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Resumen: El oxímetro de pulso, un dispositivo común en diferentes áreas hospitalarias, sobre todo en áreas críticas, es utilizado la mayoría de las ocasiones para evaluar el estado respiratorio del paciente; sin embargo, la evidencia actual muestra que este dispositivo nos puede brindar información valiosa del comportamiento hemodinámico, la respuesta del sistema nervioso autónomo y la terapéutica que se realiza al paciente crítico. Es por este motivo, que conocer los fundamentos de la oximetría, los valores más allá de la oxigenación como la forma de onda pletismográfica y el índice de perfusión resulta en una cantidad de información importante para la toma de decisiones y la respuesta a los tratamientos realizados.
Abstract: The pulse oximeter, a common device in different hospital areas, especially in critical areas, is used most of the time to assess the patient's respiratory status; however, current evidence shows that this device can provide us with valuable information on hemodynamic behavior, the response of the autonomic nervous system, and the therapy given to critically ill patients. It is for this reason that knowing the fundamentals of oximetry, values beyond oxygenation such as the plethysmographic waveform and the perfusion index results in an important amount of information for decision making and the response to the treatments performed.
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Resumo Fundamento A busca por métodos clinicamente úteis de avaliação de doenças ateroscleróticas, com boa acurácia, de baixo custo, sem invasividade e de fácil manejo, há anos vem sendo estimulada. Dessa forma, os índices aterogênicos avaliados deste estudo podem se encaixar nesta demanda crescente. Objetivos Avaliar o potencial dos índices aterogênicos como métodos de avaliação de pacientes portadores de aterosclerose clínica. Métodos Estudo transversal de centro único, por meio do qual foram avaliados os índices de Castelli I e II, índice aterogênico plasmático (IAP), índice de combinação de lipoproteínas e a variação do índice de perfusão periférica entre 90 e 120 segundos após um estímulo vasodilatador endotélio-dependente (ΔIPP90-120) na predição de aterosclerose. A significância estatística foi estabelecida em p < 0,05. Resultados A amostra foi composta por 298 indivíduos com idade média de 63,0 ± 16,1 anos, dos quais 57,4% eram mulheres. Comparações pareadas da análise curva ROC dos índices que alcançaram área sob a curva (ASC) > 0,6 mostram que ΔIPP90-120 e IAP foram superiores aos demais índices, sem diferenças observadas entre si (diferença entre ASC = 0,056; IC95% -0,003-0,115). Ademais, tanto a ΔIPP90-120 [odds ratio (OR) 9,58; IC95% 4,71-19,46] quanto o IAP (OR 5,35; IC95% 2,30-12,45) foram preditores independentes de aterosclerose clínica. Conclusões O IAP e ΔIPP90-120 apresentaram melhor acurácia para discriminar aterosclerose clínica. Além disso, foram preditores independentes de aterosclerose clínica, evidenciando uma possibilidade promissora para o desenvolvimento de estratégias preventivas e de controle para doenças cardiovasculares. Tratam-se, portanto, de marcadores adequados para estudos multicêntricos do ponto de vista de praticidade, custo e validade externa.
Abstract Background The search for clinically useful methods to assess atherosclerotic diseases (ASCVD) with good accuracy, low cost, non-invasiveness, and easy handling has been stimulated for years. Thus, the atherogenic indices evaluated in this study may fit this growing demand. Objectives To assess the potential of atherogenic indices to evaluate patients with clinical atherosclerosis. Methods Single-center cross-sectional study, through which the Castelli I and II indices, the atherogenic index of plasma (AIP), the lipoprotein combine index, and the variation in the peripheral perfusion index between 90 and 120 seconds after an endothelium-dependent (ΔPI90-120) vasodilator stimulus were evaluated in the prediction of atherosclerosis. Statistical significance was set at p < 0.05. Results The sample consisted of 298 individuals with an average age of 63.0±16.1 years, of which 57.4% were women. Paired comparisons of the ROC curve analysis of the indices that reached the area under the curve (AUC) > 0.6 show that ΔPI90-120 and AIP were superior to other indices, and no differences were observed between them (difference between AUC = 0.056; 95%CI -0.003-0.115). Furthermore, both the ΔPI90-120 [odds ratio (OR) 9.58; 95%CI 4.71-19.46)] and AIP (OR 5.35; 95%CI 2.30-12.45) were independent predictors of clinical atherosclerosis. Conclusions The AIP and ΔPI90-120 represented better accuracy in discriminating clinical ASCVD. Moreover, they were independent predictors of clinical ASCVD, evidencing a promising possibility for developing preventive and control strategies for cardiovascular diseases. Therefore, they are markers for multicenter studies from the point of view of practicality, low cost, and external validity.
