD), shoot dry weight (SDW) and root length, volume, and area under both P conditions. Also, the SD and SDW were associated with most root traits under AP. Based on low-P tolerance and performance indices, we selected a set of top 20 inbred lines to be used in our maize breeding program. We therefore concluded that there is a significant genetic diversity in the tropical maize inbred lines which have the genetic potential to be use in association mapping studies and also to develop improved low-P tolerant and P-efficient hybrids and maize breeding populations for low-P stress environments.

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Understanding transgender youth coping mechanisms may help create strategies that reduce the influence of stress on quality of life. Our study aims to measure the quality of life of Brazilian transgender youth and analyse the association with their coping strategies used for dealing with general and gender-related stress. The sample consisted of 185 participants (µ = 18.49 years; SD 2.42); of which 95 (46.34%) transgender boys, 45 (21.95%) transgender girls, 65 (31.71%) non-binary. Better quality of life was related to social support, whereas lower quality of life was related to the use of avoidance coping style in the context of general stress. The study found no association between coping strategies for gender-related stress and quality of life. Thus, the increase in quality of life in the context of gender distress among transgender youth should involve other mechanisms than promoting coping skills.

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Spine disorders are the leading cause of disability worldwide. To promote social inclusion, it is essential to ensure that people can participate in their societies by improving their ability, opportunities, and dignity, through access to high-quality, evidence-based, and affordable spine services for all.To achieve this goal, SPINE20 recommends six actions.- SPINE20 recommends that G20 countries deliver evidence-based education to the community health workers and primary care clinicians to promote best practice for spine health, especially in underserved communities.- SPINE20 recommends that G20 countries deliver evidence-based, high-quality, cost-effective spine care interventions that are accessible, affordable and beneficial to patients.- SPINE20 recommends that G20 countries invest in Health Policy and System Research (HPSR) to generate evidence to develop and implement policies aimed at integrating rehabilitation in primary care to improve spine health.- SPINE20 recommends that G20 countries support ongoing research initiatives on digital technologies including artificial intelligence, regulate digital technologies, and promote evidence-based, ethical digital solutions in all aspects of spine care, to enrich patient care with high value and quality.- SPINE20 recommends that G20 countries prioritize social inclusion by promoting equitable access to comprehensive spine care through collaborations with healthcare providers, policymakers, and community organizations.- SPINE20 recommends that G20 countries prioritize spine health to improve the well-being and productivity of their populations. Government health systems are expected to create a healthier, more productive, and equitable society for all through collaborative efforts and sustained investment in evidence-based care and promotion of spine health.

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Gynecological violence, a form of gender-based violence encountered by women, remains a significant but overlooked issue. It occurs within healthcare settings in the context of gynecological care, and despite its prevalence, there's a dearth of research exploring strategies to combat it. This qualitative study aimed to investigate the coping mechanisms adopted by women and individuals assigned female at birth (cisgender, gender nonconforming, and transgender) following experiences of violence in Chile. We conducted semi-structured interviews to explore their coping strategies. The transcriptions were analyzed employing thematic analysis, which revealed that individuals primarily coped with gynecological violence by seeking interpersonal interactions that provided emotional and instrumental support. Additionally, we identified novel coping mechanisms such as self-protecting behaviors and self-affirming behaviors.

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OBJECTIVE: Caregivers play an essential role in supporting people with Alzheimer's disease globally. User-informed research is vital to developing trans-cultural guidelines for dementia support organisations. While coping strategies of caregivers are well researched, the 'coping-effectiveness' framework falls short of representing all caregiver needs. Our aim was to develop a robust and inclusive, globally applicable framework of caregiver-informed support needs. METHODS: In partnership with Alzheimer's Disease International and Roche, we conducted qualitative online semi-structured interviews with 34 family caregivers from the Global North (UK, US) and Global South (Brazil, South Africa) in the COVID-19 context. Participant-generated photographs helped encourage discussions of hidden contextual issues. Iterative inductive narrative analysis of interviews and photographs was carried out with input from global and national charity and industry sectors. RESULTS: We identified a framework of four cross-cultural caring approaches with implications for support: (1) Empathising, using emotion-focused strategies to develop strong expertise and coping skills, with time specific information, psychosocial and peer support needs. (2) Organising, using problem-focused strategies, with strong narratives of expertise and advocacy which benefited from early structured information and professional confirmation. (3) Non-identifying caregiving, where daily aspects of caring occurred without specialist knowledge and expertise, and caregivers sought assistance in managing disease-related support. (4) Reluctance, where struggling with unwanted caring responsibilities meant caregivers looked to professionals to carry out daily care. CONCLUSION: Our findings move beyond the 'coping-effectiveness' framework of support to suggest a novel 'role-needs' framework. Our approach supports inclusive ways of tailoring support to fit individual caregiver circumstances globally.

