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PURPOSE: The issue of optimal prophylactic antibiotic administration for closed and open fracture surgeries remains controversial. The purpose of this study was to assess the role of type and duration longer than 48 h of antibiotic prophylaxis on the rates of fracture-related infection (FRI). METHODS: This is a single-center, prospective observational cohort study carried out with patients undergoing surgery for implants insertion to fracture stability. Risk estimates were calculated on the variables associated with factors for FRI and reported as a prevalence ratio (PR) with respect to the 95% confidence interval (CI). RESULTS: Overall, 132 patients were analyzed. The global rate of FRI was 15.9% (21/132), with open and closed fractures accounting for 30.5% (11/36) and 10.4% (10/96), respectively. The FRI rates in patients undergoing orthopedic surgery for fracture stabilization who received prophylactic antibiotic for up to and longer than 48 h were 8.9% and 26.4%, respectively. This difference did not reach statistical significance (prevalence ratio [PR] = 2.6, 95% confidence interval [95% CI]: 0.9-7.3. p = 0.063). CONCLUSIONS: Duration of antibiotic prophylaxis for surgical orthopedic fractures was not correlated with rates of FRI.

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OBJECTIVE: To study the incidence and magnitude of bacteremia after dental extraction and supragingival scaling. SUBJECTS AND METHODS: Blood samples were taken before and 5 and 30 min after dental extraction and supragingival scaling from individuals at high (n = 44) or negligible risk (n = 51) for infective endocarditis. The former received prophylactic antibiotic therapy. Samples were subjected to aerobic and anaerobic culture and quantitative real-time polymerase chain reaction to determine the incidence of bacteremia and total bacterial levels. RESULTS: Patients who did not receive prophylactic antibiotic therapy had a higher incidence of positive blood cultures (30% 5 min after extraction) than patients who received prophylactic antibiotic therapy (0% 5 min after extraction; p < .01). Molecular analysis did not reveal significant differences in the incidence or magnitude of bacteremia between the two patient groups either 5 or 30 min after each of the procedures evaluated. Extraction was associated with higher incidence of bacteremia than supragingival scaling by blood culture (p = .03) and molecular analysis (p = .05). CONCLUSIONS: Molecular methods revealed that dental extraction and supragingival scaling were associated with similar incidence of bacteremia in groups receiving or not prophylactic antibiotic therapy. However, blood culture revealed that antibiotic therapy reduced viable cultivable bacteria in the bloodstream in the extraction group.

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INTRODUCTION: Infective endocarditis (IE) is still associated with high mortality, and antibiotic prophylaxis strategies are under intense debate. We evaluated the incidence of bacteremia after root canal preparation in teeth with necrotic pulps and apical periodontitis. METHODS: Blood samples were taken before and 5 and 30 minutes after endodontic treatment in teeth with apical periodontitis from individuals at high (n = 21) or no risk (n = 11) for IE. The former received prophylactic antibiotic therapy. Bacteriologic samples were taken from root canals before chemomechanical preparation to confirm pulp infection. Samples were subjected to aerobic and anaerobic culture and quantitative real-time polymerase chain reaction (qPCR), the latter to determine the total bacterial and streptococcal levels. RESULTS: Culture revealed no bacteremia in all individuals. Analysis by qPCR showed that bacterial DNA occurred in all root canal samples. qPCR showed a similar incidence of bacteremia between patients who received or did not receive prophylactic antibiotic therapy (P > .05). In blood samples taken 5 minutes after endodontic procedures, bacteria were detected in 2 of 11 (18%) individuals not taking antibiotics and in 4 of 21 (19%) patients under prophylaxis. After 30 minutes, the incidence of bacteremia decreased to 2 of 21 (10%) in patients taking antibiotics and was undetectable in patients at no risk of IE. The incidence of bacteremia by streptococci was identical as that for total bacteria. CONCLUSIONS: No detectable bacteremia was evident by culture after treatment of infected root canals. Molecular analysis revealed bacterial DNA and streptococci in blood from some patients without a significant difference between individuals receiving or not receiving antibiotic prophylaxis.

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Objetivos: Evaluación en la Clínica General San Diego de Barranquilla de febrero de 2014 a diciembre de 2015 de los recién nacidos con factores de riesgo para infección y el beneficio de usar o no antibióticos profilácticos como preventivos de sepsis neonatal y el análisis de la morbilidad asociada. Material y métodos: Estudio prospectivo donde se analizan 155 casos en los cuales se utilizó o no antibiótico profiláctico en paciente con factores de ries-go de sepsis. Resultados: De un total de 4159 nacimientos, 155 recién nacidos (3,72 %) presentaron factores de riesgo; de estos pacientes en 74 se usaron antibióticos (grupo 1) y en 81 no se usaron antibióticos (grupo 2). En ninguno de los grupos se presentaron casos positivos de sepsis.

Objectives: Evaluation of newborns with risk factors for developing neonatal sepsis at San Diego General Clinic in Barranquilla between February 2014 to December 2015, and the benefit of using prophylactic antibiotics as a prevention for neonatal sepsis. Methods: A prospective study was performed in which 155 cases were followed and analyzed, both with and without antibiotic prophylaxis, in patients with risk factors for sepsis to determine whether it affects morbidity or not. Analyzes were performed. Results: From a total of 4159 births, 155 new born(3.72 %) presented risk factors; antibiotics were used in 74 patients and in 81 patients there were no use of anti-biotics.

