Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 23
Filtrar
1.
Policy Polit Nurs Pract ; : 15271544241268411, 2024 Aug 22.
Artículo en Inglés | MEDLINE | ID: mdl-39172097

RESUMEN

The success of healthcare reform hinges on policymaker, regulator, and administrator actions that shape policies at various levels. These policies can either facilitate or hinder the practice of healthcare professionals and collaborative work environments. It is imperative for all healthcare professionals to fully utilize their education and certification, as fostering an equitable workplace culture is vital for retaining staff and improving access to care. Using nurse practitioners (NPs) as an exemplar, this article aims to specify systemic barriers to healthcare reform and call for policymakers, regulators, and clinical agency administrators to enact change. Barriers to NP practice include restrictive oversight by external stakeholders, financial incentives for indirect billing, and hierarchical constraints that limit NP contributions to the healthcare system. The growing healthcare provider shortage disproportionately impacts primary care and rural settings. NPs are increasingly more likely to fill these roles than medical doctors and have documented positive patient health outcomes. Removing systemic obstacles for NP practice increases access to care. Nursing-the largest healthcare workforce with diverse roles-operates under complex oversight from multiple organizations for licensure, accreditation, certification, and education. The recent trend of external stakeholders influencing and requiring additional oversight has created barriers to nursing practice. Despite national education, accreditation, and certification standards, nursing licensure and practice are increasingly negotiated with external stakeholders and supervised at the state and institutional levels. Supporting all healthcare professionals to practice according to their education and certification can advance healthcare reform, address workforce shortages, increase access to care, and improve health.

2.
Environ Manage ; 73(1): 1-18, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-37845574

RESUMEN

Elevated contaminant levels and hydrological alterations resulting from land use are degrading aquatic ecosystems on a global scale. A range of land management actions may be used to reduce or prevent this degradation. To select among alternative management actions, decision makers require predictions of their effectiveness, their economic impacts, estimated uncertainty in the predictions, and estimated time lags between management actions and environmental responses. There are multiple methods for generating these predictions, but the most rigorous and transparent methods involve quantitative modelling. The challenge for modellers is two-fold. First, they must employ models that represent complex land-water systems, including the causal chains linking land use to contaminant loss and water use, catchment processes that alter contaminant loads and flow regimes, and ecological responses in aquatic environments. Second, they must ensure that these models meet the needs of endusers in terms of reliability, usefulness, feasibility and transparency. Integrated modelling using coupled models to represent the land-water system can meet both challenges and has advantages over alternative approaches. The need for integrated land-water system modelling is growing as the extent and intensity of human land use increases, and regulatory agencies seek more effective land management actions to counter the adverse effects. Here we present recommendations for modelling teams, to help them improve current practices and meet the growing need for land-water system models. The recommendations address several aspects of integrated modelling: (1) assembling modelling teams; (2) problem framing and conceptual modelling; (3) developing spatial frameworks; (4) integrating economic and biophysical models; (5) selecting and coupling models.


Asunto(s)
Ecosistema , Agua , Humanos , Conservación de los Recursos Naturales , Reproducibilidad de los Resultados , Abastecimiento de Agua
3.
Transpl Int ; 36: 11633, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37822447

RESUMEN

The field of transplantation has witnessed the emergence of Advanced Therapy Medicinal Products (ATMPs) as highly promising solutions to address the challenges associated with organ and tissue transplantation. ATMPs encompass gene therapy, cell therapy, and tissue-engineered products, hold immense potential for breakthroughs in overcoming the obstacles of rejection and the limited availability of donor organs. However, the development and academic research access to ATMPs face significant bottlenecks that hinder progress. This opinion paper emphasizes the importance of addressing bottlenecks in the development and academic research access to ATMPs by implementing several key strategies. These include the establishment of streamlined regulatory processes, securing increased funding for ATMP research, fostering collaborations and partnerships, setting up centralized ATMP facilities, and actively engaging with patient groups. Advocacy at the policy level is essential to provide support for the development and accessibility of ATMPs, thereby driving advancements in transplantation and enhancing patient outcomes. By adopting these strategies, the field of transplantation can pave the way for the introduction of innovative and efficacious ATMP therapies, while simultaneously fostering a nurturing environment for academic research.