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This study presents extended Immunity Agent-Based Model (IABM) simulations to evaluate vaccination strategies in controlling the spread of infectious diseases. The application of IABM in the analysis of vaccination configurations is innovative, as a vaccinated individual can be infected depending on how their immune system acts against the invading pathogen, without a pre-established infection rate. Analysis at the microscopic level demonstrates the impact of vaccination on individual immune responses and infection outcomes, providing a more realistic representation of how the humoral response caused by vaccination affects the individual's immune defense. At the macroscopic level, the effects of different population-wide vaccination strategies are explored, including random vaccination, targeted vaccination of specific demographic groups, and spatially focused vaccination. The results indicate that increased vaccination rates are correlated with decreased infection and mortality rates, highlighting the importance of achieving herd immunity. Furthermore, strategies focused on vulnerable populations or densely populated regions prove to be more effective in reducing disease transmission compared to randomly distributed vaccination. The results presented in this work show that vaccination strategies focused on highly crowded regions are more efficient in controlling epidemics and outbreaks. Results suggest that applying vaccination only in the densest region resulted in the suppression of infection in that region, with less intense viral spread in areas with lower population densities. Strategies focused on specific regions, in addition to being more efficient in reducing the number of infected and dead people, reduce costs related to transportation, storage, and distribution of doses compared to the random vaccination strategy. Considering that, despite scientific efforts to consolidate the use of mass vaccination, the accessibility, affordability, and acceptability of vaccines are problems that persist, investing in the study of strategies that mitigate such issues is crucial in the development and application of government policies that make immunization systems more efficient and robust.

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Studies involving the Cognitive Assessment System (CAS) planning scale typically use only the subtest and scale scores without assessing the strategies employed by the participants. This study addressed this gap and examined the planning strategies used by children in the CAS2: Spanish version and their relationship with planning performance. We conducted an exploratory cross-sectional study with 26 Puerto Rican children aged 8 to 11. Results showed that no strategies were consistently used by participants according to examinees' reports (f = 0-46%), but examiners observed consistent use of some strategies such as "coded left to right, top to bottom", f = 92%; "scanned the page for the next number or letter", f = 100%. Welch's t-tests did not show relationships between participants' performance and the strategies observed by examiners, | mean differences | = 0.05-0.81, ps ≥ 0.05, nor with the strategies reported by participants, | mean differences | = 0.05-1.69, ps ≥ 0.05. These findings suggest that although the examiners may observe the use of strategies, the examinees are unaware of the strategies they use, and the strategies used are not associated with their performance. Future studies are needed to confirm these findings.

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OBJECTIVE: This descriptive qualitative study aimed to gain insights into the expectations of individuals with chronic shoulder pain and to investigate how different levels of disability may influence their beliefs and expectations regarding improvement. METHODS: This qualitative study utilized the Common Sense Model (CSM) as its theoretical framework. Conducted within a public physical therapist clinic, individuals with chronic shoulder pain who were awaiting the initiation of the treatment were included. Participants, female and male [aged 30 to 69 years], were purposefully sampled. Thirty participants, categorized into 2 groups based on the Shoulder Pain and Disability Index (SPADI) scores, underwent semi-structured interviews. Group 1, lower SPADI scores (0 to 60), had 10 participants, and Group 2, higher SPADI scores (61 to 100), had 20 participants. Thematic analysis and inductive coding were employed to analyze the interviews. RESULTS: Common themes emerged in both groups: the use of medical terms for understanding the diagnosis and the multidimensional impact of pain. The last 2 themes differed between groups. Notable differences included Group 1's focus on resources for pain relief and positive expectations with physical therapy, while Group 2 emphasized rest, religion as a resource for pain relief, and God's role in improvement. CONCLUSION: These findings highlight the complexity of beliefs and expectations among patients with chronic shoulder pain. Individuals with greater disability often incorporated religious beliefs into their coping strategies, but they held lower recovery expectations and reported negative treatment experiences. These insights have implications for tailoring patient-centered care approaches. IMPACT: This study underscores the need for health care providers to consider the multidimensionality of recovery expectations, which can significantly influence patient outcomes. Clinicians can reflect on this knowledge to optimize treatment strategies and improve patient prognosis.