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La remoción quirúrgica de los terceros molares ocasiona considerable dolor, edema y disfunción. Los factores que contribuyen a estas secuelas son complejos. Las estrategias farmacológicas para minimizar las manifestaciones clínicas del trauma quirúrgico son dirigidas hacia el bloqueo de la inflamación aguda, infección y dolor. Existe mucha controversia acerca de la necesidad de tratamiento antibiótico profiláctico antes de la cirugía bucal. Objetivo: El objetivo del presente estudio fue evaluar el efecto sobre el edema, trismus y dolor, de tres regímenes de tratamiento profiláctico antes de la cirugía bucal. Pacientes y Métodos: Cuarenta y cinco pacientes fueron seleccionados al azar para recibir el protocolo antibiótico. Se establecieron tres grupos. El primer grupo recibió 500mg de Amoxicilina oral, 3 veces al día por 7 días luego de realizada la intervención quirúrgica. El segundo grupo recibió una única dosis de 2g de Amoxicilina oral, una hora antes de la cirugía. En el tercer grupo los pacientes recibieron placebo. Los parámetros evaluados fueron presencia de edema, trismus y dolor. Todos los datos fueron tabulados y estadísticamente analizados. Resultados: Los resultados obtenidos demostraron la superioridad de la terapia con Amoxicilina en el control del edema postoperatorio y del trismus. No se encontraron diferencias estadísticamente significativas en cuanto al dolor. Conclusiones: Nuestros resultados mostraron que una sola dosis de antibiótico antes de la cirugía es tan buena como el tratamiento de 7 días después de la cirugía para prevenir el trismus, y resultó mejor en el control del edema, por consiguiente debería ser recomendada.

The surgical removal of impacted third molar teeth can result in considerable pain, swelling and dysfunction. The factors contributed to postoperative pain, swelling and trismus are complex. Pharmacologic strategies for minimizing the clinical manifestation of surgical trauma are often directed toward blocking the acute inflammation, bacterial infections disease and pain. Therefore, much controversy has arisen about the necessity of prophylactic antibiotic treatment. Purpose: The aim the present study was to evaluate three regimes of prophylactic oral treatment before oral surgery. Patients and Methods: Forty five patients were assigned at randon for antibiotic protocol. Three groups were established In the first group, antibiotic treatment with oral Amoxicillin 500mg, 3 times daily was carried out for 7 days postoperatively. The second group received 2g oral Amoxicillin one hour before surgery. In the third group the patients received placebo. The parameters that we evaluated were swelling, trismus and pain. All data were tabulated and statistical analyzed by test. Results: This investigation revealed a higher efficacy of the therapy with amoxicillin to swelling and trismus postoperative control. Our results demonstrated no statically significant differences with regard to pain. Conclusions: Our results showed that a single dose before surgery is as well as the 7 day- treatment after surgery to prevent postoperative trismus, and better to swelling postoperative control and therefore should be recommended.

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La remoción quirúrgica de los terceros molares puede resultar en algunos casos en infecciones bacterianas en el período postoperatorio. Por consiguiente existe mucha controversia acerca de la necesidad de tratamiento antibiótico profiláctico. Objetivo: El objetivo del presente estudio fue evaluar la necesidad de tratamiento antibiótico sistémico profiláctico en la remoción de los terceros molares asintomáticos. Pacientes y Métodos: Cuarenta y cinco pacientes fueron seleccionados al azar para recibir el protocolo antibiótico. Se establecieron tres grupos. El primer grupo recibió 500mg de Amoxicilina oral, 3 veces al día por 7 días luego de realizada la intervención quirúrgica. El segundo grupo recibió una única dosis de 2g de Amoxicilina oral, una hora antes de la cirugía. En el tercer grupo los pacientes recibieron placebo. Los parámetros evaluados fueron infección, y los posibles efectos adversos a la medicación implementada. Todos los datos fueron tabulados y estadísticamente analizados. Resultados: Los pacientes incluidos en el grupo A y B no mostraron infección, en cambio en tres pacientes del grupo C se observó el desarrollo de un proceso infeccioso, esto fue estadísticamente significativo. No encontramos diferencia significativa entre el primer y segundo grupo. Conclusiones: Nuestros resultados mostraron que una sola dosis de antibiótico antes de la cirugía parece ser tan buena como el tratamiento de 7 días, después de la cirugía para prevenir la infección postoperatoria, y por consiguiente debería ser recomendada.

The surgical removal of third molar teeth can result in bacterial infections disease. Therefore, controversy has arisen about the necessity of prophylactic antibiotic treatment. Purpose: The aim the present study was to evaluate the need for prophylactic oral antibiotic treatment in the removal of asymtomatic third molars. Patients and Methods: Forty five patients were assigned at randon for antibiotic protocol.Three groups were established In the first group, antibiotic treatment with oral Amoxicillin 500mg, 3 times daily was carried out for 7 days postoperatively. The second group received 2g oral Amoxicillin one hour before surgery. In the third group the patients received placebo. We evaluated infection and adverse postperative side effects. All data were tabulated and statistical analyzed by test. Results: In three patients, an infection was developed. All patients belonged to the placebo group, showed significant differences. We could not find any significant difference between the first group and second group. Conclusions: Our results showed that a single dose before surgery could be so effective than the 7 day- treatment after surgery to prevent postoperative infection, and therefore should be recommended.