Asunto(s)
Tratamiento Basado en Trasplante de Células y Tejidos , Ingeniería de Tejidos , Humanos , Terapia Genética
4.
JMIR Pediatr Parent ; 6: e40463, 2023 Feb 28.
Artículo en Inglés | MEDLINE | ID: mdl-36853753

RESUMEN

BACKGROUND: Medical device development is an area facing multiple challenges, resulting in a high number of products not reaching the clinical setting. Neonatal hyperbilirubinemia, manifesting as neonatal jaundice (NNJ), is an important cause of newborn morbidity and mortality. It is important to identify infants with neonatal hyperbilirubinemia at an early stage, but currently there is a lack of tools that are both accurate and affordable. OBJECTIVE: This study aimed to develop a novel system to assess the presence of NNJ. The device should provide accurate results, be approved as a medical device, be easy to use, and be produced at a price that is affordable even in low-resource settings. METHODS: We used an iterative approach to develop a smartphone-based system to detect the presence of NNJ. We performed technical development, followed by clinical and usability testing in parallel, after which we initiated the regulatory processes for certification. We updated the system in each iteration, and the final version underwent a clinical validation study on healthy term newborns aged 1 to 15 days before all documentation was submitted for conformity assessment to obtain Conformité Européenne (CE) certification. We developed a system that incorporates a smartphone app, a color calibration card, and a server. RESULTS: Three iterations of the smartphone-based system were developed; the final version was approved as a medical device after complying with Medical Device Regulation guidelines. A total of 201 infants were included in the validation study. Bilirubin values using the system highly correlated with total serum or plasma bilirubin levels (r=0.84). The system had a high sensitivity (94%) to detect severe jaundice, defined as total serum or plasma bilirubin >250 µmol/L, and maintained a high specificity (71%). CONCLUSIONS: Our smartphone-based system has a high potential as a tool for identifying NNJ. An iterative approach to product development, conducted by working on different tasks in parallel, resulted in a functional and successful product. By adhering to the requirements for regulatory approval from the beginning of the project, we were able to develop a market-ready mobile health solution.

5.
Environ Evid ; 11(1): 4, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35154667

RESUMEN

BACKGROUND: Management actions that address local-scale stressors on coral reefs can rapidly improve water quality and reef ecosystem condition. In response to reef managers who need actionable thresholds for coastal runoff and dredging, we conducted a systematic review and meta-analysis of experimental studies that explore the effects of sediment on corals. We identified exposure levels that 'adversely' affect corals while accounting for sediment bearing (deposited vs. suspended), coral life-history stage, and species, thus providing empirically based estimates of stressor thresholds on vulnerable coral reefs. METHODS: We searched online databases and grey literature to obtain a list of potential studies, assess their eligibility, and critically appraise them for validity and risk of bias. Data were extracted from eligible studies and grouped by sediment bearing and coral response to identify thresholds in terms of the lowest exposure levels that induced an adverse physiological and/or lethal effect. Meta-regression estimated the dose-response relationship between exposure level and the magnitude of a coral's response, with random-effects structures to estimate the proportion of variance explained by factors such as study and coral species. REVIEW FINDINGS: After critical appraisal of over 15,000 records, our systematic review of corals' responses to sediment identified 86 studies to be included in meta-analyses (45 studies for deposited sediment and 42 studies for suspended sediment). The lowest sediment exposure levels that caused adverse effects in corals were well below the levels previously described as 'normal' on reefs: for deposited sediment, adverse effects occurred as low as 1 mg/cm2/day for larvae (limited settlement rates) and 4.9 mg/cm2/day for adults (tissue mortality); for suspended sediment, adverse effects occurred as low as 10 mg/L for juveniles (reduced growth rates) and 3.2 mg/L for adults (bleaching and tissue mortality). Corals take at least 10 times longer to experience tissue mortality from exposure to suspended sediment than to comparable concentrations of deposited sediment, though physiological changes manifest 10 times faster in response to suspended sediment than to deposited sediment. Threshold estimates derived from continuous response variables (magnitude of adverse effect) largely matched the lowest-observed adverse-effect levels from a summary of studies, or otherwise helped us to identify research gaps that should be addressed to better quantify the dose-response relationship between sediment exposure and coral health. CONCLUSIONS: We compiled a global dataset that spans three oceans, over 140 coral species, decades of research, and a range of field- and lab-based approaches. Our review and meta-analysis inform the no-observed and lowest-observed adverse-effect levels (NOAEL, LOAEL) that are used in management consultations by U.S. federal agencies. In the absence of more location- or species-specific data to inform decisions, our results provide the best available information to protect vulnerable reef-building corals from sediment stress. Based on gaps and limitations identified by our review, we make recommendations to improve future studies and recommend future synthesis to disentangle the potentially synergistic effects of multiple coral-reef stressors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13750-022-00256-0.