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The female orgasm remains a subject of extensive debate within evolutionary sciences, primarily due to the absence of a consensus regarding its adaptive function. Some hypotheses propose that it could function as a mechanism for mate selection, possibly linked to reproductive strategies. Studies have observed that lesbian women tend to experience orgasms more frequently than straight women, suggesting a potential link to advantageous partner characteristics. We explored the connection between the female orgasm and mate selection, aiming to ascertain its role as an adaptive tool for mate choice. A total of 939 sexually active Brazilian women (Mage = 28.3 years) engaged in committed relationships participated by completing the Marital Empathy Questionnaire, the Female Sexual Function Index, and evaluations of their partners' attributes. Analysis using structural equation models revealed that higher orgasm scores were positively associated with perceptions of partner kindness, intelligence, good health, physical attractiveness, and empathy. However, the small effect sizes of these associations warrant caution in their interpretation, and no significant association was found for relationship duration, financial prospects, dominance, and masculinity/femininity. Additionally, no differences were found between women in same-sex and other-sex relationships regarding orgasm frequency and its association with partner traits. The findings partially support the mate-choice theory, encompassing both sire-choice and pair-bond hypotheses, suggesting that female orgasm is positively associated with some partner attributes related to genetic quality and the capability for emotional connection and resource investment. Therefore, female orgasm may offer information about the partner that might not be primarily accessed and contribute to relationship maintenance.

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Higher temperatures exacerbate drought conditions by increasing evaporation rates, reducing soil moisture and altering precipitation patterns. As global temperatures rise as a result of climate change, these effects intensify, leading to more frequent and severe droughts. This link between higher temperatures and drought is particularly evident in sensitive ecosystems like the Amazon rainforest, where reduced rainfall and higher evaporation rates result in significantly lower water levels, threatening biodiversity and human livelihoods. As an example, the serious drought experienced in the Amazon basin in 2023 resulted in a significant decline in fish populations. Elevated water temperatures, reaching up to 38°C, led to mass mortality events, because these temperatures surpass the thermal tolerance of many Amazonian fish species. We know this because our group has collected data on critical thermal maxima (CTmax) for various fish species over multiple years. Additionally, warmer waters can cause hypoxia, further exacerbating fish mortality. Thus, even Amazon fish species, which have relatively high thermal tolerance, are being impacted by climate change. The Amazon drought experienced in 2023 underscores the urgent need for climate action to mitigate the devastating effects on Amazonian biodiversity. The fact that we have been able to link fish mortality events to data on the thermal tolerance of fishes emphasizes the important role of experimental biology in elucidating the mechanisms behind these events, a link that we aim to highlight in this Perspective.