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ABSTRACT Objective: To measure the prognostic value of peripheral ischemic microvascular reserve in the context of persistent sepsis-induced hyperlactatemia and measure its influence on the temporal dynamics of lactate and the strength of association between these variables. Methods: This post hoc analysis of the peripheral perfusion index/postocclusive reactive hyperemia trial, an observational cohort study that enrolled patients with sepsis who persisted with lactate levels ≥ 2mmol/L after fluid resuscitation (with or without shock). Peripheral ischemic microvascular reserve was evaluated using the association of the peripheral perfusion index and postocclusive reactive hyperemia techniques. The cutoff point of ∆ peripheral perfusion index peak values (%) defined the groups with low (≤ 62%) and high peripheral ischemic microvascular reserve (> 62%). Results: A total of 108 consecutive patients with persistent sepsis-induced hyperlactatemia were studied. The high peripheral ischemic microvascular reserve group showed higher 28-day mortality than the low peripheral ischemic microvascular reserve group (p < 0.01). The temporal dynamics of lactate within the first 48 hours showed a rapid decrease in lactate levels in the low peripheral ischemic microvascular reserve group (p < 0.01). However, this result was not reproduced in the linear mixed effects model. A weak correlation between peripheral ischemic microvascular reserve (%) and lactate level (mmol/L) was observed within the first 24 hours (r = 0.23; p < 0.05). Conclusion: The prognostic value of high peripheral ischemic microvascular reserve was confirmed in the context of persistent sepsis-induced hyperlactatemia. Although there was a weak positive correlation between peripheral ischemic microvascular reserve value and lactate level within the first 24 hours of sepsis diagnosis, the low peripheral ischemic microvascular reserve group appeared to have a faster decrease in lactate over the 48 hours of follow-up.
RESUMO Objetivo: Avaliar o valor prognóstico da reserva microvascular isquêmica periférica no contexto da hiperlactatemia persistente induzida pela sepse, determinar sua influência na dinâmica temporal de lactato e analisar a força da associação entre essas variáveis. Métodos: Análise post hoc do estudo de índice de perfusão periférica/hiperemia reativa pós-oclusiva caracterizada por uma coorte observacional que incluiu pacientes com sepse que persistiram com níveis de lactato ≥ 2mmol/L após a ressuscitação volêmica (com ou sem choque). A reserva microvascular isquêmica periférica foi mensurada utilizando-se a associação dos métodos do índice de perfusão periférica e hiperemia reativa pós-oclusiva. O ponto de corte dos valores da ∆ índice de perfusão periférica de pico (%) definiu os grupos com baixa (≤ 62%) e alta (> 62%) reserva microvascular isquêmica periférica. Resultados: Estudaram-se 108 pacientes consecutivos com hiperlactatemia persistente induzida pela sepse. O grupo com alta reserva microvascular isquêmica periférica apresentou maior mortalidade aos 28 dias em relação ao grupo com baixa reserva microvascular isquêmica periférica (p < 0,01). A dinâmica temporal de lactato nas primeiras 48 horas mostrou redução rápida dos níveis de lactato no grupo com baixa reserva microvascular isquêmica periférica (p < 0,01). No entanto, esse resultado não foi reproduzido no modelo de efeitos mistos lineares. Observou-se fraca correlação (%) entre os valores da reserva microvascular isquêmica periférica e níveis de lactato (mmol/L) nas primeiras 24 horas (r = 0,23; p < 0,05). Conclusão: O valor prognóstico da alta reserva microvascular isquêmica periférica foi confirmado no contexto da hiperlactatemia persistente induzida por sepse. Embora tenha sido observada uma baixa correlação positiva entre os valores da reserva microvascular isquêmica periférica e os níveis de lactato nas primeiras 24 horas do diagnóstico de sepse, o grupo com baixa reserva microvascular isquêmica periférica pareceu apresentar redução mais rápida do lactato nas 48 horas de seguimento.
