RESUMEN
PURPOSE: To investigate the efficacy of fertility-preserving treatment for young women with synchronous primary neoplasm of endometrium and ovary. METHODS: We retrospectively reviewed eight patients with concurrent primary grade 1 presumed stage IA endometrioid endometrial adenocarcinoma (EEA) or endometrial atypical hyperplasia (EAH) and primary stage I ovarian tumors who underwent fertility-sparing treatment in the Obstetrics and Gynecology Hospital of Fudan University between April 2016 and December 2022. RESULTS: Synchronous endometrial and ovarian cancers (SEOC) accounted for 50% of these eight patients. The median age of patients was 30.5 years (range, 28-34 years). None of them received chemotherapy. The median treatment time was 4 months (range, 3-8 months). 87.5% (7/8) cases achieved complete response (CR), and the median time to CR was 3.8 months (range, 1.5-7.7 months). Among patients who got CR, none of them showed any signs of recurrence. Pregnancies and successful deliveries were achieved in 4 of 5 patients. Till September 2023, the median follow-up period was 50.5 months (range:15.2-85.2 months). CONCLUSION: Fertility-sparing treatment is feasible for highly selected patients with synchronous neoplasm of the endometrium and ovary, but strict screening and monitoring are mandatory. Though the results of our limited cases are encouraging, long follow-up and more clinical data are required. Enrolled patients must be fully informed of the risks during conservative treatment.
Asunto(s)
Carcinoma Endometrioide , Hiperplasia Endometrial , Neoplasias Endometriales , Preservación de la Fertilidad , Neoplasias Primarias Múltiples , Embarazo , Femenino , Humanos , Adulto , Neoplasias Endometriales/patología , Estudios Retrospectivos , Resultado del Tratamiento , Recurrencia Local de Neoplasia/patología , Endometrio/patología , Hiperplasia Endometrial/tratamiento farmacológico , Hiperplasia Endometrial/patología , Carcinoma Endometrioide/patología , Neoplasias Primarias Múltiples/terapia , Neoplasias Primarias Múltiples/patologíaRESUMEN
A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen Salmonella is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating toxins encoded by a variety of Salmonella serovars. In this review, we discuss both the classical (SpvB) and novel (typhoid toxin, ArtAB, and SboC/SeoC) ADP-ribosylating toxins of Salmonella, including the structure and function of these toxins and our current understanding of their contributions to virulence.
Asunto(s)
ADP Ribosa Transferasas , Salmonella , Toxinas Biológicas , ADP Ribosa Transferasas/química , ADP Ribosa Transferasas/genética , ADP Ribosa Transferasas/toxicidad , Animales , Humanos , Toxinas Biológicas/química , Toxinas Biológicas/genética , Toxinas Biológicas/toxicidadRESUMEN
The experiment was conducted in the plots that had been enclosed for nearly 20 years in the hilly Loess Plateau region. The effects of trampling disturbance on the biological soil crust (biocrust) coverage, soil organic carbon (SOC), soil easily oxidizable carbon (SEOC), SOC mineralization amount and mineralization rate were investigated. The biocrust SOC mineralization potential after disturbance in different soil layers were simulated by a first-order kinetic equation. The results showed that the coverage of cyanobacteria biocrust and moss biocrust significantly decreased with the increases of disturbance intensity. Compared to no disturbance, the cyanobacteria coverage declined by 264%-339% and moss coverage declined by 46%-127%. Compared to no disturbance, SOC content in biocrust layer significantly decreased by 211%-300%. No significant difference was found among the five disturbance intensities. Disturbance increased SEOC content in biocrust layer, and the variation amounted to 1.5-3.4 g·kg-1, with 30%, 40% and 50% distur-bance differed significantly to no disturbance. Disturbance significantly increased biocrust SOC mineralization cumulative amount. However, SOC mineralization rate did not show any significant change. The SOC mineralization cumulative amount under 40% disturbance intensity increased by 77% compared to that under no disturbance. Disturbance significantly increased SOC mineralization potential in biocrust layer, but with no influence in 0-2 cm and 2-5 cm soil layers. The 40% disturbance intensity significantly increased SOC mineralization potential by 4.7 g·kg-1. The results of principal component analysis showed that SOC, SEOC, SMC and mineralization rate explained 76.7% of the variation of SOC mineralization potential in biocrust layer. Disturbance might be a main factor driving the increases of biocrust SOC mineralization potential in this area.