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BACKGROUND: Coffee (Coffea arabica L.) is one of the most important commodities today, with a high economic value worldwide. Coffee leaf rust (Hemileia vastatrix Berk. et Br.) has been showing a high impact on Brazilian coffee trees among the various diseases that attack coffee. The climate has a great influence on the development of diseases, especially when fungi are the causal agents. This study aimed to carry out the zoning of climate favorability for coffee leaf rust in the traditional and main coffee-producing regions of Brazil. The study was conducted in 13 locations in the states of Paraná, São Paulo, Rio de Janeiro, Espírito Santo, Minas Gerais, Goiás and Bahia. Air temperature and daily precipitation data for the current scenario were collected using the WorldClim version 2.1 platform for the last climatological normal and future climate change data. The ideal climate conditions for coffee leaf rust consist of a mean air temperature ranging from 21 to 25 °C and precipitation >30 mm per month. The Coupled Model Intercomparison Projects scenarios associated with the Intergovernmental Panel on Climate Change reports consisted of the Shared Socio-Economic Pathways SSP-1 2.6, SSP-2 4.5, SSP-3 7.0 and SSP-5 8.5, the latter being considered one of the most catastrophic. All steps to carry out the suitability zoning were performed in a tool using the QGIS geographic information system software. RESULTS: Zoning for coffee leaf rust had three classes: favorable, relatively favorable and unfavorable. Currently, the largest coffee-producing region in Brazil has 49.1% of its analyzed area classified as favorable, 39.2% as relatively favorable and 11.7% as unfavorable. In the current scenario, Patrocínio and Três Pontas are locations with high coffee production in which the favorable class is predominant. The state of Minas Gerais has an annual mean of 55.3% of its entire territory apt for the disease, with the highest occurrence between September and March. CONCLUSIONS: Climate change has a negative impact on the development of coffee leaf rust, mainly in the long term, as in the period of 2081-2100, in which the SSP-5 8.5 scenario led to a decrease in the favorable and unfavorable areas and an increase in the relatively favorable areas of 9.8%, 18.6% and 71.5% for the Brazilian territory, respectively. © 2024 Society of Chemical Industry.

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Resumo As tecnologias eHealth contribuem na promoção das práticas parentais de cuidado para bebês pré-termo. Não obstante, é notável a abundância de informações e aplicativos disponíveis, a disparidade na qualidade, facilidade de uso e confiabilidade desses recursos. Este artigo objetiva examinar as tecnologias eHealth direcionadas aos pais para o cuidado de bebês pré-termo. Realizou-se uma revisão integrativa nas principais bases de dados da área da saúde (Capes, EBSCO, BVS, PubMed, Scholar e SciELO), com a seleção de publicações de 2011 a 2022, em português e inglês, sobre a utilização de tecnologias eHealth voltadas aos cuidados de bebês pré-termo. Identificaram-se 13 artigos com temáticas sobre: as tecnologias da informação e comunicação nas estratégias de educação e a promoção da saúde de bebês pré-termo e seus pais; e importância da avaliação e validação das tecnologias eHealth na promoção da saúde materno-infantil. Tecnologias eHealth validadas adequadamente podem desempenhar um papel fundamental em apoiar os pais na promoção da saúde e na prestação de cuidados ao bebê pré-termo após a alta hospitalar. Isso, por sua vez, tem o potencial de impulsionar a evolução dos sistemas de saúde e a melhoria das práticas clínicas.

Abstract The eHealth technologies promote parental care practices for preterm infants. Nonetheless, we should underscore the abundant information and available apps and disparities in these resources' quality, usability, and reliability. This article examines eHealth technologies directed at parents to care for preterm infants. An integrative review was conducted across the principal health databases (Capes, EBSCO, BVS, PubMed, Scholar, and SciELO), selecting works published from 2011 to 2022 in Portuguese and English, focusing on the use of eHealth technologies for the care of preterm infants. We identified 13 articles related to information and communication technologies in strategies for educating and promoting the health of preterm infants and their parents and the importance of evaluating and validating eHealth technologies in maternal and child health promotion. Properly validated eHealth technologies can be crucial in supporting parents in promoting health and providing care for preterm infants after hospital discharge, which, in turn, can drive the evolution of healthcare systems and improve clinical practices.

