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Volumetric muscle loss (VML) represents a devastating extremity injury which leads to chronic functional deficits and disability and is unrecoverable through normal healing pathways. When left untreated, the VML pathophysiology creates many challenges towards successful treatment, such as altered residual muscle architecture, excessive fibrosis, and contracture(s). As such, innovative approaches and technologies are needed to prevent or reverse these adverse sequelae. Development of a rationally designed biomaterial technology which is intended to be acutely placed within a VML defect - i.e., to serve as a muscle void filler (MVF) by maintaining the VML defect - could address this clinical unmet need by preventing these adverse sequelae as well as enabling multi-staged treatment approaches. To that end, three biomaterials were evaluated for their ability to serve as a provisional MVF treatment intended to stabilize a VML defect in a rat model for an extended period (28 days): polyvinyl alcohol (PVA), hyaluronic acid and polyethylene glycol combination (HA + PEG), and silicone, a clinically used soft tissue void filler. HA + PEG biomaterial showed signs of deformation, while both PVA and silicone did not. There were no differences between treatment groups for their effects on adjacent muscle fiber count and size distribution. Not surprisingly, silicone elicited robust fibrotic response resulting in a fibrotic barrier with a large infiltration of macrophages, a response not seen with either the PVA or HA + PEG. Taken together, PVA was found to be the best material to be used as a provisional MVF for maintaining VML defect volume while minimizing adverse effects on the surrounding muscle.

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PURPOSE: In military trauma, disaster medicine, and casualties injured in remote locations, times to advanced medical and surgical treatment are often prolonged, potentially reducing survival and increasing morbidity. Since resuscitation with blood/blood components improves survival over short pre-surgical times, this study aimed to evaluate the quality of resuscitation afforded by blood/blood products or crystalloid resuscitation over extended 'pre-hospital' timelines in a porcine model of militarily relevant traumatic haemorrhagic shock. METHODS: This study underwent local ethical review and was done under the authority of Animals (Scientific Procedures) Act 1986. Forty-five terminally anaesthetised pigs received a soft tissue injury to the right thigh, haemorrhage (30% blood volume and a Grade IV liver injury) and fluid resuscitation initiated 30 min later [Group 1 (no fluid); 2 (0.9% saline); 3 (1:1 packed red blood cells:plasma); 4 (fresh whole blood); or 5 (plasma)]. Fluid (3 ml/kg bolus) was administered during the resuscitation period (maximum duration 450 min) when the systolic blood pressure fell below 80 mmHg. Surviving animals were culled with an overdose of anaesthetic. RESULTS: Survival time was significantly shorter for Group 1 compared to the other groups (P < 0.05). Despite the same triggers for resuscitation when compared to blood/blood components, saline was associated with a shorter survival time (P = 0.145), greater pathophysiological burden and significantly greater resuscitation fluid volume (P < 0.0001). CONCLUSION: When times to advanced medical care are prolonged, resuscitation with blood/blood components is recommended over saline due to the superior quality and stability of resuscitation achieved, which are likely to lead to improved patient outcomes.

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This study aims to investigate and address the issue of emergency department (ED) overcrowding, a significant problem worldwide. The study seeks to understand the impacts of ED overcrowding on emergency medical healthcare services and patient outcomes. This systematic review follows the PRISMA flow diagram and the guidelines of the Cochrane Handbook. We systematically reviewed the causes and solutions of emergency department overcrowding. We went through Google Scholar, the National Center for Biotechnology Information, the British Medical Journal, Science Direct, Ovid, Cochrane, the Saudi Journal of Emergency Medicine, Medline, and PubMed as databases. Our criteria were articles done in Saudi Arabia from 2012 to 2022. One hundred and ninety-six (196) research papers were extracted; only 28 articles met our paper inclusion-exclusion criteria. The result of these papers regarding causes, consequences, and solutions was that non-urgent and returned visits lacked knowledge of PHC, triad, and telemedicine services. Prolonged LOS is due to slow bed turnover, laboratory and consultation time, and physical response to the final decision resulting in burnout staff, wrong diagnoses, and management plans. The crowding issues can be resolved by awareness, PHC access, triad systems, and technological and telemedicine services. High demand for emergency treatment should not be a hindrance to quality treatment. Physical, technological, and strategic measures should be put in place to fight the crowding problem in EDs in Saudi Arabia, as it may cause adverse effects such as transmission of diseases and death of patients.