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RESUMO Objetivo: Avaliar possíveis mecanismos atribuídos ao valor prognóstico da reserva microvascular isquêmica periférica em pacientes com sepse. Métodos: Este estudo de coorte observacional incluiu 46 pacientes consecutivos com sepse em uma unidade de terapia intensiva entre novembro de 2020 e outubro de 2021. Após a ressuscitação volêmica com fluidos, avaliou-se a reserva microvascular isquêmica periférica mediante a associação dos testes hiperemia reativa pós-oclusão e índice de perfusão periférica. Adicionalmente, amostras de sangue venoso periférico foram coletadas para avaliar os níveis dos neuropeptídeos substância P e peptídeo relacionado ao gene da calcitonina no membro superior do paciente antes e imediatamente após o teste de hiperemia reativa pós-oclusão. Resultados: Não houve correlação estatisticamente significativa (p > 0,05) entre os valores basais ou variações dos níveis de neuropeptídeos e a reserva microvascular isquêmica periférica. Conclusão: Embora o peptídeo relacionado ao gene da calcitonina e a substância P possam desempenhar papel prognóstico na sepse, esses neuropeptídeos não parecem contribuir para a reserva microvascular isquêmica periférica.
ABSTRACT Objective: To evaluate the mechanisms attributed to the prognostic value of peripheral ischemic microvascular reserve in patients with sepsis. Methods: This observational cohort study enrolled 46 consecutive septic patients in the intensive care unit between November 2020 and October 2021. After fluid resuscitation, the peripheral ischemic microvascular reserve was evaluated using the association of postocclusion reactive hyperemia with the peripheral perfusion index. Additionally, peripheral venous blood samples were used to evaluate the neuropeptide calcitonin gene-related peptide and substance P levels in the upper limb before and immediately after postocclusion reactive hyperemia Results: There was no statistically significant correlation (p > 0.05) between basal values (pg/mL) or variations from neuropeptide levels (%) and the peripheral ischemic microvascular reserve (%). Conclusion: Although calcitonin gene-related peptide and substance P may have a prognostic role in sepsis, these neuropeptides do not appear to contribute to peripheral ischemic microvascular reserve.
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ABSTRACT BACKGROUND: Many scoring systems for predicting mortality, rebleeding and transfusion needs among patients with upper gastrointestinal bleeding (UGIB) have been developed. However, no scoring system can predict all these outcomes. OBJECTIVE: To show whether the perfusion index (PI), compared with the Rockall score (RS), helps predict transfusion needs and prognoses among patients presenting with UGIB in emergency departments. In this way, critical patients with transfusion needs can be identified at an early stage. DESIGN AND SETTING: Prospective cohort study in an emergency department in Turkey, conducted between June 2018 and June 2019. METHODS: Patients' demographic parameters, PI, RS, transfusion needs and prognosis were recorded. RESULTS: A total of 219 patients were included. Blood transfusion was performed in 174 patients (79.4%). The PI cutoff value for prediction of the need for blood transfusion was 1.17, and the RS cutoff value was 5. The area under the curve (AUC) value for PI (AUC: 0.772; 95% confidence interval, CI: 0.705-0.838; P < 0.001) was higher than for RS (AUC: 0.648; 95% CI: 0.554-0.741; P = 0.002). 185 patients (84.5%) were discharged, and 34 patients (15.5%) died. The PI cutoff value for predicting mortality was 1.1, and the RS cutoff value was 7. The AUC value for PI (AUC: 0.743; 95% CI: 0.649-0.837; P < 0.001) was higher than for RS (AUC: 0.725; 95% CI: 0.639-0.811; P < 0.001). CONCLUSION: PI values for patients admitted to emergency departments with UGIB on admission can help predict their need for transfusion and mortality risk.