6.
Expert Rev Vaccines ; 21(5): 609-619, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-35157542

RESUMEN

INTRODUCTION: The coronavirus 19 (COVID-19) pandemic triggered a simultaneous global demand for preventative vaccines, which quickly became a high priority among governments as well as academia and the pharmaceutical industry. Within less than a year after COVID-19 was declared a pandemic, vaccines had received emergency approvals and vaccination campaigns were initiated. AREAS COVERED: We discuss the several factors that led to the unprecedented, accelerated development and approval of COVID-19 vaccines, which includes optimization of processes by regulatory authorities, redesign of sequential development processes, learnings from previous pandemics, and prior development of novel vaccine platforms. EXPERT OPINION: Despite unanticipated and complex challenges presented by real-time vaccine development in the context of the evolving COVID-19 pandemic and subsequent ever-changing landscape of public health measures and recommendations, important milestones were reached within extraordinarily short periods and, following roll-out to billions worldwide, the approved vaccines have proven to be well tolerated and effective. Whilst this is an exceptional feat and an example of what can be achieved with collaboration and innovation, there are lessons that can still be learned, including the need for further harmonization between regulatory authorities, modes to react to the pandemic's ever-evolving challenges, and ensuring equitable vaccine access among low-income countries.


Asunto(s)
COVID-19 , Vacunas , COVID-19/prevención & control , Vacunas contra la COVID-19 , Humanos , Pandemias/prevención & control , SARS-CoV-2
7.
Int J Occup Saf Ergon ; 28(3): 1600-1610, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-33794758

RESUMEN

The objective of this study is a comparative analysis of the psychological adaptability of shift staff in oil and gas and diamond production in the Far North. In total, 227 shift workers took part in the study. Using the methods of psychophysiological and psychological testing, we studied the following parameters of the psychological adaptation of shift personnel: regulatory processes, subjective control, socio-psychological adaptation and personality characteristics. As a result of the study, some differences were found in the parameters of the psychological adaptation of shift workers of various industries. In conclusion, the parameters of socio-psychological adaptation as a criterion of psychological adaptation for the workers of the southern shift are much higher than for the shift workers in the Far North. The shift workers with a favorable functional status have a higher dominance rate. The workers in the Far North also have a higher level of self-regulation.


Asunto(s)
Adaptación Psicológica , Tolerancia al Trabajo Programado , Humanos , Tolerancia al Trabajo Programado/psicología
8.
Environ Evid ; 11(1): 4, 2022 Feb 07.
Artículo en Inglés | MEDLINE | ID: mdl-39294657