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Prolonged Casualty Care (PCC) is a major US military research focus area. PCC is defined as the need to provide patient care for extended periods when evacuation or mission requirements surpass capabilities and/or capacity. US military experts have called for more data relevant to PCC. In response, we aimed to develop an innovative research model using a tiered system of trauma care in the Western Cape of South Africa as a framework for studying relevant US military trauma care and outcomes in a natural prolonged care environment. The objective of this report is to describe the research model and to illustrate how various components of the model may be helpful to provide data relevant to US military PCC. To develop the model, we used a combination of published data, open access reports, and expert opinion to identify, define, and compare relevant components of the Western Cape trauma system suitable for researching aspects of US military PCC. Several key features of the research model are as follows: In the Western Cape, patients are referred from primary and secondary to tertiary facilities (analogous to escalating capabilities by advancing roles of care in the US military). Western Cape civilian trauma providers' capabilities range from prehospital basic life support to definitive trauma surgical and critical care (comparable to US military Tactical Combat Casualty Care to advanced definitive surgical care). Patterns of injuries (e.g., high rates of penetrating trauma and hemorrhagic shock) and prolonged times from injury to definitive surgical care in the Western Cape system have relevance to the US military. This civilian research model for studying PCC is promising and can inform US military research. Importantly, this model also fills gaps in the South African civilian system and is useful for other prolonged trauma care communities worldwide.

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O crescimento da população envelhecida tem apontado para a necessidade da rede de recursos para atender as demandas desta população em diversos âmbitos, sendo a saúde um destes âmbitos. Entende-se que os Determinantes Sociais em Saúde são os fatores sociais, econômicos, culturais, étnico-raciais, psicológicos e comportamentais que influenciam na ocorrência de problemas de saúde e em fatores de risco na população. O estudo se propõe a analisar as situações que implicam na internação prolongada de idosos a partir de vivências cotidianas com familiares e usuários em um hospital filantrópico de Porto Alegre. Trata-se de pesquisa documental e de campo com uma amostra intencional de 10 usuários com características de internação prolongada, isto é, com mais de noventa dias de internação. Foram utilizados como instrumento de produção de dados os prontuários de todos os usuários e entrevistas com dois usuários e um familiar, bem como os diários de campo da pesquisadora com o registro dos relatos e observações do cotidiano do hospital. A análise do material do diário de campo e entrevistas seguiu o referencial da análise de conteúdo temática. Os dados dos prontuários foram inseridos em planilha de Excel e trabalhados na perspectiva da estatística descritiva. Observou-se que os determinantes sociais em saúde, como: renda, domicílio e rede de apoio, interferem na ocorrência da internação prolongada. O estudo possibilitou entendermos a implicação dos determinantes sociais na saúde e a repercussão destes na internação prolongada dos usuários em questão.

The growth of the aging population has pointed to the need for a network of resources to meet the demands of this population in several areas, with health being one of these areas. It is understoodthat Social Determinants of Health are the social, economic, cultural, ethnic-racial, psychological and behavioral factors that influence the occurrence of health problems and their risk factors in the population. The study aims to analyze the situations that imply prolonged hospitalization of the elderly from daily experiences with family members and users in a philanthropic hospital in Porto Alegre. This is documentary and field research with an intentional sample of 10 users with characteristics of prolonged hospitalization, that is, with more than ninety days of hospitalization. The medical records of all users and interviews with two users and a family member were used as a data production instrument, as well as the researcher's field diaries with the record of the hospital's daily reports and observations. The analysis of the material from the field diary and interviews followed the thematic content analysis framework, the data from the medical records were inserted into an Excel spreadsheet and worked from the perspective of descriptive statistics. The social determinants in health, such as: income, home and support network, interfere in the occurrence of prolonged hospitalization. The study made it possible to understand the implication of social determinants in health and the repercussion in these prolonged hospitalizations of the users in question.

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Prolonged field care (PFC) has emerged as a recent area of focus for US military Special Operations Forces (SOF) medical experts. Focused on the current reality of providing medical care to military forces often deployed in remote and austere locations far from medical support or a robust casualty evacuation chain, PFC encompasses evolving operational situations not unlike many wilderness medicine practice environments. SOF currently operates in all areas of the world and on a variety of different missions, which finds these small teams far from the accustomed practice environment of robust deployed medical infrastructure commonly seen during the last 15 years of military conflicts. In light of this evolving operational situation, the Prolonged Field Care Working Group has undertaken a comprehensive approach to better define and tackle this challenge. The approach to training and educating SOF medics on PFC is based on defined capabilities and operational situations that incorporate best medical practices and seeks to place advance resuscitative capabilities into the hands of providers closest to the point of injury. By transitioning from an approach solely driven by acute trauma aide, incorporating the best practices of Tactical Combat Casualty Care (TCCC), PFC builds upon best practices for the continuing management of both medical and trauma patients in wilderness environments. PFC incorporates best practices in generally hospital-based management of serious and critical casualties to decrease both mortality and morbidity in austere, prehospital operational settings.

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