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Humanos , Triaje , Índice de Perfusión , Pronóstico , Índice de Severidad de la Enfermedad , Estudios Prospectivos , Curva ROC , Medición de Riesgo , Servicio de Urgencia en Hospital , Hemorragia Gastrointestinal/diagnóstico , Hemorragia Gastrointestinal/terapiaRESUMEN
BACKGROUND: We investigated the performance of the Perfusion Index (PI) derived from pulse oximetry waveform as a tool for assessment of anesthetic depth in comparison with A-line Autoregression Index (AAI) derived from analysis of Middle-Latency Auditory Evoked Potentials (MLAEP) waveform integrated by aepEXplus monitor in children receiving sevoflurane anesthesia for tonsillectomy. METHODS: Forty-one patients (4-12 years old) were included in this study. The PI and AAI were recorded simultaneously every minute during different stages of anesthesia delivery. The statistical tests included descriptive analysis, significance tests, correlation tests, and Receiver Operating Characteristic (ROC) curve. The AAI served as a reference. RESULTS: The PI significantly decreased during light anesthesia and recovery, and significantly increased during deeper planes of anesthesia, with an inverse mirror-image relationship with the AAI. A negative correlation of low to moderate degree was detected between PI and AAI during the study (p > 0.05), that reached a statistical significance at the 5th minute during sevoflurane mask induction (r = -0.457, p = 0.008). ROC analysis at an AAI < 25 extracted the best cut-off value for PI before intubation as 1.48 (AUC = 0.698 [0.537-0.859], 94.4% sensitivity, 44.5% specificity) and at 10-minute intraoperatively as 2.4 (AUC = 0.537 [0.354-0.721], 91.7% sensitivity, 31% specificity). During recovery, at an AAI ≥ 50, the best cutoff was 1.82 (AUC = 0.661 [0.46-0.863], 100% sensitivity and 50% specificity) 2 minutes before spontaneous eye opening. CONCLUSIONS: Compared with the AAI, the PI can track changes in depth of anesthesia in pediatric patients undergoing tonsillectomy under sevoflurane anesthesia. TRIAL REGISTRATION: Clinical Trials. Gov. Identifier: NCT03412214.
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Background: The ductus arteriosus is a necessary structure in fetal circulation, and its patency can produce hemodynamic alterations. The diagnostic gold standard is echocardiography, not always available. In the neonatal intensive care unit (NICU), they have pulse oximetry that measures perfusion index (PI), which could be used as a diagnostic tool in hemodynamically significant patent ductus arteriosus (HSPDA). Objective: The objective of the study was to correlate the PI increment (ΔPI) in 24 and 72 h after birth with HSPDA in premature newborns of NICU in a second-level hospital. Materials and methods: This is an analytic prospective study which included neonates of 26-34 weeks of gestational age, without comorbidities, who underwent echocardiography and measurement of PI in arm and leg, 24 and 72 h after birth. We did bivariate analysis with X2/exact Fisher's test and Student's t-test/Mann-Whitney U-test, besides Spearman correlation and linear regression for value prediction. Results: We included 39 premature newborns. We did not find significant differences between patients without and with HSPDA (median: 0.22 [0.06-0.58] vs. 0.03 [-0.27-0.2]; p = 0.09) at 24 h neither 72 h after birth (median: 0.2 [0-0.47] vs. 0.45 [-0.37-0.76]; p = 0.47). We found a positive correlation between ductus arteriosus diameter (DAD) and ΔPI (r: 0.78; confidence interval 95%: 0.6-0.88; p = 0.01). The prediction formula with linear regression is expressed this way: DAD = 1.31 + (2.05 × ΔIP). Conclusions: The PI does not allow us to discriminate between patient without and with HSPDA. The ΔPI could be a tool for the monitorization of DAD in neonates 72 h after birth.