RESUMEN

BACKGROUND: Management actions that address local-scale stressors on coral reefs can rapidly improve water quality and reef ecosystem condition. In response to reef managers who need actionable thresholds for coastal runoff and dredging, we conducted a systematic review and meta-analysis of experimental studies that explore the effects of sediment on corals. We identified exposure levels that 'adversely' affect corals while accounting for sediment bearing (deposited vs. suspended), coral life-history stage, and species, thus providing empirically based estimates of stressor thresholds on vulnerable coral reefs. METHODS: We searched online databases and grey literature to obtain a list of potential studies, assess their eligibility, and critically appraise them for validity and risk of bias. Data were extracted from eligible studies and grouped by sediment bearing and coral response to identify thresholds in terms of the lowest exposure levels that induced an adverse physiological and/or lethal effect. Meta-regression estimated the dose-response relationship between exposure level and the magnitude of a coral's response, with random-effects structures to estimate the proportion of variance explained by factors such as study and coral species. REVIEW FINDINGS: After critical appraisal of over 15,000 records, our systematic review of corals' responses to sediment identified 86 studies to be included in meta-analyses (45 studies for deposited sediment and 42 studies for suspended sediment). The lowest sediment exposure levels that caused adverse effects in corals were well below the levels previously described as 'normal' on reefs: for deposited sediment, adverse effects occurred as low as 1 mg/cm2/day for larvae (limited settlement rates) and 4.9 mg/cm2/day for adults (tissue mortality); for suspended sediment, adverse effects occurred as low as 10 mg/L for juveniles (reduced growth rates) and 3.2 mg/L for adults (bleaching and tissue mortality). Corals take at least 10 times longer to experience tissue mortality from exposure to suspended sediment than to comparable concentrations of deposited sediment, though physiological changes manifest 10 times faster in response to suspended sediment than to deposited sediment. Threshold estimates derived from continuous response variables (magnitude of adverse effect) largely matched the lowest-observed adverse-effect levels from a summary of studies, or otherwise helped us to identify research gaps that should be addressed to better quantify the dose-response relationship between sediment exposure and coral health. CONCLUSIONS: We compiled a global dataset that spans three oceans, over 140 coral species, decades of research, and a range of field- and lab-based approaches. Our review and meta-analysis inform the no-observed and lowest-observed adverse-effect levels (NOAEL, LOAEL) that are used in management consultations by U.S. federal agencies. In the absence of more location- or species-specific data to inform decisions, our results provide the best available information to protect vulnerable reef-building corals from sediment stress. Based on gaps and limitations identified by our review, we make recommendations to improve future studies and recommend future synthesis to disentangle the potentially synergistic effects of multiple coral-reef stressors.

9.
Biomedicines ; 9(9)2021 Aug 24.
Artículo en Inglés | MEDLINE | ID: mdl-34572267

RESUMEN

INTRODUCTION: Deficits of self-regulation (SR) are a hallmark of externalizing (EXT: offending or aggressive behaviors) symptoms in adolescence. OBJECTIVES: This scoping review aims (1) to map non-pharmaceutical interventions targeting SR processes to reduce EXT symptoms in adolescents and (2) to identify research gaps, both of which will provide recommendations for future studies. METHODS: Systematic searches were carried out in eight bibliographic databases up to March 2021, combining the following concepts: self-regulation, externalizing symptoms, adolescents, and non-pharmaceutical interventions. RESULTS: We identified 239 studies, including 24,180 youths, mainly from North America, which described a plethora of non-pharmaceutical interventions targeting SR to alleviate EXT symptoms in adolescents (10-18 years of age). The majority of studies (about 70%, k = 162) represent samples with interventions exposed to "selective" or "indicated" prevention. Curriculum-based (i.e., multiple approaches targeting several domains such as emotion, cognition, and social) interventions (31.4%) were the most common type of intervention. Moreover, studies on cognitive-based interventions, mind-based interventions, and emotional-based interventions have increased over the last decades. Network analyses allowed us to identify several hubs between curriculum-based interventions, cognitive SR processes, as well as aggressiveness, conduct problems, and irritability/anger dysregulation. In addition, we identified gaps of studies concerning the physiological SR processes and on some types of interventions (i.e., body-based interventions and externally mediated interventions) or, more specifically, on promising tools, such as biofeedback, neurofeedback, as well as programs targeting neuropsychological processes (e.g., cognitive remediation). CONCLUSIONS: This scoping review stresses the plethora of interventions, identified hubs, and emerging fields, as well as some gaps in the literature, which together may orient future studies.