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Introdução:No final de 2019 um novo coronavírus com alta taxa de transmissibilidade foi identificado na China. Em março de 2020a Organização Mundial da Saúde declarou apandemia de Covid-19. Apandemiateve impacto na vida dos indivíduos, das famílias e da sociedade em geral. As pessoas tiveram dese adaptar à nova realidadee manifestaram diferentes emoçõese sentimentosdevido à situação pandêmica. As emoções vividas eo isolamento social necessário motivarama adoção de estratégias por parte das pessoas para se sentirem mais adaptadas e equilibradas anível físico e mental no seu dia a dia.Objetivo:O presente artigo tem como objetivo descrever e analisar as emoções, sentimentose estratégias adotadas por brasileiros e portugueses durante a pandemia da Covid-19. Metodologia:Este estudo faz parte de uma pesquisa mais ampla, realizada através de um questionário sociodemográfico com perguntas abertas e fechadas, efetuadono Google Forms, aplicado onlineem maio de 2020. Noquestionário foram abordadas as emoções e estratégias desenvolvidas e adotadas pelos 438 entrevistados (257 brasileiros;181 portugueses) durante a pandemia.A análise dosdados foi realizada através deestatística descritiva e análise de conteúdo temática.Resultados:Verificou-se que nos dois países, as emoções mais manifestadas foram medo e tristeza e as principais estratégias adotadas foram a criação de horários com rotinas diárias eexercício físicomas também algumas estratégias diferentes entre brasileiros e portugueses.Conclusões:Em momentos de crise pessoas de diferentes culturas experienciam emoções semelhantes tais como medo e tristeza e ajustam as suas rotinas diárias criando diferentes estratégias para enfrentar a adversidade de acordo com o seu contexto sociocultural (AU).

Introduction:At the end of 2019, a new coronavirus with a high transmissibility rate was identified in China. In March 2020, the World Health Organization declared the Covid-19 pandemic. The pandemic situation has had an impact on people's lives, families, and society.People had to adapt to the new reality and expressed different emotions and feelings due to the pandemic situation. The emotions experienced and the necessary social isolation motivated people to adopt strategies to feel more adapted and balanced on a physical and mental level in their daily lives. Objective: This article aims to describe and analyze the emotions, feelings and strategies adopted by Brazilians and Portuguese during the Covid-19 pandemic. Methodology:This study is part of a broader research, carriedout using a sociodemographic questionnaire with open and closed questions, carried out on Google Forms, applied online in May 2020. The questionnaire addressed the emotions and strategies developed and adopted by the 438 interviewees (257 Brazilians and 181 Portuguese) during the pandemic. Data analysis was carried out using descriptive statistics and thematic content analysis. Results: It was found that in both countries, the most expressed emotions were fear and sadness and the main strategies adopted were the creation of schedules with daily routines and physical exercise but also some different strategies between Brazilians and Portuguese. Conclusions: In times of crisis, people from different cultures experience similar emotions such as fear and sadness and adjust their daily routines, creating different strategies to face adversity according to their sociocultural context (AU).

Introducción: A finales de 2019, se identificó en China un nuevo coronavirus con una alta tasa de transmisibilidad. En marzo de 2020, la Organización Mundial de la Salud declaró la pandemia de Covid-19. La situación de pandemia ha repercutido en la vida de las personas, las familias y la sociedad. Las personas han tenido que adaptarse a la nueva realidad. En este contexto pandémico, las personas han expresado diferentes emociones y sentimientos debido a la nueva realidad social que han experimentado, y han creado estrategias para sentirse más adaptadas y equilibradas a nivel físico y mental en su vida diaria.Objetivo: Identificar y describir las principales emociones y sentimientos experimentados por brasileños y portugueses, así como crear estrategias para adaptarse a la situación durante el periodo de bloqueo de la pandemia Covid-19.Metodología:Este estudio forma parte de una encuesta más amplia, llevada a cabo mediante un cuestionario sociodemográfico con preguntas abiertas y cerradas, realizado en Google Forms, aplicado onlineen mayo de 2020, que indagaba sobre las emociones y los sentimientos experimentados en relación con la situación de pandemia y las estrategias creadas. La muestra fue de 438 participantes, 181 portugueses y 257 brasileños. Los datos se analizaron mediante estadística descriptiva y análisis del discurso.Resultados: En ambos países, el miedo y la tristeza fueron las emociones más expresadas. La mayoría de las estrategias utilizadas fueron el establecimiento de un horario y el ejercicio físico, pero también hubo algunas estrategias diferentes entre brasileños y portugueses.Conclusiones: En momentos de crisis, personas de diferentes culturas experimentan emociones similares como el miedo y la tristeza y ajustan sus rutinas diarias creando diferentes estrategias para enfrentar la adversidad de acuerdo con su contexto sociocultural (AU).

