RESUMEN

Very-low field (VLF) magnetic resonance imaging (MRI) offers advantages in term of size, weight, cost, and the absence of robust shielding requirements. However, it encounters challenges in maintaining a high signal-to-noise ratio (SNR) due to low magnetic fields (below 100 mT). Developing a close-fitting radio frequency (RF) receive coil is crucial to improve the SNR. In this study, we devised and optimized a helmet-shaped dual-channel RF receive coil tailored for brain imaging at a magnetic field strength of 54 mT (2.32 MHz). The methodology integrates the inverse boundary element method (IBEM) to formulate initial coil structures and wiring patterns, followed by optimization through introducing regularization terms. This approach frames the design process as an inverse problem, ensuring a close fit to the head contour. Combining theoretical optimization with physical measurements of the coil's AC resistance, we identified the optimal loop count for both axial and radial coils as nine and eight loops, respectively. The effectiveness of the designed dual-channel coil was verified through the imaging of a CuSO4 phantom and a healthy volunteer's brain. Notably, the in-vivo images exhibited an approximate 16-25 % increase in SNR with poorer B1 homogeneity compared to those obtained using single-channel coils. The high-quality images achieved by T1, T2-weighted, and fluid-attenuated inversion-recovery (FLAIR) protocols enhance the diagnostic potential of VLF MRI, particularly in cases of cerebral stroke and trauma patients. This study underscores the adaptability of the design methodology for the customization of RF coil structures in alignment with individual imaging requirements.

Asunto(s)

RESUMEN

This work is dedicated to the development of a novel design for wireless transmission line resonators (TLRs). The TLRs are often considered as circular-shaped coils made up of two conductive circuits separated by a dielectric layer. We propose a square-shaped TLR design, wherein the coil has two square turns with two symmetrical gaps on each of the conductive layers, and the latter are rotated relative to each other by 90°. The calculation error of the resonant frequency of the square-shaped TLRs is no more than ∼3% of the measured value. The effectiveness of the square-shaped TLR design was evaluated in comparative 1H MRI studies to conventional wireless square loop of the same resonant frequency and with the same-sized inner square of the TLR. The Bruker birdcage was used as a transceiver and as inductively coupled with the wireless coils. We found that the performance of the square-shaped TLR and the square loop is comparable, but the B1+-field generated by the TLR has a wider distribution profile. It was reflected in rat brain studies, when some structures of rat head were not captured by the square loop. Comparative experiments with a standard circular-shaped TLR showed that a signal is predominantly concentrated inside the inner turn of the TLRs. The proposed TLR design can be a promising path to be explored, especially for scanning small objects of study, when the scan area is comparable to the size of the rigid lumped capacitors.

Asunto(s)

RESUMEN

Overhauser-enhanced MRI (OMRI) is an electron-proton double-resonance imaging technique of interest for its ability to non-invasively measure the concentration and distribution of free radicals. In vivo OMRI experiments are typically undertaken at ultra-low magnetic field (ULF), as both RF power absorption and penetration issues-a consequence of the high resonance frequencies of electron spins-are mitigated. However, working at ULF causes a drastic reduction in MRI sensitivity. Here, we report on the design, construction and performance of an OMRI platform optimized for high NMR sensitivity and low RF power absorbance, exploring challenges unique to probe design in the ULF regime. We use this platform to demonstrate dynamic imaging of TEMPOL in a rat model. The work presented here demonstrates improved speed and sensitivity of in vivo OMRI, extending the scope of OMRI to the study of dynamic processes such as metabolism.

Asunto(s)

RESUMEN

An experimental setup for characterizing the magnetic field of MRI RF coils was proposed and tested. The setup consisted of a specially configured 3D-printer, a network analyzer and a mid-performance desktop PC. The setup was tested on a single loop RF coil, part of a phased array for fetal imaging. Then, the setup was used for determining the magnetic field characteristics of a high-pass birdcage coil used for neonatal MR imaging with a vertical static field. The scattering parameter S21, converted into power ratio, was used for mapping the B1 magnetic field. The experimental measurements from the loop coil were close to the theoretical results (R=0.924). A high degree of homogeneity was measured for the neonatal birdcage RF coil. The development of MR RF coils is time consuming and resource intensive. The proposed experimental setup provides an alternative method for magnetic field characterization of RF coils used in MRI.

Asunto(s)

RESUMEN

Magnetic field B0 gradients are essential in modern Nuclear Magnetic Resonance spectroscopy and imaging. Although RF/B1 gradients can be used to fulfill a similar role, this is not used in common practice because of practical limitations in the design of B1 gradient coils. Here we present a new method to create B1 gradients using stripline RF coils. The conductor-width of a stripline NMR chip and the strength of its radiofrequency field are correlated, so a stripline chip can be tapered to produce any arbitrary shaped B1 field gradient. Here we show the characterization of this tapered stripline configuration and demonstrate three applications: magnetic resonance imaging on samples with nL-µL volumes, reaction monitoring of fast chemical reactions (10(-2)-10(1)s) and the compensation of B0 field gradients to obtain high-resolution spectra in inhomogeneous magnetic fields.

RESUMEN

PURPOSE: To enhance sensitivity and coverage for calf muscle studies, a novel, form-fitted, three-channel phosphorus-31 ((31) P), two-channel proton ((1) H) transceiver coil array for 7 T MR imaging and spectroscopy is presented. METHODS: Electromagnetic simulations employing individually generated voxel models were performed to design a coil array for studying nonpathological muscle metabolism. Static phase combinations of the coil elements' transmit fields were optimized based on homogeneity and efficiency for several voxel models. The best-performing design was built and tested both on phantoms and in vivo. RESULTS: Simulations revealed that a shared conductor array for (31) P provides more robust interelement decoupling and better homogeneity than an overlap array in this configuration. A static B1 (+) shim setting that suited various calf anatomies was identified and implemented. Simulations showed that the (31) P array provides signal-to-noise ratio (SNR) benefits over a single loop and a birdcage coil of equal radius by factors of 3.2 and 2.6 in the gastrocnemius and by 2.5 and 2.0 in the soleus muscle. CONCLUSION: The performance of the coil in terms of B1 (+) and achievable SNR allows for spatially localized dynamic (31) P spectroscopy studies in the human calf. The associated higher specificity with respect to nonlocalized measurements permits distinguishing the functional responses of different muscles.

Asunto(s)

RESUMEN

PURPOSE: To investigate the relative gain in sensitivity of five histology coils designed in-house to accommodate tissue sections of various sizes and compare with commercial mouse head coils. METHODS: The coil set was tailored to house tissue sections ranging from 5 to1000 µm encased in either glass slides or coverslips. RESULTS: Our simulations and experimental measurements demonstrated that although the sensitivity of this flat structure consistently underperforms relative to a birdcage head coil based on the gain expected from their respective filling factor ratios, our results demonstrate that it can still provide a remarkable gain in sensitivity. Our study also describes preparation protocols for freshly excised sections, as well as premounted tissue slides of both mouse and human specimens. Examples of the exceptional level of tissue detail and the near-perfect magnetic resonance imaging to light microscopic image coregistration are provided. CONCLUSION: The increase in filling factor achieved by the histology radiofrequency (RF) probe overcomes the losses associated with electric leaks inherent to this structure, leading to a 6.7-fold improvement in performance for the smallest coil implemented. Alternatively, the largest histology coil design exhibited equal sensitivity to the mouse head coil while nearly doubling the RF planar area coverage.

Asunto(s)

RESUMEN

PURPOSE: To develop a coil configuration for high-resolution imaging of different regions of the hand and wrist at 7 T. MATERIALS AND METHODS: A quadrature bandpass birdcage and a 12-channel high density receive array were developed for imaging metacarpus and wrist. Workbench and magnetic resonance imaging (MRI) measurements were done to characterize the coil and obtain in vivo images. Electromagnetic simulations were performed to assess the uniformity of transmit profile and calculate the specific absorption rate (SAR). RESULTS: The results obtained show that the constructed transmit coil can be used in combination with receive arrays, without the need to retune the same. The developed wrist array was used to produce images of ultrahigh resolution (0.19 × 0.19 × 0.5 mm(3) ), revealing fine anatomical details. Simulations show that a near-uniform transmit profile is possible throughout the hand. No inhomogeneities were observed in the transmit profile, unlike a human head or abdomen at 7 T, due to the small volume of the hand and its low conductive regions. CONCLUSION: While transceive arrays are usually preferred at 7 T due to issues related to decrease in wavelength, it is shown in this study that with regard to hand-imaging optimized high-density receive arrays are a good solution to obtain images of extremely fine resolution of different regions.

Asunto(s)