10.
Transfus Apher Sci ; 59(5): 102941, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32958397

RESUMEN

A shortage of blood during the pandemic outbreak of COVID-19 is a typical example in which the maintenance of a safe and adequate blood supply becomes difficult and highly demanding. So far, human RBCs have been produced in vitro using diverse sources: hematopoietic stem cells (SCs), embryonic SCs and induced pluripotent SCs. The existing, even safest core of conventional cellular bioproducts destined for transfusion have some shortcoming in respects to: donor -dependency variability in terms of hematological /immunological and process/ storage period issues. SCs-derived transfusable RBC bioproducts, as one blood group type for all, were highly complex to work out. Moreover, the strategies for their successful production are often dependent upon the right selection of starting source materials and the composition and the stability of the right expansion media and the strict compliance to GMP regulatory processes. In this mini-review we highlight some model studies, which showed that the efficiency and the functionality of RBCs that could be produced by the various types of SCs, in relation to the in-vitro culture procedures are such that they may, potentially, be used at an industrial level. However, all cultured products do not have an unlimited life due to the critical metabolic pathways or the metabolites produced. New bioreactors are needed to remove these shortcomings and the development of a new mouse model is required. Modern clinical trials based on the employment of regenerative medicine approaches in combination with novel large-scale bioengineering tools, could overcome the current obstacles in artificial RBC substitution, possibly allowing an efficient RBC industrial production.


Asunto(s)
Transfusión Sanguínea , Eritrocitos/citología , Células Madre Hematopoyéticas/citología , Línea Celular , Ensayos Clínicos como Asunto , Humanos
11.
Vaccine ; 38(33): 5082-5084, 2020 07 14.
Artículo en Inglés | MEDLINE | ID: mdl-32565341

Asunto(s)
Aviación , Vacunas
12.
Appetite ; 153: 104729, 2020 10 01.
Artículo en Inglés | MEDLINE | ID: mdl-32387199

RESUMEN

OBJECTIVE: Dual-pathway models propose that loss of control over eating (LOC) is the result of an imbalance between weaker regulatory and stronger reactive processes. However, these processes are generally captured with only one assessment method, leading to mixed findings. Additionally, it is unclear whether regulatory difficulties are generic or food-specific. Therefore, the aim of this study was twofold: (1) to investigate the interaction between regulatory and reactive processes in predicting the presence of LOC in adolescents, using both self-report questionnaires and behavioral tasks, and (2) to examine whether generic or food-specific regulatory processes interact with reactive processes to predict the presence of LOC. METHOD: A community sample of 295 adolescents (10-17 years; 67.2% girls; M = 13 years; SD = 1.99) was allocated to a LOC-Group (n = 93) or a NoLOC-Group (n = 202) based on a self-report questionnaire which assessed whether participants had experienced LOC over the past month (Children's Eating Disorder Examination Questionnaire). Both self-report questionnaires and behavioral tasks were used to measure regulatory (Behavior Rating Inventory of Executive Function and go/no-go task, respectively) and reactive (Behavioral Activation Scale and dot probe task, respectively) processes. Some adolescents completed a generic go/no-go task and others a food-specific version. Binary logistic regressions were conducted with LOC as the categorical dependent variable and regulatory and reactive processes (and their interaction) as the independent variables. RESULTS: In line with dual-pathway models, the combination of weaker regulatory and stronger reactive processes was associated with the presence of LOC. This was evident from both the self-report scales and the behavioral tasks. Preliminary results further suggest that regulatory difficulties seem to be food-specific. CONCLUSIONS: Our results provide multi-method evidence for the dual-pathway account of self-regulation in LOC among adolescents. Theoretical and practical implications are discussed.


Asunto(s)
Función Ejecutiva , Hiperfagia , Autocontrol , Adolescente , Niño , Conducta Alimentaria , Femenino , Alimentos , Humanos , Masculino , Autoinforme
13.
Adv Mater ; 32(15): e1901482, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31206827