Antecedentes: El conducto arterioso es una estructura necesaria en la circulación fetal, su persistencia puede provocar alteraciones hemodinámicas. El estándar de oro diagnóstico es la ecocardiografía, no siempre disponible. Las unidades de cuidados intensivos neonatales (UCIN) cuentan con oximetría de pulso, que mide el índice de perfusión (IP), el cual podría funcionar como auxiliar en el diagnóstico de persistencia del conducto arterioso hemodinámicamente significativo (PCAHs). Objetivo: Correlacionar el incremento del índice de perfusión (ΔIP) a las 24 y 72 h de vida extrauterina con PCAHs en recién nacidos prematuros de la UCIN de un hospital de segundo nivel. Materials y métodos: Estudio de cohorte analítico prospectivo donde se incluyeron neonatos de 26 a 34 semanas de gestación, sin comorbilidades, a quienes se les realizó ecocardiograma y medición de IP en brazo y pierna a las 24 y 72 h. Se efectuó análisis bivariante con Y2/prueba exacta de Fisher y t de Student/U de Mann-Whitney, además correlación de Spearman y regresión lineal para predicción de valores. Resultados: Se incluyeron 39 prematuros. No se encontró diferencia significativa entre los pacientes sin y con PCAHs (mediana: 0.22 [0.06, 0.58] vs. 0.03 [0.27, 0.2]; p = 0.09) a las 24 h de vida y tampoco a las 72 h de vida (mediana: 0.2 [0, 0.47] vs. 0.45 [0.37, 0.76], p = 0.47). Se encontró una correlación positiva entre el diámetro del conducto arterioso (DCA) y el ΔIP (r: 0.78; IC 95%: 0.60-0.88; p = 0.01). La fórmula de predicción por regresión lineal se expresa así: DCA = 1.31 + (2.05 x ΔIP). Conclusiones: El IP no permite discriminar entre pacientes sin y con PCAHs. El ΔIP podría ser una herramienta para la monitorización del diámetro del conducto en neonatos después de las 72 h de vida.
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Conducto Arterioso Permeable/diagnóstico , Índice de Perfusión , Correlación de Datos , Conducto Arterioso Permeable/fisiopatología , Femenino , Hemodinámica , Humanos , Recién Nacido , Recien Nacido Prematuro , Masculino , Estudios Prospectivos , Factores de TiempoRESUMEN
Background: The ductus arteriosus is a necessary structure in fetal circulation, and its patency can produce hemodynamic alterations. The diagnostic gold standard is echocardiography, not always available. In the neonatal intensive care unit (NICU) they have pulse oximetry that measures perfusion index (PI), which could be used as a diagnostic tool in hemodynamic significant patent ductus arteriosus (HSPDA). Objective: To correlate the perfusion index increment (ΔPI) in 24 and 72 h after birth with HSPDA in premature newborns of NICU in a second level hospital. Materials and methods: This is an analytic prospective study which included neonates of 26-34 weeks of gestational age, without comorbidities, who underwent echocardiography and measurement of PI in arm and leg, 24 and 72 h after birth. We did bivariate analysis with Y2/exact Fisher test and Student t-test/Mann-Whitney U test, besides Spearman correlation and linear regression for value prediction. Results: We included 39 premature newborns. We did not find significant differences between patients without and with HSPDA (Median: 0.22 [0.06-0.58] vs. 0.03 [-0.27-0.2]; p = 0.09) at 24 h neither 72 h after birth (Median: 0.2 [0-0.47] vs. 0.45 [-0.37-0.76]; p = 0.47). We found a positive correlation between ductus arteriosus diameter (DAD) and ΔPI (r: 0.78; CI 95%: 0.6-0.88; p = 0.01). The prediction formula with linear regression is expressed this way: DAD = 1.31 + (2.05 x ΔIP). Conclusions: The PI doesn´t allow us to discriminate between patient without and with HSPDA. The ΔPI could be a tool for the monitorization of DAD in neonates 72 h after birth.