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INTRODUCTION: To date, there are no sufficient studies aimed to determine a correlation between personal, academic, and psychological variables with academic achievement, measured with the grade point average (GPA) and intelligence in university students according to each sex. STUDY AIM: To determine the correlation between studying strategies, personal and psychological factors with GPA and intelligence in a sample of health sciences university students. METHODS: Health Sciences university students, were invited to participate, those who accepted were cited in a computer room where they signed an informed consent and filled an electronic questionnaire with sociodemographic, behavioral, psychological variables and studying strategies (from the MLSQ instrument) afterwards they performed a verbal and non-verbal intelligence test (Shipley-2). RESULTS: A total of 439 students were included, from which 297 (67.7%) were women. The mean of age was 20.34 ± 2.61 years old. We found that no differences in GPA where observed between sexes. We detected a higher correlation between combined intelligence and GPA in women than in men. In addition, most studying strategies showed a higher correlation with GPA than intelligence scores in men´s sample. All these findings coincide with the fact that preparatory GPA was the most correlated variable with university GPA in both sexes. Finally, women showed higher levels of the sum of diseases, somatization, anxiety, depression and academic stress than men, and all these variables showed low significant correlations with the combined intelligence score only in women´s sample. CONCLUSION: Verbal and non-verbal intelligence scores show a lower association to GPA in men than in women, while studying strategies showed a higher association with GPA in men than in women.

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Rosacea is a chronic dermatological condition that currently lacks a clear treatment approach due to an uncomprehensive knowledge of its pathogenesis. The main obstacle lies in understanding its etiology and the mode of action of the different drugs used. This study aims to clarify these aspects by employing drug repositioning. Using an in silico approach, we performed a transcriptomic analysis comparing samples from individuals with diverse types of rosacea to those from healthy controls to identify genes deregulated in this disease. Subsequently, we realized molecular docking and molecular dynamics studies to assess the binding affinity of drugs currently used to treat rosacea and drugs that target proteins interacting with, and thus affecting, proteins deregulated in rosacea. Our findings revealed that the downregulation of SKAP2 and upregulation of S100A7A in rosacea, could be involved in the pathogenesis of the disease. Furthermore, considering the drugs currently used for rosacea management, we demonstrated stable interactions between isotretinoin and BFH772 with SKAP2, and permethrin and PAC-14028 with S100A7A. Similarly, considering drugs targeting SKAP2 and S100A7A interactome proteins, we found that pitavastatin and dasatinib exert stable interactions with SKAP2, and lovastatin and tirbanibulin with S100A7A. In addition, we determine that the types of bonds involved in the interactions were different in SKAP2 from S100A7A. The drug-SKAP2 interactions are hydrogen bonds, whereas the drug-S100A7A interactions are of the hydrophobic type. In conclusion, our study provides evidence for the possible contribution of SKAP2 and S100A7A to rosacea pathology. Furthermore, it provides significant information on the molecular interactions between drugs and these proteins, highlighting the importance of considering structural features and binding interactions in the design of targeted therapies for skin disorders such as rosacea.

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Rabies, a zoonotic viral disease, poses a significant threat due to its adaptability to diverse environments. Herbivore rabies, predominantly affecting cattle, horses, and goats in Brazil, remains a concern, results in substantial losses in the livestock industry, and poses risks to public health. Rabies virus transmission, primarily through hematophagous bats in Latin America, underscores the need for effective strategies, and vaccination plays a crucial role in controlling herbivorous rabies, with systematic vaccination beingly the primary method. Efforts to control rabies in herbivores include vaccination campaigns, public awareness programs, and the enhancement of surveillance systems. Despite these initiatives, rabies persists and imposes an economic burden and a significant health risk. Economic impacts include losses in the livestock industry, trade restrictions on livestock products, and financial burdens on governments and farmers owing to control measures. Despite the considerable costs of campaigns, surveillance, and control, investing in rabies vaccination and control not only safeguards livestock, but also preserves public health, reduces human cases, and strengthens the sustainability of the livestock industry. Mitigating the impact of herbivorous rabies in Brazil requires integrated approaches and continuous investments in vaccination, surveillance, and control measures to protect public health and ensure the sustainability of the livestock industry, thus contributing to food and economic security.