RESUMEN

The past two decades have seen unprecedented progress in the development of novel materials, form factors, and functionalities in neuroimplantable technologies, including electrocorticography (ECoG) systems, multielectrode arrays (MEAs), Stentrode, and deep brain probes. The key considerations for the development of such devices intended for acute implantation and chronic use, from the perspective of biocompatible hybrid materials incorporation, conformable device design, implantation procedures, and mechanical and biological risk factors, are highlighted. These topics are connected with the role that the U.S. Food and Drug Administration (FDA) plays in its regulation of neuroimplantable technologies based on the above parameters. Existing neuroimplantable devices and efforts to improve their materials and implantation protocols are first discussed in detail. The effects of device implantation with regards to biocompatibility and brain heterogeneity are then explored. Topics examined include brain-specific risk factors, such as bacterial infection, tissue scarring, inflammation, and vasculature damage, as well as efforts to manage these dangers through emerging hybrid, bioelectronic device architectures. The current challenges of gaining clinical approval by the FDA-in particular, with regards to biological, mechanical, and materials risk factors-are summarized. The available regulatory pathways to accelerate next-generation neuroimplantable devices to market are then discussed.


Asunto(s)
Encéfalo/fisiología , Regulación Gubernamental , Prótesis e Implantes , Animales , Electrocorticografía , Electrodos Implantados , Humanos , Optogenética , Factores de Riesgo , Tecnología Inalámbrica
14.
Disabil Rehabil ; 42(7): 1031-1040, 2020 04.
Artículo en Inglés | MEDLINE | ID: mdl-30426782

RESUMEN

Purpose: Children's resiliency is seen as important in pediatric rehabilitation, but is seldom the focus of research or intervention. This article presents a resiliency framework to inform pediatric rehabilitation research, service design, and practice.Methods: The development of the framework was guided by a transactional, life course perspective, and a review of self-constructs in the resiliency literature.Results: The framework comprises health-related adversities, self-capacities, self-regulatory processes, and adaptive benefits. Four adaptive self-capacities are highlighted (activity self-efficacy, capacity to marshal resources and supports to achieve goals, capacity to adapt to changing life situations, and capacity to envision a positive future). These self-capacities are linked to common adversities experienced by children with disabilities, namely activity limitations, functioning and participation restrictions, transition issues, and anticipated future life challenges. The self-capacities are also associated with empowered, optimistic, adaptive, and hopeful mindsets, which influence accommodative and assimilative self-regulatory strategies affecting children's adaptive benefits.Conclusions: The framework can inform resiliency-related research exploring self-capacities and resiliency processes. The framework points to what is modifiable through intervention targeting the person-in-context, namely self-capacities, mindsets, and situated experiences. Implications for service design and delivery include providing opportunities and interacting with clients in ways that support the development of these self-capacities.Implications for rehabilitationFostering resiliency means preparing children with disabilities to negotiate and navigate the adversities and challenges they will encounter over their lives.Important resiliency-related self-capacities include activity self-efficacy, capacity to marshal resources and supports to achieve goals, capacity to adapt to changing life situations, and capacity to envision a positive future.The resiliency framework suggests the importance of enhancing children's views of themselves as empowered, optimistic, adaptive, and hopeful.Practice will be enriched by acknowledging that a range of health concerns are relevant to practice, including issues of impairment, functioning, participation, and adaptation.


Asunto(s)
Adaptación Fisiológica , Personas con Discapacidad , Niño , Humanos , Investigación en Rehabilitación , Autoeficacia
15.
Artículo en Inglés | MEDLINE | ID: mdl-31652709

RESUMEN

Lower cardiac vagal control (CVC), which is often understood as an indicator for impaired regulatory processes, is assumed to predict the development of depressive symptoms. As this link has not been consistently demonstrated, sleep quality has been proposed as a moderating factor. However, previous studies were limited by non-representative samples, cross-sectional data, and focused on CVC as a physiological indicator for impaired regulatory processes, but neglected corresponding subjective measures. Therefore, we investigated whether sleep quality moderates the effects of CVC (quantified by high-frequency heart rate variability) and self-reported regulatory processes (self- and emotion-regulation) on concurrent depressive symptoms and on depressive symptoms after three months in a representative sample (N = 125). Significant interactions between CVC and sleep quality (in women only), as well as self-/emotion-regulation and sleep quality emerged, whereby higher sleep quality attenuated the relation between all risk factors and current depressive symptoms (cross-sectional data). However, there were no significant interactions between those variables in predicting depressive symptoms three months later (longitudinal data). Our cross-sectional findings extend previous findings on sleep quality as a protective factor against depressive symptoms in the presence of lower CVC and subjective indices of impaired regulatory processes. In contrast, our conflicting longitudinal results stress the need for further investigations.