Antecedentes: El conducto arterioso es una estructura necesaria en la circulación fetal, su persistencia puede provocar alteraciones hemodinámicas. El estándar de oro diagnóstico es la ecocardiografía, no siempre disponible. Las unidades de cuidados intensivos neonatales (UCIN) cuentan con oximetría de pulso, que mide el índice de perfusión (IP), el cual podría funcionar como auxiliar en el diagnóstico de persistencia del conducto arterioso hemodinámicamente significativo (PCAHs). Objetivo: Correlacionar el incremento del índice de perfusión (ΔIP) a las 24 y 72 h de vida extrauterina con PCAHs en recién nacidos prematuros de la UCIN de un hospital de segundo nivel. Material y métodos: Estudio de cohorte analítico prospectivo donde se incluyeron neonatos de 26 a 34 semanas de gestación, sin comorbilidades, a quienes se les realizó ecocardiograma y medición de IP en brazo y pierna a las 24 y 72 h. Se efectuó análisis bivariante con Y2/prueba exacta de Fisher y t de Student/U de Mann-Whitney, además correlación de Spearman y regresión lineal para predicción de valores. Resultados: Se incluyeron 39 prematuros. No se encontró diferencia significativa entre los pacientes sin y con PCAHs (mediana: 0.22 [0.06, 0.58] vs. 0.03 [0.27, 0.2]; p = 0.09) a las 24 h de vida y tampoco a las 72 h de vida (mediana: 0.2 [0, 0.47] vs. 0.45 [0.37, 0.76], p = 0.47). Se encontró una correlación positiva entre el diámetro del conducto arterioso (DCA) y el ΔIP (r: 0.78; IC 95%: 0.60-0.88; p = 0.01). La fórmula de predicción por regresión lineal se expresa así: DCA = 1.31 + (2.05 x ΔIP). Conclusiones: El IP no permite discriminar entre pacientes sin y con PCAHs. El ΔIP podría ser una herramienta para la monitorización del diámetro del conducto en neonatos después de las 72 h de vida.
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Resumen Antecedentes: El conducto arterioso es una estructura necesaria en la circulación fetal, su persistencia puede provocar alteraciones hemodinámicas. El estándar de oro diagnóstico es la ecocardiografía, no siempre disponible. Las unidades de cuidados intensivos neonatales (UCIN) cuentan con oximetría de pulso, que mide el índice de perfusión (IP), el cual podría funcionar como auxiliar en el diagnóstico de persistencia del conducto arterioso hemodinámicamente significativo (PCAHs). Objetivo: Correlacionar el incremento del índice de perfusión (ΔIP) a las 24 y 72 h de vida extrauterina con PCAHs en recién nacidos prematuros de la UCIN de un hospital de segundo nivel. Material y métodos: Estudio de cohorte analítico prospectivo donde se incluyeron neonatos de 26 a 34 semanas de gestación, sin comorbilidades, a quienes se les realizó ecocardiograma y medición de IP en brazo y pierna a las 24 y 72 h. Se efectuó análisis bivariante con Y2/prueba exacta de Fisher y t de Student/U de Mann-Whitney, además correlación de Spearman y regresión lineal para predicción de valores. Resultados: Se incluyeron 39 prematuros. No se encontró diferencia significativa entre los pacientes sin y con PCAHs (mediana: 0.22 [0.06, 0.58] vs. 0.03 [0.27, 0.2]; p = 0.09) a las 24 h de vida y tampoco a las 72 h de vida (mediana: 0.2 [0, 0.47] vs. 0.45 [0.37, 0.76], p = 0.47). Se encontró una correlación positiva entre el diámetro del conducto arterioso (DCA) y el ΔIP (r: 0.78; IC 95%: 0.60-0.88; p = 0.01). La fórmula de predicción por regresión lineal se expresa así: DCA = 1.31 + (2.05 x ΔIP). Conclusiones: El IP no permite discriminar entre pacientes sin y con PCAHs. El ΔIP podría ser una herramienta para la monitorización del diámetro del conducto en neonatos después de las 72 h de vida.
