RESUMEN
INTRODUCTION: Comorbidity has a significant influence in the management of patients with epilepsy. MATERIAL AND METHODS: A descriptive study of all patients with epilepsy, from a suburban area in the Community of Madrid followed up for at least 1 year. Children under 2 years, those with symptomatic acute febrile seizures were excluded. RESULTS: Out of a total of 46 patients (54% male, age median 9.1 years), more than half (52.5%) were on monotherapy, 45.7% were "free of seizures", 23.9% had "drug resistant epilepsy", and 30.4% were "undetermined". As regards comorbidities, 28.3% had chronic medical conditions, and 41.3% associated neuropsychiatric disorders. In32.6%, the seizures were of sudden onset, and those with chronic medical and neuropsychiatric comorbidities had a risk of 15 and 8.3 times, respectively, than those patients without comorbidities. CONCLUSIONS: Comorbidities may have an important role in the course of epilepsy.
Asunto(s)
Epilepsia/complicaciones , Trastornos Mentales/etiología , Adolescente , Niño , Preescolar , Femenino , Humanos , Masculino , Enfermedades del Sistema Nervioso/etiología , Estudios RetrospectivosRESUMEN
OBJECTIVES: We aimed to translate and validate a short-form of Quality of Life Inventory in Epilepsy-89 (QOLIE-89)-QOLIE-10 for use in the busy clinical setting. METHODS: Accepted procedures were adopted to translate the QOLIE-10. Patients with epilepsy from two tertiary hospitals in China were asked to complete a standardized questionnaire including QOLIE-10, EQ-5D, QWB-SA and Mini Mental State Examination (MMSE). Construct validity was assessed via factor analysis. Convergent validity was explored via the correlations between QOLIE-10 and other external measures. The ability of QOLIE-10 to differentiate between epilepsy-specific variables was tested to examine the discriminant validity. Cronbach's alpha was calculated to test the reliability. Additionally, HRQoL according to different epilepsy-specific variables was compared. RESULTS: 220 Respondents completed QOLIE-10 and EQ-5D, among which 141 subjects completed QWB-SA and MMSE. Two subscales were yielded in the factor analysis. The correlations between QOLIE-10 scores and EQ-5D, QWB-SA, MMSE were significant thus demonstrated the convergent validity. Furthermore, QOLIE-10 was able to differentiate patients with various seizure frequency, refractory epilepsy and antiepileptic treatment. The Cronbach's alpha was 0.853. In general, more predictive variables were identified to associate with QOLIE-10 scores than the other two instruments. Comorbidity (0.015), numbers of AEDs (0.037), seizure types (0.041) and refractory epilepsy (0.016) were potential predictors of HRQoLQOLIE-10, whereas there were fewer predictors for HRQoLEQ-5D or HRQoLQWB-SA. CONCLUSIONS: QOLIE-10 appeared to be a reliable and sensitive instrument to assess the HRQoL for epilepsy patients. According to the MLR analyses, numbers of AEDs, refractory epilepsy, comorbidity depression, and cognitive function were demonstrated to be predictors of HRQoL dependent on different tools. Comparisons between the tools suggested epilepsy-specific instrument was more competent to discriminate HRQoL based on condition variables. However, a longitudinal study is still needed to examine the responsiveness of Chinese QOLIE-10.
Asunto(s)
Epilepsia/diagnóstico , Epilepsia/psicología , Calidad de Vida/psicología , Encuestas y Cuestionarios , Adolescente , Adulto , Pueblo Asiatico/psicología , Análisis Factorial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Escalas de Valoración Psiquiátrica , Psicometría , Reproducibilidad de los Resultados , Traducción , Adulto JovenRESUMEN
Introducción: La epilepsia es una enfermedad crónica que se origina en el cerebro debido a descargas neuronales anormales. Este padecimiento no respeta geografía, raza, sexo o condición social, teniendo en ocasiones graves consecuencias psicológicas, sociales y económicas. Objetivos: Evaluar la calidad de vida de niños y adolescentes con epilepsia y describir factores que pueden incidir en la calidad de vida de estos pacientes. Métodos: se realizó un estudio descriptivo de corte transversal en el cual se emplearon técnicas cuantitativas y cualitativas como el cuestionario y la entrevista en profundidad. Se trabajó con 22 pacientes comprendidos entre las edades pediátricas de 6 a 13 años que asisten a la consulta de neurología del Hospital William Soler. Resultados: se demostró que el nivel de calidad de vida que predomina en los niños y adolescentes con epilepsia estudiados es bueno, se evidenció que la categoría calidad de vida es el resultado de la compleja interacción entre lo social y lo psicológico y que factores tales como el tipo de epilepsia, edad de debut y tiempo transcurrido desde la última crisis, pueden incidir en la calidad de vida de estos pacientes. Conclusiones: la calidad de vida que predomina en los niños y adolescentes con epilepsia estudiados es buena. El aprendizaje es el parámetro de mayor afectación en estos pacientes, mientras que la autonomía resultó ser el de mejor resultado(AU)
Introduction: Epilepsy is a chronic disease that originates in the brain due to abnormal neuronal discharges. This ailment does not respect geography, race, gender or social condition, sometimes with severe psychological, social and economic consequences. Objectives: To evaluate the quality of life of children and adolescents with epilepsy and to describe factors that may affect the quality of life of these patients. Methods: It was conducted a descriptive study of cross section in which quantitative and qualitative techniques were used, like the questionnaire and the interview in depth. We worked with 22 patients ranging from the pediatric ages of 6 to 13 years attending the consultation of neurology of William Soler Hospital. Results: it was demonstrated that the level of quality of life that predominates in the studied children and adolescents with epilepsy is good, it was proved that the category quality of life is the result of the complex interaction between the social and the psychological and factors such as the type of epilepsy, age of debut and time elapsed since the last crisis, may affect in the quality of life of these patients. Conclusions: the quality of life that predominates in the studied children and adolescents with epilepsy is good. Learning is the parameter most affected in these patients, while autonomy proved to be the best result(AU)