Asunto(s)
Depresión/fisiopatología , Frecuencia Cardíaca/fisiología , Sueño/fisiología , Nervio Vago/fisiopatología , Adolescente , Adulto , Estudios Transversales , Depresión/etiología , Depresión/prevención & control , Depresión/psicología , Femenino , Humanos , Masculino , Factores Protectores , Factores de Riesgo , Autoinforme , Autocontrol , Adulto Joven
17.
Photosynth Res ; 136(2): 183-198, 2018 May.
Artículo en Inglés | MEDLINE | ID: mdl-29090427

RESUMEN

The slow kinetic phases of the chlorophyll a fluorescence transient (induction) are valuable tools in studying dynamic regulation of light harvesting, light energy distribution between photosystems, and heat dissipation in photosynthetic organisms. However, the origin of these phases are not yet fully understood. This is especially true in the case of prokaryotic oxygenic photoautotrophs, the cyanobacteria. To understand the origin of the slowest (tens of minutes) kinetic phase, the M-T fluorescence decline, in the context of light acclimation of these globally important microorganisms, we have compared spectrally resolved fluorescence induction data from the wild type Synechocystis sp. PCC 6803 cells, using orange (λ = 593 nm) actinic light, with those of mutants, ΔapcD and ΔOCP, that are unable to perform either state transition or fluorescence quenching by orange carotenoid protein (OCP), respectively. Our results suggest a multiple origin of the M-T decline and reveal a complex interplay of various known regulatory processes in maintaining the redox homeostasis of a cyanobacterial cell. In addition, they lead us to suggest that a new type of regulatory process, operating on the timescale of minutes to hours, is involved in dissipating excess light energy in cyanobacteria.


Asunto(s)
Clorofila/química , Clorofila/metabolismo , Synechocystis/química , Proteínas Bacterianas/genética , Proteínas Bacterianas/metabolismo , Clorofila/genética , Clorofila A , Diurona/química , Fluorescencia , Luz , Mediciones Luminiscentes , Ficobilisomas/genética , Ficobilisomas/metabolismo , Cianuro de Potasio/química , Espectrometría de Fluorescencia , Synechocystis/genética , Synechocystis/metabolismo , Temperatura
18.
Span J Psychol ; 19: E35, 2016 Jun 10.
Artículo en Inglés | MEDLINE | ID: mdl-27282079

RESUMEN

Based on research on the motivational processes involved in preventing and controlling stereotypes, we aimed to assess whether temporary activation of egalitarian goals - by means of a task that gives respondents exposure to a text on gender inequality - can prevent stereotyped answers on the task. The task asks participants to place women and men into a hierarchical organizational structure. Two specific objectives were established: first, to control the effect of prejudice and egalitarian commitment on the dependent variable; and second, to study gender differences in task responses. The study included 474 college students, 153 men and 321 women. Their mean age was 20.04 (SD = 4.43). ANCOVA indicated main effects of condition, F(1) = 4.15, p = .042, η2 = .081 (control condition without goal activation vs. experimental condition with goal activation) and sex, F(1) = 40.46, p < .001, η2 = .081, on the dependent variable (female candidates placed in the chart). Specifically, responses from participants in the experimental condition avoided stereotyped answers more than participants in the control condition. Furthermore, women's performance on the task was more egalitarian than men's. Finally, there was a significant interaction effect of condition and type of organization, F(2) = 3.97, p = .019, η2 = .017; participants assigning candidates to the feminized organization differed the most across conditions.