Abstract Background: The ductus arteriosus is a necessary structure in fetal circulation, and its patency can produce hemodynamic alterations. The diagnostic gold standard is echocardiography, not always available. In the neonatal intensive care unit (NICU) they have pulse oximetry that measures perfusion index (PI), which could be used as a diagnostic tool in hemodynamic significant patent ductus arteriosus (HSPDA). Objective: To correlate the perfusion index increment (ΔPI) in 24 and 72 h after birth with HSPDA in premature newborns of NICU in a second level hospital. Materials and methods: This is an analytic prospective study which included neonates of 26-34 weeks of gestational age, without comorbidities, who underwent echocardiography and measurement of PI in arm and leg, 24 and 72 h after birth. We did bivariate analysis with Y2/exact Fisher test and Student t-test/Mann-Whitney U test, besides Spearman correlation and linear regression for value prediction. Results: We included 39 premature newborns. We did not find significant differences between patients without and with HSPDA (Median: 0.22 [0.06-0.58] vs. 0.03 [0.27-0.2]; p = 0.09) at 24 h neither 72 h after birth (Median: 0.2 [0-0.47] vs. 0.45 [0.37-0.76]; p = 0.47). We found a positive correlation between ductus arteriosus diameter (DAD) and ΔPI (r: 0.78; CI 95%: 0.6-0.88; p = 0.01). The prediction formula with linear regression is expressed this way: DAD = 1.31 + (2.05 x ΔIP). Conclusions: The PI doesn´t allow us to discriminate between patient without and with HSPDA. The ΔPI could be a tool for the monitorization of DAD in neonates 72 h after birth.
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Femenino , Humanos , Recién Nacido , Masculino , Conducto Arterioso Permeable/diagnóstico , Índice de Perfusión , Factores de Tiempo , Recien Nacido Prematuro , Estudios Prospectivos , Conducto Arterioso Permeable/fisiopatología , Correlación de Datos , HemodinámicaRESUMEN
RESUMO Objetivo: Os distúrbios microcirculatórios estão implicados no prognóstico do choque séptico. A hiporresponsividade microvascular pode ser avaliada por meio do índice de perfusão, derivado da oximetria de pulso e hiperemia reativa. Com utilização do índice de perfusão, investigamos a hiperemia reativa e sua relação com a perfusão periférica e os parâmetros clínico-hemodinâmicos no choque séptico. Métodos: Avaliaram-se 82 pacientes, 47 deles com choque séptico e 35 controles. Os exames foram realizados dentro de 24 horas após a admissão. O índice de perfusão foi avaliado antes e após uma oclusão do fluxo sanguíneo durante 3 minutos, utilizando-se análise de resposta temporal por 5 minutos. O índice de perfusão foi também avaliado nas fases hiperêmicas, principalmente com derivação de mecanismos mecanossensitivos (ΔIP0-60) e metabólicos (ΔIP60-120). Realizaram-se testes de correlação entre a hiperemia reativa e dados clínicos hemodinâmicos. Resultados: A hiperemia reativa, medida pelo índice de perfusão, foi significantemente mais baixa no choque séptico apenas até 45 segundos após a desinflação do manguito. No período restante, não houve diferenças estatisticamente significantes entre os grupos. Os picos de índice de perfusão foram similares entre os grupos, embora o pico tenha sido atingido de forma mais lenta no grupo séptico. Os valores de ΔIP0-60 foram mais baixos no choque [1% (-19% - -40%) versus 39% (6% - 75%); p = 0,001]. No entanto, o ΔIP60-120 foi similar entre os grupos [43% (18% - 93%) versus 48% (18% - 98%); p = 0,58]. O tempo até o pico do índice de perfusão se correlacionou de forma positiva com o SOFA e negativamente com os níveis de proteína C-reativa. O pico de índice de perfusão se correlacionou de forma positiva com as doses de vasopressores; os valores de ΔIP60-120 tiveram correlação positiva com o nível de proteína C-reativa e as doses de vasopressores. Não ocorreram outras correlações significantes. Conclusões: Este estudo com base no índice de perfusão sugere que o choque séptico promove hiporresponsividade vascular periférica, enquanto a reatividade vascular posterior é consideravelmente preservada. Estes resultados demonstram resposta hiperêmica periférica dependente do tempo e significante reserva isquêmica no choque séptico.
ABSTRACT Objective: Microcirculation disturbances are implicated in the prognosis of septic shock. Microvascular hyporesponsiveness can be assessed by an oximetry-derived perfusion index and reactive hyperemia. Using this perfusion index, we investigated reactive hyperemia and its relationship with peripheral perfusion and clinical-hemodynamic parameters in septic shock. Methods: Eighty-two patients were evaluated: 47 with septic shock and 35 controls. Tests were performed within 24 hours after admission. The perfusion index was evaluated before and after a 3-min blood flow occlusion using a time-response analysis for 5 min. The perfusion index was also evaluated in the hyperemic phases and was mainly derived by mechanosensitive (ΔPI0-60) and metabolic mechanisms (ΔPI60-120). Correlation tests were performed between reactive hyperemia and clinical-hemodynamic data. Results: Reactive hyperemia measured by the perfusion index was significantly lower in patients with septic shock, but this was only observed for the first 45 seconds after cuff-deflation. In the remaining period, there were no statistical differences between the groups. The peaks in the perfusion index were similar between groups, although the peak was reached more slowly in the septic group. Values of ΔPI0-60 were lower in shock [01% (-19% - -40%) versus 39% (6% - 75%); p = 0.001]. However, ΔPI60-120 was similar between the groups [43% (18% - 93%) versus 48% (18% - 98%); p = 0.58]. The time-to-peak of the perfusion index was correlated positively with the SOFA scores and negatively with C-reactive protein; the peak of the perfusion index was positively correlated with vasopressor doses; and the ΔPI60-120 values were positively correlated with C-reactive protein and vasopressor doses. No other significant correlations occurred. Conclusions: This perfusion index-based study suggests that septic shock promotes initial peripheral vascular hyporesponsiveness and preserves posterior vascular reactivity to a considerable degree. These results demonstrate a time-dependent peripheral hyperemic response and a significant ischemic reserve in septic shock.
Asunto(s)
Humanos , Masculino , Femenino , Anciano , Choque Séptico/terapia , Fluidoterapia/métodos , Hiperemia/metabolismo , Choque Séptico/fisiopatología , Factores de Tiempo , Vasoconstrictores/administración & dosificación , Proteína C-Reactiva/metabolismo , Oximetría/métodos , Estudios de Casos y Controles , Puntuaciones en la Disfunción de Órganos , Hemodinámica , Microcirculación , Persona de Mediana EdadRESUMEN
OBJECTIVE: To evaluate the efficacy of combined pulse oximetry (POX) and perfusion index (PI) neonatal screening for severe congenital heart defects (sCHD) and assess different impacts of screening in tertiary and nontertiary hospitals. STUDY DESIGN: A multicenter, prospective study in 10 tertiary and 6 nontertiary maternity hospitals. A total of 42 169 asymptomatic newborns from among 50 244 neonates were screened; exclusion criteria were antenatal sCHD diagnosis, postnatal clinically suspected sCHD, and neonatal intensive care unit admission. Eligible infants underwent pre- and postductal POX and PI screening after routine discharge examination. Targeted sCHD were anatomically defined. Positivity was defined as postductal oxygen saturation (SpO2) ≤95%, prepostductal SpO2 gradient >3%, or PI <0.90. Confirmed positive cases underwent echocardiography for definitive diagnosis. Missed cases were identified by consulting clinical registries at 6 regional pediatric heart centers. Main outcomes were incidence of unexpected sCHD; proportion of undetected sCHD after discharge in tertiary and nontertiary hospitals; and specificity, sensitivity, positive predictive value, and negative predictive value of combined screening. RESULTS: One hundred forty-two sCHD were detected prenatally. Prevalence of unexpected sCHD was 1 in 1115 live births, similar in tertiary and nontertiary hospitals. Screening identified 3 sCHD (low SpO2, 2; coarctation for low PI, 1). Four cases were missed. In tertiary hospitals, 95% of unsuspected sCHDs were identified clinically, whereas only 28% in nontertiary units; in nontertiary units PI-POX screening increased the detection rate to 71%. CONCLUSIONS: PI-POX predischarge screening provided benefits in nontertiary units, where clinical recognition rate was low. PI can help identify coarctation cases missed by POX but requires further evaluation in populations with higher rates of missed cases.