Asunto(s)
Autocontrol/psicología , Sexismo/psicología , Estereotipo , Adulto , Femenino , Humanos , Masculino , Adulto Joven
19.
Cienc. Trab ; 18(55): 9-15, 2016. ilus, tab
Artículo en Inglés | LILACS | ID: lil-784117

RESUMEN

INTRODUCTION: The number of publications related to prosocial organizational behaviors (POB) increased in the past years. However, only a small number of studies focus on the intrapersonal process associated with these individual differences. GOALS: The present article investigated the mediation role that three self-regulatory processes (SRP) play on the relationship between POB and perceived partner responsiveness (PPR). METHOD: Participants were 206 Brazilian professionals (56 % women), with mean age of 34.4 years (SD = 9.16 years), hired in different organizations, who answered an online survey. Most participants worked in the services (31.1%) and industry (27.7%) fields. Data provided was analyzed using Structural Equation Modeling. Results: SRP help to understand the interpersonal relationships at the work place in their complexity. They also stress the need to help professionals to be aware of the existence of SRP and the ways in which they influence their behaviors. DISCUSSION: SRP might interfere significantly, for example, on how the PPR contributes to promote POB. CONCLUSIONS: Our findings encourage researchers to pay closer attention to the relationship between the constructs of PPR and POB in the future, and to explore other possible mediating or moderating variables within the larger social network of organizations.


INTRODUCCIÓN: El número de publicaciones relacionadas con los comportamientos organizacionales prosociales (POB) aumentó en los últimos años. Sin embargo, sólo un pequeño número de estudios se centran en el proceso intrapersonal asociado a las diferencias individuales. OBJETIVOS: El presente artículo investigó el papel de mediación que los procesos de autorregulación (SRP) juegan en la relación entre POB y la sensibilidad percibida en la pareja (PPR). MÉTODO: Fueron participantes 206 profesionales brasileños (56% mujeres), con edad media de 34,4 años (SD = 9.16 años), contratados por diferentes organizaciones, que respondieron a una encuesta en línea. La mayoría trabajaban en servicios (31,1%) e industria (27,7%). Los datos fueron analizados con modelos de ecuaciones estructurales. RESULTADOS: SRP ayudan a entender las relaciones interpersonales en el lugar de trabajo en su complejidad. También afirman la necesidad de ayudar a los profesionales a ser conscientes de la existencia de SRP y la forma en que influyen en sus comportamientos. DISCUSIÓN: SRP puede interferir significativamente, por ejemplo, sobre cómo el PPR contribuye a promover POB. CONCLUSIONES: Es necesario prestar más atención a la relación entre los constructos de PPR y POB en el futuro, y explorar otros de sus mediadores y moderadores en las organizaciones.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Conducta Social , Parejas Sexuales , Regulación Emocional , Relaciones Interpersonales , Brasil , Encuestas y Cuestionarios , Negociación , Retroalimentación Psicológica , Autocontrol , Satisfacción en el Trabajo
20.
Psicol. teor. pesqui ; 32(2): e322216, 2016. graf
Artículo en Inglés | LILACS | ID: biblio-955912

RESUMEN

ABSTRACT This pilot study assessed the effects of a five day focused meditation training on the interplay between emotional interference and anxiety in a non clinical sample randomized into two groups (experimental=13; control=18). Emotional interference was indexed comparing the reaction times in an attention span task with negative or neutral distracting images. Anxiety experienced during the task was also assessed through self-report. Only in the control group higher anxiety levels interacted with greater emotional interference and a worse evaluation of valence and arousal of emotional images. These preliminary findings suggest that meditation may help modulating anxiety effects on bias to negative stimuli, and that even a short training may facilitate self-regulatory processes.


RESUMO Este estudo piloto avaliou os efeitos de cinco dias de meditação focada na relação entre interferência emocional e ansiedade em amostra não clínica randomizada em dois grupos (experimental=13; controle=18). A interferência emocional foi indexada comparando os tempos de reação em uma tarefa de atenção com imagens distratoras negativas ou neutras. Também foi avaliado o autorrelato da ansiedade durante a tarefa. Apenas no grupo controle uma maior ansiedade interagiu com uma maior interferência emocional e uma pior avaliação de valência e alerta (arousal) das imagens emocionais. Esses achados preliminares sugerem que a meditação pode ajudar a modular o efeito da ansiedade no viés para estímulos negativos, e que mesmo um treino breve pode facilitar processos autorregulatórios.

SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA